-
1
-
-
77956612339
-
Megalin interacts with APP and the intracellular adapter protein FE65 in neurons
-
Alvira-Botero, X., Perez-Gonzalez, R., Spuch, C., Vargas, T., Antequera, D., Garzon, M., Bermejo-Pareja, F. and Carro, E. (2010). Megalin interacts with APP and the intracellular adapter protein FE65 in neurons. Mol. Cell. Neurosci. 45, 306-315.
-
(2010)
Mol. Cell. Neurosci.
, vol.45
, pp. 306-315
-
-
Alvira-Botero, X.1
Perez-Gonzalez, R.2
Spuch, C.3
Vargas, T.4
Antequera, D.5
Garzon, M.6
Bermejo-Pareja, F.7
Carro, E.8
-
2
-
-
26444607532
-
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
-
Andersen, O. M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C. A., Breiderhoff, T., Jansen, P., Wu, X. et al. (2005). Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 102, 13461-13466.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13461-13466
-
-
Andersen, O.M.1
Reiche, J.2
Schmidt, V.3
Gotthardt, M.4
Spoelgen, R.5
Behlke, J.6
von Arnim, C.A.7
Breiderhoff, T.8
Jansen, P.9
Wu, X.10
-
3
-
-
33644516276
-
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11
-
Andersen, O. M., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W. J., Parker, M. W., Masters, C. L., Hyman, B. T. et al. (2006). Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry 45, 2618-2628.
-
(2006)
Biochemistry
, vol.45
, pp. 2618-2628
-
-
Andersen, O.M.1
Schmidt, V.2
Spoelgen, R.3
Gliemann, J.4
Behlke, J.5
Galatis, D.6
McKinstry, W.J.7
Parker, M.W.8
Masters, C.L.9
Hyman, B.T.10
-
4
-
-
34548301693
-
beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment
-
Back, S., Haas, P., Tschape, J. A., Gruebl, T., Kirsch, J., Muller, U., Beyreuther, K. and Kins, S. (2007). beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J. Neurosci. Res. 85, 2580-2590.
-
(2007)
J. Neurosci. Res.
, vol.85
, pp. 2580-2590
-
-
Back, S.1
Haas, P.2
Tschape, J.A.3
Gruebl, T.4
Kirsch, J.5
Muller, U.6
Beyreuther, K.7
Kins, S.8
-
5
-
-
49849086825
-
SORL1 is genetically associated with increased risk for late-onset alzheimer disease in the Belgian population
-
Bettens, K., Brouwers, N., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C. and Sleegers, K. (2008). SORL1 is genetically associated with increased risk for late-onset alzheimer disease in the Belgian population. Hum. Mutat. 29, 769-770.
-
(2008)
Hum. Mutat.
, vol.29
, pp. 769-770
-
-
Bettens, K.1
Brouwers, N.2
Engelborghs, S.3
De Deyn, P.P.4
Van Broeckhoven, C.5
Sleegers, K.6
-
6
-
-
33746310315
-
Alzheimer's disease
-
Blennow, K., de Leon, M. J. and Zetterberg, H. (2006). Alzheimer's disease. Lancet 368, 387-403.
-
(2006)
Lancet
, vol.368
, pp. 387-403
-
-
Blennow, K.1
de Leon, M.J.2
Zetterberg, H.3
-
7
-
-
33744965388
-
SorLA signaling by regulated intramembrane proteolysis
-
Böhm, C., Seibel, N. M., Henkel, B., Steiner, H., Haass, C. and Hampe, W. (2006). SorLA signaling by regulated intramembrane proteolysis. J. Biol. Chem. 281, 1454714553.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1454714553
-
-
Bohm, C.1
Seibel, N.M.2
Henkel, B.3
Steiner, H.4
Haass, C.5
Hampe, W.6
-
8
-
-
0036668808
-
The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and Ypp0 sorting signals at distinct sites
-
Boll, W., Rapoport, I., Brunner, C., Modis, Y., Prehn, S. and Kirchhausen, T. (2002). The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and Ypp0 sorting signals at distinct sites. Traffic 3, 590-600.
-
(2002)
Traffic
, vol.3
, pp. 590-600
-
-
Boll, W.1
Rapoport, I.2
Brunner, C.3
Modis, Y.4
Prehn, S.5
Kirchhausen, T.6
-
9
-
-
67349270965
-
-
Bu, G. (2009). Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 10, 333-344.
-
(2009)
Nat. Rev. Neurosci.
, vol.10
, pp. 333-344
-
-
Bu, G.1
-
10
-
-
77950550447
-
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex
-
Burgos, P. V., Mardones, G. A., Rojas, A. L., daSilva, L. L., Prabhu, Y., Hurley, J. H. and Bonifacino, J. S. (2010). Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev. Cell 18, 425-436.
-
(2010)
Dev. Cell
, vol.18
, pp. 425-436
-
-
Burgos, P.V.1
Mardones, G.A.2
Rojas, A.L.3
daSilva, L.L.4
Prabhu, Y.5
Hurley, J.H.6
Bonifacino, J.S.7
-
11
-
-
84858599262
-
-
Caglayan, S., Bauerfeind, A., Schmidt, V., Carlo, A. S., Prabakaran, T., Hiibner, N. and Willnow, T. E. (2012). Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain. Arch. Neurol. 69, 373-379.
-
(2012)
Arch. Neurol.
, vol.69
, pp. 373-379
-
-
Caglayan, S.1
Bauerfeind, A.2
Schmidt, V.3
Carlo, A.S.4
Prabakaran, T.5
Hiibner, N.6
Willnow, T.E.7
-
12
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
-
Cai, H. B., Wang, Y. S., McCarthy, D., Wen, H. J., Borchelt, D. R., Price, D. L. and Wong, P. C. (2001). BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4, 233-234.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 233-234
-
-
Cai, H.B.1
Wang, Y.S.2
McCarthy, D.3
Wen, H.J.4
Borchelt, D.R.5
Price, D.L.6
Wong, P.C.7
-
13
-
-
3142717640
-
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
-
Cam, J. A., Zerbinatti, C. V., Knisely, J. M., Hecimovic, S., Li, Y. and Bu, G. (2004). The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. J. Biol. Chem. 279, 29639-29646.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 29639-29646
-
-
Cam, J.A.1
Zerbinatti, C.V.2
Knisely, J.M.3
Hecimovic, S.4
Li, Y.5
Bu, G.6
-
14
-
-
17644421882
-
Rapid endocytosis ofthe low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein
-
Cam, J. A., Zerbinatti, C. V., Li, Y. and Bu, G. (2005). Rapid endocytosis ofthe low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. J. Biol. Chem. 280, 15464-15470.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15464-15470
-
-
Cam, J.A.1
Zerbinatti, C.V.2
Li, Y.3
Bu, G.4
-
15
-
-
34547136377
-
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein
-
Carey, R. M., Balcz, B. A., Lopez-Coviella, I. and Slack, B. E. (2005). Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 6, 30.
-
(2005)
BMC Cell Biol.
, vol.6
, pp. 30
-
-
Carey, R.M.1
Balcz, B.A.2
Lopez-Coviella, I.3
Slack, B.E.4
-
16
-
-
0037762690
-
Neurotrophins and their receptors: a convergence point for many signalling pathways
-
Chao, M. V. (2003). Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309.
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 299-309
-
-
Chao, M.V.1
-
17
-
-
84864359816
-
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid p (Ap) production in the trans-Golgi network
-
Choy, R. W. Y., Cheng, Z. L. and Schekman, R. (2012). Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid p (Ap) production in the trans-Golgi network. Proc. Natl. Acad. Sci. USA 109, E2077-E2082.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
-
-
Choy, R.W.Y.1
Cheng, Z.L.2
Schekman, R.3
-
18
-
-
0345803941
-
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface
-
Chyung, J. H. and Selkoe, D. J. (2003). Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J. Biol. Chem.278, 51035-51043.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 51035-51043
-
-
Chyung, J.H.1
Selkoe, D.J.2
-
19
-
-
29144487182
-
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
-
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S. and Holtzman, D. M. (2005). Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48, 913-922.
