Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Journal of Cell Biology

Volumn 166, Issue 7, 2004, Pages 1041-1054

  Esselens, Gary ^a   Oorschot, Viola ^b   Baert, Veerle ^a   Raemaekers, Tim ^a   Spittaels, Kurt ^c   Serneels, Lutgarde ^a   Zheng, Hui ^e   Saftig, Paul ^d   De Strooper, Bart ^a   Klumperman, Judith ^b   Annaert, Wim ^a,f  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c GALAPAGOS NV   (Belgium)

^d UNIVERSITY OF KIEL   (Germany)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Autophagic vacuole; Hippocampal neuron; Phagocytosis; Presenilin 1; Telencephalin

Indexed keywords

ADENOVIRUS VECTOR; AMYLOID PRECURSOR PROTEIN; CALCIUM; CATHEPSIN D; CELL ADHESION MOLECULE; FLAVINE ADENINE NUCLEOTIDE; GAMMA SECRETASE; INTERCELLULAR ADHESION MOLECULE 5; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN 1; TELENCEPHALIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CALCIUM TRANSPORT; CELL VACUOLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; HELA CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYSOSOME; NERVE CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; WILD TYPE;

ACTINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; AUTOPHAGY; CATHEPSIN D; CELL ADHESION MOLECULES; ENDOPEPTIDASES; ENDOSOMES; HELA CELLS; HIPPOCAMPUS; HUMANS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PRESENILIN-1; PROTEINS; SIGNAL TRANSDUCTION; VACUOLES;

ADENOVIRIDAE;

EID: 4644257963     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200406060     Document Type: Article

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