-
1
-
-
33646461282
-
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
COI: 1:CAS:528:DC%2BD28XktlCltbc%3D, PID: 16624948
-
Almeida CG, Takahashi RH, Gouras GK (2006) Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26(16):4277–4288. doi:10.1523/JNEUROSCI.5078-05.2006
-
(2006)
J Neurosci
, vol.26
, Issue.16
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
2
-
-
0029999787
-
Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
COI: 1:CAS:528:DyaK28XjvF2isr0%3D, PID: 8673924
-
Alonso AC, Grundke-Iqbal I, Iqbal K (1996) Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2(7):783–787
-
(1996)
Nat Med
, vol.2
, Issue.7
, pp. 783-787
-
-
Alonso, A.C.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
3
-
-
0035923750
-
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
-
COI: 1:CAS:528:DC%2BD3MXovFOis74%3D, PID: 11719200
-
Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B (2001) Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron 32(4):579–589
-
(2001)
Neuron
, vol.32
, Issue.4
, pp. 579-589
-
-
Annaert, W.G.1
Esselens, C.2
Baert, V.3
Boeve, C.4
Snellings, G.5
Cupers, P.6
Craessaerts, K.7
De Strooper, B.8
-
4
-
-
79959654327
-
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment
-
COI: 1:CAS:528:DC%2BC3MXos1yis7w%3D, PID: 21697390
-
Aqul A, Liu B, Ramirez CM, Pieper AA, Estill SJ, Burns DK, Repa JJ, Turley SD, Dietschy JM (2011) Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment. J Neurosci 31(25):9404–9413. doi:10.1523/JNEUROSCI.1317-11.2011
-
(2011)
J Neurosci
, vol.31
, Issue.25
, pp. 9404-9413
-
-
Aqul, A.1
Liu, B.2
Ramirez, C.M.3
Pieper, A.A.4
Estill, S.J.5
Burns, D.K.6
Repa, J.J.7
Turley, S.D.8
Dietschy, J.M.9
-
5
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease
-
COI: 1:STN:280:DyaK387psFCktw%3D%3D, PID: 1549228
-
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42(3 Pt 1):631–639
-
(1992)
Neurology
, vol.42
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
6
-
-
38349014705
-
Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling
-
COI: 1:CAS:528:DC%2BD1cXovVGhsw%3D%3D, PID: 18184791
-
Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK (2008) Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. J Neurosci 28(2):483–490. doi:10.1523/JNEUROSCI.4067-07.2008
-
(2008)
J Neurosci
, vol.28
, Issue.2
, pp. 483-490
-
-
Baki, L.1
Neve, R.L.2
Shao, Z.3
Shioi, J.4
Georgakopoulos, A.5
Robakis, N.K.6
-
7
-
-
3343005434
-
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
-
COI: 1:CAS:528:DC%2BD2cXlsVWgt7Y%3D, PID: 15192701
-
Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J 23(13):2586–2596. doi:10.1038/sj.emboj.7600251
-
(2004)
EMBO J
, vol.23
, Issue.13
, pp. 2586-2596
-
-
Baki, L.1
Shioi, J.2
Wen, P.3
Shao, Z.4
Schwarzman, A.5
Gama-Sosa, M.6
Neve, R.7
Robakis, N.K.8
-
8
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
-
COI: 1:CAS:528:DC%2BD2sXpt1Crt78%3D, PID: 17684513
-
Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders. Nat Rev Neurosci 8(9):663–672. doi:10.1038/nrn2194
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.9
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
9
-
-
0032555641
-
Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes
-
COI: 1:CAS:528:DyaK1cXlsFOqsbo%3D, PID: 9705327
-
Berg TO, Fengsrud M, Stromhaug PE, Berg T, Seglen PO (1998) Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes. J Biol Chem 273(34):21883–21892
-
(1998)
J Biol Chem
, vol.273
, Issue.34
, pp. 21883-21892
-
-
Berg, T.O.1
Fengsrud, M.2
Stromhaug, P.E.3
Berg, T.4
Seglen, P.O.5
-
10
-
-
27444437758
-
Disease-related modifications in tau affect the interaction between Fyn and Tau
-
COI: 1:CAS:528:DC%2BD2MXhtFWmtbrK, PID: 16115884
-
Bhaskar K, Yen SH, Lee G (2005) Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem 280(42):35119–35125. doi:10.1074/jbc.M505895200
-
(2005)
J Biol Chem
, vol.280
, Issue.42
, pp. 35119-35125
-
-
Bhaskar, K.1
Yen, S.H.2
Lee, G.3
-
11
-
-
14644442872
-
Intraneuronal Abeta causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic mice
-
COI: 1:CAS:528:DC%2BD2MXis1yrs7s%3D, PID: 15748844
-
Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic mice. Neuron 45(5):675–688. doi:10.1016/j.neuron.2005.01.040
-
(2005)
Neuron
, vol.45
, Issue.5
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
McGaugh, J.L.4
LaFerla, F.M.5
-
12
-
-
0022365608
-
The distribution of tau in the mammalian central nervous system
-
COI: 1:CAS:528:DyaL2MXlslKjs78%3D, PID: 3930508
-
Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101(4):1371–1378
-
(1985)
J Cell Biol
, vol.101
, Issue.4
, pp. 1371-1378
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
13
-
-
33746310315
-
Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD28XnsFymsbY%3D, PID: 16876668
-
Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer’s disease. Lancet 368(9533):387–403. doi:10.1016/S0140-6736(06)69113-7
-
(2006)
Lancet
, vol.368
, Issue.9533
, pp. 387-403
-
-
Blennow, K.1
de Leon, M.J.2
Zetterberg, H.3
-
14
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD1cXot1OqtLk%3D, PID: 18596167
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer’s disease. J Neurosci 28(27):6926–6937. doi:10.1523/JNEUROSCI.0800-08.2008
-
(2008)
J Neurosci
, vol.28
, Issue.27
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
Nixon, R.A.7
-
15
-
-
78549273390
-
Macroautophagy is not directly involved in the metabolism of amyloid precursor protein
-
COI: 1:CAS:528:DC%2BC3cXhsVCrt77F, PID: 20864542
-
Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM (2010) Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. J Biol Chem 285(48):37415–37426. doi:10.1074/jbc.M110.186411
-
(2010)
J Biol Chem
, vol.285
, Issue.48
, pp. 37415-37426
-
-
Boland, B.1
Smith, D.A.2
Mooney, D.3
Jung, S.S.4
Walsh, D.M.5
Platt, F.M.6
-
16
-
-
33749150163
-
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
-
PID: 16906426
-
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112(4):389–404. doi:10.1007/s00401-006-0127-z
-
(2006)
Acta Neuropathol
, vol.112
, Issue.4
, pp. 389-404
-
-
Braak, H.1
Alafuzoff, I.2
Arzberger, T.3
Kretzschmar, H.4
Del Tredici, K.5
-
17
-
-
84896360551
-
Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer’s disease mutation
-
Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Fuchtbauer EM, Fuchtbauer A, Holtzman DM, Takagi J, Willnow TE (2014) Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer’s disease mutation. Sci Transl Med 6(223):223ra220. doi:10.1126/scitranslmed.3007747
-
(2014)
Sci Transl Med
, vol.6
, Issue.223
, pp. 223220
-
-
Caglayan, S.1
Takagi-Niidome, S.2
Liao, F.3
Carlo, A.S.4
Schmidt, V.5
Burgert, T.6
Kitago, Y.7
Fuchtbauer, E.M.8
Fuchtbauer, A.9
Holtzman, D.M.10
Takagi, J.11
Willnow, T.E.12
-
18
-
-
34447096691
-
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
-
PID: 17579875
-
Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL 3rd, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DM (2007) Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114(1):5–22. doi:10.1007/s00401-007-0237-2
-
(2007)
Acta Neuropathol
, vol.114
, Issue.1
, pp. 5-22
-
-
Cairns, N.J.1
Bigio, E.H.2
Mackenzie, I.R.3
Neumann, M.4
Lee, V.M.5
Hatanpaa, K.J.6
White, C.L.7
Schneider, J.A.8
Grinberg, L.T.9
Halliday, G.10
Duyckaerts, C.11
Lowe, J.S.12
Holm, I.E.13
Tolnay, M.14
Okamoto, K.15
Yokoo, H.16
Murayama, S.17
Woulfe, J.18
Munoz, D.G.19
Dickson, D.W.20
Ince, P.G.21
Trojanowski, J.Q.22
Mann, D.M.23
more..