-
(2005)
Neuron
, vol.48
, pp. 913-922
-
-
Cirrito, J.R.1
Yamada, K.A.2
Finn, M.B.3
Sloviter, R.S.4
Bales, K.R.5
May, P.C.6
Schoepp, D.D.7
Paul, S.M.8
Mennerick, S.9
Holtzman, D.M.10
-
20
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
Cirrito, J. R., Kang, J. E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G. J., Mennerick, S. and Holtzman, D. M. (2008). Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58, 42-51.
-
(2008)
Neuron
, vol.58
, pp. 42-51
-
-
Cirrito, J.R.1
Kang, J.E.2
Lee, J.3
Stewart, F.R.4
Verges, D.K.5
Silverio, L.M.6
Bu, G.J.7
Mennerick, S.8
Holtzman, D.M.9
-
21
-
-
73549122575
-
GGA autoinhibition revisited
-
Cramer, J. F., Gustafsen, C., Behrens, M. A., Oliveira, C. L., Pedersen, J. S., Madsen, P., Petersen, C. M. and Thirup, S. S. (2010). GGA autoinhibition revisited. Traffic 11, 259-273.
-
(2010)
Traffic
, vol.11
, pp. 259-273
-
-
Cramer, J.F.1
Gustafsen, C.2
Behrens, M.A.3
Oliveira, C.L.4
Pedersen, J.S.5
Madsen, P.6
Petersen, C.M.7
Thirup, S.S.8
-
22
-
-
61449117869
-
Association ofdistinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
-
MIRAGE Study Group
-
Cuenco, K. T., Lunetta, K. L., Baldwin, C. T., McKee, A. C., Guo, J., Cupples, L. A., Green, R. C., St George-Hyslop, P. H., Chui, H., DeCarli, C. et al.; MIRAGE Study Group (2008). Association ofdistinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch. Neurol. 65, 16401648.
-
(2008)
Arch. Neurol.
, vol.65
, pp. 16401648
-
-
Cuenco, K.T.1
Lunetta, K.L.2
Baldwin, C.T.3
McKee, A.C.4
Guo, J.5
Cupples, L.A.6
Green, R.C.7
St George-Hyslop, P.H.8
Chui, H.9
DeCarli, C.10
-
23
-
-
0028892096
-
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence
-
De Strooper, B., Simons, M., Multhaup, G., Van Leuven, F., Beyreuther, K. and Dotti, C. G. (1995a). Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. EMBO J. 14, 4932-4938.
-
(1995)
EMBO J.
, vol.14
, pp. 4932-4938
-
-
De Strooper, B.1
Simons, M.2
Multhaup, G.3
Van Leuven, F.4
Beyreuther, K.5
Dotti, C.G.6
-
24
-
-
0028906488
-
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease
-
De Strooper, B., Craessaerts, K., Dewachter, I., Moechars, D., Greenberg, B., Van Leuven, F. and Van den Berghe, H. (1995b). Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. J. Biol. Chem. 270, 4058-4065.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 4058-4065
-
-
De Strooper, B.1
Craessaerts, K.2
Dewachter, I.3
Moechars, D.4
Greenberg, B.5
Van Leuven, F.6
Van den Berghe, H.7
-
25
-
-
48249102303
-
Role ofaxonal transport in neurodegenerative diseases
-
De Vos, K. J., Grierson, A. J., Ackerley, S. and Miller, C. C. (2008). Role ofaxonal transport in neurodegenerative diseases. Annu. Rev. Neurosci. 31, 151-173.
-
(2008)
Annu. Rev. Neurosci.
, vol.31
, pp. 151-173
-
-
De Vos, K.J.1
Grierson, A.J.2
Ackerley, S.3
Miller, C.C.4
-
26
-
-
33748536734
-
LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease
-
Dodson, S. E., Gearing, M., Lippa, C. F., Montine, T. J., Levey, A. I. and Lah, J. J. (2006). LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease. J. Neuropathol. Exp. Neurol. 65, 866-872.
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 866-872
-
-
Dodson, S.E.1
Gearing, M.2
Lippa, C.F.3
Montine, T.J.4
Levey, A.I.5
Lah, J.J.6
-
27
-
-
58149373433
-
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease
-
Dodson, S. E., Andersen, O. M., Karmali, V., Fritz, J. J., Cheng, D., Peng, J., Levey, A. I., Willnow, T. E. and Lah, J. J. (2008). Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J. Neurosci. 28, 12877-12886.
-
(2008)
J. Neurosci.
, vol.28
, pp. 12877-12886
-
-
Dodson, S.E.1
Andersen, O.M.2
Karmali, V.3
Fritz, J.J.4
Cheng, D.5
Peng, J.6
Levey, A.I.7
Willnow, T.E.8
Lah, J.J.9
-
28
-
-
84858300270
-
FE65 as a link between VLDLR and APP to regulate their trafficking and processing
-
Dumanis, S. B., Chamberlain, K. A., Jin Sohn, Y., Jin Lee, Y., Guenette, S. Y., Suzuki, T., Mathews, P. M., Pak, D. T., Rebeck, G. W., Suh, Y. H. et al. (2012). FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol. Neurodegener. 7,9.
-
(2012)
Mol. Neurodegener.
, vol.7
, pp. 9
-
-
Dumanis, S.B.1
Chamberlain, K.A.2
Jin Sohn, Y.3
Jin Lee, Y.4
Guenette, S.Y.5
Suzuki, T.6
Mathews, P.M.7
Pak, D.T.8
Rebeck, G.W.9
Suh, Y.H.10
-
29
-
-
79953297068
-
BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin
-
Finan, G. M., Okada, H. and Kim, T. W. (2011). BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J. Biol. Chem. 286, 1260212616.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1260212616
-
-
Finan, G.M.1
Okada, H.2
Kim, T.W.3
-
30
-
-
84863011338
-
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing
-
Fjorback, A. W., Seaman, M., Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R. et al. (2012). Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J. Neurosci. 32, 1467-1480.
-
(2012)
J. Neurosci.
, vol.32
, pp. 1467-1480
-
-
Fjorback, A.W.1
Seaman, M.2
Gustafsen, C.3
Mehmedbasic, A.4
Gokool, S.5
Wu, C.6
Militz, D.7
Schmidt, V.8
Madsen, P.9
Nyengaard, J.R.10
-
31
-
-
3142680780
-
The mosaic receptor sorLA/LR11 binds components ofthe plasminogen activating system and PDGF-BB similarly to low density lipoprotein receptor-related protein (LRP1) but mediates slow internalization of bound ligand
-
Gliemann, J., Hermey, G., Nykjaer, A., Petersen, C. M., Jacobsen, C. and Andreasen, P. A. (2004). The mosaic receptor sorLA/LR11 binds components ofthe plasminogen activating system and PDGF-BB similarly to low density lipoprotein receptor-related protein (LRP1) but mediates slow internalization of bound ligand. Biochem. J. 381, 203-212.
-
(2004)
Biochem. J.
, vol.381
, pp. 203-212
-
-
Gliemann, J.1
Hermey, G.2
Nykjaer, A.3
Petersen, C.M.4
Jacobsen, C.5
Andreasen, P.A.6
-
32
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L. et al. (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
33
-
-
0026539090
-
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
-
Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J. and Younkin, S. G. (1992). Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730.
-
(1992)
Science
, vol.255
, pp. 728-730
-
-
Golde, T.E.1
Estus, S.2
Younkin, L.H.3
Selkoe, D.J.4
Younkin, S.G.5
-
34
-
-
72849132718
-
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
-
Grear, K. E., Ling, I. F., Simpson, J. F., Furman, J. L., Simmons, C. R., Peterson, S. L., Schmitt, F. A., Markesbery, W. R., Liu, Q., Crook, J. E. et al. (2009). Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol. Neurodegener. 4, 46.
-
(2009)
Mol. Neurodegener.
