메뉴 건너뛰기




Volumn 45, Issue , 2015, Pages 30-57

Retinal microglia: Just bystander or target for therapy?

Author keywords

Age related macular degeneration; Aging; Complement system; Diabetic retinopathy; Glaucoma; Neuroinflammation; Retinal dystrophies; Retinal microglia

Indexed keywords

DOCOSAHEXAENOIC ACID; MINOCYCLINE; BIOLOGICAL MARKER; COMPLEMENT;

EID: 84925348553     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2014.11.004     Document Type: Review
Times cited : (436)

References (355)
  • 1
    • 84898432100 scopus 로고    scopus 로고
    • Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment
    • Abcouwer S.F., Gardner T.W. Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment. Ann. N. Y. Acad. Sci. 2014, 1311:174-190.
    • (2014) Ann. N. Y. Acad. Sci. , vol.1311 , pp. 174-190
    • Abcouwer, S.F.1    Gardner, T.W.2
  • 2
    • 0030799291 scopus 로고    scopus 로고
    • Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype
    • Aguirre G.D., Acland G.M., Maude M.B., Anderson R.E. Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype. Investig. Ophthalmol. Vis. Sci. 1997, 38:2387-2407.
    • (1997) Investig. Ophthalmol. Vis. Sci. , vol.38 , pp. 2387-2407
    • Aguirre, G.D.1    Acland, G.M.2    Maude, M.B.3    Anderson, R.E.4
  • 4
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B., Bennett J.L., Krieger C., Tetzlaff W., Rossi F.M. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 2007, 10:1538-1543.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 7
    • 0026093041 scopus 로고
    • Pharmacology of Curcuma longa
    • Ammon H.P., Wahl M.A. Pharmacology of Curcuma longa. Planta Med. 1991, 57:1-7.
    • (1991) Planta Med. , vol.57 , pp. 1-7
    • Ammon, H.P.1    Wahl, M.A.2
  • 10
    • 0036974437 scopus 로고    scopus 로고
    • Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations
    • Anderson R.E., Maude M.B., McClellan M., Matthes M.T., Yasumura D., LaVail M.M. Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. Mol. Vis. 2002, 8:351-358.
    • (2002) Mol. Vis. , vol.8 , pp. 351-358
    • Anderson, R.E.1    Maude, M.B.2    McClellan, M.3    Matthes, M.T.4    Yasumura, D.5    LaVail, M.M.6
  • 11
    • 0031080167 scopus 로고    scopus 로고
    • Lipids of plasma, retina, and retinal pigment epithelium in Swedish briard dogs with a slowly progressive retinal dystrophy
    • Anderson R.E., Maude M.B., Narfstrom K., Nilsson S.E. Lipids of plasma, retina, and retinal pigment epithelium in Swedish briard dogs with a slowly progressive retinal dystrophy. Exp. Eye Res. 1997, 64:181-187.
    • (1997) Exp. Eye Res. , vol.64 , pp. 181-187
    • Anderson, R.E.1    Maude, M.B.2    Narfstrom, K.3    Nilsson, S.E.4
  • 14
    • 84887402319 scopus 로고    scopus 로고
    • Aging is not a disease: distinguishing age-related macular degeneration from aging
    • Ardeljan D., Chan C.C. Aging is not a disease: distinguishing age-related macular degeneration from aging. Prog. Retin. Eye Res. 2013, 37:68-89.
    • (2013) Prog. Retin. Eye Res. , vol.37 , pp. 68-89
    • Ardeljan, D.1    Chan, C.C.2
  • 16
    • 34047259195 scopus 로고    scopus 로고
    • Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats
    • Bakalash S., Rolls A., Lider O., Schwartz M. Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats. Investig. Ophthalmol. Vis. Sci. 2007, 48:1181-1190.
    • (2007) Investig. Ophthalmol. Vis. Sci. , vol.48 , pp. 1181-1190
    • Bakalash, S.1    Rolls, A.2    Lider, O.3    Schwartz, M.4
  • 17
    • 0036850086 scopus 로고    scopus 로고
    • Visualising microglial activation invivo
    • Banati R.B. Visualising microglial activation invivo. Glia 2002, 40:206-217.
    • (2002) Glia , vol.40 , pp. 206-217
    • Banati, R.B.1
  • 18
    • 4243131475 scopus 로고    scopus 로고
    • Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats
    • Banerjee D., Dick A.D. Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats. Ocul. Immunol. Inflamm. 2004, 12:115-125.
    • (2004) Ocul. Immunol. Inflamm. , vol.12 , pp. 115-125
    • Banerjee, D.1    Dick, A.D.2
  • 20
    • 63249089707 scopus 로고    scopus 로고
    • Characterization of the sickness response in young and aging rats following E. coli infection
    • Barrientos R.M., Watkins L.R., Rudy J.W., Maier S.F. Characterization of the sickness response in young and aging rats following E. coli infection. Brain Behav. Immun. 2009, 23:450-454.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 450-454
    • Barrientos, R.M.1    Watkins, L.R.2    Rudy, J.W.3    Maier, S.F.4
  • 21
    • 84883745507 scopus 로고    scopus 로고
    • Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient
    • Baumgartner W.A., Baumgartner A.M. Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient. Med. Hypotheses 2013, 81:720-728.
    • (2013) Med. Hypotheses , vol.81 , pp. 720-728
    • Baumgartner, W.A.1    Baumgartner, A.M.2
  • 23
    • 77956460474 scopus 로고    scopus 로고
    • Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1
    • Bazan N.G., Calandria J.M., Serhan C.N. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J.Lipid Res. 2010, 51:2018-2031.
    • (2010) J.Lipid Res. , vol.51 , pp. 2018-2031
    • Bazan, N.G.1    Calandria, J.M.2    Serhan, C.N.3
  • 24
    • 9644259008 scopus 로고    scopus 로고
    • Inflammation and apoptosis: linked therapeutic targets in spinal cord injury
    • Beattie M.S. Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol. Med. 2004, 10:580-583.
    • (2004) Trends Mol. Med. , vol.10 , pp. 580-583
    • Beattie, M.S.1
  • 25
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • Bessis A., Béchade C., Bernard D., Roumier A. Microglial control of neuronal death and synaptic properties. Glia 2007, 55:233-238.
    • (2007) Glia , vol.55 , pp. 233-238
    • Bessis, A.1    Béchade, C.2    Bernard, D.3    Roumier, A.4
  • 26
    • 84888348687 scopus 로고    scopus 로고
    • TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement
    • Bialas A.R., Stevens B. TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat. Neurosci. 2013, 16:1773-1782.
    • (2013) Nat. Neurosci. , vol.16 , pp. 1773-1782
    • Bialas, A.R.1    Stevens, B.2
  • 28
    • 15544372950 scopus 로고    scopus 로고
    • Complement protein C1q recognizes a conformationally modified form of the prion protein
    • Blanquet-Grossard F., Thielens N.M., Vendrely C., Jamin M., Arlaud G.J. Complement protein C1q recognizes a conformationally modified form of the prion protein. Biochemistry 2005, 44:4349-4356.
    • (2005) Biochemistry , vol.44 , pp. 4349-4356
    • Blanquet-Grossard, F.1    Thielens, N.M.2    Vendrely, C.3    Jamin, M.4    Arlaud, G.J.5
  • 29
    • 0033780270 scopus 로고    scopus 로고
    • Migration of phagocytotic cells and development of the murine intraretinal microglial network: an invivo study using fluorescent dyes
    • Bodeutsch N., Thanos S. Migration of phagocytotic cells and development of the murine intraretinal microglial network: an invivo study using fluorescent dyes. Glia 2000, 32:91-101.
    • (2000) Glia , vol.32 , pp. 91-101
    • Bodeutsch, N.1    Thanos, S.2
  • 31
    • 78751489896 scopus 로고    scopus 로고
    • Early microglia activation in a mouse model of chronic glaucoma
    • Bosco A., Steele M.R., Vetter M.L. Early microglia activation in a mouse model of chronic glaucoma. J.Comp. Neurol. 2011, 519:599-620.
    • (2011) J.Comp. Neurol. , vol.519 , pp. 599-620
    • Bosco, A.1    Steele, M.R.2    Vetter, M.L.3
  • 32
    • 0032462810 scopus 로고    scopus 로고
    • C1q knock-out mice for the study of complement deficiency in autoimmune disease
    • Botto M. C1q knock-out mice for the study of complement deficiency in autoimmune disease. Exp. Clin. Immunogenet. 1998, 15:231-234.
    • (1998) Exp. Clin. Immunogenet. , vol.15 , pp. 231-234
    • Botto, M.1
  • 34
    • 0036841128 scopus 로고    scopus 로고
    • Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis
    • Broderick C., Hoek R.M., Forrester J.V., Liversidge J., Sedgwick J.D., Dick A.D. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am. J. Pathol. 2002, 161:1669-1677.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1669-1677
    • Broderick, C.1    Hoek, R.M.2    Forrester, J.V.3    Liversidge, J.4    Sedgwick, J.D.5    Dick, A.D.6
  • 35
    • 84864322419 scopus 로고    scopus 로고
    • Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'
    • Brown G.C., Neher J.J. Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'. Trends Biochem. Sci. 2012, 37:325-332.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 325-332
    • Brown, G.C.1    Neher, J.J.2
  • 36
    • 84897859634 scopus 로고    scopus 로고
    • Microglial phagocytosis of live neurons
    • Brown G.C., Neher J.J. Microglial phagocytosis of live neurons. Nat. Rev. Neurosci. 2014, 15:209-216.
