The Arctic Alzheimer mutation favors intracellular amyloid-β production by making amyloid precursor protein less available to α-secretase

Journal of Neurochemistry

Volumn 101, Issue 3, 2007, Pages 854-862

  Sahlin, Charlotte ^a   Lord, Anna ^a   Magnusson, Kristina ^b   Englund, Hillevi ^a   Almeida, Claudia G ^c   Greengard, Paul ^d   Nyberg, Fred ^b   Gouras, Gunnar K ^c   Lannfelt, Lars ^a   Nilsson, Lars N G ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

secretase; Alzheimer's disease; Amyloid precursor protein processing; Amyloid peptide; Arctic mutation; Intracellular amyloid

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DISINTEGRIN; METALLOPROTEINASE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARCTIC; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; ENZYME DEGRADATION; GENE MUTATION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MOUSE; NERVE CELL; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; STEADY STATE; SYMPTOMATOLOGY;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE, TUMOR; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROBLASTOMA; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

EID: 34247516510     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04443.x     Document Type: Article

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