, vol.4
, pp. 46
-
-
Grear, K.E.1
Ling, I.F.2
Simpson, J.F.3
Furman, J.L.4
Simmons, C.R.5
Peterson, S.L.6
Schmitt, F.A.7
Markesbery, W.R.8
Liu, Q.9
Crook, J.E.10
-
35
-
-
84871815475
-
Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
-
Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjaer, A., Madsen, P. and Petersen, C. M. (2013). Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J. Neurosci. 33, 64-71.
-
(2013)
J. Neurosci.
, vol.33
, pp. 64-71
-
-
Gustafsen, C.1
Glerup, S.2
Pallesen, L.T.3
Olsen, D.4
Andersen, O.M.5
Nykjaer, A.6
Madsen, P.7
Petersen, C.M.8
-
36
-
-
0026735070
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
-
Haass, C., Koo, E. H., Mellon, A., Hung, A. Y. and Selkoe, D. J. (1992). Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
-
(1992)
Nature
, vol.357
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
37
-
-
0028985176
-
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
-
Haass, C., Koo, E. H., Capell, A., Teplow, D. B. and Selkoe, D. J. (1995). Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J. Cell Biol. 128, 537-547.
-
(1995)
J. Cell Biol.
, vol.128
, pp. 537-547
-
-
Haass, C.1
Koo, E.H.2
Capell, A.3
Teplow, D.B.4
Selkoe, D.J.5
-
38
-
-
84862633779
-
Trafficking and proteolytic processing of APP
-
Haass, C., Kaether, C., Thinakaran, G. and Sisodia, S. (2012). Trafficking and proteolytic processing of APP. Cold Spring Harbor perspectives in medicine 2, a006270.
-
(2012)
Cold Spring Harbor perspectives in medicine
, vol.2
-
-
Haass, C.1
Kaether, C.2
Thinakaran, G.3
Sisodia, S.4
-
39
-
-
0034502960
-
Ectodomain shedding, translocation and synthesis ofSorLA are stimulated by its ligand head activator
-
Hampe, W., Riedel, I. B., Lintzel, J., Bader, C. O., Franke, I. and Schaller, H. C. (2000). Ectodomain shedding, translocation and synthesis ofSorLA are stimulated by its ligand head activator. J. Cell Sci. 113, 4475-4485.
-
(2000)
J. Cell Sci.
, vol.113
, pp. 4475-4485
-
-
Hampe, W.1
Riedel, I.B.2
Lintzel, J.3
Bader, C.O.4
Franke, I.5
Schaller, H.C.6
-
40
-
-
0034919191
-
The genes for the human VPS10 domain-containing receptors are large and contain many small exons
-
Hampe, W., Rezgaoui, M., Hermans-Borgmeyer, I. and Schaller, H. C. (2001). The genes for the human VPS10 domain-containing receptors are large and contain many small exons. Hum. Genet. 108, 529-536.
-
(2001)
Hum. Genet.
, vol.108
, pp. 529-536
-
-
Hampe, W.1
Rezgaoui, M.2
Hermans-Borgmeyer, I.3
Schaller, H.C.4
-
41
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy, J. A. and Higgins, G. A. (1992). Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
42
-
-
0033590160
-
-
Hermey, G., Riedel, I. B., Hampe, W., Schaller, H. C. and Hermans-Borgmeyer, I. (1999). Identification and characterization of SorCS, a third member of a novel receptor family. Biochem. Biophys. Res. Commun. 266, 347-351.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.266
, pp. 347-351
-
-
Hermey, G.1
Riedel, I.B.2
Hampe, W.3
Schaller, H.C.4
Hermans-Borgmeyer, I.5
-
43
-
-
33645763676
-
Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members
-
Hermey, G., Sjogaard, S. S., Petersen, C. M., Nykjaer, A. and Gliemann, J. (2006). Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members. Biochem. J. 395, 285-293.
-
(2006)
Biochem. J.
, vol.395
, pp. 285-293
-
-
Hermey, G.1
Sjogaard, S.S.2
Petersen, C.M.3
Nykjaer, A.4
Gliemann, J.5
-
44
-
-
79953221858
-
Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production
-
Herskowitz, J. H., Seyfried, N. T., Gearing, M., Kahn, R. A., Peng, J. M., Levey, A. I. and Lah, J. J. (2011). Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. J. Biol. Chem. 286, 6117-6127.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6117-6127
-
-
Herskowitz, J.H.1
Seyfried, N.T.2
Gearing, M.3
Kahn, R.A.4
Peng, J.M.5
Levey, A.I.6
Lah, J.J.7
-
45
-
-
84863934372
-
GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-p production
-
Herskowitz, J. H., Offe, K., Deshpande, A., Kahn, R. A., Levey, A. I. and Lah, J. J. (2012). GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-p production. Mol. Biol. Cell 23, 2645-2657.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2645-2657
-
-
Herskowitz, J.H.1
Offe, K.2
Deshp, A.3
Kahn, R.A.4
Levey, A.I.5
Lah, J.J.6
-
46
-
-
67049155952
-
Apolipoprotein E receptors in the nervous system
-
Herz, J. (2009). Apolipoprotein E receptors in the nervous system. Curr. Opin. Lipidol. 20, 190-196.
-
(2009)
Curr. Opin. Lipidol
, vol.20
, pp. 190-196
-
-
Herz, J.1
-
47
-
-
27144504391
-
F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein
-
Hoe, H. S., Wessner, D., Beffert, U., Becker, A. G., Matsuoka, Y. and Rebeck, G. W. (2005). F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol. Cell. Biol. 25, 9259-9268.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 9259-9268
-
-
Hoe, H.S.1
Wessner, D.2
Beffert, U.3
Becker, A.G.4
Matsuoka, Y.5
Rebeck, G.W.6
-
48
-
-
33747692276
-
FE65 interaction with the ApoE receptor ApoEr2
-
Hoe, H. S., Magill, L. A., Guenette, S., Fu, Z., Vicini, S. and Rebeck, G. W. (2006). FE65 interaction with the ApoE receptor ApoEr2. J. Biol. Chem. 281, 24521-24530.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 24521-24530
-
-
Hoe, H.S.1
Magill, L.A.2
Guenette, S.3
Fu, Z.4
Vicini, S.5
Rebeck, G.W.6
-
49
-
-
33845411954
-
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
-
Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S. and Malinow, R. (2006). AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52, 831-843.
-
(2006)
Neuron
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
Boehm, J.2
Sato, C.3
Iwatsubo, T.4
Tomita, T.5
Sisodia, S.6
Malinow, R.7
-
50
-
-
0034721842
-
Maturation and endosomal targeting ofbeta-site amyloid precursor protein-cleaving enzyme
-
The Alzheimer's disease beta-secretase
-
Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M. and Doms, R. W. (2000). Maturation and endosomal targeting ofbeta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J. Biol. Chem. 275, 33729-33737.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.4
Doms, R.W.5
-
51
-
-
0029769923
-
Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway
-
Ikin, A. F., Annaert, W. G., Takei, K., De Camilli, P., Jahn, R., Greengard, P. and Buxbaum, J. D. (1996). Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J. Biol. Chem. 271, 31783-31786.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31783-31786
-
-
Ikin, A.F.1
Annaert, W.G.2
Takei, K.3
De Camilli, P.4
Jahn, R.5
Greengard, P.6
Buxbaum, J.D.7
-
52
-
-
0029962505
-
Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein
-
Jacobsen, L., Madsen, P., Moestrup, S. K., Lund, A. H., Tommerup, N., Nykjaer, A., Sottrup-Jensen, L., Gliemann, J. and Petersen, C. M. (1996). Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J. Biol. Chem. 271, 31379-31383.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31379-31383
-
-
Jacobsen, L.1
Madsen, P.2
Moestrup, S.K.3
Lund, A.H.4
Tommerup, N.5
Nykjaer, A.6
Sottrup-Jensen, L.7
Gliemann, J.8
Petersen, C.M.9
-
53
-
-
0035933822
-
Activation and functional characterization of the mosaic receptor SorLA/LR11
-
Jacobsen, L., Madsen, P., Jacobsen, C., Nielsen, M. S., Gliemann, J. and Petersen, C. M. (2001). Activation and functional characterization of the mosaic receptor SorLA/LR11. J. Biol. Chem. 276, 22788-22796.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22788-22796
-
-
Jacobsen, L.1
Madsen, P.2
Jacobsen, C.3
Nielsen, M.S.4
Gliemann, J.5
Petersen, C.M.6
-
54
-
-
0037196416
-
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding
-
Jacobsen, L., Madsen, P., Nielsen, M. S., Geraerts, W. P., Gliemann, J., Smit, A. B. and Petersen, C. M. (2002). The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett. 511, 155158.
