Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

Science Translational Medicine

Volumn 6, Issue 223, 2014, Pages

  Caglayan, Safak ^a   Takagi Niidome, Shizuka ^b   Liao, Fan ^c   Carlo, Anne Sophie ^a   Schmidt, Vanessa ^a   Burgert, Tilman ^a   Kitago, Yu ^b   Fuc̈htbauer, Ernst Martin ^d   Fuc̈htbauer, Annette ^d   Holtzman, David M ^c   Takagi, Junichi ^b   Willnow, Thomas E ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b OSAKA UNIVERSITY   (Japan)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MEMBRANE PROTEIN; PROTEIN SORLA; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; CARRIER PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SORL1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DISEASE MODEL; FAMILIAL DISEASE; GENE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LYSOSOME; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN TARGETING; SORL1 GENE; ANIMAL; BRAIN; CELL LINE; GENETICS; METABOLISM; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; LDL-RECEPTOR RELATED PROTEINS; LYSOSOMES; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, TRANSGENIC;

EID: 84896360551     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3007747     Document Type: Article

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