-
19
-
-
4644319713
-
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
-
COI: 1:CAS:528:DC%2BD2cXotFCmuro%3D, PID: 15465622
-
Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA (2004) Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging 25(10):1263–1272. doi:10.1016/j.neurobiolaging.2004.02.027
-
(2004)
Neurobiol Aging
, vol.25
, Issue.10
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Mehta, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
20
-
-
3843114301
-
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
-
COI: 1:CAS:528:DC%2BD2cXntlWitbo%3D, PID: 15330337
-
Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA (2004) Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol 63(8):821–830
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, Issue.8
, pp. 821-830
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Schmidt, S.D.3
Terio, N.B.4
Duff, K.5
Beard, M.6
Mathews, P.M.7
Nixon, R.A.8
-
22
-
-
84861194622
-
The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease
-
COI: 1:CAS:528:DC%2BC38XlsFWjsbg%3D, PID: 22505025
-
Chavez-Gutierrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B (2012) The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease. EMBO J 31(10):2261–2274. doi:10.1038/emboj.2012.79
-
(2012)
EMBO J
, vol.31
, Issue.10
, pp. 2261-2274
-
-
Chavez-Gutierrez, L.1
Bammens, L.2
Benilova, I.3
Vandersteen, A.4
Benurwar, M.5
Borgers, M.6
Lismont, S.7
Zhou, L.8
Van Cleynenbreugel, S.9
Esselmann, H.10
Wiltfang, J.11
Serneels, L.12
Karran, E.13
Gijsen, H.14
Schymkowitz, J.15
Rousseau, F.16
Broersen, K.17
De Strooper, B.18
-
23
-
-
56749152364
-
Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
-
COI: 1:CAS:528:DC%2BD1cXhtlyhsbfO, PID: 18974993
-
Christensen DZ, Kraus SL, Flohr A, Cotel MC, Wirths O, Bayer TA (2008) Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta Neuropathol 116(6):647–655. doi:10.1007/s00401-008-0451-6
-
(2008)
Acta Neuropathol
, vol.116
, Issue.6
, pp. 647-655
-
-
Christensen, D.Z.1
Kraus, S.L.2
Flohr, A.3
Cotel, M.C.4
Wirths, O.5
Bayer, T.A.6
-
24
-
-
84865086929
-
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
-
COI: 1:CAS:528:DC%2BC38XhtVOhtLnK, PID: 22753898
-
Coen K, Flannagan RS, Baron S, Carraro-Lacroix LR, Wang D, Vermeire W, Michiels C, Munck S, Baert V, Sugita S, Wuytack F, Hiesinger PR, Grinstein S, Annaert W (2012) Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J Cell Biol 198(1):23–35. doi:10.1083/jcb.201201076
-
(2012)
J Cell Biol
, vol.198
, Issue.1
, pp. 23-35
-
-
Coen, K.1
Flannagan, R.S.2
Baron, S.3
Carraro-Lacroix, L.R.4
Wang, D.5
Vermeire, W.6
Michiels, C.7
Munck, S.8
Baert, V.9
Sugita, S.10
Wuytack, F.11
Hiesinger, P.R.12
Grinstein, S.13
Annaert, W.14
-
25
-
-
84862166355
-
The phospholipase D1 pathway modulates macroautophagy
-
PID: 21266992
-
Dall’Armi C, Hurtado-Lorenzo A, Tian H, Morel E, Nezu A, Chan RB, Yu WH, Robinson KS, Yeku O, Small SA, Duff K, Frohman MA, Wenk MR, Yamamoto A, Di Paolo G (2010) The phospholipase D1 pathway modulates macroautophagy. Nat Commun 1:142. doi:10.1038/ncomms1144
-
(2010)
Nat Commun
, vol.1
, pp. 142
-
-
Dall’Armi, C.1
Hurtado-Lorenzo, A.2
Tian, H.3
Morel, E.4
Nezu, A.5
Chan, R.B.6
Yu, W.H.7
Robinson, K.S.8
Yeku, O.9
Small, S.A.10
Duff, K.11
Frohman, M.A.12
Wenk, M.R.13
Yamamoto, A.14
Di Paolo, G.15
-
26
-
-
84925489422
-
Autophagy in neuronal cells: general principles and physiological and pathological functions. Acta Neuropathol
-
Damme M, Suntio T, Saftig P, Eskelinen EL (2014) Autophagy in neuronal cells: general principles and physiological and pathological functions. Acta Neuropathol. doi:10.1007/s00401-014-1361-4
-
(2014)
doi:10.1007/s00401-014-1361-4
-
-
Damme, M.1
Suntio, T.2
Saftig, P.3
Eskelinen, E.L.4
-
27
-
-
77953808475
-
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3cXnvVOmsb8%3D, PID: 20434528
-
Dawson HN, Cantillana V, Jansen M, Wang H, Vitek MP, Wilcock DM, Lynch JR, Laskowitz DT (2010) Loss of tau elicits axonal degeneration in a mouse model of Alzheimer’s disease. Neuroscience 169(1):516–531. doi:10.1016/j.neuroscience.2010.04.037
-
(2010)
Neuroscience
, vol.169
, Issue.1
, pp. 516-531
-
-
Dawson, H.N.1
Cantillana, V.2
Jansen, M.3
Wang, H.4
Vitek, M.P.5
Wilcock, D.M.6
Lynch, J.R.7
Laskowitz, D.T.8
-
28
-
-
78049374467
-
Novel research horizons for presenilins and gamma-secretases in cell biology and disease
-
PID: 20604710
-
De Strooper B, Annaert W (2010) Novel research horizons for presenilins and gamma-secretases in cell biology and disease. Annu Rev Cell Dev Biol 26:235–260. doi:10.1146/annurev-cellbio-100109-104117
-
(2010)
Annu Rev Cell Dev Biol
, vol.26
, pp. 235-260
-
-
De Strooper, B.1
Annaert, W.2
-
29
-
-
84877351078
-
TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity
-
COI: 1:CAS:528:DC%2BC3sXptFeisrs%3D, PID: 23610405
-
Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Bjorklund A (2013) TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci USA 110(19):E1817–E1826. doi:10.1073/pnas.1305623110
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.19
, pp. 1817-1826
-
-
Decressac, M.1
Mattsson, B.2
Weikop, P.3
Lundblad, M.4
Jakobsson, J.5
Bjorklund, A.6
-
30
-
-
84862882173
-
Amyloid-beta–associated clinical decline occurs only in the presence of elevated P-tau
-
PID: 22529247
-
Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM (2012) Amyloid-beta–associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol 69(6):709–713. doi:10.1001/archneurol.2011.3354
-
(2012)
Arch Neurol
, vol.69
, Issue.6
, pp. 709-713
-
-
Desikan, R.S.1
McEvoy, L.K.2
Thompson, W.K.3
Holland, D.4
Brewer, J.B.5
Aisen, P.S.6
Sperling, R.A.7
Dale, A.M.8
-
31
-
-
0035110055
-
Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD3MXpvVSqsw%3D%3D, PID: 11162237
-
Ditaranto K, Tekirian TL, Yang AJ (2001) Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer’s disease. Neurobiol Dis 8(1):19–31. doi:10.1006/nbdi.2000.0364
-
(2001)
Neurobiol Dis
, vol.8
, Issue.1
, pp. 19-31
-
-
Ditaranto, K.1
Tekirian, T.L.2
Yang, A.J.3
-
32
-
-
39749165656
-
Differential regulation of dynein and kinesin motor proteins by tau
-
COI: 1:CAS:528:DC%2BD1cXit1yhsbo%3D, PID: 18202255
-
Dixit R, Ross JL, Goldman YE, Holzbaur EL (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science 319(5866):1086–1089. doi:10.1126/science.1152993
-
(2008)
Science
, vol.319
, Issue.5866
, pp. 1086-1089
-
-
Dixit, R.1
Ross, J.L.2
Goldman, Y.E.3
Holzbaur, E.L.4
-
33
-
-
84870407757
-
Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment
-
COI: 1:CAS:528:DC%2BC38XhvVWns77P, PID: 23122960
-
Dobrowolski R, Vick P, Ploper D, Gumper I, Snitkin H, Sabatini DD, De Robertis EM (2012) Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment. Cell Rep 2(5):1316–1328. doi:10.1016/j.celrep.2012.09.026
-
(2012)
Cell Rep
, vol.2
, Issue.5
, pp. 1316-1328
-
-
Dobrowolski, R.1
Vick, P.2
Ploper, D.3
Gumper, I.4
Snitkin, H.5
Sabatini, D.D.6
De Robertis, E.M.7
-
34
-
-
58149373433
-
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD1cXhsVKgsbjJ, PID: 19036982
-
Dodson SE, Andersen OM, Karmali V, Fritz JJ, Cheng D, Peng J, Levey AI, Willnow TE, Lah JJ (2008) Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer’s disease. J Neurosci 28(48):12877–12886. doi:10.1523/JNEUROSCI.4582-08.2008
-
(2008)
J Neurosci
, vol.28
, Issue.48
, pp. 12877-12886
-
-
Dodson, S.E.1
Andersen, O.M.2
Karmali, V.3
Fritz, J.J.4
Cheng, D.5
Peng, J.6
Levey, A.I.7
Willnow, T.E.8
Lah, J.J.9
-
35
-
-
0032787598
-
Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport
-
COI: 1:CAS:528:DyaK1MXkslSlsbo%3D, PID: 10369872
-
Dumanchin C, Czech C, Campion D, Cuif MH, Poyot T, Martin C, Charbonnier F, Goud B, Pradier L, Frebourg T (1999) Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum Mol Genet 8(7):1263–1269
-
(1999)
Hum Mol Genet
, vol.8
, Issue.7
, pp. 1263-1269
-
-
Dumanchin, C.1
Czech, C.2
Campion, D.3
Cuif, M.H.4
Poyot, T.5
Martin, C.6
Charbonnier, F.7
Goud, B.8
Pradier, L.9
Frebourg, T.10
-
36
-
-
84868102987
-
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease
-
COI: 1:CAS:528:DC%2BC38XhsFOqsLzE, PID: 22872701
-
Elrick MJ, Yu T, Chung C, Lieberman AP (2012) Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. Hum Mol Genet 21(22):4876–4887. doi:10.1093/hmg/dds324
-
(2012)
Hum Mol Genet
, vol.21
, Issue.22
, pp. 4876-4887
-
-
Elrick, M.J.1
Yu, T.2
Chung, C.3
Lieberman, A.P.4
-
37
-
-
4644257963
-
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
-
COI: 1:CAS:528:DC%2BD2cXotVehtLk%3D, PID: 15452145
-
Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W (2004) Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol 166(7):1041–1054. doi:10.1083/jcb.200406060
-
(2004)
J Cell Biol
, vol.166
, Issue.7
, pp. 1041-1054
-
-
Esselens, C.1
Oorschot, V.2
Baert, V.3
Raemaekers, T.4
Spittaels, K.5
Serneels, L.6
Zheng, H.7
Saftig, P.8
De Strooper, B.9
Klumperman, J.10
Annaert, W.11
-
38
-
-
84865498471
-
Peptides based on the presenilin-APP binding domain inhibit APP processing and Abeta production through interfering with the APP transmembrane domain
-
COI: 1:CAS:528:DC%2BC38XhtlGrsrzN, PID: 22661005
-
Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De Strooper B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W (2012) Peptides based on the presenilin-APP binding domain inhibit APP processing and Abeta production through interfering with the APP transmembrane domain. FASEB J 26(9):3765–3778. doi:10.1096/fj.11-201368
-
(2012)
FASEB J
, vol.26
, Issue.9
, pp. 3765-3778
-
-
Esselens, C.1
Sannerud, R.2
Gallardo, R.3
Baert, V.4
Kaden, D.5
Serneels, L.6
De Strooper, B.7
Rousseau, F.8
Multhaup, G.9
Schymkowitz, J.10
Langedijk, J.P.11
Annaert, W.12
-
39
-
-
38149044992
-
Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells
-
COI: 1:CAS:528:DC%2BD1cXit1SgsbY%3D, PID: 17999726
-
Fader CM, Sanchez D, Furlan M, Colombo MI (2008) Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic 9(2):230–250. doi:10.1111/j.1600-0854.2007.00677.x
-
(2008)
Traffic
, vol.9
, Issue.2
, pp. 230-250
-
-
Fader, C.M.1
Sanchez, D.2
Furlan, M.3
Colombo, M.I.4
-
40
-
-
35948983328
-
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
-
COI: 1:CAS:528:DC%2BD2sXht12jsbzO, PID: 17984323
-
Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerod L, Fisher EM, Isaacs A, Brech A, Stenmark H, Simonsen A (2007) Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol 179(3):485–500. doi:10.1083/jcb.200702115
-
(2007)
J Cell Biol
, vol.179
, Issue.3
, pp. 485-500
-
-
Filimonenko, M.1
Stuffers, S.2
Raiborg, C.3
Yamamoto, A.4
Malerod, L.5
Fisher, E.M.6
Isaacs, A.7
Brech, A.8
Stenmark, H.9
Simonsen, A.10
-
41
-
-
76649116890
-
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity
-
COI: 1:CAS:528:DC%2BC3cXhvFSnsL8%3D, PID: 20133839
-
Friedrich RP, Tepper K, Ronicke R, Soom M, Westermann M, Reymann K, Kaether C, Fandrich M (2010) Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci USA 107(5):1942–1947. doi:10.1073/pnas.0904532106
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.5