-
(2002)
FEBS Lett.
, vol.511
, pp. 155158
-
-
Jacobsen, L.1
Madsen, P.2
Nielsen, M.S.3
Geraerts, W.P.4
Gliemann, J.5
Smit, A.B.6
Petersen, C.M.7
-
55
-
-
33746860830
-
Potentialroleofdietaryn-3 fattyacidsinthe prevention of dementia and macular degeneration
-
Johnson,E.J.and Schaefer,E.J.(2006). Potentialroleofdietaryn-3 fattyacidsinthe prevention of dementia and macular degeneration. Am. J. Clin. Nutr. 83 Suppl., 1494S-1498S.
-
(2006)
Am. J. Clin. Nutr.
, vol.83
, Issue.SUPPL.
-
-
Johnson, E.J.1
Schaefer, E.J.2
-
56
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S. and Malinow, R. (2003). APP processing and synaptic function. Neuron 37, 925-937.
-
(2003)
Neuro
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
57
-
-
0026733343
-
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region
-
Kamino, K., Orr, H. T., Payami, H., Wijsman, E. M., Alonso, M. E., Pulst, S. M., Anderson, L., O'dahl, S., Nemens, E., White, J. A. et al. (1992). Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am. J. Hum. Genet. 51, 998-1014.
-
(1992)
Am. J. Hum. Genet.
, vol.51
, pp. 998-1014
-
-
Kamino, K.1
Orr, H.T.2
Payami, H.3
Wijsman, E.M.4
Alonso, M.E.5
Pulst, S.M.6
Anderson, L.7
O'dahl, S.8
Nemens, E.9
White, J.A.10
-
58
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
-
Karran, E., Mercken, M. and De Strooper, B. (2011). The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10, 698-712.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
59
-
-
79953134227
-
SorLAregulates the activity oflipoprotein lipase by intracellular trafficking
-
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G., Prabakaran, T., Nilsson, S. K., Kjaergaard, M. M., Bakke, O. et al. (2011). SorLAregulates the activity oflipoprotein lipase by intracellular trafficking. J. Cell Sci. 124, 1095-1105.
-
(2011)
J. Cell Sci.
, vol.124
, pp. 1095-1105
-
-
Klinger, S.C.1
Glerup, S.2
Raarup, M.K.3
Mari, M.C.4
Nyegaard, M.5
Koster, G.6
Prabakaran, T.7
Nilsson, S.K.8
Kjaergaard, M.M.9
Bakke, O.10
-
60
-
-
0028276801
-
Evidence that production and release ofamyloid beta-protein involves the endocytic pathway
-
Koo, E. H. and Squazzo, S. L. (1994). Evidence that production and release ofamyloid beta-protein involves the endocytic pathway. J. Biol. Chem. 269, 17386-17389.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
61
-
-
0025056563
-
Precursor ofamyloid protein in Alzheimer disease undergoes fast anterograde axonal transport
-
Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L. and Price, D. L. (1990). Precursor ofamyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc. Natl. Acad. Sci. USA 87, 1561-1565.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 1561-1565
-
-
Koo, E.H.1
Sisodia, S.S.2
Archer, D.R.3
Martin, L.J.4
Weidemann, A.5
Beyreuther, K.6
Fischer, P.7
Masters, C.L.8
Price, D.L.9
-
62
-
-
77956392552
-
ADAM10 is the physiologically relevant, constitutive alpha-secretase ofthe amyloid precursorprotein in primary neurons
-
Kuhn, P. H., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Rossner, S. and Lichtenthaler, S. F. (2010). ADAM10 is the physiologically relevant, constitutive alpha-secretase ofthe amyloid precursorprotein in primary neurons. EMBO J. 29, 3020-3032.
-
(2010)
EMBO J.
, vol.29
, pp. 3020-3032
-
-
Kuhn, P.H.1
Wang, H.2
Dislich, B.3
Colombo, A.4
Zeitschel, U.5
Ellwart, J.W.6
Kremmer, E.7
Rossner, S.8
Lichtenthaler, S.F.9
-
63
-
-
0028966092
-
Characterization ofsorting signals in the beta-amyloid precursor protein cytoplasmic domain
-
Lai, A., Sisodia, S. S. and Trowbridge, I. S. (1995). Characterization ofsorting signals in the beta-amyloid precursor protein cytoplasmic domain. J. Biol. Chem. 270, 35653573.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 35653573
-
-
Lai, A.1
Sisodia, S.S.2
Trowbridge, I.S.3
-
64
-
-
78650627732
-
Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1
-
Lane, R. F., Gatson, J. W., Small, S. A., Ehrlich, M. E. and Gandy, S. (2010a). Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. Mol. Neurodegener. 5, 62.
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 62
-
-
Lane, R.F.1
Gatson, J.W.2
Small, S.A.3
Ehrlich, M.E.4
Gandy, S.5
-
65
-
-
77957326612
-
Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex
-
Lane, R. F., Raines, S. M., Steele, J. W., Ehrlich, M. E., Lah, J. A., Small, S. A., Tanzi, R. E., Attie, A. D. and Gandy, S. (2010b). Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J. Neurosci. 30, 13110-13115.
-
(2010)
J. Neurosci.
, vol.30
, pp. 13110-13115
-
-
Lane, R.F.1
Raines, S.M.2
Steele, J.W.3
Ehrlich, M.E.4
Lah, J.A.5
Small, S.A.6
Tanzi, R.E.7
Attie, A.D.8
Gandy, S.9
-
66
-
-
84876231726
-
Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-p Peptide
-
Lane, R. F., Steele, J. W., Cai, D., Ehrlich, M. E., Attie, A. D. and Gandy, S. (2013). Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-p Peptide. J. Neurosci. 33, 7099-7107.
-
(2013)
J. Neurosci.
, vol.33
, pp. 7099-7107
-
-
Lane, R.F.1
Steele, J.W.2
Cai, D.3
Ehrlich, M.E.4
Attie, A.D.5
Gandy, S.6
-
67
-
-
40549105438
-
Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease
-
Lee, J. H., Cheng, R., Honig, L. S., Vonsattel, J. P., Clark, L. and Mayeux, R. (2008). Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease. Neurology 70, 887-889.
-
(2008)
Neurology
, vol.70
, pp. 887-889
-
-
Lee, J.H.1
Cheng, R.2
Honig, L.S.3
Vonsattel, J.P.4
Clark, L.5
Mayeux, R.6
-
68
-
-
33644875726
-
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42
-
Leuchtenberger, S., Kummer, M. P., Kukar, T., Czirr, E., Teusch, N., Sagi, S. A., Berdeaux, R., Pietrzik, C. U., Ladd, T. B., Golde, T. E. et al. (2006). Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J. Neurochem. 96, 355-365.
-
(2006)
J. Neurochem.
, vol.96
, pp. 355-365
-
-
Leuchtenberger, S.1
Kummer, M.P.2
Kukar, T.3
Czirr, E.4
Teusch, N.5
Sagi, S.A.6
Berdeaux, R.7
Pietrzik, C.U.8
Ladd, T.B.9
Golde, T.E.10
-
69
-
-
0034796509
-
Low-density lipoprotein receptor family: endocytosis and signal transduction
-
Li, Y., Cam, J. and Bu, G. (2001). Low-density lipoprotein receptor family: endocytosis and signal transduction. Mol. Neurobiol. 23, 53-67.
-
(2001)
Mol. Neurobiol.
, vol.23
, pp. 53-67
-
-
Li, Y.1
Cam, J.2
Bu, G.3
-
70
-
-
37549040611
-
Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention
-
Ma, Q. L., Teter, B., Ubeda, O. J., Morihara, T., Dhoot, D., Nyby, M. D., Tuck, M.L.,Frautschy, S.A. and Cole,G.M. (2007). Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J. Neurosci. 27, 14299-14307.