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 209-216
    • Brown, G.C.1    Neher, J.J.2
  • 37
    • 46249110091 scopus 로고    scopus 로고
    • Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
    • Buchanan J.B., Sparkman N.L., Chen J., Johnson R.W. Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice. Psychoneuroendocrinology 2008, 33:755-765.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 755-765
    • Buchanan, J.B.1    Sparkman, N.L.2    Chen, J.3    Johnson, R.W.4
  • 38
    • 79960671469 scopus 로고    scopus 로고
    • Age related macular degeneration and drusen: neuroinflammation in the retina
    • Buschini E., Piras A., Nuzzi R., Vercelli A. Age related macular degeneration and drusen: neuroinflammation in the retina. Prog. Neurobiol. 2011, 95:14-25.
    • (2011) Prog. Neurobiol. , vol.95 , pp. 14-25
    • Buschini, E.1    Piras, A.2    Nuzzi, R.3    Vercelli, A.4
  • 40
    • 0032573378 scopus 로고    scopus 로고
    • Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
    • Caron E., Hall A. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 1998, 282:1717-1721.
    • (1998) Science , vol.282 , pp. 1717-1721
    • Caron, E.1    Hall, A.2
  • 41
    • 4143088416 scopus 로고    scopus 로고
    • CD200 maintains microglial potential to migrate in adult human retinal explant model
    • Carter D.A., Dick A.D. CD200 maintains microglial potential to migrate in adult human retinal explant model. Curr. Eye Res. 2004, 28:427-436.
    • (2004) Curr. Eye Res. , vol.28 , pp. 427-436
    • Carter, D.A.1    Dick, A.D.2
  • 42
    • 33847388338 scopus 로고    scopus 로고
    • Early growth response transcriptional regulators are dispensable for macrophage differentiation
    • Carter J.H., Tourtellotte W.G. Early growth response transcriptional regulators are dispensable for macrophage differentiation. J.Immunol. 2007, 178:3038-3047.
    • (2007) J.Immunol. , vol.178 , pp. 3038-3047
    • Carter, J.H.1    Tourtellotte, W.G.2
  • 43
    • 0032098247 scopus 로고    scopus 로고
    • Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF
    • Carwile M.E., Culbert R.B., Sturdivant R.L., Kraft T.W. Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF. Exp. Eye Res. 1998, 66:791-805.
    • (1998) Exp. Eye Res. , vol.66 , pp. 791-805
    • Carwile, M.E.1    Culbert, R.B.2    Sturdivant, R.L.3    Kraft, T.W.4
  • 44
    • 77956389310 scopus 로고    scopus 로고
    • Alook at autoimmunity and inflammation in the eye
    • Caspi R.R. Alook at autoimmunity and inflammation in the eye. J.Clin. Investig. 2010, 120:3073-3083.
    • (2010) J.Clin. Investig. , vol.120 , pp. 3073-3083
    • Caspi, R.R.1
  • 45
    • 84896993161 scopus 로고    scopus 로고
    • Understanding autoimmunity in the eye: from animal models to novel therapies
    • Caspi R.R. Understanding autoimmunity in the eye: from animal models to novel therapies. Discov. Med. 2014, 17:155-162.
    • (2014) Discov. Med. , vol.17 , pp. 155-162
    • Caspi, R.R.1
  • 49
    • 0027521914 scopus 로고
    • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice
    • Chang G.Q., Hao Y., Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 1993, 11:595-605.
    • (1993) Neuron , vol.11 , pp. 595-605
    • Chang, G.Q.1    Hao, Y.2    Wong, F.3
  • 50
    • 79961159284 scopus 로고    scopus 로고
    • Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice
    • Chen M., Forrester J.V., Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PloS One 2011, 6:e22818.
    • (2011) PloS One , vol.6 , pp. e22818
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 51
    • 84862815733 scopus 로고    scopus 로고
    • Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent
    • Chen M., Zhao J., Luo C., Pandi S.P., Penalva R.G., Fitzgerald D.C., Xu H. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent. Glia 2012, 60:833-842.
    • (2012) Glia , vol.60 , pp. 833-842
    • Chen, M.1    Zhao, J.2    Luo, C.3    Pandi, S.P.4    Penalva, R.G.5    Fitzgerald, D.C.6    Xu, H.7
  • 52
    • 84880921562 scopus 로고    scopus 로고
    • Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retina
    • Chen X., Kezic J., Bernard C., McMenamin P.G. Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retina. J.Neuropathol. Exp. Neurol. 2013, 72:782-790.
    • (2013) J.Neuropathol. Exp. Neurol. , vol.72 , pp. 782-790
    • Chen, X.1    Kezic, J.2    Bernard, C.3    McMenamin, P.G.4
  • 53
    • 84877717463 scopus 로고    scopus 로고
    • Changes in gene expression associated with retinal degeneration in the rd3 mouse
    • Cheng C.L., Molday R.S. Changes in gene expression associated with retinal degeneration in the rd3 mouse. Mol. Vis. 2013, 19:955-969.
    • (2013) Mol. Vis. , vol.19 , pp. 955-969
    • Cheng, C.L.1    Molday, R.S.2
  • 57
    • 0344382052 scopus 로고    scopus 로고
    • Anti-glycated albumin therapy ameliorates early retinal microvascular pathology in db/db mice
    • Clements R.S., Robison W.G., Cohen M.P. Anti-glycated albumin therapy ameliorates early retinal microvascular pathology in db/db mice. J.Diabetes Complicat. 1998, 12:28-33.
    • (1998) J.Diabetes Complicat. , vol.12 , pp. 28-33
    • Clements, R.S.1    Robison, W.G.2    Cohen, M.P.3
  • 58
    • 0038693797 scopus 로고    scopus 로고
    • Beyond lysis: how complement influences cell fate
    • Cole D.S., Morgan B.P. Beyond lysis: how complement influences cell fate. Clin. Sci. 2003, 104:455-466.
    • (2003) Clin. Sci. , vol.104 , pp. 455-466
    • Cole, D.S.1    Morgan, B.P.2
  • 59
    • 84855176037 scopus 로고    scopus 로고
    • Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist
    • Collier R.J., Wang Y., Smith S.S., Martin E., Ornberg R., Rhoades K., Romano C. Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Investig. Ophthalmol. Vis. Sci. 2011, 52:8108-8116.
    • (2011) Investig. Ophthalmol. Vis. Sci. , vol.52 , pp. 8108-8116
    • Collier, R.J.1    Wang, Y.2    Smith, S.S.3    Martin, E.4    Ornberg, R.5    Rhoades, K.6    Romano, C.7
  • 64
    • 65649106136 scopus 로고    scopus 로고
    • Mechanisms of apoptosis in retinitis pigmentosa
    • Cottet S., Schorderet D.F. Mechanisms of apoptosis in retinitis pigmentosa. Curr. Mol. Med. 2009, 9:375-383.
    • (2009) Curr. Mol. Med. , vol.9 , pp. 375-383
    • Cottet, S.1    Schorderet, D.F.2
  • 65
    • 84903304197 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation
    • Couturier A., Bousquet E., Zhao M., Naud M.C., Klein C., Jonet L., Tadayoni R., de Kozak Y., Behar-Cohen F. Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation. Mol. Vis. 2014, 20:908-920.
    • (2014) Mol. Vis. , vol.20 , pp. 908-920
    • Couturier, A.1    Bousquet, E.2    Zhao, M.3    Naud, M.C.4    Klein, C.5    Jonet, L.6    Tadayoni, R.7    de Kozak, Y.8    Behar-Cohen, F.9
  • 67
    • 84866756933 scopus 로고    scopus 로고
    • Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study
    • Cukras C.A., Petrou P., Chew E.Y., Meyerle C.B., Wong W.T. Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study. Investig. Ophthalmol. Vis. Sci. 2012, 53:3865-3874.
    • (2012) Investig. Ophthalmol. Vis. Sci. , vol.53 , pp. 3865-3874
    • Cukras, C.A.1    Petrou, P.2    Chew, E.Y.3    Meyerle, C.B.4    Wong, W.T.5
  • 68
    • 0032030582 scopus 로고    scopus 로고
    • Anovel role for TGF-beta and IL-10 in the induction of immune privilege
    • D'Orazio T.J., Niederkorn J.Y. Anovel role for TGF-beta and IL-10 in the induction of immune privilege. J.Immunol. 1998, 160:2089-2098.
    • (1998) J.Immunol. , vol.160 , pp. 2089-2098
    • D'Orazio, T.J.1    Niederkorn, J.Y.2
  • 69
    • 68249095210 scopus 로고    scopus 로고
    • CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis
    • Dagkalis A., Wallace C., Hing B., Liversidge J., Crane I.J. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Immunology 2009, 128:25-33.