, pp. 1942-1947
-
-
Friedrich, R.P.1
Tepper, K.2
Ronicke, R.3
Soom, M.4
Westermann, M.5
Reymann, K.6
Kaether, C.7
Fandrich, M.8
-
42
-
-
77953543377
-
The Beclin 1-VPS34 complex–at the crossroads of autophagy and beyond
-
Funderburk SF, Wang QJ, Yue Z (2010) The Beclin 1-VPS34 complex–at the crossroads of autophagy and beyond. Trends Cell Biol 20(6):355–362. doi:10.1016/j.tcb.2010.03.002
-
(2010)
Trends Cell Biol
, vol.20
, Issue.6
, pp. 355-362
-
-
Funderburk SF, Wang QJ, Yue, Z.1
-
43
-
-
79951790558
-
Granulovacuolar degeneration (GVD) bodies of Alzheimer’s disease (AD) resemble late-stage autophagic organelles
-
COI: 1:STN:280:DC%2BC3M3gs1aqtg%3D%3D, PID: 20946470
-
Funk KE, Mrak RE, Kuret J (2011) Granulovacuolar degeneration (GVD) bodies of Alzheimer’s disease (AD) resemble late-stage autophagic organelles. Neuropathol Appl Neurobiol 37(3):295–306. doi:10.1111/j.1365-2990.2010.01135.x
-
(2011)
Neuropathol Appl Neurobiol
, vol.37
, Issue.3
, pp. 295-306
-
-
Funk, K.E.1
Mrak, R.E.2
Kuret, J.3
-
44
-
-
84897865127
-
Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2
-
PID: 24637612
-
Ghossoub R, Lembo F, Rubio A, Gaillard CB, Bouchet J, Vitale N, Slavik J, Machala M, Zimmermann P (2014) Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2. Nat Commun 5:3477. doi:10.1038/ncomms4477
-
(2014)
Nat Commun
, vol.5
, pp. 3477
-
-
Ghossoub, R.1
Lembo, F.2
Rubio, A.3
Gaillard, C.B.4
Bouchet, J.5
Vitale, N.6
Slavik, J.7
Machala, M.8
Zimmermann, P.9
-
45
-
-
0344653664
-
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease
-
COI: 1:STN:280:DyaK2s7lvVGjsw%3D%3D, PID: 9005861
-
Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease. Ann Neurol 41(1):17–24. doi:10.1002/ana.410410106
-
(1997)
Ann Neurol
, vol.41
, Issue.1
, pp. 17-24
-
-
Gomez-Isla, T.1
Hollister, R.2
West, H.3
Mui, S.4
Growdon, J.H.5
Petersen, R.C.6
Parisi, J.E.7
Hyman, B.T.8
-
46
-
-
0035943436
-
Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta 42 fibrils
-
COI: 1:STN:280:DC%2BD3MvnslKjsA%3D%3D, PID: 11520988
-
Gotz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta 42 fibrils. Science 293(5534):1491–1495. doi:10.1126/science.1062097
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
47
-
-
84883536024
-
What renders TAU toxic
-
PID: 23772223
-
Gotz J, Xia D, Leinenga G, Chew YL, Nicholas H (2013) What renders TAU toxic. Front Neurol 4:72. doi:10.3389/fneur.2013.00072
-
(2013)
Front Neurol
, vol.4
, pp. 72
-
-
Gotz, J.1
Xia, D.2
Leinenga, G.3
Chew, Y.L.4
Nicholas, H.5
-
48
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
COI: 1:CAS:528:DC%2BD1MXhsF2qtrjK, PID: 19653858
-
He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67–93. doi:10.1146/annurev-genet-102808-114910
-
(2009)
Annu Rev Genet
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
49
-
-
77951237303
-
The Beclin 1 interactome
-
COI: 1:CAS:528:DC%2BC3cXks1SrtLo%3D, PID: 20097051
-
He C, Levine B (2010) The Beclin 1 interactome. Curr Opin Cell Biol 22(2):140–149. doi:10.1016/j.ceb.2010.01.001
-
(2010)
Curr Opin Cell Biol
, vol.22
, Issue.2
, pp. 140-149
-
-
He, C.1
Levine, B.2
-
50
-
-
78650251838
-
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
-
COI: 1:CAS:528:DC%2BC3cXhsFykt7vO, PID: 21172610
-
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D (2010) Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron 68(6):1067–1081. doi:10.1016/j.neuron.2010.11.030
-
(2010)
Neuron
, vol.68
, Issue.6
, pp. 1067-1081
-
-
Hoover, B.R.1
Reed, M.N.2
Su, J.3
Penrod, R.D.4
Kotilinek, L.A.5
Grant, M.K.6
Pitstick, R.7
Carlson, G.A.8
Lanier, L.M.9
Yuan, L.L.10
Ashe, K.H.11
Liao, D.12
-
51
-
-
73949089674
-
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
-
COI: 1:CAS:528:DC%2BC3cXjtFSqsw%3D%3D, PID: 19910533
-
Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM (2009) Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci USA 106(48):20324–20329. doi:10.1073/pnas.0911281106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.48
, pp. 20324-20329
-
-
Hu, X.1
Crick, S.L.2
Bu, G.3
Frieden, C.4
Pappu, R.V.5
Lee, J.M.6
-
52
-
-
84866519178
-
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
-
COI: 1:CAS:528:DC%2BC3sXitVymsr0%3D, PID: 22998728
-
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A (2012) Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener 7:48. doi:10.1186/1750-1326-7-48
-
(2012)
Mol Neurodegener
, vol.7
, pp. 48
-
-
Inoue, K.1
Rispoli, J.2
Kaphzan, H.3
Klann, E.4
Chen, E.I.5
Kim, J.6
Komatsu, M.7
Abeliovich, A.8
-
53
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
COI: 1:CAS:528:DC%2BD1cXhsVynu77M, PID: 18843052
-
Itakura E, Kishi C, Inoue K, Mizushima N (2008) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 19(12):5360–5372. doi:10.1091/mbc.E08-01-0080
-
(2008)
Mol Biol Cell
, vol.19
, Issue.12
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
54
-
-
66349103167
-
Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes
-
COI: 1:CAS:528:DC%2BD1MXnvVyrsb8%3D, PID: 19223761
-
Itakura E, Mizushima N (2009) Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy 5(4):534–536
-
(2009)
Autophagy
, vol.5
, Issue.4
, pp. 534-536
-
-
Itakura, E.1
Mizushima, N.2
-
55
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models
-
COI: 1:CAS:528:DC%2BC3cXpvFKrtr4%3D, PID: 20655099
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wolfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Gotz J (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell 142(3):387–397. doi:10.1016/j.cell.2010.06.036
-
(2010)
Cell
, vol.142
, Issue.3
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
van Eersel, J.6
Wolfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Gotz, J.14
-
56
-
-
68949105821
-
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
-
COI: 1:CAS:528:DC%2BD1MXovFWrtLg%3D, PID: 19491104
-
Ittner LM, Ke YD, Gotz J (2009) Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem 284(31):20909–20916. doi:10.1074/jbc.M109.014472
-
(2009)
J Biol Chem
, vol.284
, Issue.31
, pp. 20909-20916
-
-
Ittner, L.M.1
Ke, Y.D.2
Gotz, J.3
-
57
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the Beclin 1 complex
-
PID: 20559548
-
Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T (2010) Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One 5(6):e11102. doi:10.1371/journal.pone.0011102
-
(2010)
PLoS One
, vol.5
, Issue.6
, pp. 11102
-
-
Jaeger, P.A.1
Pickford, F.2
Sun, C.H.3
Lucin, K.M.4
Masliah, E.5
Wyss-Coray, T.6
-
58
-
-
1242316263
-
Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities
-
COI: 1:CAS:528:DC%2BD2cXitl2jt7s%3D, PID: 14982851
-
Jin LW, Shie FS, Maezawa I, Vincent I, Bird T (2004) Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol 164(3):975–985
-
(2004)
Am J Pathol
, vol.164
, Issue.3
, pp. 975-985
-
-
Jin, L.W.1
Shie, F.S.2
Maezawa, I.3
Vincent, I.4
Bird, T.5
-
59
-
-
30044435325
-
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling
-
COI: 1:CAS:528:DC%2BD28Xjslaltw%3D%3D, PID: 16280360
-
Jovanovic OA, Brown FD, Donaldson JG (2006) An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling. Mol Biol Cell 17(1):327–335. doi:10.1091/mbc.E05-06-0523
-
(2006)
Mol Biol Cell
, vol.17
, Issue.1
, pp. 327-335
-
-
Jovanovic, O.A.1
Brown, F.D.2
Donaldson, J.G.3
-
60
-
-
84885088410
-
A fast growing spectrum of biological functions of gamma-secretase in development and disease
-
COI: 1:CAS:528:DC%2BC3sXhsFOgtLfE, PID: 24099003
-
Jurisch-Yaksi N, Sannerud R, Annaert W (2013) A fast growing spectrum of biological functions of gamma-secretase in development and disease. Biochim Biophys Acta 1828(12):2815–2827. doi:10.1016/j.bbamem.2013.04.016
-
(2013)
Biochim Biophys Acta
, vol.1828
, Issue.12
, pp. 2815-2827
-
-
Jurisch-Yaksi, N.1
Sannerud, R.2
Annaert, W.3
-
61
-
-
33646234697
-
Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions
-
COI: 1:CAS:528:DC%2BD28XktFSqtrk%3D, PID: 16557393
-
Kannanayakal TJ, Tao H, Vandre DD, Kuret J (2006) Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions. Acta Neuropathol 111(5):413–421. doi:10.1007/s00401-006-0049-9
-
(2006)
Acta Neuropathol
, vol.111
, Issue.5
, pp. 413-421
-
-
Kannanayakal, T.J.1
Tao, H.2
Vandre, D.D.3
Kuret, J.4
-
62
-
-
79956048660
-
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models
-
COI: 1:CAS:528:DC%2BC3MXmtVyqt7c%3D, PID: 21378096
-
Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE (2011) Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet 20(11):2091–2102. doi:10.1093/hmg/ddr091
-
(2011)
Hum Mol Genet
, vol.20
, Issue.11
, pp. 2091-2102
-
-
Khandelwal, P.J.1
Herman, A.M.2
Hoe, H.S.3
Rebeck, G.W.4
Moussa, C.E.5
-
63
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
-
COI: 1:CAS:528:DC%2BD3MXhtVGqtLc%3D, PID: 11157979
-
Kihara A, Noda T, Ishihara N, Ohsumi Y (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519–530
-
(2001)
J Cell Biol
, vol.152
, Issue.3
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
64
-
-
84871002075
-
Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
-
COI: 1:CAS:528:DC%2BC3sXhs1Oht7s%3D, PID: 22797916
-
Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU (2012) Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci 125(Pt 20):4740–4750. doi:10.1242/jcs.100339
-
(2012)
J Cell Sci
, vol.125
, pp. 4740-4750
-
-
Kim, H.J.1
Zhong, Q.2
Sheng, Z.H.3
Yoshimori, T.4
Liang, C.5
Jung, J.U.6
-
65
-
-
34447564164
-
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice
-
COI: 1:CAS:528:DC%2BD2sXotlahs7o%3D, PID: 16876915
-
Knobloch M, Konietzko U, Krebs DC, Nitsch RM (2007) Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging 28(9):1297–1306. doi:10.1016/j.neurobiolaging.2006.06.019
-
(2007)
Neurobiol Aging
, vol.28
, Issue.9
, pp. 1297-1306
-
-
Knobloch, M.1
Konietzko, U.2
Krebs, D.C.3
Nitsch, R.M.4
-
66
-
-
78649338141
-
Autophagy and the integrated stress response
-
COI: 1:CAS:528:DC%2BC3cXhtlCjtr%2FM, PID: 20965422
-
Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40(2):280–293. doi:10.1016/j.molcel.2010.09.023
-
(2010)
Mol Cell
, vol.40
, Issue.2
, pp. 280-293
-
-
Kroemer, G.1
Marino, G.2
Levine, B.3
-
67
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
COI: 1:CAS:528:DC%2BD2cXhtFeisrnJ, PID: 15525940
-
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N (2004) The role of autophagy during the early neonatal starvation period. Nature 432(7020):1032–1036. doi:10.1038/nature03029
-
(2004)
Nature
, vol.432
, Issue.7020
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
68
-
-
84876231726
-
Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer’s amyloid-beta peptide
-
COI: 1:CAS:528:DC%2BC3sXhtlOjs73M, PID: 23595767
-
Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S (2013) Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer’s amyloid-beta peptide. J Neurosci 33(16):7099–7107. doi:10.1523/JNEUROSCI.5270-12.2013
-
(2013)
J Neurosci
, vol.33
, Issue.16
, pp. 7099-7107
-
-
Lane, R.F.1
Steele, J.W.2
Cai, D.3
Ehrlich, M.E.4
Attie, A.D.5
Gandy, S.6
-
69
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