-
(2007)
J. Neurosci.
, vol.27
, pp. 14299-14307
-
-
Ma, Q.L.1
Teter, B.2
Ubeda, O.J.3
Morihara, T.4
Dhoot, D.5
Nyby, M.D.6
Tuck, M.L.7
Frautschy, S.A.8
Cole, G.M.9
-
71
-
-
65249177703
-
Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid
-
Ma, Q. L., Galasko, D. R., Ringman, J. M., Vinters, H. V., Edland, S. D., Pomakian, J., Ubeda, O. J., Rosario, E. R., Teter, B., Frautschy, S. A. et al. (2009). Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch. Neurol. 66, 448-457.
-
(2009)
Arch. Neurol.
, vol.66
, pp. 448-457
-
-
Ma, Q.L.1
Galasko, D.R.2
Ringman, J.M.3
Vinters, H.V.4
Edland, S.D.5
Pomakian, J.6
Ubeda, O.J.7
Rosario, E.R.8
Teter, B.9
Frautschy, S.A.10
-
72
-
-
0028332917
-
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene
-
Marcusson, E. G., Horazdovsky, B. F., Cereghino, J. L., Gharakhanian, E. and Emr, S. D. (1994). The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 77, 579-586.
-
(1994)
Cell
, vol.77
, pp. 579-586
-
-
Marcusson, E.G.1
Horazdovsky, B.F.2
Cereghino, J.L.3
Gharakhanian, E.4
Emr, S.D.5
-
73
-
-
0031031006
-
Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling
-
Marquez-Sterling, N. R., Lo, A. C., Sisodia, S. S. and Koo, E. H. (1997). Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. J. Neurosci. 17, 140-151.
-
(1997)
J. Neurosci.
, vol.17
, pp. 140-151
-
-
Marquez-Sterling, N.R.1
Lo, A.C.2
Sisodia, S.S.3
Koo, E.H.4
-
74
-
-
40549100696
-
Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells
-
Matrone, C., Di Luzio, A., Meli, G., D'Aguanno, S., Severini, C., Ciotti, M. T., Cattaneo, A. and Calissano, P. (2008). Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells. J. Alzheimers Dis. 13, 81-96.
-
(2008)
J. Alzheimers Dis.
, vol.13
, pp. 81-96
-
-
Matrone, C.1
Di Luzio, A.2
Meli, G.3
D'Aguanno, S.4
Severini, C.5
Ciotti, M.T.6
Cattaneo, A.7
Calissano, P.8
-
75
-
-
0030779677
-
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
-
Mattson, M. P. (1997). Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77, 1081-1132.
-
(1997)
Physiol. Rev.
, vol.77
, pp. 1081-1132
-
-
Mattson, M.P.1
-
76
-
-
37349015908
-
Association between SORL1 and Alzheimer's disease in a genome-wide study
-
Meng, Y., Lee, J. H., Cheng, R., St George-Hyslop, P., Mayeux, R. and Farrer, L. A. (2007). Association between SORL1 and Alzheimer's disease in a genome-wide study. Neuroreport 18, 1761-1764.
-
(2007)
Neuroreport
, vol.18
, pp. 1761-1764
-
-
Meng, Y.1
Lee, J.H.2
Cheng, R.3
St George-Hyslop, P.4
Mayeux, R.5
Farrer, L.A.6
-
77
-
-
4143089383
-
Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells
-
Morinville, A., Martin, S., Lavallée, M., Vincent, J. P., Beaudet, A. and Mazella, J. (2004). Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells. Int. J. Biochem. Cell Biol. 36, 2153-2168.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2153-2168
-
-
Morinville, A.1
Martin, S.2
Lavallée, M.3
Vincent, J.P.4
Beaudet, A.5
Mazella, J.6
-
78
-
-
0033519877
-
Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain
-
Motoi, Y., Aizawa, T., Haga, S., Nakamura, S., Namba, Y. and Ikeda, K. (1999). Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain. Brain Res. 833, 209-215.
-
(1999)
Brain Res.
, vol.833
, pp. 209-215
-
-
Motoi, Y.1
Aizawa, T.2
Haga, S.3
Nakamura, S.4
Namba, Y.5
Ikeda, K.6
-
79
-
-
44449165118
-
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
-
Muhammad, A., Flores, I., Zhang, H., Yu, R., Staniszewski, A., Planel, E., Herman, M., Ho, L., Kreber, R., Honig, L. S. et al. (2008). Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc. Natl. Acad. Sci. USA 105, 7327-7332.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7327-7332
-
-
Muhammad, A.1
Flores, I.2
Zhang, H.3
Yu, R.4
Staniszewski, A.5
Planel, E.6
Herman, M.7
Ho, L.8
Kreber, R.9
Honig, L.S.10
-
80
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B. and Lannfelt, L. (1992). A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat. Genet. 1, 345-347.
-
(1992)
Nat. Genet.
, vol.1
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
Lannfelt, L.7
-
81
-
-
27944444156
-
Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1
-
Muresan, Z. and Muresan, V. (2005). Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J. Cell Biol. 171, 615-625.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 615-625
-
-
Muresan, Z.1
Muresan, V.2
-
82
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset alzheimer's disease
-
Naj, A. C., Jun, G., Beecham, G. W., Wang, L. S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K. et al. (2011). Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset alzheimer's disease. Nat. Genet. 43, 436-441.
-
(2011)
Nat. Genet.
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
Jun, G.2
Beecham, G.W.3
Wang, L.S.4
Vardarajan, B.N.5
Buros, J.6
Gallins, P.J.7
Buxbaum, J.D.8
Jarvik, G.P.9
Crane, P.K.10
-
83
-
-
0035341211
-
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein
-
Nielsen, M. S., Madsen, P., Christensen, E. I., Nykjaer, A., Gliemann, J., Kasper, D., Pohlmann, R. and Petersen, C. M. (2001). The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J. 20, 2180-2190.
-
(2001)
EMBO J.
, vol.20
, pp. 2180-2190
-
-
Nielsen, M.S.1
Madsen, P.2
Christensen, E.I.3
Nykjaer, A.4
Gliemann, J.5
Kasper, D.6
Pohlmann, R.7
Petersen, C.M.8
-
84
-
-
34748899949
-
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA
-
Nielsen, M. S., Gustafsen, C., Madsen, P., Nyengaard, J. R., Hermey, G., Bakke, O., Mari, M., Schu, P., Pohlmann, R., Dennes, A. et al. (2007). Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol. Cell. Biol. 27, 6842-6851.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6842-6851
-
-
Nielsen, M.S.1
Gustafsen, C.2
Madsen, P.3
Nyengaard, J.R.4
Hermey, G.5
Bakke, O.6
Mari, M.7
Schu, P.8
Pohlmann, R.9
Dennes, A.10
-
85
-
-
43149090737
-
Different motifs regulate trafficking of SorCS1 isoforms
-
Nielsen, M. S., Keat, S. J., Hamati, J. W., Madsen, P., Gutzmann, J. J., Engelsberg, A., Pedersen, K. M., Gustafsen, C., Nykjaer, A., Gliemann, J. et al. (2008). Different motifs regulate trafficking of SorCS1 isoforms. Traffic 9, 980-994.
-
(2008)
Traffic
, vol.9
, pp. 980-994
-
-
Nielsen, M.S.1
Keat, S.J.2
Hamati, J.W.3
Madsen, P.4
Gutzmann, J.J.5
Engelsberg, A.6
Pedersen, K.M.7
Gustafsen, C.8
Nykjaer, A.9
Gliemann, J.10
-
86
-
-
33747388358
-
Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease
-
Nixon, R. A. and Cataldo, A. M. (2006). Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. J. Alzheimers Dis. 9 Suppl, 277-289.
-
(2006)
J. Alzheimers Dis.
, vol.9
, Issue.SUPPL.
, pp. 277-289
-
-
Nixon, R.A.1
Cataldo, A.M.2
-
87
-
-
0034675999
-
Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p
-
Nothwehr, S. F., Ha, S. A. and Bruinsma, P. (2000). Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p. J. Cell Biol. 151, 297-310.