    • (2009) Immunology , vol.128 , pp. 25-33
    • Dagkalis, A.1    Wallace, C.2    Hing, B.3    Liversidge, J.4    Crane, I.J.5
  • 75
    • 41749120975 scopus 로고    scopus 로고
    • Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization
    • De Smedt-Peyrusse V., Sargueil F., Moranis A., Harizi H., Mongrand S., Laye S. Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. J.Neurochem. 2008, 105:296-307.
    • (2008) J.Neurochem. , vol.105 , pp. 296-307
    • De Smedt-Peyrusse, V.1    Sargueil, F.2    Moranis, A.3    Harizi, H.4    Mongrand, S.5    Laye, S.6
  • 79
    • 0028325939 scopus 로고
    • Immunomodulation of experimental autoimmune uveoretinitis: a model of tolerance induction with retinal antigens
    • Dick A.D., Cheng Y.F., Liversidge J., Forrester J.V. Immunomodulation of experimental autoimmune uveoretinitis: a model of tolerance induction with retinal antigens. Eye (Lond., Engl.) 1994, 8(Pt 1):52-59.
    • (1994) Eye (Lond., Engl.) , vol.8 , pp. 52-59
    • Dick, A.D.1    Cheng, Y.F.2    Liversidge, J.3    Forrester, J.V.4
  • 83
    • 84855932333 scopus 로고    scopus 로고
    • Microglial activation and transcriptomic changes in the blue light-exposed mouse retina
    • Ebert S., Walczak Y., Reme C., Langmann T. Microglial activation and transcriptomic changes in the blue light-exposed mouse retina. Adv. Exp. Med. Biol. 2012, 723:619-632.
    • (2012) Adv. Exp. Med. Biol. , vol.723 , pp. 619-632
    • Ebert, S.1    Walczak, Y.2    Reme, C.3    Langmann, T.4
  • 87
    • 49049092624 scopus 로고    scopus 로고
    • Invivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye
    • Eter N., Engel D.R., Meyer L., Helb H.M., Roth F., Maurer J., Holz F.G., Kurts C. Invivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye. Investig. Ophthalmol. Vis. Sci. 2008, 49:3649-3658.
    • (2008) Investig. Ophthalmol. Vis. Sci. , vol.49 , pp. 3649-3658
    • Eter, N.1    Engel, D.R.2    Meyer, L.3    Helb, H.M.4    Roth, F.5    Maurer, J.6    Holz, F.G.7    Kurts, C.8
  • 89
    • 78751540649 scopus 로고    scopus 로고
    • Early involvement of Immune/Inflammatory response genes in retinal degeneration in DBA/2J mice
    • Fan W., Li X., Wang W., Mo J.S., Kaplan H., Cooper N.G. Early involvement of Immune/Inflammatory response genes in retinal degeneration in DBA/2J mice. Ophthalmol. Eye Dis. 2010, 1:23-41.
    • (2010) Ophthalmol. Eye Dis. , vol.1 , pp. 23-41
    • Fan, W.1    Li, X.2    Wang, W.3    Mo, J.S.4    Kaplan, H.5    Cooper, N.G.6
  • 90
    • 0019336725 scopus 로고
    • Current concepts in immunology: the alternative pathway of complement - a system for host resistance to microbial infection
    • Fearon D.T., Austen K.F. Current concepts in immunology: the alternative pathway of complement - a system for host resistance to microbial infection. N.Engl. J. Med. 1980, 303:259-263.
    • (1980) N.Engl. J. Med. , vol.303 , pp. 259-263
    • Fearon, D.T.1    Austen, K.F.2
  • 92
    • 84857697198 scopus 로고    scopus 로고
    • Immunohistochemical localization of complement regulatory proteins in the human retina
    • Fett A.L., Hermann M.M., Muether P.S., Kirchhof B., Fauser S. Immunohistochemical localization of complement regulatory proteins in the human retina. Histol. Histopathol. 2012, 27:357-364.
    • (2012) Histol. Histopathol. , vol.27 , pp. 357-364
    • Fett, A.L.1    Hermann, M.M.2    Muether, P.S.3    Kirchhof, B.4    Fauser, S.5
  • 93
    • 79551570269 scopus 로고    scopus 로고
    • Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission
    • Fontainhas A.M., Wang M., Liang K.J., Chen S., Mettu P., Damani M., Fariss R.N., Li W., Wong W.T. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission. PloS One 2011, 6:e15973.
    • (2011) PloS One , vol.6 , pp. e15973
    • Fontainhas, A.M.1    Wang, M.2    Liang, K.J.3    Chen, S.4    Mettu, P.5    Damani, M.6    Fariss, R.N.7    Li, W.8    Wong, W.T.9
  • 94
    • 0031934936 scopus 로고    scopus 로고
    • Microglia-derived nerve growth factor causes cell death in the developing retina
    • Frade J.M., Barde Y.A. Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron 1998, 20:35-41.
    • (1998) Neuron , vol.20 , pp. 35-41
    • Frade, J.M.1    Barde, Y.A.2
  • 96
    • 0025781819 scopus 로고
    • The role of complement in inflammation and phagocytosis
    • Frank M.M., Fries L.F. The role of complement in inflammation and phagocytosis. Immunol. Today 1991, 12:322-326.
    • (1991) Immunol. Today , vol.12 , pp. 322-326
    • Frank, M.M.1    Fries, L.F.2
  • 100
    • 0036147042 scopus 로고    scopus 로고
    • Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema
    • Funatsu H., Yamashita H., Noma H., Mimura T., Yamashita T., Hori S. Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am. J. Ophthalmol. 2002, 133:70-77.
    • (2002) Am. J. Ophthalmol. , vol.133 , pp. 70-77
    • Funatsu, H.1    Yamashita, H.2    Noma, H.3    Mimura, T.4    Yamashita, T.5    Hori, S.6
  • 102
    • 13244257265 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy
    • Gardiner T.A., Gibson D.S., de Gooyer T.E., de la Cruz V.F., McDonald D.M., Stitt A.W. Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy. Am. J. Pathol. 2005, 166:637-644.
    • (2005) Am. J. Pathol. , vol.166 , pp. 637-644
    • Gardiner, T.A.1    Gibson, D.S.2    de Gooyer, T.E.3    de la Cruz, V.F.4    McDonald, D.M.5    Stitt, A.W.6
  • 105
    • 5144222255 scopus 로고    scopus 로고
    • Complement: a unique innate immune sensor for danger signals
    • Gasque P. Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 2004, 41:1089-1098.
    • (2004) Mol. Immunol. , vol.41 , pp. 1089-1098
    • Gasque, P.1
  • 110
    • 0017066391 scopus 로고
    • Production of spontaneous diabetic rats by repetition of selective breeding
    • Goto Y., Kakizaki M., Masaki N. Production of spontaneous diabetic rats by repetition of selective breeding. Tohoku J. Exp. Med. 1976, 119:85-90.
    • (1976) Tohoku J. Exp. Med. , vol.119 , pp. 85-90
    • Goto, Y.1    Kakizaki, M.2    Masaki, N.3
  • 112
    • 77952991172 scopus 로고    scopus 로고
    • Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration
    • Green A.J., McQuaid S., Hauser S.L., Allen I.V., Lyness R. Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration. Brain: J. Neurol. 2010, 133:1591-1601.
    • (2010) Brain: J. Neurol. , vol.133 , pp. 1591-1601
    • Green, A.J.1    McQuaid, S.2    Hauser, S.L.3    Allen, I.V.4    Lyness, R.5
  • 114
  • 115
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification
    • Guillemin G.J., Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J.Leukoc. Biol. 2004, 75:388-397.
    • (2004) J.Leukoc. Biol. , vol.75 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 117
    • 0037375042 scopus 로고    scopus 로고
    • Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration
    • Gupta N., Brown K.E., Milam A.H. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp. Eye Res. 2003, 76:463-471.
    • (2003) Exp. Eye Res. , vol.76 , pp. 463-471
    • Gupta, N.1    Brown, K.E.2    Milam, A.H.3
  • 121
    • 84879944618 scopus 로고    scopus 로고
    • Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia
    • Halder S.K., Matsunaga H., Ishii K.J., Akira S., Miyake K., Ueda H. Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia. J.Neurochem. 2013, 126:243-260.
    • (2013) J.Neurochem. , vol.126 , pp. 243-260
    • Halder, S.K.1    Matsunaga, H.2    Ishii, K.J.3    Akira, S.4    Miyake, K.5    Ueda, H.6
  • 122
    • 0142195831 scopus 로고    scopus 로고
    • Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration
    • Harada C., Harada T., Quah H.M., Maekawa F., Yoshida K., Ohno S., Wada K., Parada L.F., Tanaka K. Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration. Neuroscience 2003, 122:229-235.
    • (2003) Neuroscience , vol.122 , pp. 229-235
    • Harada, C.1    Harada, T.2    Quah, H.M.3    Maekawa, F.4    Yoshida, K.5    Ohno, S.6    Wada, K.7    Parada, L.F.8    Tanaka, K.9
  • 126
    • 77952744918 scopus 로고    scopus 로고
    • Curcumin protects pre-oligodendrocytes from activated microglia invitro and invivo
    • He L.F., Chen H.J., Qian L.H., Chen G.Y., Buzby J.S. Curcumin protects pre-oligodendrocytes from activated microglia invitro and invivo. Brain Res. 2010, 1339:60-69.