COI: 1:CAS:528:DC%2BC3cXovFartbs%3D, PID: 20541250
-
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141(7):1146–1158. doi:10.1016/j.cell.2010.05.008
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
Uchiyama, Y.11
Westaway, D.12
Cuervo, A.M.13
Nixon, R.A.14
-
70
-
-
0032929762
-
Signalling through phosphoinositide 3-kinases: the lipids take centre stage
-
COI: 1:CAS:528:DyaK1MXisFWlsbw%3D, PID: 10209156
-
Leevers SJ, Vanhaesebroeck B, Waterfield MD (1999) Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 11(2):219–225
-
(1999)
Curr Opin Cell Biol
, vol.11
, Issue.2
, pp. 219-225
-
-
Leevers, S.J.1
Vanhaesebroeck, B.2
Waterfield, M.D.3
-
71
-
-
0036942638
-
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD38XjsFGhsQ%3D%3D, PID: 11810173
-
Leroy K, Boutajangout A, Authelet M, Woodgett JR, Anderton BH, Brion JP (2002) The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer’s disease. Acta Neuropathol 103(2):91–99. doi:10.1007/s004010100435
-
(2002)
Acta Neuropathol
, vol.103
, Issue.2
, pp. 91-99
-
-
Leroy, K.1
Boutajangout, A.2
Authelet, M.3
Woodgett, J.R.4
Anderton, B.H.5
Brion, J.P.6
-
72
-
-
46449120732
-
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
-
COI: 1:CAS:528:DC%2BD1cXnvFSju70%3D, PID: 18552835
-
Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU (2008) Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 10(7):776–787. doi:10.1038/ncb1740
-
(2008)
Nat Cell Biol
, vol.10
, Issue.7
, pp. 776-787
-
-
Liang, C.1
Lee, J.S.2
Inn, K.S.3
Gack, M.U.4
Li, Q.5
Roberts, E.A.6
Vergne, I.7
Deretic, V.8
Feng, P.9
Akazawa, C.10
Jung, J.U.11
-
73
-
-
34548860918
-
−/− mouse brain
-
COI: 1:CAS:528:DC%2BD2sXhtV2murbE, PID: 17631520
-
−/− mouse brain. Am J Pathol 171(3):962–975. doi:10.2353/ajpath.2007.070052
-
(2007)
Am J Pathol
, vol.171
, Issue.3
, pp. 962-975
-
-
Liao, G.1
Yao, Y.2
Liu, J.3
Yu, Z.4
Cheung, S.5
Xie, A.6
Liang, X.7
Bi, X.8
-
74
-
-
58449101589
-
Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
-
PID: 19145255
-
Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM (2009) Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 4(1):e4201. doi:10.1371/journal.pone.0004201
-
(2009)
PLoS One
, vol.4
, Issue.1
, pp. 4201
-
-
Ling, D.1
Song, H.J.2
Garza, D.3
Neufeld, T.P.4
Salvaterra, P.M.5
-
75
-
-
0031031041
-
The autophagic and endocytic pathways converge at the nascent autophagic vacuoles
-
COI: 1:CAS:528:DyaK2sXltFKltQ%3D%3D, PID: 9008703
-
Liou W, Geuze HJ, Geelen MJ, Slot JW (1997) The autophagic and endocytic pathways converge at the nascent autophagic vacuoles. J Cell Biol 136(1):61–70
-
(1997)
J Cell Biol
, vol.136
, Issue.1
, pp. 61-70
-
-
Liou, W.1
Geuze, H.J.2
Geelen, M.J.3
Slot, J.W.4
-
76
-
-
55549134611
-
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
-
COI: 1:CAS:528:DC%2BD1cXhtlCjtLrL, PID: 18953351
-
Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM (2008) Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 14(11):1247–1255. doi:10.1038/nm.1876
-
(2008)
Nat Med
, vol.14
, Issue.11
, pp. 1247-1255
-
-
Lloyd-Evans, E.1
Morgan, A.J.2
He, X.3
Smith, D.A.4
Elliot-Smith, E.5
Sillence, D.J.6
Churchill, G.C.7
Schuchman, E.H.8
Galione, A.9
Platt, F.M.10
-
77
-
-
84862611041
-
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
-
COI: 1:CAS:528:DC%2BC38XotFWgur8%3D, PID: 22613832
-
Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA (2012) TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol 197(5):659–675. doi:10.1083/jcb.201111079
-
(2012)
J Cell Biol
, vol.197
, Issue.5
, pp. 659-675
-
-
Longatti, A.1
Lamb, C.A.2
Razi, M.3
Yoshimura, S.4
Barr, F.A.5
Tooze, S.A.6
-
78
-
-
0028929548
-
Neurofibrillary tangles in Niemann-Pick disease type C
-
PID: 7894998
-
Love S, Bridges LR, Case CP (1995) Neurofibrillary tangles in Niemann-Pick disease type C. Brain 118(Pt 1):119–129
-
(1995)
Brain
, vol.118
, pp. 119-129
-
-
Love, S.1
Bridges, L.R.2
Case, C.P.3
-
79
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer’s disease
-
COI: 1:STN:280:DyaK1MvhvFarsA%3D%3D, PID: 10487842
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J (1999) Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer’s disease. Am J Pathol 155(3):853–862
-
(1999)
Am J Pathol
, vol.155
, Issue.3
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
80
-
-
84883291965
-
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
-
COI: 1:CAS:528:DC%2BC3sXht1WrsL%2FF, PID: 23921551
-
Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T (2013) Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J 32(17):2336–2347. doi:10.1038/emboj.2013.171
-
(2013)
EMBO J
, vol.32
, Issue.17
, pp. 2336-2347
-
-
Maejima, I.1
Takahashi, A.2
Omori, H.3
Kimura, T.4
Takabatake, Y.5
Saitoh, T.6
Yamamoto, A.7
Hamasaki, M.8
Noda, T.9
Isaka, Y.10
Yoshimori, T.11
-
81
-
-
84861388527
-
Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells
-
COI: 1:CAS:528:DC%2BC38XosVejtro%3D, PID: 22551668
-
Malnar M, Kosicek M, Lisica A, Posavec M, Krolo A, Njavro J, Omerbasic D, Tahirovic S, Hecimovic S (2012) Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. Biochim Biophys Acta 1822(8):1270–1283. doi:10.1016/j.bbadis.2012.04.002
-
(2012)
Biochim Biophys Acta
, vol.1822
, Issue.8
, pp. 1270-1283
-
-
Malnar, M.1
Kosicek, M.2
Lisica, A.3
Posavec, M.4
Krolo, A.5
Njavro, J.6
Omerbasic, D.7
Tahirovic, S.8
Hecimovic, S.9
-
82
-
-
84867339738
-
Tau protein phosphatases in Alzheimer’s disease: the leading role of PP2A
-
COI: 1:CAS:528:DC%2BC3sXhtFKksb0%3D, PID: 22771380
-
Martin L, Latypova X, Wilson CM, Magnaudeix A, Perrin ML, Terro F (2013) Tau protein phosphatases in Alzheimer’s disease: the leading role of PP2A. Ageing Res Rev 12(1):39–49. doi:10.1016/j.arr.2012.06.008
-
(2013)
Ageing Res Rev
, vol.12
, Issue.1
, pp. 39-49
-
-
Martin, L.1
Latypova, X.2
Wilson, C.M.3
Magnaudeix, A.4
Perrin, M.L.5
Terro, F.6
-
83
-
-
84867608068
-
Tau protein kinases: involvement in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3sXhtFKmt7w%3D, PID: 22742992
-
Martin L, Latypova X, Wilson CM, Magnaudeix A, Perrin ML, Yardin C, Terro F (2013) Tau protein kinases: involvement in Alzheimer’s disease. Ageing Res Rev 12(1):289–309. doi:10.1016/j.arr.2012.06.003
-
(2013)
Ageing Res Rev
, vol.12
, Issue.1
, pp. 289-309
-
-
Martin, L.1
Latypova, X.2
Wilson, C.M.3
Magnaudeix, A.4
Perrin, M.L.5
Yardin, C.6
Terro, F.7
-
84
-
-
84888153445
-
Autophagy proteins regulate ERK phosphorylation
-
PID: 24240988
-
Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R (2013) Autophagy proteins regulate ERK phosphorylation. Nat Commun 4:2799. doi:10.1038/ncomms3799
-
(2013)
Nat Commun
, vol.4
, pp. 2799
-
-
Martinez-Lopez, N.1
Athonvarangkul, D.2
Mishall, P.3
Sahu, S.4
Singh, R.5
-
85
-
-
84896963702
-
ATGs: Scaffolds for MAPK/ERK signaling
-
COI: 1:CAS:528:DC%2BC2cXitVGmtb7I, PID: 24412893
-
Martinez-Lopez N, Singh R (2014) ATGs: Scaffolds for MAPK/ERK signaling. Autophagy 10(3):535–537. doi:10.4161/auto.27642
-
(2014)
Autophagy
, vol.10
, Issue.3
, pp. 535-537
-
-
Martinez-Lopez, N.1
Singh, R.2
-
86
-
-
64049086758
-
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
COI: 1:CAS:528:DC%2BD1MXjvVymsr4%3D, PID: 19270696
-
Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, Akira S, Noda T, Yoshimori T (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 11(4):385–396. doi:10.1038/ncb1846
-
(2009)
Nat Cell Biol
, vol.11
, Issue.4
, pp. 385-396
-
-
Matsunaga, K.1
Saitoh, T.2
Tabata, K.3
Omori, H.4
Satoh, T.5
Kurotori, N.6
Maejima, I.7
Shirahama-Noda, K.8
Ichimura, T.9
Isobe, T.10
Akira, S.11
Noda, T.12
Yoshimori, T.13
-
87
-
-
77951928742
-
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
-
PID: 20403962
-
Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM (2010) The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain 133(Pt 5):1328–1341. doi:10.1093/brain/awq065
-
(2010)
Brain
, vol.133
, pp. 1328-1341
-
-
Mc Donald, J.M.1
Savva, G.M.2
Brayne, C.3
Welzel, A.T.4
Forster, G.5
Shankar, G.M.6
Selkoe, D.J.7
Ince, P.G.8
Walsh, D.M.9
-
88
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD3cXhsFyrug%3D%3D, PID: 10589538
-
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease. Ann Neurol 46(6):860–866
-
(1999)
Ann Neurol
, vol.46
, Issue.6
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
89
-
-
84901190201
-
Pharmacological chaperones stabilize retromer to limit APP processing
-
COI: 1:CAS:528:DC%2BC2cXmsVKmsrY%3D, PID: 24747528
-
Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA (2014) Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol 10(6):443–449. doi:10.1038/nchembio.1508
-
(2014)
Nat Chem Biol
, vol.10
, Issue.6
, pp. 443-449
-
-
Mecozzi, V.J.1
Berman, D.E.2
Simoes, S.3
Vetanovetz, C.4
Awal, M.R.5
Patel, V.M.6
Schneider, R.T.7
Petsko, G.A.8
Ringe, D.9
Small, S.A.10
-
90
-
-
3142592401
-
Not just a sink: endosomes in control of signal transduction
-
COI: 1:CAS:528:DC%2BD2cXlsl2lurg%3D, PID: 15261672
-
Miaczynska M, Pelkmans L, Zerial M (2004) Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol 16(4):400–406. doi:10.1016/j.ceb.2004.06.005
-
(2004)
Curr Opin Cell Biol
, vol.16
, Issue.4
, pp. 400-406
-
-
Miaczynska, M.1
Pelkmans, L.2
Zerial, M.3
-
91
-
-
84860679761
-
Beta-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage
-
COI: 1:CAS:528:DC%2BC38XntFOqsLY%3D, PID: 22573671
-
Mohamed A, Saavedra L, Di Pardo A, Sipione S, Posse de Chaves E (2012) Beta-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage. J Neurosci 32(19):6490–6500. doi:10.1523/JNEUROSCI.0630-12.2012
-
(2012)
J Neurosci
, vol.32
, Issue.19
, pp. 6490-6500
-
-
Mohamed, A.1
Saavedra, L.2
Di Pardo, A.3
Sipione, S.4
Posse de Chaves, E.5
-
92
-
-
84859965801
-
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D
-
COI: 1:CAS:528:DC%2BC38XjtV2hsb0%3D, PID: 22351926
-
Moreau K, Ravikumar B, Puri C, Rubinsztein DC (2012) Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D. J Cell Biol 196(4):483–496. doi:10.1083/jcb.201110114
-
(2012)
J Cell Biol
, vol.196
, Issue.4
, pp. 483-496
-
-
Moreau, K.1
Ravikumar, B.2
Puri, C.3
Rubinsztein, D.C.4
-
93
-
-
84881324927
-
Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
-
PID: 23907271
-
Morel E, Chamoun Z, Lasiecka ZM, Chan RB, Williamson RL, Vetanovetz C, Dall’Armi C, Simoes S, Point Du, Jour KS, McCabe BD, Small SA, Di Paolo G (2013) Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun 4:2250. doi:10.1038/ncomms3250
-
(2013)
Nat Commun
, vol.4
, pp. 2250
-
-
Morel, E.1
Chamoun, Z.2
Lasiecka, Z.M.3
Chan, R.B.4
Williamson, R.L.5
Vetanovetz, C.6
Dall’Armi, C.7
Simoes, S.8
Point, D.9
Jour, K.S.10
McCabe, B.D.11
Small, S.A.12
Di Paolo, G.13
-
94
-
-
84880759156
-
Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction
-
PID: 22762015
-
Mucke L, Selkoe DJ (2012) Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2(7):a006338. doi:10.1101/cshperspect.a006338
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.7
, pp. 006338
-
-
Mucke, L.1
Selkoe, D.J.2
-
95
-
-
84896828502
-
Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC2cXivVCmt7w%3D, PID: 24029627
-
Mufson EJ, Ward S, Binder L (2014) Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer’s disease. Neurodegener Dis 13(2–3):151–153. doi:10.1159/000353687
-
(2014)
Neurodegener Dis
, vol.13
, Issue.2-3
, pp. 151-153
-
-
Mufson, E.J.1
Ward, S.2
Binder, L.3
-
96
-
-
84869488059
-
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function
-
COI: 1:CAS:528:DC%2BC38Xhs1agtL7P, PID: 23103503
-
Neely Kayala KM, Dickinson GD, Minassian A, Walls KC, Green KN, Laferla FM (2012) Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function. Brain Res 1489:8–16. doi:10.1016/j.brainres.2012.10.036
-
(2012)
Brain Res
, vol.1489
, pp. 8-16
-
-
Neely Kayala, K.M.1
Dickinson, G.D.2
Minassian, A.3
Walls, K.C.4
Green, K.N.5
Laferla, F.M.6
-
97
-
-
79951985639
-
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a gamma-secretase-independent manner
-
COI: 1:CAS:528:DC%2BC3MXislGisb0%3D, PID: 21414900
-
Neely KM, Green KN, LaFerla FM (2011) Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a gamma-secretase-independent manner. J Neurosci 31(8):2781–2791. doi:10.1523/JNEUROSCI.5156-10.2010
-
(2011)
J Neurosci
, vol.31
, Issue.8
, pp. 2781-2791
-
-
Neely, K.M.1
Green, K.N.2
LaFerla, F.M.3
-
98
-
-
34248185927
-
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
-
COI: 1:CAS:528:DC%2BD2sXlt1Omt7g%3D, PID: 17431506
-
Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest 117(5):1230–1239. doi:10.1172/JCI30447
-
(2007)
J Clin Invest
, vol.117
, Issue.5
, pp. 1230-1239
-
-
Nelson, O.1
Tu, H.2
Lei, T.3
Bentahir, M.4
de Strooper, B.5
Bezprozvanny, I.6
-
99
-
-
17944368176
-
The ‘Arctic’ APP mutation (E693G) causes Alzheimer’s disease by enhanced Abeta protofibril formation
-
COI: 1:CAS:528:DC%2BD3MXmtlaqu7k%3D, PID: 11528419
-
Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Naslund J, Lannfelt L (2001) The ‘Arctic’ APP mutation (E693G) causes Alzheimer’s disease by enhanced Abeta protofibril formation. Nat Neurosci 4(9):887–893. doi:10.1038/nn0901-887
-
(2001)
Nat Neurosci
, vol.4
, Issue.9
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
Stenh, C.7
Luthman, J.8
Teplow, D.B.9
Younkin, S.G.10
Naslund, J.11
Lannfelt, L.12
-
100
-
-
84898778667
-
Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles
-
PID: 23631697
-
Nishikawa T, Takahashi T, Nakamori M, Yamazaki Y, Kurashige T, Nagano Y, Nishida Y, Izumi Y, Matsumoto M (2014) Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles. Neuropathol Appl Neurobiol. doi:10.1111/nan.12056
-
(2014)
Neuropathol Appl Neurobiol
-
-
Nishikawa, T.1
Takahashi, T.2
Nakamori, M.3
Yamazaki, Y.4
Kurashige, T.5
Nagano, Y.6
Nishida, Y.7
Izumi, Y.8
Matsumoto, M.9
-
101
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
PID: 15751225
-
Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM (2005) Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 64(2):113–122
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, Issue.2
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
102
-
-
79955969705
-
Autophagy failure in Alzheimer’s disease—locating the primary defect
-
COI: 1:CAS:528:DC%2BC3MXmtFCktbw%3D, PID: 21296668
-
Nixon RA, Yang DS (2011) Autophagy failure in Alzheimer’s disease—locating the primary defect. Neurobiol Dis 43(1):38–45. doi:10.1016/j.nbd.2011.01.021
-
(2011)
Neurobiol Dis
, vol.43
, Issue.1
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
103
-
-
77956178575
-
Regulation of membrane biogenesis in autophagy via PI3P dynamics
-
COI: 1:CAS:528:DC%2BC3cXhtVymurzJ, PID: 20403452
-
Noda T, Matsunaga K, Taguchi-Atarashi N, Yoshimori T (2010) Regulation of membrane biogenesis in autophagy via PI3P dynamics. Semin Cell Dev Biol 21(7):671–676. doi:10.1016/j.semcdb.2010.04.002
-
(2010)
Semin Cell Dev Biol
, vol.21
, Issue.7
, pp. 671-676
-
-
Noda, T.1
Matsunaga, K.2
Taguchi-Atarashi, N.3
Yoshimori, T.4
-
104
-
-
33745086418
-
Assortment of phosphatidylinositol 3-kinase complexes—Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae
-
COI: 1:CAS:528:DC%2BD28XltlSqu78%3D, PID: 16421251
-
Obara K, Sekito T, Ohsumi Y (2006) Assortment of phosphatidylinositol 3-kinase complexes—Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell 17(4):1527–1539. doi:10.1091/mbc.E05-09-0841
-
(2006)
Mol Biol Cell
, vol.17
, Issue.4
, pp. 1527-1539
-
-
Obara, K.1
Sekito, T.2
Ohsumi, Y.3
-
105
-
-
0026051511
-
Reexamination of granulovacuolar degeneration
-
COI: 1:STN:280:DyaK387hs1OisA%3D%3D, PID: 1722607
-
Okamoto K, Hirai S, Iizuka T, Yanagisawa T, Watanabe M (1991) Reexamination of granulovacuolar degeneration. Acta Neuropathol 82(5):340–345
-
(1991)
Acta Neuropathol
, vol.82
, Issue.5
, pp. 340-345
-
-
Okamoto, K.1
Hirai, S.2
Iizuka, T.3
Yanagisawa, T.4
Watanabe, M.5
-
106
-
-
0031026639
-
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex
-
COI: 1:CAS:528:DyaK2sXotFersg%3D%3D, PID: 8999962
-
Panaretou C, Domin J, Cockcroft S, Waterfield MD (1997) Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex. J Biol Chem 272(4):2477–2485
-
(1997)
J Biol Chem
, vol.272
, Issue.4
, pp. 2477-2485
-
-
Panaretou, C.1
Domin, J.2
Cockcroft, S.3
Waterfield, M.D.4
-
107
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
COI: 1:CAS:528:DC%2BD1cXntVCmuro%3D, PID: 18497889
-
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 118(6):2190–2199. doi:10.1172/JCI33585
-
(2008)
J Clin Invest
, vol.118
, Issue.6
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
Wyss-Coray, T.11
-
108
-
-
79960717910
-
Endocytosis and signaling
-
COI: 1:CAS:528:DC%2BC3MXps1ejtLg%3D, PID: 21474295
-
Platta HW, Stenmark H (2011) Endocytosis and signaling. Curr Opin Cell Biol 23(4):393–403. doi:10.1016/j.ceb.2011.03.008
-
(2011)
Curr Opin Cell Biol
, vol.23
, Issue.4
, pp. 393-403
-
-
Platta, H.W.1
Stenmark, H.2
-
109
-
-
84916928995
-
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
-
COI: 1:CAS:528:DC%2BC2cXhsVCmurzI, PID: 25069841
-
Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H (2014) Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med 6(9):1142–1160. doi:10.15252/emmm.201303671
-
(2014)
EMBO Mol Med
, vol.6
, Issue.9
, pp. 1142-1160
-
-
Polito, V.A.1
Li, H.2
Martini-Stoica, H.3
Wang, B.4
Yang, L.5
Xu, Y.6
Swartzlander, D.B.7
Palmieri, M.8
di Ronza, A.9
Lee, V.M.10
Sardiello, M.11
Ballabio, A.12
Zheng, H.13
-
110
-
-
84884220705
-
Diverse autophagosome membrane sources coalesce in recycling endosomes
-
COI: 1:CAS:528:DC%2BC3sXhsVClsrrM, PID: 24034251
-
Puri C, Renna M, Bento CF, Moreau K, Rubinsztein DC (2013) Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell 154(6):1285–1299. doi:10.1016/j.cell.2013.08.044
-
(2013)
Cell
, vol.154
, Issue.6
, pp. 1285-1299
-
-
Puri, C.1
Renna, M.2
Bento, C.F.3
Moreau, K.4
Rubinsztein, D.C.5
-
111
-
-
84864886909
-
ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation
-
COI: 1:CAS:528:DC%2BC38XpvFGhu78%3D, PID: 22781129
-
Raemaekers T, Peric A, Baatsen P, Sannerud R, Declerck I, Baert V, Michiels C, Annaert W (2012) ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. EMBO J 31(15):3252–3269. doi:10.1038/emboj.2012.182
-
(2012)
EMBO J
, vol.31
, Issue.15
, pp. 3252-3269
-
-
Raemaekers, T.1
Peric, A.2
Baatsen, P.3
Sannerud, R.4
Declerck, I.5
Baert, V.6
Michiels, C.7
Annaert, W.8
-
112
-
-
84878766832
-
Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
-
COI: 1:CAS:528:DC%2BC3sXovVShtr0%3D, PID: 23289851
-
Raiborg C, Schink KO, Stenmark H (2013) Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic. FEBS J 280(12):2730–2742. doi:10.1111/febs.12116
-
(2013)
FEBS J
, vol.280
, Issue.12
, pp. 2730-2742
-
-
Raiborg, C.1
Schink, K.O.2
Stenmark, H.3
-
113
-
-
84860919373
-
Membrane trafficking pathways in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC38XoslCltrY%3D, PID: 22269004
-
Rajendran L, Annaert W (2012) Membrane trafficking pathways in Alzheimer’s disease. Traffic 13(6):759–770. doi:10.1111/j.1600-0854.2012.01332.x
-
(2012)
Traffic
, vol.13
, Issue.6
, pp. 759-770
-
-
Rajendran, L.1
Annaert, W.2
-
114
-
-
65349155174
-
Early endosomes and endosomal coatomer are required for autophagy
-
COI: 1:CAS:528:DC%2BD1MXlt1yjtLw%3D, PID: 19364919
-
Razi M, Chan EY, Tooze SA (2009) Early endosomes and endosomal coatomer are required for autophagy. J Cell Biol 185(2):305–321. doi:10.1083/jcb.200810098
-
(2009)
J Cell Biol
, vol.185
, Issue.2
, pp. 305-321
-
-
Razi, M.1
Chan, E.Y.2
Tooze, S.A.3
-
115
-
-
0032708117
-
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells
-
COI: 1:CAS:528:DyaK1MXns1ehurs%3D, PID: 10582597
-
Refolo LM, Eckman C, Prada CM, Yager D, Sambamurti K, Mehta N, Hardy J, Younkin SG (1999) Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells. J Neurochem 73(6):2383–2388
-
(1999)
J Neurochem
, vol.73
, Issue.6
, pp. 2383-2388
-
-
Refolo, L.M.1
Eckman, C.2
Prada, C.M.3
Yager, D.4
Sambamurti, K.5
Mehta, N.6
Hardy, J.7
Younkin, S.G.8
-
116
-
-
35748940970
-
Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway
-
COI: 1:CAS:528:DC%2BD2sXhtFykurbN, PID: 17716970
-
Repetto E, Yoon IS, Zheng H, Kang DE (2007) Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem 282(43):31504–31516. doi:10.1074/jbc.M704273200
-
(2007)
J Biol Chem
, vol.282
, Issue.43
, pp. 31504-31516
-
-
Repetto, E.1
Yoon, I.S.2
Zheng, H.3
Kang, D.E.4
-
117
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model
-
COI: 1:CAS:528:DC%2BD2sXkvVWrtrw%3D, PID: 17478722
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model. Science 316(5825):750–754. doi:10.1126/science.1141736
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
118
-
-
79953652969
-
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans
-
COI: 1:CAS:528:DC%2BC3MXlvVWntbY%3D, PID: 21183797
-
Ruck A, Attonito J, Garces KT, Nunez L, Palmisano NJ, Rubel Z, Bai Z, Nguyen KC, Sun L, Grant BD, Hall DH, Melendez A (2011) The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy 7(4):386–400
-
(2011)
Autophagy
, vol.7
, Issue.4
, pp. 386-400
-
-
Ruck, A.1
Attonito, J.2
Garces, K.T.3
Nunez, L.4
Palmisano, N.J.5
Rubel, Z.6
Bai, Z.7
Nguyen, K.C.8
Sun, L.9
Grant, B.D.10
Hall, D.H.11
Melendez, A.12
-
119
-
-
0036523031
-
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
-
COI: 1:CAS:528:DC%2BD38XhvValt7w%3D, PID: 11880497
-
Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T (2002) Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci 22(5):1679–1689
-
(2002)
J Neurosci
, vol.22
, Issue.5
, pp. 1679-1689
-
-
Runz, H.1
Rietdorf, J.2
Tomic, I.3
de Bernard, M.4
Beyreuther, K.5
Pepperkok, R.6
Hartmann, T.7
-
120
-
-
84880331368
-
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
-
COI: 1:CAS:528:DC%2BC3sXnvVSitb0%3D, PID: 23685627
-
Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 15(7):741–750. doi:10.1038/ncb2757
-
(2013)
Nat Cell Biol
, vol.15
, Issue.7
, pp. 741-750
-
-
Russell, R.C.1
Tian, Y.2
Yuan, H.3
Park, H.W.4
Chang, Y.Y.5
Kim, J.6
Kim, H.7
Neufeld, T.P.8
Dillin, A.9
Guan, K.L.10
-
121
-
-
69449089915
-
How do ESCRT proteins control autophagy?
