-
1
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., and Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 3 Pt 1 (1992) 631-639
-
(1992)
Neurology
, vol.42
, Issue.3 PART 1
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
2
-
-
14644442872
-
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
-
Billings L.M., Oddo S., Green K.N., McGaugh J.L., and Laferla F.M. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45 5 (2005) 675-688
-
(2005)
Neuron
, vol.45
, Issue.5
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
McGaugh, J.L.4
Laferla, F.M.5
-
3
-
-
0030499678
-
A vector for expressing foreign genes in the brains and hearts of transgenic mice
-
Borchelt D.R., Davis J., Fischer M., Lee M.K., Slunt H.H., Ratovitsky T., et al. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13 6 (1996) 159-163
-
(1996)
Genet Anal
, vol.13
, Issue.6
, pp. 159-163
-
-
Borchelt, D.R.1
Davis, J.2
Fischer, M.3
Lee, M.K.4
Slunt, H.H.5
Ratovitsky, T.6
-
4
-
-
0033360356
-
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
-
Chapman P.F., White G.L., Jones M.W., Cooper-Blacketer D., Marshall V.J., Irizarry M., et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2 3 (1999) 271-276
-
(1999)
Nat Neurosci
, vol.2
, Issue.3
, pp. 271-276
-
-
Chapman, P.F.1
White, G.L.2
Jones, M.W.3
Cooper-Blacketer, D.4
Marshall, V.J.5
Irizarry, M.6
-
5
-
-
9144272296
-
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
-
Cheng I.H., Palop J.J., Esposito L.A., Bien-Ly N., Yan F., and Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med 10 11 (2004) 1190-1192
-
(2004)
Nat Med
, vol.10
, Issue.11
, pp. 1190-1192
-
-
Cheng, I.H.1
Palop, J.J.2
Esposito, L.A.3
Bien-Ly, N.4
Yan, F.5
Mucke, L.6
-
6
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
Cleary J.P., Walsh D.M., Hofmeister J.J., Shankar G.M., Kuskowski M.A., Selkoe D.J., et al. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8 1 (2005) 79-84
-
(2005)
Nat Neurosci
, vol.8
, Issue.1
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
-
7
-
-
0033578272
-
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
-
Crawley J.N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 835 1 (1999) 18-26
-
(1999)
Brain Res
, vol.835
, Issue.1
, pp. 18-26
-
-
Crawley, J.N.1
-
8
-
-
0037200117
-
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
-
Dahlgren K.N., Manelli A.M., Stine Jr. W.B., Baker L.K., Krafft G.A., and LaDu M.J. Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem 277 35 (2002) 32046-32053
-
(2002)
J Biol Chem
, vol.277
, Issue.35
, pp. 32046-32053
-
-
Dahlgren, K.N.1
Manelli, A.M.2
Stine Jr., W.B.3
Baker, L.K.4
Krafft, G.A.5
LaDu, M.J.6
-
9
-
-
4043061467
-
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
-
Deane R., Wu Z., Sagare A., Davis J., Du Yan S., Hamm K., et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43 3 (2004) 333-344
-
(2004)
Neuron
, vol.43
, Issue.3
, pp. 333-344
-
-
Deane, R.1
Wu, Z.2
Sagare, A.3
Davis, J.4
Du Yan, S.5
Hamm, K.6
-
10
-
-
0042838303
-
Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong Y., Chang L., Viola K.L., Lacor P.N., Lambert M.P., Finch C.E., et al. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA 100 18 (2003) 10417-10422
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.18
, pp. 10417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
Lacor, P.N.4
Lambert, M.P.5
Finch, C.E.6
-
11
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J., Chen F., van Dorpe J., and Nitsch R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293 5534 (2001) 1491-1495
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
12
-
-
25144501662
-
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease
-
Gouras G.K., Almeida C.G., and Takahashi R.H. Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging (2005)
-
(2005)
Neurobiol Aging
-
-
Gouras, G.K.1
Almeida, C.G.2
Takahashi, R.H.3
-
13
-
-
0033622324
-
Intraneuronal Abeta42 accumulation in human brain
-
Gouras G.K., Tsai J., Naslund J., Vincent B., Edgar M., Checler F., et al. Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 156 1 (2000) 15-20
-
(2000)
Am J Pathol
, vol.156
, Issue.1
, pp. 15-20
-
-
Gouras, G.K.1
Tsai, J.2
Naslund, J.3
Vincent, B.4
Edgar, M.5
Checler, F.6
-
14
-
-
0034869176
-
Protofibrils, the unifying toxic molecule of neurodegenerative disorders?