    • (2010) Brain Res. , vol.1339 , pp. 60-69
    • He, L.F.1    Chen, H.J.2    Qian, L.H.3    Chen, G.Y.4    Buzby, J.S.5
  • 129
    • 0035176139 scopus 로고    scopus 로고
    • Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination
    • Hisahara S., Yuan J., Momoi T., Okano H., Miura M. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J.Exp. Med. 2001, 193:111-122.
    • (2001) J.Exp. Med. , vol.193 , pp. 111-122
    • Hisahara, S.1    Yuan, J.2    Momoi, T.3    Okano, H.4    Miura, M.5
  • 133
    • 77955085670 scopus 로고    scopus 로고
    • Ahapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration
    • Hollyfield J.G., Perez V.L., Salomon R.G. Ahapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. Mol. Neurobiol. 2010, 41:290-298.
    • (2010) Mol. Neurobiol. , vol.41 , pp. 290-298
    • Hollyfield, J.G.1    Perez, V.L.2    Salomon, R.G.3
  • 134
    • 84884923616 scopus 로고    scopus 로고
    • Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model
    • Horstmann L., Schmid H., Heinen A.P., Kurschus F.C., Dick H.B., Joachim S.C. Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model. J.Neuroinflamm. 2013, 10:120.
    • (2013) J.Neuroinflamm. , vol.10 , pp. 120
    • Horstmann, L.1    Schmid, H.2    Heinen, A.P.3    Kurschus, F.C.4    Dick, H.B.5    Joachim, S.C.6
  • 139
    • 84871233554 scopus 로고    scopus 로고
    • Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats
    • Huang J.J., Ma W.J., Yokoyama S. Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats. Brain Behav. 2012, 2:85-96.
    • (2012) Brain Behav. , vol.2 , pp. 85-96
    • Huang, J.J.1    Ma, W.J.2    Yokoyama, S.3
  • 141
    • 0020536689 scopus 로고
    • Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers
    • Hume D.A., Perry V.H., Gordon S. Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J.Cell Biol. 1983, 97:253-257.
    • (1983) J.Cell Biol. , vol.97 , pp. 253-257
    • Hume, D.A.1    Perry, V.H.2    Gordon, S.3
  • 145
    • 48249096770 scopus 로고    scopus 로고
    • C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes
    • Jakobsdottir J., Conley Y.P., Weeks D.E., Ferrell R.E., Gorin M.B. C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. PloS One 2008, 3:e2199.
    • (2008) PloS One , vol.3 , pp. e2199
    • Jakobsdottir, J.1    Conley, Y.P.2    Weeks, D.E.3    Ferrell, R.E.4    Gorin, M.B.5
  • 147
    • 84940257897 scopus 로고    scopus 로고
    • Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis
    • Jiang Z., Jiang J.X., Zhang G.X. Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis. Immunol. Lett. 2014, 160:17-22.
    • (2014) Immunol. Lett. , vol.160 , pp. 17-22
    • Jiang, Z.1    Jiang, J.X.2    Zhang, G.X.3
  • 148
    • 84864388752 scopus 로고    scopus 로고
    • Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens
    • Joachim S.C., Gramlich O.W., Laspas P., Schmid H., Beck S., von Pein H.D., Dick H.B., Pfeiffer N., Grus F.H. Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens. PloS One 2012, 7:e40616.
    • (2012) PloS One , vol.7 , pp. e40616
    • Joachim, S.C.1    Gramlich, O.W.2    Laspas, P.3    Schmid, H.4    Beck, S.5    von Pein, H.D.6    Dick, H.B.7    Pfeiffer, N.8    Grus, F.H.9
  • 150
    • 84894257621 scopus 로고    scopus 로고
    • Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions
    • Joachim S.C., Mondon C., Gramlich O.W., Grus F.H., Dick H.B. Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions. J.Mol. Neurosci. 2014, 52:216-224.
    • (2014) J.Mol. Neurosci. , vol.52 , pp. 216-224
    • Joachim, S.C.1    Mondon, C.2    Gramlich, O.W.3    Grus, F.H.4    Dick, H.B.5
  • 151
    • 77957091293 scopus 로고    scopus 로고
    • Enhanced characterization of serum autoantibody reactivity following HSP 60 immunization in a rat model of experimental autoimmune glaucoma
    • Joachim S.C., Wax M.B., Seidel P., Pfeiffer N., Grus F.H. Enhanced characterization of serum autoantibody reactivity following HSP 60 immunization in a rat model of experimental autoimmune glaucoma. Curr. Eye Res. 2010, 35:900-908.
    • (2010) Curr. Eye Res. , vol.35 , pp. 900-908
    • Joachim, S.C.1    Wax, M.B.2    Seidel, P.3    Pfeiffer, N.4    Grus, F.H.5
  • 153
    • 58149385608 scopus 로고    scopus 로고
    • Leukemia inhibitory factor extends the lifespan of injured photoreceptors invivo
    • Joly S., Lange C., Thiersch M., Samardzija M., Grimm C. Leukemia inhibitory factor extends the lifespan of injured photoreceptors invivo. J.Neurosci. 2008, 28:13765-13774.
    • (2008) J.Neurosci. , vol.28 , pp. 13765-13774
    • Joly, S.1    Lange, C.2    Thiersch, M.3    Samardzija, M.4    Grimm, C.5
  • 156
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung S., Aliberti J., Graemmel P., Sunshine M.J., Kreutzberg G.W., Sher A., Littman D.R. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 2000, 20:4106-4114.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5    Sher, A.6    Littman, D.R.7
  • 161
    • 78649825320 scopus 로고    scopus 로고
    • The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response
    • Karlstetter M., Walczak Y., Weigelt K., Ebert S., Van den Brulle J., Schwer H., Fuchshofer R., Langmann T. The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response. J.Immunol. 2010, 185:3379-3390.
    • (2010) J.Immunol. , vol.185 , pp. 3379-3390
    • Karlstetter, M.1    Walczak, Y.2    Weigelt, K.3    Ebert, S.4    Van den Brulle, J.5    Schwer, H.6    Fuchshofer, R.7    Langmann, T.8
  • 162
    • 0013893075 scopus 로고
    • Retinal degeneration in the mouse is rodless retina
    • Keeler C. Retinal degeneration in the mouse is rodless retina. J.Hered. 1966, 57:47-50.
    • (1966) J.Hered. , vol.57 , pp. 47-50
    • Keeler, C.1
  • 163
    • 0000087516 scopus 로고
    • The inheritance of a retinal abnormality in white mice
    • Keeler C.E. The inheritance of a retinal abnormality in white mice. Proc. Natl. Acad. Sci. U. S. A. 1924, 10:329-333.
    • (1924) Proc. Natl. Acad. Sci. U. S. A. , vol.10 , pp. 329-333
    • Keeler, C.E.1
  • 165
    • 41149099068 scopus 로고    scopus 로고
    • Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
    • Kern T.S. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp. Diabetes Res. 2007, 2007:95103.
    • (2007) Exp. Diabetes Res. , vol.2007 , pp. 95103
    • Kern, T.S.1
  • 166
    • 53549119666 scopus 로고    scopus 로고
    • The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis
    • Kerr E.C., Copland D.A., Dick A.D., Nicholson L.B. The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis. Prog. Retin. Eye Res. 2008, 27:527-535.
    • (2008) Prog. Retin. Eye Res. , vol.27 , pp. 527-535
    • Kerr, E.C.1    Copland, D.A.2    Dick, A.D.3    Nicholson, L.B.4
  • 168
    • 50849130262 scopus 로고    scopus 로고
    • Differential turnover rates of monocyte-derived cells in varied ocular tissue microenvironments
    • Kezic J., McMenamin P.G. Differential turnover rates of monocyte-derived cells in varied ocular tissue microenvironments. J.Leukoc. Biol. 2008, 84:721-729.
    • (2008) J.Leukoc. Biol. , vol.84 , pp. 721-729
    • Kezic, J.1    McMenamin, P.G.2
  • 169
    • 77958134581 scopus 로고    scopus 로고
    • The monocyte chemokine receptor CX3CR1 does not play a significant role in the pathogenesis of experimental autoimmune uveoretinitis
    • Kezic J., McMenamin P.G. The monocyte chemokine receptor CX3CR1 does not play a significant role in the pathogenesis of experimental autoimmune uveoretinitis. Investig. Ophthalmol. Vis. Sci. 2010, 51:5121-5127.
    • (2010) Investig. Ophthalmol. Vis. Sci. , vol.51 , pp. 5121-5127
    • Kezic, J.1    McMenamin, P.G.2
  • 170
    • 84874745535 scopus 로고    scopus 로고
    • The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse
    • Kezic J.M., Chen X., Rakoczy E.P., McMenamin P.G. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. Investig. Ophthalmol. Vis. Sci. 2013, 54:854-863.