-
COI: 1:CAS:528:DC%2BD1MXps1ehsb0%3D, PID: 19535733
-
Rusten TE, Stenmark H (2009) How do ESCRT proteins control autophagy? J Cell Sci 122(Pt 13):2179–2183. doi:10.1242/jcs.050021
-
(2009)
J Cell Sci
, vol.122
, pp. 2179-2183
-
-
Rusten, T.E.1
Stenmark, H.2
-
122
-
-
34247516510
-
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase
-
COI: 1:CAS:528:DC%2BD2sXlsV2ksbs%3D, PID: 17448150
-
Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN (2007) The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase. J Neurochem 101(3):854–862. doi:10.1111/j.1471-4159.2006.04443.x
-
(2007)
J Neurochem
, vol.101
, Issue.3
, pp. 854-862
-
-
Sahlin, C.1
Lord, A.2
Magnusson, K.3
Englund, H.4
Almeida, C.G.5
Greengard, P.6
Nyberg, F.7
Gouras, G.K.8
Lannfelt, L.9
Nilsson, L.N.10
-
123
-
-
79960819248
-
Potent amyloidogenicity and pathogenicity of Abeta43
-
COI: 1:CAS:528:DC%2BC3MXotlClsLs%3D, PID: 21725313
-
Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC (2011) Potent amyloidogenicity and pathogenicity of Abeta43. Nat Neurosci 14(8):1023–1032. doi:10.1038/nn.2858
-
(2011)
Nat Neurosci
, vol.14
, Issue.8
, pp. 1023-1032
-
-
Saito, T.1
Suemoto, T.2
Brouwers, N.3
Sleegers, K.4
Funamoto, S.5
Mihira, N.6
Matsuba, Y.7
Yamada, K.8
Nilsson, P.9
Takano, J.10
Nishimura, M.11
Iwata, N.12
Van Broeckhoven, C.13
Ihara, Y.14
Saido, T.C.15
-
124
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
COI: 1:CAS:528:DC%2BD1cXhtlKmtLzN, PID: 18849965
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456(7219):264–268. doi:10.1038/nature07383
-
(2008)
Nature
, vol.456
, Issue.7219
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
Tanaka, K.11
Kawai, T.12
Tsujimura, T.13
Takeuchi, O.14
Yoshimori, T.15
Akira, S.16
-
125
-
-
63649164073
-
Trafficking, a key player in regulated intramembrane proteolysis
-
COI: 1:CAS:528:DC%2BD1MXksVajtro%3D, PID: 19056506
-
Sannerud R, Annaert W (2009) Trafficking, a key player in regulated intramembrane proteolysis. Semin Cell Dev Biol 20(2):183–190. doi:10.1016/j.semcdb.2008.11.004
-
(2009)
Semin Cell Dev Biol
, vol.20
, Issue.2
, pp. 183-190
-
-
Sannerud, R.1
Annaert, W.2
-
126
-
-
80052149544
-
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
-
COI: 1:CAS:528:DC%2BC3MXhtFams7fF, PID: 21825135
-
Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W (2011) ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci USA 108(34):E559–E568. doi:10.1073/pnas.1100745108
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.34
, pp. 559-568
-
-
Sannerud, R.1
Declerck, I.2
Peric, A.3
Raemaekers, T.4
Menendez, G.5
Zhou, L.6
Veerle, B.7
Coen, K.8
Munck, S.9
De Strooper, B.10
Schiavo, G.11
Annaert, W.12
-
127
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
COI: 1:CAS:528:DC%2BD2cXjs1ygtL8%3D, PID: 15066262
-
Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42(1):23–36
-
(2004)
Neuron
, vol.42
, Issue.1
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.Y.2
Beglopoulos, V.3
Malkani, S.4
Zhang, D.5
Shankaranarayana Rao, B.S.6
Chattarji, S.7
Kelleher, R.J.8
Kandel, E.R.9
Duff, K.10
Kirkwood, A.11
Shen, J.12
-
128
-
-
0035971218
-
Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice
-
COI: 1:CAS:528:DC%2BD3MXis1OktL8%3D, PID: 11152466
-
Sawamura N, Gong JS, Garver WS, Heidenreich RA, Ninomiya H, Ohno K, Yanagisawa K, Michikawa M (2001) Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice. J Biol Chem 276(13):10314–10319. doi:10.1074/jbc.M009733200
-
(2001)
J Biol Chem
, vol.276
, Issue.13
, pp. 10314-10319
-
-
Sawamura, N.1
Gong, J.S.2
Garver, W.S.3
Heidenreich, R.A.4
Ninomiya, H.5
Ohno, K.6
Yanagisawa, K.7
Michikawa, M.8
-
129
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
COI: 1:CAS:528:DyaK3sXit12qsLY%3D, PID: 8385367
-
Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260(5104):88–91
-
(1993)
Science
, vol.260
, Issue.5104
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
130
-
-
65349184122
-
ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease
-
PID: 19365558
-
Schweitzer JK, Pietrini SD, D’Souza-Schorey C (2009) ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease. PLoS One 4(4):e5193. doi:10.1371/journal.pone.0005193
-
(2009)
PLoS One
, vol.4
, Issue.4
, pp. 5193
-
-
Schweitzer, J.K.1
Pietrini, S.D.2
D’Souza-Schorey, C.3
-
131
-
-
84872183810
-
The retromer complex - endosomal protein recycling and beyond
-
COI: 1:CAS:528:DC%2BC3sXhs1Ohtrg%3D, PID: 23148298
-
Seaman MN (2012) The retromer complex - endosomal protein recycling and beyond. J Cell Sci 125(Pt 20):4693–4702. doi:10.1242/jcs.103440
-
(2012)
J Cell Sci
, vol.125
, pp. 4693-4702
-
-
Seaman, M.N.1
-
132
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
COI: 1:CAS:528:DC%2BC3MXntlOltLw%3D, PID: 21617040
-
Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A (2011) TFEB links autophagy to lysosomal biogenesis. Science 332(6036):1429–1433. doi:10.1126/science.1204592
-
(2011)
Science
, vol.332
, Issue.6036
, pp. 1429-1433
-
-
Settembre, C.1
Di Malta, C.2
Polito, V.A.3
Garcia Arencibia, M.4
Vetrini, F.5
Erdin, S.6
Erdin, S.U.7
Huynh, T.8
Medina, D.9
Colella, P.10
Sardiello, M.11
Rubinsztein, D.C.12
Ballabio, A.13
-
133
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer’s beta-peptide from biological fluids
-
COI: 1:CAS:528:DyaK38XmtFSisrc%3D, PID: 1406936
-
Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C et al (1992) Isolation and quantification of soluble Alzheimer’s beta-peptide from biological fluids. Nature 359(6393):325–327. doi:10.1038/359325a0
-
(1992)
Nature
, vol.359
, Issue.6393
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
Davis, D.6
Sinha, S.7
Schlossmacher, M.8
Whaley, J.9
Swindlehurst, C.10
-
134
-
-
84874531109
-
Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila
-
COI: 1:CAS:528:DC%2BC3sXntVCrtrk%3D, PID: 23406899
-
Shravage BV, Hill JH, Powers CM, Wu L, Baehrecke EH (2013) Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila. Development 140(6):1321–1329. doi:10.1242/dev.089490
-
(2013)
Development
, vol.140
, Issue.6
, pp. 1321-1329
-
-
Shravage, B.V.1
Hill, J.H.2
Powers, C.M.3
Wu, L.4
Baehrecke, E.H.5
-
135
-
-
27744576858
-
Model-guided microarray implicates the retromer complex in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2MXhtlaks7jN, PID: 16315276
-
Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, Honig L, Vonsattel JP, Kim TW (2005) Model-guided microarray implicates the retromer complex in Alzheimer’s disease. Ann Neurol 58(6):909–919. doi:10.1002/ana.20667
-
(2005)
Ann Neurol
, vol.58
, Issue.6
, pp. 909-919
-
-
Small, S.A.1
Kent, K.2
Pierce, A.3
Leung, C.4
Kang, M.S.5
Okada, H.6
Honig, L.7
Vonsattel, J.P.8
Kim, T.W.9
-
136
-
-
57549094368
-
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
-
COI: 1:CAS:528:DC%2BD1cXhtlKqsbfJ, PID: 18768753
-
Sou YS, Waguri S, Iwata J, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M (2008) The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 19(11):4762–4775. doi:10.1091/mbc.E08-03-0309
-
(2008)
Mol Biol Cell
, vol.19
, Issue.11
, pp. 4762-4775
-
-
Sou, Y.S.1
Waguri, S.2
Iwata, J.3
Ueno, T.4
Fujimura, T.5
Hara, T.6
Sawada, N.7
Yamada, A.8
Mizushima, N.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Komatsu, M.13
-
137
-
-
84877601173
-
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
-
COI: 1:CAS:528:DC%2BC3sXntV2hsLw%3D, PID: 23606558
-
Spampanato C, Feeney E, Li L, Cardone M, Lim JA, Annunziata F, Zare H, Polishchuk R, Puertollano R, Parenti G, Ballabio A, Raben N (2013) Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol Med 5(5):691–706. doi:10.1002/emmm.201202176
-
(2013)
EMBO Mol Med
, vol.5
, Issue.5
, pp. 691-706
-
-
Spampanato, C.1
Feeney, E.2
Li, L.3
Cardone, M.4
Lim, J.A.5
Annunziata, F.6
Zare, H.7
Polishchuk, R.8
Puertollano, R.9
Parenti, G.10
Ballabio, A.11
Raben, N.12
-
138
-
-
40949159198
-
Building gamma-secretase: the bits and pieces
-
COI: 1:CAS:528:DC%2BD1cXjs1agtrs%3D, PID: 18256384
-
Spasic D, Annaert W (2008) Building gamma-secretase: the bits and pieces. J Cell Sci 121(Pt 4):413–420. doi:10.1242/jcs.015255
-
(2008)
J Cell Sci
, vol.121
, pp. 413-420
-
-
Spasic, D.1
Annaert, W.2
-
139
-
-
33748746861
-
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway
-
COI: 1:CAS:528:DC%2BD28XovF2js7s%3D, PID: 16846981
-
Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W (2006) Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J Biol Chem 281(36):26569–26577. doi:10.1074/jbc.M600592200
-
(2006)
J Biol Chem
, vol.281
, Issue.36
, pp. 26569-26577
-
-
Spasic, D.1
Tolia, A.2
Dillen, K.3
Baert, V.4
De Strooper, B.5
Vrijens, S.6
Annaert, W.7
-
140
-
-
58049192897
-
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
-
COI: 1:CAS:528:DC%2BD1cXhsFamu7zM, PID: 19050071
-
Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q (2008) Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 105(49):19211–19216. doi:10.1073/pnas.0810452105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.49
