Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

Journal of Neuroscience Research

Volumn 89, Issue 7, 2011, Pages 1031-1042

  Umeda, Tomohiro ^a,b   Tomiyama, Takami ^a,b   Sakama, Naomi ^a   Tanaka, Saya ^a,c   Lambert, Mary P ^d   Klein, William L ^d   Mori, Hiroshi ^a,b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; APP E693 mutation; Transgenic mouse

Indexed keywords

AMYLOID BETA PROTEIN; CATHEPSIN D; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; OLIGOMER; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; ENDOSOME; FEMALE; HIPPOCAMPUS; HUMAN; IN VIVO STUDY; LYSOSOME; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL DEATH; CERCOPITHECUS AETHIOPS; COS CELLS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NERVE DEGENERATION; STRESS, PHYSIOLOGICAL;

EID: 79955601720     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22640     Document Type: Article

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