    • (2013) Investig. Ophthalmol. Vis. Sci. , vol.54 , pp. 854-863
    • Kezic, J.M.1    Chen, X.2    Rakoczy, E.P.3    McMenamin, P.G.4
  • 172
    • 0025086052 scopus 로고
    • Macrophages related to Bruch's membrane in age-related macular degeneration
    • Killingsworth M.C., Sarks J.P., Sarks S.H. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye (Lond., Engl.) 1990, 4(Pt 4):613-621.
    • (1990) Eye (Lond., Engl.) , vol.4 , pp. 613-621
    • Killingsworth, M.C.1    Sarks, J.P.2    Sarks, S.H.3
  • 174
    • 84878264043 scopus 로고    scopus 로고
    • Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal
    • Kohno H., Chen Y., Kevany B.M., Pearlman E., Miyagi M., Maeda T., Palczewski K., Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J.Biol. Chem. 2013, 288:15326-15341.
    • (2013) J.Biol. Chem. , vol.288 , pp. 15326-15341
    • Kohno, H.1    Chen, Y.2    Kevany, B.M.3    Pearlman, E.4    Miyagi, M.5    Maeda, T.6    Palczewski, K.7    Maeda, A.8
  • 175
    • 0031569975 scopus 로고    scopus 로고
    • C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited
    • Korb L.C., Ahearn J.M. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J.Immunol. 1997, 158:4525-4528.
    • (1997) J.Immunol. , vol.158 , pp. 4525-4528
    • Korb, L.C.1    Ahearn, J.M.2
  • 176
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • Krady J.K., Basu A., Allen C.M., Xu Y., LaNoue K.F., Gardner T.W., Levison S.W. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 2005, 54:1559-1565.
    • (2005) Diabetes , vol.54 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3    Xu, Y.4    LaNoue, K.F.5    Gardner, T.W.6    Levison, S.W.7
  • 178
    • 84896970708 scopus 로고    scopus 로고
    • Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change
    • Kumar A., Zhao L., Fariss R.N., McMenamin P.G., Wong W.T. Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change. Investig. Ophthalmol. Vis. Sci. 2014, 55:1787-1796.
    • (2014) Investig. Ophthalmol. Vis. Sci. , vol.55 , pp. 1787-1796
    • Kumar, A.1    Zhao, L.2    Fariss, R.N.3    McMenamin, P.G.4    Wong, W.T.5
  • 179
    • 84863852522 scopus 로고    scopus 로고
    • Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease
    • Kur J., Newman E.A., Chan-Ling T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog. Retin. Eye Res. 2012, 31:377-406.
    • (2012) Prog. Retin. Eye Res. , vol.31 , pp. 377-406
    • Kur, J.1    Newman, E.A.2    Chan-Ling, T.3
  • 180
    • 84889066890 scopus 로고    scopus 로고
    • Animal models of diabetic retinopathy: summary and comparison
    • Lai A.K., Lo A.C. Animal models of diabetic retinopathy: summary and comparison. J.Diabetes Res. 2013, 2013:106594.
    • (2013) J.Diabetes Res. , vol.2013 , pp. 106594
    • Lai, A.K.1    Lo, A.C.2
  • 182
    • 34249744612 scopus 로고    scopus 로고
    • Microglia activation in retinal degeneration
    • Langmann T. Microglia activation in retinal degeneration. J.Leukoc. Biol. 2007, 81:1345-1351.
    • (2007) J.Leukoc. Biol. , vol.81 , pp. 1345-1351
    • Langmann, T.1
  • 185
    • 0026552605 scopus 로고
    • Turnover of resident microglia in the normal adult mouse brain
    • Lawson L.J., Perry V.H., Gordon S. Turnover of resident microglia in the normal adult mouse brain. Neuroscience 1992, 48:405-415.
    • (1992) Neuroscience , vol.48 , pp. 405-415
    • Lawson, L.J.1    Perry, V.H.2    Gordon, S.3
  • 186
    • 53149116704 scopus 로고    scopus 로고
    • Exvivo dynamic imaging of retinal microglia using time-lapse confocal microscopy
    • Lee J.E., Liang K.J., Fariss R.N., Wong W.T. Exvivo dynamic imaging of retinal microglia using time-lapse confocal microscopy. Investig. Ophthalmol. Vis. Sci. 2008, 49:4169.
    • (2008) Investig. Ophthalmol. Vis. Sci. , vol.49 , pp. 4169
    • Lee, J.E.1    Liang, K.J.2    Fariss, R.N.3    Wong, W.T.4
  • 187
    • 84870832562 scopus 로고    scopus 로고
    • Reciprocal regulation between resting microglial dynamics and neuronal activity invivo
    • Li Y., Du X.F., Liu C.S., Wen Z.L., Du J.L. Reciprocal regulation between resting microglial dynamics and neuronal activity invivo. Dev. Cell. 2012, 23:1189-1202.
    • (2012) Dev. Cell. , vol.23 , pp. 1189-1202
    • Li, Y.1    Du, X.F.2    Liu, C.S.3    Wen, Z.L.4    Du, J.L.5
  • 190
    • 79952002918 scopus 로고    scopus 로고
    • Organ-specific innate immune responses in a mouse model of invasive candidiasis
    • Lionakis M.S., Lim J.K., Lee C.C., Murphy P.M. Organ-specific innate immune responses in a mouse model of invasive candidiasis. J.Innate Immun. 2011, 3:180-199.
    • (2011) J.Innate Immun. , vol.3 , pp. 180-199
    • Lionakis, M.S.1    Lim, J.K.2    Lee, C.C.3    Murphy, P.M.4
  • 191
    • 84881590982 scopus 로고    scopus 로고
    • Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice
    • Liu J., Copland D.A., Horie S., Wu W.K., Chen M., Xu Y., Paul Morgan B., Mack M., Xu H., Nicholson L.B., Dick A.D. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PloS One 2013, 8:e72935.
    • (2013) PloS One , vol.8 , pp. e72935
    • Liu, J.1    Copland, D.A.2    Horie, S.3    Wu, W.K.4    Chen, M.5    Xu, Y.6    Paul Morgan, B.7    Mack, M.8    Xu, H.9    Nicholson, L.B.10    Dick, A.D.11
  • 193
    • 84875412113 scopus 로고    scopus 로고
    • Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology
    • London A., Benhar I., Mattapallil M.J., Mack M., Caspi R.R., Schwartz M. Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology. J.Immunol. 2013, 190:3570-3578.
    • (2013) J.Immunol. , vol.190 , pp. 3570-3578
    • London, A.1    Benhar, I.2    Mattapallil, M.J.3    Mack, M.4    Caspi, R.R.5    Schwartz, M.6
  • 197
    • 79959966904 scopus 로고    scopus 로고
    • Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid
    • Luo C., Chen M., Xu H. Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Mol. Vis. 2011, 17:1588-1597.
    • (2011) Mol. Vis. , vol.17 , pp. 1588-1597
    • Luo, C.1    Chen, M.2    Xu, H.3
  • 198
    • 78149489635 scopus 로고    scopus 로고
    • Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling
    • Luo C., Yang X., Kain A.D., Powell D.W., Kuehn M.H., Tezel G. Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling. Investig. Ophthalmol. Vis. Sci. 2010, 51:5697-5707.
    • (2010) Investig. Ophthalmol. Vis. Sci. , vol.51 , pp. 5697-5707
    • Luo, C.1    Yang, X.2    Kain, A.D.3    Powell, D.W.4    Kuehn, M.H.5    Tezel, G.6
  • 200
    • 84879881897 scopus 로고    scopus 로고
    • Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation
    • Ma W., Cojocaru R., Gotoh N., Gieser L., Villasmil R., Cogliati T., Swaroop A., Wong W.T. Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation. Neurobiol. Aging 2013, 34:2310-2321.
    • (2013) Neurobiol. Aging , vol.34 , pp. 2310-2321
    • Ma, W.1    Cojocaru, R.2    Gotoh, N.3    Gieser, L.4    Villasmil, R.5    Cogliati, T.6    Swaroop, A.7    Wong, W.T.8
  • 201
    • 84870515243 scopus 로고    scopus 로고
    • A2E accumulation influences retinal microglial activation and complement regulation
    • Ma W., Coon S., Zhao L., Fariss R.N., Wong W.T. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiol. Aging 2013, 34:943-960.
    • (2013) Neurobiol. Aging , vol.34 , pp. 943-960
    • Ma, W.1    Coon, S.2    Zhao, L.3    Fariss, R.N.4    Wong, W.T.5
  • 202
    • 70949092319 scopus 로고    scopus 로고
    • Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD
    • Ma W., Zhao L., Fontainhas A.M., Fariss R.N., Wong W.T. Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PloS One 2009, 4:e7945.
    • (2009) PloS One , vol.4 , pp. e7945
    • Ma, W.1    Zhao, L.2    Fontainhas, A.M.3    Fariss, R.N.4    Wong, W.T.5
  • 203
    • 84863400997 scopus 로고    scopus 로고
    • Microglia in the outer retina and their relevance to pathogenesis of age-related macular degeneration
    • Ma W., Zhao L., Wong W.T. Microglia in the outer retina and their relevance to pathogenesis of age-related macular degeneration. Adv. Exp. Med. Biol. 2012, 723:37-42.
