Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid β42 in transfected cells

Journal of Neurochemistry

Volumn 73, Issue 6, 1999, Pages 2383-2388

  Refolo, Lawrence M ^a,b   Eckman, Chris ^a   Prada, Christian Mihail ^a   Yager, Debora ^a   Sambamurti, Kumar ^a   Mehta, Nitin ^a   Hardy, John ^a   Younkin, Steven G ^a  

^a MAYO CLINIC   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Amyloid peptide; Doxycyclin; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY RNA; PRESENILIN 1; PRESENILIN 2; TUBULIN;

ALZHEIMER DISEASE; ARTICLE; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE LOSS; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CELL LINE; DOXYCYCLINE; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1; RNA, ANTISENSE; TRANSFECTION; TUBULIN;

MUS MUSCULUS;

EID: 0032708117     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0732383.x     Document Type: Article

References (32)

1. Baumeister R., Leimer U., Zweckbronner I., Jakubek C., Grunberg J., and Haas C. (1997) The sel-12 mutant phenotype of C. elegans is rescued independent of proteolytic processing by wt but not mutant presenilin. Genes Func. 1, 149-159.
2. Borchelt D. R., Thinakaran G., Eckman C. B., Lee M. K., Davenport F., Ratovitsky T., Prada C.-M., Kim G., Seekins S., Yager D., Slunt H. H., Wang R., Seeger M., Levey A. I., Gandy S. E., Copeland N. G., Jenkins N. A., Price D. L., Younkin S. G., and Sisodia S. S. (1996) Familial Alzheimer's disease-linked presenilin I variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
3. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St. George Hyslop P., and Selkoe D. J. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3, 67-72.
4. Clark R., Hutton M., Fuldner R. A., et al. (1995) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat. Genet. 11, 219-222.
5. Davis J. A., Naruse S., Chen H., Eckman C., Younkin S., Price D. L., Borchelt D. R., Sisodia S. S., and Wong P. C. (1998) An Alzheimer's disease linked PS1 variant rescues the developmental abnormalities of PS1 deficient embryos. Neuron 20, 603-609.
6. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., and Van Leuven F. (1998) Deficiency of presenilin-1 inhibits normal cleavage of amyloid precursor protein. Nature 391, 387-390.
7. Duff K., Eckman C., Zehr C., Yu X., Prada C-M., Perez-Tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M. N., Holcombs L., Refolo L., Zenk B., Hardy J., and Younkin S. (1996) Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
8. Gossen M. and Bujard H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad Sci. USA 89, 5547-5551.
9. Gossen M., Freundlieb S., Bender G., Muller G., Hillen W., and Bujard H. (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769.
10. Holcomb L., Gordon M. N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C-M., Eckman C., Younkin S., Hsiao K., and Duff K. (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Natl. Med. 4, 97-100.
11. Hutton M. and Hardy J. (1997) The presenilins and Alzheimer's disease. Hum. Mol. Genet. 6, 1639-1646.
12. Kelly R. and Grote E. (1993) Protein targeting in neurons. Annu. Rev. Neurosci. 6, 95-127.
13. Levitan D. and Greenwald I. (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354.
14. Levitan D. and Greenwald I. (1998) Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Development 125, 3599-3606.
15. Levitan D., Doyle T. G., Brousseau D., Lee M. K., Thinakaran G., Slunt H. H., Sisodia S. S., and Greenwald I. (1996) Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93, 14940-14944.
16. Mehta N. D., Refolo L. M., Eckman C., Sanders S., Yager D., Perez-Tur J., Younkin S. D., Hardy J., and Hutton M. (1998) Increased Aβ42(43) from cell lines expressing presenilin 1 mutations. Ann. Neurol. 43, 256-258.
17. Qian S., Jiang P., Guan X. M., Singh G., Trumbauer M. E., Yu H., Chen H. Y., Van de Ploeg L. H., and Zheng H. (1998) Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Aβ1-42/43 expression. Neuron 20, 610-617.
18. Resnitzky D., Gossen M., Bujard H., and Reed S. I. (1994) Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14, 1669-1679.
19. Sambamurti K., Sevlever D., Koothan T., Refolo L. M., Pinnix I., Gandhi S., Onstead L., Younkin L., Prada C. M., Yager D., Ohyagi Y., Eckman C. B., Rosenberry T. L., and Younkin S. G. (1999) Glycosylphosphatidylinositol anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid β protein. J. Biol. Chem. 274, 26810-26814.
20. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T, D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., and Younkin S. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
21. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
22. Suzuki N., Cheung T. T., Cai X.-D., Odaka A., Otvos L. Jr., Eckman C., Golde T. E., and Younkin S. G. (1994) An increased percentage of long amyloid β protein secreted by FAD amyloid. Science 264, 1336-1340.
23. Thinakaran G., Borchelt D. R., Lee M. K., Slunt H. H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A. I., Gandy S. E., Jenkins N. A., Copeland N. G., Price D. L., and Sisodia S. (1996) Endoproteolysis of presenilin-1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.
24. Thinakaran G., Harris C. L., Ratovitski T., Davenport F., Slunt H. H., Price D. L., Borchelt D. R., and Sisodia S. S. (1997) Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J. Biol. Chem. 272, 28415-28422.
25. Tienari P. J., Ida N., Ikonen E., Simons M., Weidemann A., Multhaup G., Masters C. L., Dotti C. G., and Beyreuther K. P. (1997) Intracellular and secreted amyloid β-protein species are generated by distinct mechanisms in cultured neurons. Proc. Natl. Acad. Sci. USA 4, 4125-4130.
26. Tysoe C., Whittaker J., Xuereb J., Cairns N. J., Cruts M., Van Broeckhoven C., Wilcock G., and Rubinsztein D. C. (1998) A presenilin-1 truncating mutation is present in two cases with autopsy confirmed early onset Alzheimer's disease. Am. J. Hum. Genet. 62, 70-76.
27. Weidemann A., Paliga K., Durrwang U., Czech C., Evin G., Masters C. L., and Beyreuther K. (1997) Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein. Nat. Med. 3, 328-332.
28. Wolfe M. S., Citron M., Diehl T. S., Xia W., Donkor I. O., and Selkoe D. J. (1998) A substrate based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity. J. Med. Chem. 41, 6-9.
29. Wolfe M. S., Xia W., Ostaszewski B. L., Diehl T. S., Kimberly W. T., and Selkoe D. J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517.
30. Wong P., Zheng H., Chen H., Becher M. W., Sirinathsinghji D. J., Trumbauer M. E., Chen H. Y., Price D. L., Van der Ploeg L. H., and Sisodia S. S. (1997) Presenilin 1 is required for notch 1 and D111 expression in the paraxial mesoderm. Nature 387, 288-291.
31. Xia W., Zhang J., Perez R., Koo E. H., and Selkoe D. J. (1997) Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 8208-8213.
32. Yamazaki T., Selkoe D., and Koo E. (1995) Trafficking of cell surface amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J. Cell Biol. 129, 431-442.