-
Haass C., and Steiner H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders?. Nat Neurosci 4 9 (2001) 859-860
-
(2001)
Nat Neurosci
, vol.4
, Issue.9
, pp. 859-860
-
-
Haass, C.1
Steiner, H.2
-
15
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy J.A., and Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256 5054 (1992) 184-185
-
(1992)
Science
, vol.256
, Issue.5054
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
16
-
-
0033551440
-
Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease
-
Harper J.D., Wong S.S., Lieber C.M., and Lansbury Jr. P.T. Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease. Biochemistry 38 28 (1999) 8972-8980
-
(1999)
Biochemistry
, vol.38
, Issue.28
, pp. 8972-8980
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury Jr., P.T.4
-
17
-
-
0026879650
-
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
-
Hendriks L., van Duijn C.M., Cras P., Cruts M., Van Hul W., van Harskamp F., et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1 3 (1992) 218-221
-
(1992)
Nat Genet
, vol.1
, Issue.3
, pp. 218-221
-
-
Hendriks, L.1
van Duijn, C.M.2
Cras, P.3
Cruts, M.4
Van Hul, W.5
van Harskamp, F.6
-
18
-
-
4344648449
-
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
-
Herzig M.C., Winkler D.T., Burgermeister P., Pfeifer M., Kohler E., Schmidt S.D., et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci 7 9 (2004) 954-960
-
(2004)
Nat Neurosci
, vol.7
, Issue.9
, pp. 954-960
-
-
Herzig, M.C.1
Winkler, D.T.2
Burgermeister, P.3
Pfeifer, M.4
Kohler, E.5
Schmidt, S.D.6
-
19
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C., Konietzko U., Streffer J.R., Tracy J., Signorell A., Muller-Tillmanns B., et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38 4 (2003) 547-554
-
(2003)
Neuron
, vol.38
, Issue.4
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
Muller-Tillmanns, B.6
-
20
-
-
0032756213
-
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
-
Holcomb L.A., Gordon M.N., Jantzen P., Hsiao K., Duff K., and Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 29 3 (1999) 177-185
-
(1999)
Behav Genet
, vol.29
, Issue.3
, pp. 177-185
-
-
Holcomb, L.A.1
Gordon, M.N.2
Jantzen, P.3
Hsiao, K.4
Duff, K.5
Morgan, D.6
-
21
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274 5284 (1996) 99-102
-
(1996)
Science
, vol.274
, Issue.5284
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
-
22
-
-
0027490070
-
The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
-
Hyman B.T., Marzloff K., and Arriagada P.V. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropathol Exp Neurol 52 6 (1993) 594-600
-
(1993)
J Neuropathol Exp Neurol
, vol.52
, Issue.6
, pp. 594-600
-
-
Hyman, B.T.1
Marzloff, K.2
Arriagada, P.V.3
-
23
-
-
0026733343
-
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region
-
Kamino K., Orr H.T., Payami H., Wijsman E.M., Alonso M.E., Pulst S.M., et al. Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am J Hum Genet 51 5 (1992) 998-1014
-
(1992)
Am J Hum Genet
, vol.51
, Issue.5
, pp. 998-1014
-
-
Kamino, K.1
Orr, H.T.2
Payami, H.3
Wijsman, E.M.4
Alonso, M.E.5
Pulst, S.M.6
-
24
-
-
0036968368
-
Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric
-
Kumar-Singh S., Cras P., Wang R., Kros J.M., van Swieten J., Lubke U., et al. Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric. Am J Pathol 161 2 (2002) 507-520
-
(2002)
Am J Pathol
, vol.161
, Issue.2
, pp. 507-520
-
-
Kumar-Singh, S.1
Cras, P.2
Wang, R.3
Kros, J.M.4
van Swieten, J.5
Lubke, U.6
-
25
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 95 11 (1998) 6448-6453
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.11
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
-
26
-
-
0041825430
-
Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores
-