    • (2012) Adv. Exp. Med. Biol. , vol.723 , pp. 37-42
    • Ma, W.1    Zhao, L.2    Wong, W.T.3
  • 204
    • 34748819371 scopus 로고    scopus 로고
    • Variation in complement factor 3 is associated with risk of age-related macular degeneration
    • Maller J.B., Fagerness J.A., Reynolds R.C., Neale B.M., Daly M.J., Seddon J.M. Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat. Genet. 2007, 39:1200-1201.
    • (2007) Nat. Genet. , vol.39 , pp. 1200-1201
    • Maller, J.B.1    Fagerness, J.A.2    Reynolds, R.C.3    Neale, B.M.4    Daly, M.J.5    Seddon, J.M.6
  • 208
    • 2342464938 scopus 로고    scopus 로고
    • P23H and S334ter opsin mutations: increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration
    • Martin R.E., Ranchon-Cole I., Brush R.S., Williamson C.R., Hopkins S.A., Li F., Anderson R.E. P23H and S334ter opsin mutations: increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration. Mol. Vis. 2004, 10:199-207.
    • (2004) Mol. Vis. , vol.10 , pp. 199-207
    • Martin, R.E.1    Ranchon-Cole, I.2    Brush, R.S.3    Williamson, C.R.4    Hopkins, S.A.5    Li, F.6    Anderson, R.E.7
  • 209
    • 0032742416 scopus 로고    scopus 로고
    • Retinal microglia differentially express phenotypic markers of antigen-presenting cells invitro
    • Matsubara T., Pararajasegaram G., Wu G.S., Rao N.A. Retinal microglia differentially express phenotypic markers of antigen-presenting cells invitro. Investig. Ophthalmol. Vis. Sci. 1999, 40:3186-3193.
    • (1999) Investig. Ophthalmol. Vis. Sci. , vol.40 , pp. 3186-3193
    • Matsubara, T.1    Pararajasegaram, G.2    Wu, G.S.3    Rao, N.A.4
  • 210
    • 84863723643 scopus 로고    scopus 로고
    • The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes
    • Mattapallil M.J., Wawrousek E.F., Chan C.C., Zhao H., Roychoudhury J., Ferguson T.A., Caspi R.R. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Investig. Ophthalmol. Vis. Sci. 2012, 53:2921-2927.
    • (2012) Investig. Ophthalmol. Vis. Sci. , vol.53 , pp. 2921-2927
    • Mattapallil, M.J.1    Wawrousek, E.F.2    Chan, C.C.3    Zhao, H.4    Roychoudhury, J.5    Ferguson, T.A.6    Caspi, R.R.7
  • 211
    • 84881115282 scopus 로고    scopus 로고
    • Absence of clinical correlates of diabetic retinopathy in the Ins2Akita retina
    • McLenachan S., Chen X., McMenamin P.G., Rakoczy E.P. Absence of clinical correlates of diabetic retinopathy in the Ins2Akita retina. Clin. Exp. Ophthalmol. 2013, 41:582-592.
    • (2013) Clin. Exp. Ophthalmol. , vol.41 , pp. 582-592
    • McLenachan, S.1    Chen, X.2    McMenamin, P.G.3    Rakoczy, E.P.4
  • 213
    • 84885062246 scopus 로고    scopus 로고
    • Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation
    • Mirza M., Volz C., Karlstetter M., Langiu M., Somogyi A., Ruonala M.O., Tamm E.R., Jagle H., Langmann T. Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. PloS One 2013, 8:e75963.
    • (2013) PloS One , vol.8 , pp. e75963
    • Mirza, M.1    Volz, C.2    Karlstetter, M.3    Langiu, M.4    Somogyi, A.5    Ruonala, M.O.6    Tamm, E.R.7    Jagle, H.8    Langmann, T.9
  • 215
    • 0029996739 scopus 로고    scopus 로고
    • The concept of microglia in relation to central nervous system disease and regeneration
    • Moore S., Thanos S. The concept of microglia in relation to central nervous system disease and regeneration. Prog. Neurobiol. 1996, 48:441-460.
    • (1996) Prog. Neurobiol. , vol.48 , pp. 441-460
    • Moore, S.1    Thanos, S.2
  • 217
    • 0036727499 scopus 로고    scopus 로고
    • Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma
    • Naskar R., Wissing M., Thanos S. Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma. Investig. Ophthalmol. Vis. Sci. 2002, 43:2962-2968.
    • (2002) Investig. Ophthalmol. Vis. Sci. , vol.43 , pp. 2962-2968
    • Naskar, R.1    Wissing, M.2    Thanos, S.3
  • 218
    • 0035228049 scopus 로고    scopus 로고
    • Putting the brakes on innate immunity: a regulatory role for CD200?
    • Nathan C., Muller W.A. Putting the brakes on innate immunity: a regulatory role for CD200?. Nat. Immunol. 2001, 2:17-19.
    • (2001) Nat. Immunol. , vol.2 , pp. 17-19
    • Nathan, C.1    Muller, W.A.2
  • 219
    • 56149112559 scopus 로고    scopus 로고
    • Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study
    • Natoli R., Provis J., Valter K., Stone J. Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study. Mol. Vis. 2008, 14:1983.
    • (2008) Mol. Vis. , vol.14 , pp. 1983
    • Natoli, R.1    Provis, J.2    Valter, K.3    Stone, J.4
  • 220
    • 0033054390 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and complement deficiency: clues to a novel role for the classical complement pathway in the maintenance of immune tolerance
    • Navratil J.S., Korb L.C., Ahearn J.M. Systemic lupus erythematosus and complement deficiency: clues to a novel role for the classical complement pathway in the maintenance of immune tolerance. Immunopharmacology 1999, 42:47-52.
    • (1999) Immunopharmacology , vol.42 , pp. 47-52
    • Navratil, J.S.1    Korb, L.C.2    Ahearn, J.M.3
  • 221
    • 84904388188 scopus 로고    scopus 로고
    • Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia invitro and invivo
    • Neher J.J., Neniskyte U., Hornik T., Brown G.C. Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia invitro and invivo. Glia 2014, 62:1463-1475.
    • (2014) Glia , vol.62 , pp. 1463-1475
    • Neher, J.J.1    Neniskyte, U.2    Hornik, T.3    Brown, G.C.4
  • 222
    • 79955008182 scopus 로고    scopus 로고
    • Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    • Neher J.J., Neniskyte U., Zhao J.W., Bal-Price A., Tolkovsky A.M., Brown G.C. Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J.Immunol. 2011, 186:4973-4983.
    • (2011) J.Immunol. , vol.186 , pp. 4973-4983
    • Neher, J.J.1    Neniskyte, U.2    Zhao, J.W.3    Bal-Price, A.4    Tolkovsky, A.M.5    Brown, G.C.6
  • 223
    • 0032809910 scopus 로고    scopus 로고
    • Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma
    • Neufeld A.H. Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma. Arch. Ophthalmol. 1999, 117:1050-1056.
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 1050-1056
    • Neufeld, A.H.1
  • 225
    • 77956800319 scopus 로고    scopus 로고
    • Thrombospondin-1-mediated regulation of microglia activation after retinal injury
    • Ng T.F., Turpie B., Masli S. Thrombospondin-1-mediated regulation of microglia activation after retinal injury. Investig. Ophthalmol. Vis. Sci. 2009, 50:5472-5478.
    • (2009) Investig. Ophthalmol. Vis. Sci. , vol.50 , pp. 5472-5478
    • Ng, T.F.1    Turpie, B.2    Masli, S.3
  • 226
    • 33644876641 scopus 로고    scopus 로고
    • Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia
    • Nikodemova M., Duncan I.D., Watters J.J. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia. J.Neurochem. 2006, 96:314-323.
    • (2006) J.Neurochem. , vol.96 , pp. 314-323
    • Nikodemova, M.1    Duncan, I.D.2    Watters, J.J.3
  • 227
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma invivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma invivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 228
    • 0033824729 scopus 로고    scopus 로고
    • Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia
    • Ohsawa K., Imai Y., Kanazawa H., Sasaki Y., Kohsaka S. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J.Cell Sci. 2000, 113(Pt 17):3073-3084.
    • (2000) J.Cell Sci. , vol.113 , pp. 3073-3084
    • Ohsawa, K.1    Imai, Y.2    Kanazawa, H.3    Sasaki, Y.4    Kohsaka, S.5
  • 229
    • 80052430852 scopus 로고    scopus 로고
    • Microglia/macrophages migrate through retinal epithelium barrier by a transcellular route in diabetic retinopathy: role of PKCzeta in the Goto Kakizaki rat model
    • Omri S., Behar-Cohen F., de Kozak Y., Sennlaub F., Verissimo L.M., Jonet L., Savoldelli M., Omri B., Crisanti P. Microglia/macrophages migrate through retinal epithelium barrier by a transcellular route in diabetic retinopathy: role of PKCzeta in the Goto Kakizaki rat model. Am. J. Pathol. 2011, 179:942-953.