-
(2000)
J. Cell Biol.
, vol.151
, pp. 297-310
-
-
Nothwehr, S.F.1
Ha, S.A.2
Bruinsma, P.3
-
88
-
-
34248169119
-
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates
-
Nyborg, A. C., Ladd, T. B., Zwizinski, C. W., Lah, J. J. and Golde, T. E. (2006). Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol. Neurodegener. 1, 3.
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 3
-
-
Nyborg, A.C.1
Ladd, T.B.2
Zwizinski, C.W.3
Lah, J.J.4
Golde, T.E.5
-
89
-
-
32544435097
-
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
-
Offe, K., Dodson, S. E., Shoemaker, J. T., Fritz, J. J., Gearing, M., Levey, A. I. and Lah, J. J. (2006). The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J. Neurosci. 26, 1596-1603.
-
(2006)
J. Neurosci.
, vol.26
, pp. 1596-1603
-
-
Offe, K.1
Dodson, S.E.2
Shoemaker, J.T.3
Fritz, J.J.4
Gearing, M.5
Levey, A.I.6
Lah, J.J.7
-
90
-
-
84655166492
-
The physiology of the β-amyloid precursor protein intracellular domain AICD
-
Pardossi-Piquard, R. and Checler, F. (2012). The physiology of the β-amyloid precursor protein intracellular domain AICD. J. Neurochem. 120 Suppl 1, 109-124.
-
(2012)
J. Neurochem.
, vol.120
, Issue.SUPPL. 1
, pp. 109-124
-
-
Pardossi-Piquard, R.1
Checler, F.2
-
91
-
-
0036200884
-
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta)
-
Pastorino, L., Ikin, A. F., Nairn, A. C., Pursnani, A. and Buxbaum, J. D. (2002). The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol. Cell. Neurosci. 19, 175-185.
-
(2002)
Mol. Cell. Neurosci.
, vol.19
, pp. 175-185
-
-
Pastorino, L.1
Ikin, A.F.2
Nairn, A.C.3
Pursnani, A.4
Buxbaum, J.D.5
-
92
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation ofsecreted fragments, including Abeta42
-
Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W. M., Selkoe, D. J., Chen, X. H., Stokin, G. B. and Koo, E. H. (1999). Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation ofsecreted fragments, including Abeta42. J. Biol. Chem. 274, 18851-18856.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
Ostaszewski, B.4
Xia, W.M.5
Selkoe, D.J.6
Chen, X.H.7
Stokin, G.B.8
Koo, E.H.9
-
93
-
-
14444281750
-
Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography
-
Petersen, C. M., Nielsen, M. S., Nykjaer, A., Jacobsen, L., Tommerup, N., Rasmussen, H. H., Roigaard, H., Gliemann, J., Madsen, P. and Moestrup, S. K. (1997). Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J. Biol. Chem. 272, 3599-3605.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3599-3605
-
-
Petersen, C.M.1
Nielsen, M.S.2
Nykjaer, A.3
Jacobsen, L.4
Tommerup, N.5
Rasmussen, H.H.6
Roigaard, H.7
Gliemann, J.8
Madsen, P.9
Moestrup, S.K.10
-
94
-
-
2442498577
-
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
-
Pietrzik, C. U., Yoon, I. S., Jaeger, S., Busse, T., Weggen, S. and Koo, E. H. (2004). FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J. Neurosci. 24, 4259-4265.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4259-4265
-
-
Pietrzik, C.U.1
Yoon, I.S.2
Jaeger, S.3
Busse, T.4
Weggen, S.5
Koo, E.H.6
-
95
-
-
84866368227
-
High frequency ofpotentially pathogenic SORL1 mutations in autosomal dominant early-onset alzheimer disease
-
Pottier, C., Hannequin, D., Coutant, S., Rovelet-Lecrux, A., Wallon, D., Rousseau, S., Legallic, S., Paquet, C., Bombois, S., Pariente, J. et al.; PHRC GMAJ Collaborators (2012). High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset alzheimer disease. Mol. Psychiatry 17, 875-879.
-
(2012)
Mol. Psychiatry
, vol.17
, pp. 875-879
-
-
Pottier, C.1
Hannequin, D.2
Coutant, S.3
Rovelet-Lecrux, A.4
Wallon, D.5
Rousseau, S.6
Legallic, S.7
Paquet, C.8
Bombois, S.9
Pariente, J.10
-
96
-
-
58149267525
-
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
-
Quistgaard, E. M., Madsen, P., Groftehauge, M. K., Nissen, P., Petersen, C. M. and Thirup, S. S. (2009). Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat. Struct. Mol. Biol. 16, 96-98.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 96-98
-
-
Quistgaard, E.M.1
Madsen, P.2
Groftehauge, M.K.3
Nissen, P.4
Petersen, C.M.5
Thirup, S.S.6
-
97
-
-
84860919373
-
Membrane trafficking pathways in Alzheimer's disease
-
Rajendran, L. and Annaert, W. (2012). Membrane trafficking pathways in Alzheimer's disease. Traffic 13, 759-770.
-
(2012)
Traffic 13,
, vol.13
, pp. 759-770
-
-
Rajendran, L.1
Annaert, W.2
-
98
-
-
42549148456
-
Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting
-
Rajendran, L., Schneider, A., Schlechtingen, G., Weidlich, S., Ries, J., Braxmeier, T., Schwille, P., Schulz, J. B., Schroeder, C., Simons, M. et al. (2008). Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting. Science 320, 520-523.
-
(2008)
Science
, vol.320
, pp. 520-523
-
-
Rajendran, L.1
Schneider, A.2
Schlechtingen, G.3
Weidlich, S.4
Ries, J.5
Braxmeier, T.6
Schwille, P.7
Schulz, J.B.8
Schroeder, C.9
Simons, M.10
-
99
-
-
78651297619
-
Genetic and Environmental Risk in Alzheimer Disease 1 Consortium
-
Meta-analysis of the association between variants in SORL1 and Alzheimer disease
-
Reitz, C., Cheng, R., Rogaeva, E., Lee, J. H., Tokuhiro, S., Zou, F., Bettens, K., Sleegers, K., Tan, E. K., Kimura, R. et al.; Genetic and Environmental Risk in Alzheimer Disease 1 Consortium (2011). Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch. Neurol. 68, 99-106.
-
(2011)
Arch. Neurol.
, vol.68
, pp. 99-106
-
-
Reitz, C.1
Cheng, R.2
Rogaeva, E.3
Lee, J.H.4
Tokuhiro, S.5
Zou, F.6
Bettens, K.7
Sleegers, K.8
Tan, E.K.9
Kimura, R.10
-
100
-
-
0035143458
-
Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain
-
Rezgaoui, M., Hermey, G., Riedel, I. B., Hampe, W., Schaller, H. C. and Hermans-Borgmeyer, I. (2001). Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain. Mech. Dev. 100, 335-338.
-
(2001)
Mech. Dev.
, vol.100
, pp. 335-338
-
-
Rezgaoui, M.1
Hermey, G.2
Riedel, I.B.3
Hampe, W.4
Schaller, H.C.5
Hermans-Borgmeyer, I.6
-
101
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H. et al. (2007). The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 39, 168-177.
-
(2007)
Nat. Genet.
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
Gu, Y.4
Kawarai, T.5
Zou, F.6
Katayama, T.7
Baldwin, C.T.8
Cheng, R.9
Hasegawa, H.10
-
102
-
-
47249144294
-
Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
-
Rohe, M., Carlo, A. S., Breyhan, H., Sporbert, A., Militz, D., Schmidt, V., Wozny, C., Harmeier, A., Erdmann, B., Bales, K. R. et al. (2008). Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J. Biol. Chem. 283, 1482614834.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1482614834
-
-
Rohe, M.1
Carlo, A.S.2
Breyhan, H.3
Sporbert, A.4
Militz, D.5
Schmidt, V.6
Wozny, C.7
Harmeier, A.8
Erdmann, B.9
Bales, K.R.10
-
103
-
-
71849109591
-
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression
-
Rohe, M., Synowitz, M., Glass, R., Paul, S. M., Nykjaer, A. and Willnow, T. E. (2009). Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J. Neurosci. 29, 15472-15478.
