Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles

Neuropathology and Applied Neurobiology

Volumn 40, Issue 4, 2014, Pages 489-501

  Nishikawa, Tomokazu ^a   Takahashi, Tetsuya ^a   Nakamori, Masahiro ^a   Yamazaki, Yu ^b   Kurashige, Takashi ^a   Nagano, Yoshito ^a   Nishida, Yoshihiko ^c   Izumi, Yuishin ^d   Matsumoto, Masayasu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA PREFECTURAL HOSPITAL   (Japan)

^c Itsuki Hospital   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

5 bisphosphate; Alzheimer's disease; Granulovacuolar degeneration; Lipid raft; Neurofibrillary tangle; Phosphatidylinositol 4

Indexed keywords

FLOTILLIN 1; LIPOCORTIN 2; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENTORHINAL CORTEX; FEMALE; GRANULOVACUOLAR DEGENERATION BODY; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPID COMPOSITION; LIPID RAFT; MALE; NEOCORTEX; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; BRAIN; CELL GRANULE; METABOLISM; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; CYTOPLASMIC GRANULES; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; NEOCORTEX; NEUROFIBRILLARY TANGLES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; VACUOLES;

EID: 84898778667     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12056     Document Type: Article

References (31)

1. Kadokura A, Yamazaki T, Kakuda S, Makioka K, Lemere CA, Fujita Y, Takatama M, Okamoto K. Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration. Neurosci Lett 2009; 463: 87-92
2. Baig S, van Helmond Z, Love S. Tau hyperphosphorylation affects Smad 2/3 translocation. Neuroscience 2009; 163: 561-570
3. Yamazaki Y, Takahashi T, Hiji M, Kurashige T, Izumi Y, Yamawaki T, Matsumoto M. Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus. Neurosci Lett 2010; 477: 86-90
4. Leroy K, Boutajangout A, Authelet M, Woodgett JR, Anderton BH, Brion JP. The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta Neuropathol 2002; 103: 91-99
5. Nakamori M, Takahashi T, Yamazaki Y, Kurashige T, Yamawaki T, Matsumoto M. Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration. Neuroreport 2012; 23: 867-872
6. Girardot N, Allinquant B, Langui D, Laquerriere A, Dubois B, Hauw JJ, Duyckaerts C. Accumulation of flotillin-1 in tangle-bearing neurones of Alzheimer's disease. Neuropathol Appl Neurobiol 2003; 29: 451-461
7. Sui Z, Kovacs AD, Maggirwar SB. Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. Biochem Biophys Res Commun 2006; 345: 1643-1648
8. Hernandez P, Lee G, Sjoberg M, Maccioni RB. Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid rafts. J Alzheimers Dis 2009; 16: 149-156
9. Rushworth JV, Hooper NM. Lipid rafts: linking Alzheimer's amyloid-beta production, aggregation, and toxicity at neuronal membranes. Int J Alzheimers Dis 2010; 2011: 603052
10. Taylor DR, Hooper NM. Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Sem Cell Dev Biol 2007; 18: 638-648
11. Hooper NM. Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein. Biochem Soc Trans 2005; 33: 335-338
12. Cordy JM, Hooper NM, Turner AJ. The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol 2006; 23: 111-122
13. Williamson R, Usardi A, Hanger DP, Anderton BH. Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J 2008; 22: 1552-1559
14. Sobo K, Chevallier J, Parton RG, Gruenberg J, van der Goot FG. Diversity of raft-like domains in late endosomes. PLoS ONE 2007; 2: e391
15. Golub T, Caroni P. PI(4, 5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility. J Cell Biol 2005; 169: 151-165
16. Roth MG. Phosphoinositides in constitutive membrane traffic. Physiol Rev 2004; 84: 699-730
17. Thal DR, Del Tredici K, Ludolph AC, Hoozemans JJ, Rozemuller AJ, Braak H, Knippschild U. Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response. Acta Neuropathol 2011; 122: 577-589
18. Thal DR, Rüb U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002; 58: 1791-1800
19. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-259
20. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-486
21. Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement 2012; 8: 1-13
22. Watt SA, Kular G, Fleming IN, Downes CP, Lucocq JM. Subcellular localization of phosphatidylinositol 4, 5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J 2002; 363: 657-666
23. Thomas CL, Steel J, Prestwich GD, Schiavo G. Generation of phosphatidylinositol-specific antibodies and their characterization. Biochem Soc Trans 1999; 27: 648-652
24. Osborne SL, Thomas CL, Gschmeissner S, Schiavo G. Nuclear PtdIns(4, 5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J Cell Sci 2001; 114: 2501-2511
25. Hammond GR, Dove SK, Nicol A, Pinxteren JA, Zicha D, Schiavo G. Elimination of plasma membrane phosphatidylinositol (4, 5)-bisphosphate is required for exocytosis from mast cells. J Cell Sci 2006; 119: 2084-2094
26. Huang CL, Feng S, Hilgemann DW. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 1998; 391: 803-806
27. Kirkham M, Parton RG. Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochim Biophys Acta 2005; 1746: 349-363
28. Zhang X, Hartz PA, Philip E, Racusen LC, Majerus PW. Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4, 5-bisphosphate. J Biol Chem 1998; 273: 1574-1582
29. Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carreno S. The inositol 5-phosphatase dOCRL controls PI(4, 5)P2 homeostasis and is necessary for cytokinesis. Curr Biol 2011; 21: 1074-1079
30. Funk KE, Mrak RE, Kuret J. Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles. Neuropathol Appl Neurobiol 2011; 37: 295-306
31. Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PLR, Coller JM, Perry G, Lee H, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Lab Invest 2011; 91: 1777-1786