    • (2011) Am. J. Pathol. , vol.179 , pp. 942-953
    • Omri, S.1    Behar-Cohen, F.2    de Kozak, Y.3    Sennlaub, F.4    Verissimo, L.M.5    Jonet, L.6    Savoldelli, M.7    Omri, B.8    Crisanti, P.9
  • 230
    • 0344013136 scopus 로고    scopus 로고
    • TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes
    • Paglinawan R., Malipiero U., Schlapbach R., Frei K., Reith W., Fontana A. TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes. Glia 2003, 44:219-231.
    • (2003) Glia , vol.44 , pp. 219-231
    • Paglinawan, R.1    Malipiero, U.2    Schlapbach, R.3    Frei, K.4    Reith, W.5    Fontana, A.6
  • 232
    • 34547887607 scopus 로고    scopus 로고
    • Rodent models for glaucoma retinopathy and optic neuropathy
    • Pang I.H., Clark A.F. Rodent models for glaucoma retinopathy and optic neuropathy. J.Glaucoma 2007, 16:483-505.
    • (2007) J.Glaucoma , vol.16 , pp. 483-505
    • Pang, I.H.1    Clark, A.F.2
  • 239
    • 0026235629 scopus 로고
    • Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina
    • Penfold P.L., Madigan M.C., Provis J.M. Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina. Vis. Neurosci. 1991, 7:383-388.
    • (1991) Vis. Neurosci. , vol.7 , pp. 383-388
    • Penfold, P.L.1    Madigan, M.C.2    Provis, J.M.3
  • 240
    • 84902143838 scopus 로고    scopus 로고
    • Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa
    • Peng B., Xiao J., Wang K., So K.F., Tipoe G.L., Lin B. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. J.Neurosci. 2014, 34:8139-8150.
    • (2014) J.Neurosci. , vol.34 , pp. 8139-8150
    • Peng, B.1    Xiao, J.2    Wang, K.3    So, K.F.4    Tipoe, G.L.5    Lin, B.6
  • 241
    • 0023893302 scopus 로고
    • Macrophages and microglia in the nervous system
    • Perry V.H., Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci. 1988, 11:273-277.
    • (1988) Trends Neurosci. , vol.11 , pp. 273-277
    • Perry, V.H.1    Gordon, S.2
  • 242
    • 0027363757 scopus 로고
    • PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect
    • Pittler S.J., Keeler C.E., Sidman R.L., Baehr W. PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:9616-9619.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 9616-9619
    • Pittler, S.J.1    Keeler, C.E.2    Sidman, R.L.3    Baehr, W.4
  • 244
    • 0034824634 scopus 로고    scopus 로고
    • Development of the primate retinal vasculature
    • Provis J.M. Development of the primate retinal vasculature. Prog. Retin. Eye Res. 2001, 20:799-821.
    • (2001) Prog. Retin. Eye Res. , vol.20 , pp. 799-821
    • Provis, J.M.1
  • 245
    • 0030330923 scopus 로고    scopus 로고
    • Microglia in human retina: a heterogeneous population with distinct ontogenies
    • Provis J.M., Diaz C.M., Penfold P.L. Microglia in human retina: a heterogeneous population with distinct ontogenies. Perspect. Dev. Neurobiol. 1996, 3:213-222.
    • (1996) Perspect. Dev. Neurobiol. , vol.3 , pp. 213-222
    • Provis, J.M.1    Diaz, C.M.2    Penfold, P.L.3
  • 246
    • 33644655886 scopus 로고    scopus 로고
    • The number of people with glaucoma worldwide in 2010 and 2020
    • Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 2006, 90:262-267.
    • (2006) Br. J. Ophthalmol. , vol.90 , pp. 262-267
    • Quigley, H.A.1    Broman, A.T.2
  • 247
    • 36448995831 scopus 로고    scopus 로고
    • Microgliosis: the questions shape the answers
    • Ransohoff R.M. Microgliosis: the questions shape the answers. Nat. Neurosci. 2007, 10:1507-1509.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1507-1509
    • Ransohoff, R.M.1
  • 249
    • 48949116059 scopus 로고    scopus 로고
    • Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells
    • Raoul W., Keller N., Rodero M., Behar-Cohen F., Sennlaub F., Combadiere C. Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells. J.Neuroimmunol. 2008, 198:56-61.
    • (2008) J.Neuroimmunol. , vol.198 , pp. 56-61
    • Raoul, W.1    Keller, N.2    Rodero, M.3    Behar-Cohen, F.4    Sennlaub, F.5    Combadiere, C.6
  • 251
    • 31344433995 scopus 로고    scopus 로고
    • Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis
    • Read R.W., Szalai A.J., Vogt S.D., McGwin G., Barnum S.R. Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis. Exp. Eye Res. 2006, 82:389-394.
    • (2006) Exp. Eye Res. , vol.82 , pp. 389-394
    • Read, R.W.1    Szalai, A.J.2    Vogt, S.D.3    McGwin, G.4    Barnum, S.R.5
  • 252
    • 84880617242 scopus 로고    scopus 로고
    • New functions of Muller cells
    • Reichenbach A., Bringmann A. New functions of Muller cells. Glia 2013, 61:651-678.
    • (2013) Glia , vol.61 , pp. 651-678
    • Reichenbach, A.1    Bringmann, A.2
  • 253
    • 34248226374 scopus 로고    scopus 로고
    • Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses
    • Ripoll V.M., Irvine K.M., Ravasi T., Sweet M.J., Hume D.A. Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J.Immunol. 2007, 178:6557-6566.
    • (2007) J.Immunol. , vol.178 , pp. 6557-6566
    • Ripoll, V.M.1    Irvine, K.M.2    Ravasi, T.3    Sweet, M.J.4    Hume, D.A.5
  • 254
    • 33845297656 scopus 로고    scopus 로고
    • Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
    • Ritter M.R., Banin E., Moreno S.K., Aguilar E., Dorrell M.I., Friedlander M. Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. J.Clin. Investig. 2006, 116:3266-3276.
    • (2006) J.Clin. Investig. , vol.116 , pp. 3266-3276
    • Ritter, M.R.1    Banin, E.2    Moreno, S.K.3    Aguilar, E.4    Dorrell, M.I.5    Friedlander, M.6
  • 256
    • 33751315254 scopus 로고    scopus 로고
    • Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse
    • Rohrer B., Demos C., Frigg R., Grimm C. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp. Eye Res. 2007, 84:82-91.
    • (2007) Exp. Eye Res. , vol.84 , pp. 82-91
    • Rohrer, B.1    Demos, C.2    Frigg, R.3    Grimm, C.4
  • 257
    • 4744338189 scopus 로고    scopus 로고
    • Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling
    • Rohrer B., Pinto F.R., Hulse K.E., Lohr H.R., Zhang L., Almeida J.S. Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling. J.Biol. Chem. 2004, 279:41903-41910.
    • (2004) J.Biol. Chem. , vol.279 , pp. 41903-41910
    • Rohrer, B.1    Pinto, F.R.2    Hulse, K.E.3    Lohr, H.R.4    Zhang, L.5    Almeida, J.S.6
  • 259
    • 33645805413 scopus 로고    scopus 로고
    • Asulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration
    • Rolls A., Cahalon L., Bakalash S., Avidan H., Lider O., Schwartz M. Asulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration. FASEB J. 2006, 20:547-549.
    • (2006) FASEB J. , vol.20 , pp. 547-549
    • Rolls, A.1    Cahalon, L.2    Bakalash, S.3    Avidan, H.4    Lider, O.5    Schwartz, M.6
  • 260
    • 49649086873 scopus 로고    scopus 로고
    • Neuroinflammation and cognitive function in aged mice following minor surgery
    • Rosczyk H.A., Sparkman N.L., Johnson R.W. Neuroinflammation and cognitive function in aged mice following minor surgery. Exp. Gerontol. 2008, 43:840-846.
    • (2008) Exp. Gerontol. , vol.43 , pp. 840-846
    • Rosczyk, H.A.1    Sparkman, N.L.2    Johnson, R.W.3
  • 263
    • 80052920397 scopus 로고    scopus 로고
    • Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration
    • Rutar M., Natoli R., Kozulin P., Valter K., Gatenby P., Provis J.M. Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration. Investig. Ophthalmol. Vis. Sci. 2011, 52:5347-5358.
    • (2011) Investig. Ophthalmol. Vis. Sci. , vol.52 , pp. 5347-5358
    • Rutar, M.1    Natoli, R.2    Kozulin, P.3    Valter, K.4    Gatenby, P.5    Provis, J.M.6
  • 265
    • 84899420731 scopus 로고    scopus 로고
    • Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina
    • Rutar M., Valter K., Natoli R., Provis J.M. Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina. PloS One 2014, 9:e93343.
    • (2014) PloS One , vol.9 , pp. e93343
    • Rutar, M.1    Valter, K.2    Natoli, R.3    Provis, J.M.4
  • 266
    • 79251551934 scopus 로고    scopus 로고
    • Atwo-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures
    • Rymo S.F., Gerhardt H., Wolfhagen Sand F., Lang R., Uv A., Betsholtz C. Atwo-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures. PloS One 2011, 6:e15846.