-
(2009)
J. Neurosci.
, vol.29
, pp. 15472-15478
-
-
Rohe, M.1
Synowitz, M.2
Glass, R.3
Paul, S.M.4
Nykjaer, A.5
Willnow, T.E.6
-
104
-
-
37149049553
-
Neuronal LR11/sorLA expression is reduced in mild cognitive impairment
-
Sager, K. L., Wuu, J., Leurgans, S. E., Rees, H. D., Gearing, M., Mufson, E. J., Levey, A. I. and Lah, J. J. (2007). Neuronal LR11/sorLA expression is reduced in mild cognitive impairment. Ann. Neurol. 62, 640-647.
-
(2007)
Ann. Neurol.
, vol.62
, pp. 640-647
-
-
Sager, K.L.1
Wuu, J.2
Leurgans, S.E.3
Rees, H.D.4
Gearing, M.5
Mufson, E.J.6
Levey, A.I.7
Lah, J.J.8
-
105
-
-
84865154896
-
Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brains
-
Sager, K. L., Wuu, J., Herskowitz, J. H., Mufson, E. J., Levey, A. I. and Lah, J. J. (2012). Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brains. PLoS ONE 7, e40527.
-
(2012)
PLoS ONE
, vol.7
-
-
Sager, K.L.1
Wuu, J.2
Herskowitz, J.H.3
Mufson, E.J.4
Levey, A.I.5
Lah, J.J.6
-
106
-
-
63649164073
-
Trafficking, a key player in regulated intramembrane proteolysis
-
Sannerud, R. and Annaert, W. (2009). Trafficking, a key player in regulated intramembrane proteolysis. Semin. Cell Dev. Biol. 20, 183-190.
-
(2009)
Semin. Cell Dev. Biol.
, vol.20
, pp. 183-190
-
-
Sannerud, R.1
Annaert, W.2
-
107
-
-
80052149544
-
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
-
Sannerud, R., Declerck, I., Peric, A., Raemaekers, T., Menendez, G., Zhou, L., Veerle, B., Coen, K., Munck, S., De Strooper, B. et al. (2011). ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc. Natl. Acad. Sci. USA 108, E559-E568.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
-
-
Sannerud, R.1
Declerck, I.2
Peric, A.3
Raemaekers, T.4
Menendez, G.5
Zhou, L.6
Veerle, B.7
Coen, K.8
Munck, S.9
De Strooper, B.10
-
108
-
-
79955944449
-
Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
-
Santosa, C., Rasche, S., Barakat, A., Bellingham, S. A., Ho, M., Tan, J., Hill, A. F., Masters, C. L., McLean, C. and Evin, G. (2011). Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein. Neurobiol. Dis. 43, 176-183.
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 176-183
-
-
Santosa, C.1
Rasche, S.2
Barakat, A.3
Bellingham, S.A.4
Ho, M.5
Tan, J.6
Hill, A.F.7
Masters, C.L.8
McLean, C.9
Evin, G.10
-
109
-
-
4043141580
-
Loss of apolipoprotein E receptor LR11 in Alzheimer disease
-
Scherzer, C. R., Offe, K., Gearing, M., Rees, H. D., Fang, G., Heilman, C. J., Schaller, C., Bujo, H., Levey, A. I. and Lah, J. J. (2004). Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch. Neurol. 61, 1200-1205.
-
(2004)
Arch. Neurol.
, vol.61
, pp. 1200-1205
-
-
Scherzer, C.R.1
Offe, K.2
Gearing, M.3
Rees, H.D.4
Fang, G.5
Heilman, C.J.6
Schaller, C.7
Bujo, H.8
Levey, A.I.9
Lah, J.J.10
-
110
-
-
36349025159
-
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
-
Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O. M. and Willnow, T. E. (2007). SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J. Biol. Chem. 282, 3295632964.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3295632964
-
-
Schmidt, V.1
Sporbert, A.2
Rohe, M.3
Reimer, T.4
Rehm, A.5
Andersen, O.M.6
Willnow, T.E.7
-
111
-
-
84855356440
-
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
-
Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B., Petersen, C. M., Nykjaer, A., Wolf, J. et al. (2012). Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 31, 187-200.
-
(2012)
EMBO J.
, vol.31
, pp. 187-200
-
-
Schmidt, V.1
Baum, K.2
Lao, A.3
Rateitschak, K.4
Schmitz, Y.5
Teichmann, A.6
Wiesner, B.7
Petersen, C.M.8
Nykjaer, A.9
Wolf, J.10
-
112
-
-
33749348509
-
A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking
-
Scott, G. K., Fei, H., Thomas, L., Medigeshi, G. R. and Thomas, G. (2006). A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. EMBO J. 25, 4423-4435.
-
(2006)
EMBO J.
, vol.25
, pp. 4423-4435
-
-
Scott, G.K.1
Fei, H.2
Thomas, L.3
Medigeshi, G.R.4
Thomas, G.5
-
113
-
-
2442509574
-
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
-
Seaman, M. N. (2004). Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J. Cell Biol. 165, 111-122.
-
(2004)
J. Cell Biol.
, vol.165
, pp. 111-122
-
-
Seaman, M.N.1
-
114
-
-
34547796509
-
Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval
-
Seaman, M. N. (2007). Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval. J. Cell Sci. 120, 2378-2389.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 2378-2389
-
-
Seaman, M.N.1
-
115
-
-
84872183810
-
The retromer complex-endosomal protein recycling and beyond
-
Seaman, M. N. (2012). The retromer complex-endosomal protein recycling and beyond. J. Cell Sci. 125, 4693-4702.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4693-4702
-
-
Seaman, M.N.1
-
116
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
Selkoe, D. J. (1991). The molecular pathology of Alzheimer's disease. Neuron 6, 487498.
-
(1991)
Neuron
, vol.6
, pp. 487498
-
-
Selkoe, D.J.1
-
117
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
789-791
-
Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791.
-
(2002)
Science
, vol.298
-
-
Selkoe, D.J.1
-
119
-
-
0028988649
-
Intracellular routing of human amyloid protein precursor: axonal delivery followed by transport to the dendrites
-
Simons, M., Ikonen, E., Tienari, P. J., Cid-Arregui, A., Mönning, U., Beyreuther, K. and Dotti, C. G. (1995). Intracellular routing of human amyloid protein precursor: axonal delivery followed by transport to the dendrites. J. Neurosci. Res. 41, 121-128.
-
(1995)
J. Neurosci. Res.
, vol.41
, pp. 121-128
-
-
Simons, M.1
Ikonen, E.2
Tienari, P.J.3
Cid-Arregui, A.4
Mönning, U.5
Beyreuther, K.6
Dotti, C.G.7
-
120
-
-
27744576858
-
Model-guided microarray implicates the retromer complex in Alzheimer's disease
-
Small, S. A., Kent, K., Pierce, A., Leung, C., Kang, M. S., Okada, H., Honig, L., Vonsattel, J. P. and Kim, T. W. (2005). Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann. Neurol. 58, 909-919.
-
(2005)
Ann. Neurol.
, vol.58
, pp. 909-919
-
-
Small, S.A.1
Kent, K.2
Pierce, A.3
Leung, C.4
Kang, M.S.5
Okada, H.6
Honig, L.7
Vonsattel, J.P.8
Kim, T.W.9
-
121
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K. et al. (2005). Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8, 1051-1058.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
Paul, S.4
Moran, T.5
Choi, E.Y.6
Nairn, A.C.7
Salter, M.W.8
Lombroso, P.J.9
Gouras, G.K.10
-
122
-
-
32544432195
-
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
-
Spoelgen, R., von Arnim, C. A., Thomas, A. V., Peltan, I. D., Koker, M., Deng, A., Irizarry, M. C., Andersen, O. M., Willnow, T. E. and Hyman, B. T. (2006). Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J. Neurosci. 26, 418-428.