, pp. 19211-19216
-
-
Sun, Q.1
Fan, W.2
Chen, K.3
Ding, X.4
Chen, S.5
Zhong, Q.6
-
141
-
-
78650600158
-
Rubicon controls endosome maturation as a Rab7 effector
-
COI: 1:CAS:528:DC%2BC3cXhsVGlsr7J, PID: 20974968
-
Sun Q, Westphal W, Wong KN, Tan I, Zhong Q (2010) Rubicon controls endosome maturation as a Rab7 effector. Proc Natl Acad Sci USA 107(45):19338–19343. doi:10.1073/pnas.1010554107
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.45
, pp. 19338-19343
-
-
Sun, Q.1
Westphal, W.2
Wong, K.N.3
Tan, I.4
Zhong, Q.5
-
142
-
-
78650936005
-
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
-
COI: 1:CAS:528:DC%2BC3MXmslyk, PID: 21062745
-
Sun Q, Zhang J, Fan W, Wong KN, Ding X, Chen S, Zhong Q (2011) The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J Biol Chem 286(1):185–191. doi:10.1074/jbc.M110.126425
-
(2011)
J Biol Chem
, vol.286
, Issue.1
, pp. 185-191
-
-
Sun, Q.1
Zhang, J.2
Fan, W.3
Wong, K.N.4
Ding, X.5
Chen, S.6
Zhong, Q.7
-
143
-
-
84894275180
-
Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization
-
COI: 1:CAS:528:DC%2BC2cXmsVyhsbo%3D, PID: 24356450
-
Szatmari Z, Kis V, Lippai M, Hegedus K, Farago T, Lorincz P, Tanaka T, Juhasz G, Sass M (2014) Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Mol Biol Cell 25(4):522–531. doi:10.1091/mbc.E13-10-0574
-
(2014)
Mol Biol Cell
, vol.25
, Issue.4
, pp. 522-531
-
-
Szatmari, Z.1
Kis, V.2
Lippai, M.3
Hegedus, K.4
Farago, T.5
Lorincz, P.6
Tanaka, T.7
Juhasz, G.8
Sass, M.9
-
144
-
-
1842732209
-
Oligomerization of Alzheimer’s beta-amyloid within processes and synapses of cultured neurons and brain
-
COI: 1:CAS:528:DC%2BD2cXjsFelsL0%3D, PID: 15071107
-
Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK (2004) Oligomerization of Alzheimer’s beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci 24(14):3592–3599. doi:10.1523/JNEUROSCI.5167-03.2004
-
(2004)
J Neurosci
, vol.24
, Issue.14
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
Yu, F.4
Lin, M.T.5
Milner, T.A.6
Gouras, G.K.7
-
145
-
-
82355169512
-
Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response
-
COI: 1:CAS:528:DC%2BC3MXhsVehtr3K, PID: 21935637
-
Thal DR, Del Tredici K, Ludolph AC, Hoozemans JJ, Rozemuller AJ, Braak H, Knippschild U (2011) Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response. Acta Neuropathol 122(5):577–589. doi:10.1007/s00401-011-0871-6
-
(2011)
Acta Neuropathol
, vol.122
, Issue.5
, pp. 577-589
-
-
Thal, D.R.1
Del Tredici, K.2
Ludolph, A.C.3
Hoozemans, J.J.4
Rozemuller, A.J.5
Braak, H.6
Knippschild, U.7
-
146
-
-
0242515917
-
Alzheimer-associated C allele of the promoter polymorphism −22C > T causes a critical neuron-specific decrease of presenilin 1 expression
-
COI: 1:CAS:528:DC%2BD3sXjvVyktrw%3D, PID: 12668610
-
Theuns J, Remacle J, Killick R, Corsmit E, Vennekens K, Huylebroeck D, Cruts M, Van Broeckhoven C (2003) Alzheimer-associated C allele of the promoter polymorphism −22C > T causes a critical neuron-specific decrease of presenilin 1 expression. Hum Mol Genet 12(8):869–877
-
(2003)
Hum Mol Genet
, vol.12
, Issue.8
, pp. 869-877
-
-
Theuns, J.1
Remacle, J.2
Killick, R.3
Corsmit, E.4
Vennekens, K.5
Huylebroeck, D.6
Cruts, M.7
Van Broeckhoven, C.8
-
147
-
-
80055066891
-
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes
-
PID: 22027552
-
Thimiri Govinda Raj DB, Ghesquiere B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W (2011) A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Mol Syst Biol 7:541. doi:10.1038/msb.2011.74
-
(2011)
Mol Syst Biol
, vol.7
, pp. 541
-
-
Thimiri Govinda Raj, D.B.1
Ghesquiere, B.2
Tharkeshwar, A.K.3
Coen, K.4
Derua, R.5
Vanderschaeghe, D.6
Rysman, E.7
Bagadi, M.8
Baatsen, P.9
De Strooper, B.10
Waelkens, E.11
Borghs, G.12
Callewaert, N.13
Swinnen, J.14
Gevaert, K.15
Annaert, W.16
-
148
-
-
78049271501
-
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
-
COI: 1:CAS:528:DC%2BC3cXhtl2gu7zE, PID: 20643123
-
Thoresen SB, Pedersen NM, Liestol K, Stenmark H (2010) A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res 316(20):3368–3378. doi:10.1016/j.yexcr.2010.07.008
-
(2010)
Exp Cell Res
, vol.316
, Issue.20
, pp. 3368-3378
-
-
Thoresen, S.B.1
Pedersen, N.M.2
Liestol, K.3
Stenmark, H.4
-
149
-
-
84867412992
-
Hyperphosphorylation of Tau induced by naturally secreted amyloid-beta at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3beta signaling pathway
-
COI: 1:CAS:528:DC%2BC38XhsFSgsL3J, PID: 22910909
-
Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T (2012) Hyperphosphorylation of Tau induced by naturally secreted amyloid-beta at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3beta signaling pathway. J Biol Chem 287(42):35222–35233. doi:10.1074/jbc.M112.348300
-
(2012)
J Biol Chem
, vol.287
, Issue.42
, pp. 35222-35233
-
-
Tokutake, T.1
Kasuga, K.2
Yajima, R.3
Sekine, Y.4
Tezuka, T.5
Nishizawa, M.6
Ikeuchi, T.7
-
150
-
-
77950617631
-
A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
-
COI: 1:CAS:528:DC%2BC3cXlvVKntr0%3D, PID: 20371804
-
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H (2010) A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci 30(14):4845–4856. doi:10.1523/JNEUROSCI.5825-09.2010
-
(2010)
J Neurosci
, vol.30
, Issue.14
, pp. 4845-4856
-
-
Tomiyama, T.1
Matsuyama, S.2
Iso, H.3
Umeda, T.4
Takuma, H.5
Ohnishi, K.6
Ishibashi, K.7
Teraoka, R.8
Sakama, N.9
Yamashita, T.10
Nishitsuji, K.11
Ito, K.12
Shimada, H.13
Lambert, M.P.14
Klein, W.L.15
Mori, H.16
-
151
-
-
82755197062
-
Functional links between Abeta toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast
-
COI: 1:CAS:528:DC%2BC3MXhsFCms7nE, PID: 22033521
-
Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S (2011) Functional links between Abeta toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast. Science 334(6060):1241–1245. doi:10.1126/science.1213210
-
(2011)
Science
, vol.334
, Issue.6060
, pp. 1241-1245
-
-
Treusch, S.1
Hamamichi, S.2
Goodman, J.L.3
Matlack, K.E.4
Chung, C.Y.5
Baru, V.6
Shulman, J.M.7
Parrado, A.8
Bevis, B.J.9
Valastyan, J.S.10
Han, H.11
Lindhagen-Persson, M.12
Reiman, E.M.13
Evans, D.A.14
Bennett, D.A.15
Olofsson, A.16
DeJager, P.L.17
Tanzi, R.E.18
Caldwell, K.A.19
Caldwell, G.A.20
Lindquist, S.21
more..
-
152
-
-
84863923855
-
PGC-1alpha rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function
-
Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR (2012) PGC-1alpha rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci Transl Med 4(142):142ra197. doi:10.1126/scitranslmed.3003799
-
(2012)
Sci Transl Med
, vol.4
, Issue.142
, pp. 142197
-
-
Tsunemi, T.1
Ashe, T.D.2
Morrison, B.E.3
Soriano, K.R.4
Au, J.5
Roque, R.A.6
Lazarowski, E.R.7
Damian, V.A.8
Masliah, E.9
La Spada, A.R.10
-
153
-
-
33748140720
-
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer’s disease-linked mutations
-
COI: 1:CAS:528:DC%2BD28XpvVKiuro%3D, PID: 16959576
-
Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I (2006) Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer’s disease-linked mutations. Cell 126(5):981–993. doi:10.1016/j.cell.2006.06.059
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 981-993
-
-
Tu, H.1
Nelson, O.2
Bezprozvanny, A.3
Wang, Z.4
Lee, S.F.5
Hao, Y.H.6
Serneels, L.7
De Strooper, B.8
Yu, G.9
Bezprozvanny, I.10
-
154
-
-
84890919877
-
A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production
-
COI: 1:CAS:528:DC%2BC2cXlslSq, PID: 24373285
-
Udayar V, Buggia-Prevot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J, Simons M, Ries J, Puthenveedu MA, Hardy J, Thinakaran G, Rajendran L (2013) A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production. Cell Rep 5(6):1536–1551. doi:10.1016/j.celrep.2013.12.005
-
(2013)
Cell Rep
, vol.5
, Issue.6
, pp. 1536-1551
-
-
Udayar, V.1
Buggia-Prevot, V.2
Guerreiro, R.L.3
Siegel, G.4
Rambabu, N.5
Soohoo, A.L.6
Ponnusamy, M.7
Siegenthaler, B.8
Bali, J.9
Simons, M.10
Ries, J.11
Puthenveedu, M.A.12
Hardy, J.13
Thinakaran, G.14
Rajendran, L.15
-
155
-
-
79955601720
-
Intraneuronal amyloid beta oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo
-
COI: 1:CAS:528:DC%2BC3MXlsF2jtbg%3D, PID: 21488093
-
Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, Klein WL, Mori H (2011) Intraneuronal amyloid beta oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo. J Neurosci Res 89(7):1031–1042. doi:10.1002/jnr.22640
-
(2011)
J Neurosci Res
, vol.89
, Issue.7
, pp. 1031-1042
-
-
Umeda, T.1
Tomiyama, T.2
Sakama, N.3
Tanaka, S.4
Lambert, M.P.5
Klein, W.L.6
Mori, H.7
-
156
-
-
0141886877
-
Niemann-Pick disease type C
-
COI: 1:STN:280:DC%2BD3svos1ektw%3D%3D, PID: 12974729
-
Vanier MT, Millat G (2003) Niemann-Pick disease type C. Clin Genet 64(4):269–281
-
(2003)
Clin Genet
, vol.64
, Issue.4
, pp. 269-281
-
-
Vanier, M.T.1
Millat, G.2
-
157
-
-
70349330773
-
The regulation of aging: does autophagy underlie longevity?
