Differential regulation of dynein and kinesin motor proteins by tau

Science

Volumn 319, Issue 5866, 2008, Pages 1086-1089

  Dixit, Ram ^a   Ross, Jennifer L ^a,b   Goldman, Yale E ^a   Holzbaur, Erika L F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; MICROTUBULE ASSOCIATED PROTEIN; MOLECULAR MOTOR; TAU PROTEIN;

CONCENTRATION (COMPOSITION); MOTILITY; PROTEIN;

ARTICLE; CELL TRANSPORT; MAMMAL CELL; MICROTUBULE; NERVE CELL; NERVE FIBER TRANSPORT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ALZHEIMER DISEASE; ANIMALS; AXONAL TRANSPORT; DYNEIN ATPASE; KINESIN; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MODELS, NEUROLOGICAL; NEURONS; PROTEIN BINDING; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; TAU PROTEINS;

EID: 39749165656     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1152993     Document Type: Article

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21. We thank E. Mandelkow for the tau constructs, R. Kudaravalli for purified kinesin, S. Shah for data analysis, and M. Ostap and members of the Holzbaur and Goldman labs for helpful comments. This work was supported by NIH grants P01-AR-051174 to the Pennsylvania Muscle Institute and GM-48661 to E.L.F.H., and NSF grant NSEC DMR04-25780 to the Penn Nano/Bio Interface Center.