-
(2006)
J. Neurosci.
, vol.26
, pp. 418-428
-
-
Spoelgen, R.1
von Arnim, C.A.2
Thomas, A.V.3
Peltan, I.D.4
Koker, M.5
Deng, A.6
Irizarry, M.C.7
Andersen, O.M.8
Willnow, T.E.9
Hyman, B.T.10
-
123
-
-
0035573660
-
LR11,amosaicLDLreceptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro
-
Taira, K., Bujo, H., Hirayama, S., Yamazaki, H., Kanaki, T., Takahashi, K., Ishii, I.,Miida,T.,Schneider,W.J.andSaito,Y.(2001). LR11,amosaicLDLreceptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. Arterioscler. Thromb. Vasc. Biol. 21, 1501-1506.
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 1501-1506
-
-
Taira, K.1
Bujo, H.2
Hirayama, S.3
Yamazaki, H.4
Kanaki, T.5
Takahashi, K.6
Ishii, I.7
Miida, T.8
Schneider, W.J.9
Saito, Y.10
-
124
-
-
67049171648
-
Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors
-
Tang, B. L. (2009). Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors. Cell Adh. Migr. 3, 118-128.
-
(2009)
Cell Adh. Migr.
, vol.3
, pp. 118-128
-
-
Tang, B.L.1
-
125
-
-
34249734831
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
-
Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S. H., Zhong, Z., Shen, Y. et al. (2007). Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54, 721-737.
-
(2007)
Neuron
, vol.54
, pp. 721-737
-
-
Tesco, G.1
Koh, Y.H.2
Kang, E.L.3
Cameron, A.N.4
Das, S.5
Sena-Esteves, M.6
Hiltunen, M.7
Yang, S.H.8
Zhong, Z.9
Shen, Y.10
-
126
-
-
0032509346
-
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
-
Trommsdorff, M., Borg, J. P., Margolis, B. and Herz, J. (1998). Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273, 33556-33560.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33556-33560
-
-
Trommsdorff, M.1
Borg, J.P.2
Margolis, B.3
Herz, J.4
-
127
-
-
73749085462
-
Localization of Golgi-resident glycosyltransferases
-
Tu, L. and Banfield, D. K. (2010). Localization of Golgi-resident glycosyltransferases. Cell. Mol. Life Sci. 67, 29-41.
-
(2010)
Cell. Mol. Life Sci.
, vol.67
, pp. 29-41
-
-
Tu, L.1
Banfield, D.K.2
-
128
-
-
0034629292
-
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease
-
Ulery, P. G., Beers, J., Mikhailenko, I., Tanzi, R. E., Rebeck, G. W., Hyman, B. T. and Strickland, D. K. (2000). Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J. Biol. Chem. 275, 7410-7415.
-
(2000)
J. Biol. Chem.
, pp. 7410-7415
-
-
Ulery, P.G.1
Beers, J.2
Mikhailenko, I.3
Tanzi, R.E.4
Rebeck, G.W.5
Hyman, B.T.6
Strickl, D.K.7
-
129
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R. et al. (1999). Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
-
130
-
-
84862687835
-
The role of lipoprotein receptors on the physiological function of APP
-
Wagner, T. and Pietrzik, C. U. (2012). The role of lipoprotein receptors on the physiological function of APP. Exp. Brain Res. 217, 377-387.
-
(2012)
Exp. Brain Res.
, vol.217
, pp. 377-387
-
-
Wagner, T.1
Pietrzik, C.U.2
-
131
-
-
37849034999
-
Sorl1 as an Alzheimer's disease predisposition gene? Neurodegener
-
Webster, J. A., Myers, A. J., Pearson, J. V., Craig, D. W., Hu-Lince, D., Coon, K. D., Zismann, V. L., Beach, T., Leung, D., Bryden, L. et al. (2008). Sorl1 as an Alzheimer's disease predisposition gene? Neurodegener. Dis. 5, 60-64.
-
(2008)
Neurodegener. Dis.
, vol.5
, pp. 60-64
-
-
Webster, J.A.1
Myers, A.J.2
Pearson, J.V.3
Craig, D.W.4
Hu-Lince, D.5
Coon, K.D.6
Zismann, V.L.7
Beach, T.8
Leung, D.9
Bryden, L.10
-
132
-
-
9644295728
-
Functional organization of the sortilin Vps10p domain
-
Westergaard, U. B., Sorensen, E. S., Hermey, G., Nielsen, M. S., Nykjaer, A., Kirkegaard, K., Jacobsen, C., Gliemann, J., Madsen, P. and Petersen, C. M. (2004). Functional organization of the sortilin Vps10p domain. J. Biol. Chem. 279, 50221-50229.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 50221-50229
-
-
Westergaard, U.B.1
Sorensen, E.S.2
Hermey, G.3
Nielsen, M.S.4
Nykjaer, A.5
Kirkegaard, K.6
Jacobsen, C.7
Gliemann, J.8
Madsen, P.9
Petersen, C.M.10
-
133
-
-
84884211307
-
What's happening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders
-
Westmark, C. J. (2013). What's happening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders. Mol. Psychiatry 18, 425-434.
-
(2013)
Mol. Psychiatry
, vol.18
, pp. 425-434
-
-
Westmark, C.J.1
-
134
-
-
56549111118
-
VPS10P-domainreceptors-regulators of neuronal viability and function
-
Willnow,T.E., Petersen,C.M. and Nykjaer,A.(2008). VPS10P-domainreceptors-regulators of neuronal viability and function. Nat. Rev. Neurosci. 9, 899-909.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 899-909
-
-
Willnow, T.E.1
Petersen, C.M.2
Nykjaer, A.3
-
135
-
-
0028913471
-
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
-
Yamazaki, T., Selkoe, D. J. and Koo, E. H. (1995). Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J. Cell Biol. 129, 431-442.
-
(1995)
J. Cell Biol.
, vol.129
, pp. 431-442
-
-
Yamazaki, T.1
Selkoe, D.J.2
Koo, E.H.3
-
136
-
-
0029764109
-
Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member
-
Yamazaki, H., Bujo, H., Kusunoki, J., Seimiya, K., Kanaki, T., Morisaki, N., Schneider, W. J. and Saito, Y. (1996). Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J. Biol. Chem. 271, 24761-24768.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24761-24768
-
-
Yamazaki, H.1
Bujo, H.2
Kusunoki, J.3
Seimiya, K.4
Kanaki, T.5
Morisaki, N.6
Schneider, W.J.7
Saito, Y.8
-
137
-
-
10744231924
-
Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
-
Zerbinatti, C. V., Wozniak, D. F., Cirrito, J., Cam, J. A., Osaka, H., Bales, K. R., Zhuo, M., Paul, S. M., Holtzman, D. M. and Bu, G. (2004). Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc. Natl. Acad. Sci. USA 101, 1075-1080.
-
(2004)
Proc. Natl. Acad. Sci. USA 101,
, vol.101
, pp. 1075-1080
-
-
Zerbinatti, C.V.1
Wozniak, D.F.2
Cirrito, J.3
Cam, J.A.4
Osaka, H.5
Bales, K.R.6
Zhuo, M.7
Paul, S.M.8
Holtzman, D.M.9
Bu, G.10
-
138
-
-
34250876949
-
Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells
-
Zhao, Y., Cui, J. G. and Lukiw, W. J. (2007). Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells. Neuroreport 18, 1187-1191.
-
(2007)
Neuroreport
, vol.18
, pp. 1187-1191
-
-
Zhao, Y.1
Cui, J.G.2
Lukiw, W.J.3
-
139
-
-
0242414463
-
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
-
Zhou, Y., Su, Y., Li, B., Liu, F., Ryder, J. W., Wu, X., Gonzalez-DeWhitt, P. A., Gelfanova, V., Hale, J. E., May, P. C. et al. (2003). Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science 302, 1215-1217.
-
(2003)
Science
, vol.302
, pp. 1215-1217
-
-
Zhou, Y.1
Su, Y.2
Li, B.3
Liu, F.4
Ryder, J.W.5
Wu, X.6
Gonzalez-DeWhitt, P.A.7
Gelfanova, V.8
Hale, J.E.9
May, P.C.10
|