Lashuel H.A., Hartley D.M., Petre B.M., Wall J.S., Simon M.N., Walz T., et al. Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol 332 4 (2003) 795-808
-
(2003)
J Mol Biol
, vol.332
, Issue.4
, pp. 795-808
-
-
Lashuel, H.A.1
Hartley, D.M.2
Petre, B.M.3
Wall, J.S.4
Simon, M.N.5
Walz, T.6
-
27
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne S., Koh M.T., Kotilinek L., Kayed R., Glabe C.G., Yang A., et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440 7082 (2006) 352-357
-
(2006)
Nature
, vol.440
, Issue.7082
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
-
28
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
Levy E., Carman M.D., Fernandez-Madrid I.J., Power M.D., Lieberburg I., van Duinen S.G., et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248 4959 (1990) 1124-1126
-
(1990)
Science
, vol.248
, Issue.4959
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
Power, M.D.4
Lieberburg, I.5
van Duinen, S.G.6
-
29
-
-
27744512118
-
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
-
Lord A., Kalimo H., Eckman C., Zhang X.Q., Lannfelt L., and Nilsson L.N. The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol Aging 27 1 (2006) 67-77
-
(2006)
Neurobiol Aging
, vol.27
, Issue.1
, pp. 67-77
-
-
Lord, A.1
Kalimo, H.2
Eckman, C.3
Zhang, X.Q.4
Lannfelt, L.5
Nilsson, L.N.6
-
30
-
-
0036227489
-
Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood
-
Monro O.R., Mackic J.B., Yamada S., Segal M.B., Ghiso J., Maurer C., et al. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging 23 3 (2002) 405-412
-
(2002)
Neurobiol Aging
, vol.23
, Issue.3
, pp. 405-412
-
-
Monro, O.R.1
Mackic, J.B.2
Yamada, S.3
Segal, M.B.4
Ghiso, J.5
Maurer, C.6
-
31
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1 5 (1992) 345-347
-
(1992)
Nat Genet
, vol.1
, Issue.5
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
-
32
-
-
17944368176
-
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
-
Nilsberth C., Westlind-Danielsson A., Eckman C.B., Condron M.M., Axelman K., Forsell C., et al. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci 4 9 (2001) 887-893
-
(2001)
Nat Neurosci
, vol.4
, Issue.9
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
-
33
-
-
10744230072
-
Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease
-
Richardson J.C., Kendal C.E., Anderson R., Priest F., Gower E., Soden P., et al. Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease. Neuroscience 122 1 (2003) 213-228
-
(2003)
Neuroscience
, vol.122
, Issue.1
, pp. 213-228
-
-
Richardson, J.C.1
Kendal, C.E.2
Anderson, R.3
Priest, F.4
Gower, E.5
Soden, P.6
-
34
-
-
0031038918
-
Alzheimer's disease: genotypes, phenotypes, and treatments
-
Selkoe D.J. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 275 5300 (1997) 630-631
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 630-631
-
-
Selkoe, D.J.1
-
35
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 6880 (2002) 535-539
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
36
-
-
7244236841
-
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade
-
Wirths O., Multhaup G., and Bayer T.A. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J Neurochem 91 3 (2004) 513-520
-
(2004)
J Neurochem
, vol.91
, Issue.3
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
37
-
-
16544366118
-
Laboratory animal welfare: cage enrichment and mouse behaviour
-
Wolfer D.P., Litvin O., Morf S., Nitsch R.M., Lipp H.P., and Wurbel H. Laboratory animal welfare: cage enrichment and mouse behaviour. Nature 432 7019 (2004) 821-822
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 821-822
-
-
Wolfer, D.P.1
Litvin, O.2
Morf, S.3
Nitsch, R.M.4
Lipp, H.P.5
Wurbel, H.6
-
38
-
-
13544268809
-
Neurovascular mechanisms of Alzheimer's neurodegeneration
-
Zlokovic B.V. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 28 4 (2005) 202-208
-
(2005)
Trends Neurosci
, vol.28
, Issue.4
, pp. 202-208
-
-
Zlokovic, B.V.1
|