-
COI: 1:CAS:528:DC%2BD1MXhtFygsrrP, PID: 19726187
-
Vellai T, Takacs-Vellai K, Sass M, Klionsky DJ (2009) The regulation of aging: does autophagy underlie longevity? Trends Cell Biol 19(10):487–494. doi:10.1016/j.tcb.2009.07.007
-
(2009)
Trends Cell Biol
, vol.19
, Issue.10
, pp. 487-494
-
-
Vellai, T.1
Takacs-Vellai, K.2
Sass, M.3
Klionsky, D.J.4
-
158
-
-
0028981018
-
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
-
COI: 1:CAS:528:DyaK2MXnt1amtrs%3D, PID: 7628435
-
Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (1995) A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J 14(14):3339–3348
-
(1995)
EMBO J
, vol.14
, Issue.14
, pp. 3339-3348
-
-
Volinia, S.1
Dhand, R.2
Vanhaesebroeck, B.3
MacDougall, L.K.4
Stein, R.5
Zvelebil, M.J.6
Domin, J.7
Panaretou, C.8
Waterfield, M.D.9
-
159
-
-
84878847155
-
Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3sXhtlGnsbw%3D, PID: 23138650
-
Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O (2013) Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease. Acta Neuropathol 125(2):187–199. doi:10.1007/s00401-012-1065-6
-
(2013)
Acta Neuropathol
, vol.125
, Issue.2
, pp. 187-199
-
-
Wahlster, L.1
Arimon, M.2
Nasser-Ghodsi, N.3
Post, K.L.4
Serrano-Pozo, A.5
Uemura, K.6
Berezovska, O.7
-
160
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
COI: 1:CAS:528:DC%2BD38XivVOntL8%3D, PID: 11932745
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416(6880):535–539. doi:10.1038/416535a
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
161
-
-
43249124363
-
Microtubule-associated protein tau in development, degeneration and protection of neurons
-
COI: 1:CAS:528:DC%2BD1cXmtVSjsrY%3D, PID: 18448228
-
Wang JZ, Liu F (2008) Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol 85(2):148–175. doi:10.1016/j.pneurobio.2008.03.002
-
(2008)
Prog Neurobiol
, vol.85
, Issue.2
, pp. 148-175
-
-
Wang, J.Z.1
Liu, F.2
-
162
-
-
84862907635
-
VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
-
COI: 1:CAS:528:DC%2BC3MXhs1ShsbrO, PID: 22105352
-
Wen L, Tang FL, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, Xiong WC (2011) VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology. J Cell Biol 195(5):765–779. doi:10.1083/jcb.201105109
-
(2011)
J Cell Biol
, vol.195
, Issue.5
, pp. 765-779
-
-
Wen, L.1
Tang, F.L.2
Hong, Y.3
Luo, S.W.4
Wang, C.L.5
He, W.6
Shen, C.7
Jung, J.U.8
Xiong, F.9
Lee, D.H.10
Zhang, Q.G.11
Brann, D.12
Kim, T.W.13
Yan, R.14
Mei, L.15
Xiong, W.C.16
-
163
-
-
84880688558
-
Sorting receptor SORLA–a trafficking path to avoid Alzheimer disease
-
COI: 1:CAS:528:DC%2BC3sXht1Omsb%2FO, PID: 23813966
-
Willnow TE, Andersen OM (2013) Sorting receptor SORLA–a trafficking path to avoid Alzheimer disease. J Cell Sci 126(Pt 13):2751–2760. doi:10.1242/jcs.125393
-
(2013)
J Cell Sci
, vol.126
, pp. 2751-2760
-
-
Willnow, T.E.1
Andersen, O.M.2
-
164
-
-
2442421944
-
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons
-
COI: 1:CAS:528:DC%2BD2cXjvFKjsrc%3D, PID: 15123735
-
Wilson CA, Murphy DD, Giasson BI, Zhang B, Trojanowski JQ, Lee VM (2004) Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol 165(3):335–346. doi:10.1083/jcb.200403061
-
(2004)
J Cell Biol
, vol.165
, Issue.3
, pp. 335-346
-
-
Wilson, C.A.1
Murphy, D.D.2
Giasson, B.I.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.6
-
165
-
-
65249116483
-
Tau mutations in neurodegenerative diseases
-
COI: 1:CAS:528:DC%2BD1MXisVSks7Y%3D, PID: 18948254
-
Wolfe MS (2009) Tau mutations in neurodegenerative diseases. J Biol Chem 284(10):6021–6025. doi:10.1074/jbc.R800013200
-
(2009)
J Biol Chem
, vol.284
, Issue.10
, pp. 6021-6025
-
-
Wolfe, M.S.1
-
166
-
-
14844297330
-
Intracellular retention of caveolin 1 in presenilin-deficient cells
-
COI: 1:CAS:528:DC%2BD2MXhsV2qsbY%3D, PID: 15613480
-
Wood DR, Nye JS, Lamb NJ, Fernandez A, Kitzmann M (2005) Intracellular retention of caveolin 1 in presenilin-deficient cells. J Biol Chem 280(8):6663–6668. doi:10.1074/jbc.M410332200
-
(2005)
J Biol Chem
, vol.280
, Issue.8
, pp. 6663-6668
-
-
Wood, D.R.1
Nye, J.S.2
Lamb, N.J.3
Fernandez, A.4
Kitzmann, M.5
-
167
-
-
39249084075
-
Cholesterol retention in Alzheimer’s brain is responsible for high beta- and gamma-secretase activities and Abeta production
-
COI: 1:CAS:528:DC%2BD1cXisVWns74%3D, PID: 18086530
-
Xiong H, Callaghan D, Jones A, Walker DG, Lue LF, Beach TG, Sue LI, Woulfe J, Xu H, Stanimirovic DB, Zhang W (2008) Cholesterol retention in Alzheimer’s brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol Dis 29(3):422–437. doi:10.1016/j.nbd.2007.10.005
-
(2008)
Neurobiol Dis
, vol.29
, Issue.3
, pp. 422-437
-
-
Xiong, H.1
Callaghan, D.2
Jones, A.3
Walker, D.G.4
Lue, L.F.5
Beach, T.G.6
Sue, L.I.7
Woulfe, J.8
Xu, H.9
Stanimirovic, D.B.10
Zhang, W.11
-
168
-
-
80455158143
-
Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders
-
COI: 1:CAS:528:DC%2BC3MXhsFSiu7%2FJ, PID: 22073234
-
Yamazaki Y, Matsubara T, Takahashi T, Kurashige T, Dohi E, Hiji M, Nagano Y, Yamawaki T, Matsumoto M (2011) Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. PLoS One 6(11):e26996. doi:10.1371/journal.pone.0026996
-
(2011)
PLoS One
, vol.6
, Issue.11
, pp. 26996
-
-
Yamazaki, Y.1
Matsubara, T.2
Takahashi, T.3
Kurashige, T.4
Dohi, E.5
Hiji, M.6
Nagano, Y.7
Yamawaki, T.8
Matsumoto, M.9
-
169
-
-
0032526652
-
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis
-
COI: 1:CAS:528:DyaK1cXktFWms7g%3D, PID: 9669318
-
Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG (1998) Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis. J Neurosci Res 52(6):691–698
-
(1998)
J Neurosci Res
, vol.52
, Issue.6
, pp. 691-698
-
-
Yang, A.J.1
Chandswangbhuvana, D.2
Margol, L.3
Glabe, C.G.4
-
170
-
-
78650716872
-
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits
-
PID: 21186265
-
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA (2011) Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits. Brain 134(Pt 1):258–277. doi:10.1093/brain/awq341
-
(2011)
Brain
, vol.134
, pp. 258-277
-
-
Yang, D.S.1
Stavrides, P.2
Mohan, P.S.3
Kaushik, S.4
Kumar, A.5
Ohno, M.6
Schmidt, S.D.7
Wesson, D.8
Bandyopadhyay, U.9
Jiang, Y.10
Pawlik, M.11
Peterhoff, C.M.12
Yang, A.J.13
Wilson, D.A.14
St George-Hyslop, P.15
Westaway, D.16
Mathews, P.M.17
Levy, E.18
Cuervo, A.M.19
Nixon, R.A.20
more..
-
171
-
-
84871905647
-
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease
-
COI: 1:CAS:528:DC%2BC38XhvVOitb3K, PID: 23209315
-
Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF (2012) Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med 209(13):2501–2513. doi:10.1084/jem.20121239
-
(2012)
J Exp Med
, vol.209
, Issue.13
, pp. 2501-2513
-
-
Yao, J.1
Ho, D.2
Calingasan, N.Y.3
Pipalia, N.H.4
Lin, M.T.5
Beal, M.F.6
-
172
-
-
26444587508
-
Macroautophagy–a novel Beta-amyloid peptide-generating pathway activated in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2MXhtFWitrjI, PID: 16203860
-
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA (2005) Macroautophagy–a novel Beta-amyloid peptide-generating pathway activated in Alzheimer’s disease. J Cell Biol 171(1):87–98. doi:10.1083/jcb.200505082
-
(2005)
J Cell Biol
, vol.171
, Issue.1
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
Jiang, Y.11
Duff, K.12
Uchiyama, Y.13
Naslund, J.14
Mathews, P.M.15
Cataldo, A.M.16
Nixon, R.A.17
-
173
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
COI: 1:CAS:528:DC%2BD3sXpvFaqtbg%3D, PID: 14657337
-
Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100(25):15077–15082. doi:10.1073/pnas.2436255100
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.25
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
174
-
-
32244442749
-
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
-
COI: 1:CAS:528:DC%2BD28Xhs1eitLo%3D, PID: 16390869
-
Zeng X, Overmeyer JH, Maltese WA (2006) Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 119(Pt 2):259–270. doi:10.1242/jcs.02735
-
(2006)
J Cell Sci
, vol.119
, pp. 259-270
-
-
Zeng, X.1
Overmeyer, J.H.2
Maltese, W.A.3
-
175
-
-
84862883617
-
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2
-
COI: 1:CAS:528:DC%2BC38XpsV2hsr0%3D, PID: 22723704
-
Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS (2012) A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci 32(25):8633–8648. doi:10.1523/JNEUROSCI.0556-12.2012
-
(2012)
J Neurosci
, vol.32
, Issue.25
, pp. 8633-8648
-
-
Zhang, X.1
Garbett, K.2
Veeraraghavalu, K.3
Wilburn, B.4
Gilmore, R.5
Mirnics, K.6
Sisodia, S.S.7
-
176
-
-
79551528853
-
The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation
-
COI: 1:CAS:528:DC%2BC3MXhtlWltbg%3D, PID: 21283715
-
Zhou X, Takatoh J, Wang F (2011) The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. PLoS One 6(1):e16358. doi:10.1371/journal.pone.0016358
-
(2011)
PLoS One
, vol.6
, Issue.1
-
-
Zhou, X.1
Takatoh, J.2
Wang, F.3
-
177
-
-
77952722628
-
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
-
COI: 1:CAS:528:DC%2BC3cXmslGru78%3D, PID: 20439739
-
Zhou X, Wang L, Hasegawa H, Amin P, Han BX, Kaneko S, He Y, Wang F (2010) Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci USA 107(20):9424–9429. doi:10.1073/pnas.0914725107
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.20
, pp. 9424-9429
-
-
Zhou, X.1
Wang, L.2
Hasegawa, H.3
Amin, P.4
Han, B.X.5
Kaneko, S.6
He, Y.7
Wang, F.8
|