    • (2011) PloS One , vol.6 , pp. e15846
    • Rymo, S.F.1    Gerhardt, H.2    Wolfhagen Sand, F.3    Lang, R.4    Uv, A.5    Betsholtz, C.6
  • 267
    • 58149383380 scopus 로고    scopus 로고
    • Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology
    • Ryu J.K., Cho T., Choi H.B., Wang Y.T., McLarnon J.G. Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. J.Neurosci. 2009, 29:3-13.
    • (2009) J.Neurosci. , vol.29 , pp. 3-13
    • Ryu, J.K.1    Cho, T.2    Choi, H.B.3    Wang, Y.T.4    McLarnon, J.G.5
  • 268
    • 84904009117 scopus 로고    scopus 로고
    • Sublime microglia: expanding roles for the Guardians of the CNS
    • Salter M.W., Beggs S. Sublime microglia: expanding roles for the Guardians of the CNS. Cell 2014, 158:15-24.
    • (2014) Cell , vol.158 , pp. 15-24
    • Salter, M.W.1    Beggs, S.2
  • 273
    • 48249116728 scopus 로고    scopus 로고
    • Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure
    • Sappington R.M., Calkins D.J. Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Investig. Ophthalmol. Vis. Sci. 2008, 49:3004-3017.
    • (2008) Investig. Ophthalmol. Vis. Sci. , vol.49 , pp. 3004-3017
    • Sappington, R.M.1    Calkins, D.J.2
  • 274
    • 42449093785 scopus 로고    scopus 로고
    • Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis
    • Saraswathy S., Rao N.A. Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis. Ophthalmic Res. 2008, 40:160-164.
    • (2008) Ophthalmic Res. , vol.40 , pp. 160-164
    • Saraswathy, S.1    Rao, N.A.2
  • 275
    • 0037307026 scopus 로고    scopus 로고
    • Amacrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
    • Sasmono R.T., Oceandy D., Pollard J.W., Tong W., Pavli P., Wainwright B.J., Ostrowski M.C., Himes S.R., Hume D.A. Amacrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 2003, 101:1155-1163.
    • (2003) Blood , vol.101 , pp. 1155-1163
    • Sasmono, R.T.1    Oceandy, D.2    Pollard, J.W.3    Tong, W.4    Pavli, P.5    Wainwright, B.J.6    Ostrowski, M.C.7    Himes, S.R.8    Hume, D.A.9
  • 278
    • 4544250720 scopus 로고    scopus 로고
    • Microglia-targeted pharmacotherapy in retinal neurodegenerative diseases
    • Schuetz E., Thanos S. Microglia-targeted pharmacotherapy in retinal neurodegenerative diseases. Curr. Drug Targets 2004, 5:619-627.
    • (2004) Curr. Drug Targets , vol.5 , pp. 619-627
    • Schuetz, E.1    Thanos, S.2
  • 281
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A., Gottfried-Blackmore A.C., McEwen B.S., Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007, 55:412-424.
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 283
    • 79955823910 scopus 로고    scopus 로고
    • Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina
    • Sivakumar V., Foulds W.S., Luu C.D., Ling E.A., Kaur C. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J.Pathol. 2011, 224:245-260.
    • (2011) J.Pathol. , vol.224 , pp. 245-260
    • Sivakumar, V.1    Foulds, W.S.2    Luu, C.D.3    Ling, E.A.4    Kaur, C.5
  • 289
    • 77953260611 scopus 로고    scopus 로고
    • Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy
    • Stevenson L., Matesanz N., Colhoun L., Edgar K., Devine A., Gardiner T.A., McDonald D.M. Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy. Investig. Ophthalmol. Vis. Sci. 2010, 51:3291-3299.
    • (2010) Investig. Ophthalmol. Vis. Sci. , vol.51 , pp. 3291-3299
    • Stevenson, L.1    Matesanz, N.2    Colhoun, L.3    Edgar, K.4    Devine, A.5    Gardiner, T.A.6    McDonald, D.M.7
  • 291
    • 84862308462 scopus 로고    scopus 로고
    • The Brain's aging immune system
    • Streit W.J., Xue Q.S. The Brain's aging immune system. Aging Dis. 2010, 1:254-261.
    • (2010) Aging Dis. , vol.1 , pp. 254-261
    • Streit, W.J.1    Xue, Q.S.2
  • 292
    • 14844363449 scopus 로고    scopus 로고
    • Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    • Stuart L.M., Takahashi K., Shi L., Savill J., Ezekowitz R.A. Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J.Immunol. 2005, 174:3220-3226.
    • (2005) J.Immunol. , vol.174 , pp. 3220-3226
    • Stuart, L.M.1    Takahashi, K.2    Shi, L.3    Savill, J.4    Ezekowitz, R.A.5
  • 293
    • 84879575822 scopus 로고    scopus 로고
    • Neuroprotective effect of minocycline in a rat model of branch retinal vein occlusion
    • Sun C., Li X.X., He X.J., Zhang Q., Tao Y. Neuroprotective effect of minocycline in a rat model of branch retinal vein occlusion. Exp. Eye Res. 2013, 113:105-116.
    • (2013) Exp. Eye Res. , vol.113 , pp. 105-116
    • Sun, C.1    Li, X.X.2    He, X.J.3    Zhang, Q.4    Tao, Y.5
  • 295
    • 0035575742 scopus 로고    scopus 로고
    • Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions
    • Tacnet-Delorme P., Chevallier S., Arlaud G.J. Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions. J.Immunol. 2001, 167:6374-6381.
    • (2001) J.Immunol. , vol.167 , pp. 6374-6381
    • Tacnet-Delorme, P.1    Chevallier, S.2    Arlaud, G.J.3
  • 296
    • 84904654930 scopus 로고    scopus 로고
    • Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy
    • Takeda S., Sato N., Morishita R. Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front. Aging Neurosci. 2014, 6:171.
    • (2014) Front. Aging Neurosci. , vol.6 , pp. 171
    • Takeda, S.1    Sato, N.2    Morishita, R.3
  • 297
    • 79960190061 scopus 로고    scopus 로고
    • Inflammation in diabetic retinopathy
    • Tang J., Kern T.S. Inflammation in diabetic retinopathy. Prog. Retin. Eye Res. 2011, 30:343-358.
    • (2011) Prog. Retin. Eye Res. , vol.30 , pp. 343-358
    • Tang, J.1    Kern, T.S.2
  • 299
    • 79955152463 scopus 로고    scopus 로고
    • Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma
    • Taylor S., Calder C.J., Albon J., Erichsen J.T., Boulton M.E., Morgan J.E. Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma. Exp. Eye Res. 2011, 92:338-343.
    • (2011) Exp. Eye Res. , vol.92 , pp. 338-343
    • Taylor, S.1    Calder, C.J.2    Albon, J.3    Erichsen, J.T.4    Boulton, M.E.5    Morgan, J.E.6
  • 301
    • 0034548875 scopus 로고    scopus 로고
    • Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells
    • Tezel G., Wax M.B. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J.Neurosci. 2000, 20:8693-8700.
    • (2000) J.Neurosci. , vol.20 , pp. 8693-8700
    • Tezel, G.1    Wax, M.B.2
  • 302
    • 0034657707 scopus 로고    scopus 로고
    • The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells
    • Tezel G., Wax M.B. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J.Neurosci. 2000, 20:3552-3562.
    • (2000) J.Neurosci. , vol.20 , pp. 3552-3562
    • Tezel, G.1    Wax, M.B.2
  • 303
    • 0037329386 scopus 로고    scopus 로고
    • Glial modulation of retinal ganglion cell death in glaucoma
    • Tezel G., Wax M.B. Glial modulation of retinal ganglion cell death in glaucoma. J.Glaucoma 2003, 12:63-68.
    • (2003) J.Glaucoma , vol.12 , pp. 63-68
    • Tezel, G.1    Wax, M.B.2
  • 305
    • 0026356353 scopus 로고
    • The relationship of microglial cells to dying neurons during natural neuronal cell death and axotomy-induced degeneration of the rat retina
    • Thanos S. The relationship of microglial cells to dying neurons during natural neuronal cell death and axotomy-induced degeneration of the rat retina. Eur. J. Neurosci. 1991, 3:1189-1207.
    • (1991) Eur. J. Neurosci. , vol.3 , pp. 1189-1207
    • Thanos, S.1
  • 306
    • 0026700123 scopus 로고
    • Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy
    • Thanos S. Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy. Brain Res. 1992, 588:21-28.
    • (1992) Brain Res. , vol.588 , pp. 21-28
    • Thanos, S.1
  • 307
    • 0012205849 scopus 로고
    • Old dyes for new scopes: the phagocytosis-dependent long-term fluorescence labelling of microglial cells invivo
    • Thanos S., Kacza J., Seeger J., Mey J. Old dyes for new scopes: the phagocytosis-dependent long-term fluorescence labelling of microglial cells invivo. Trends Neurosci. 1994, 17:177-182.
    • (1994) Trends Neurosci. , vol.17 , pp. 177-182
    • Thanos, S.1    Kacza, J.2    Seeger, J.3    Mey, J.4
  • 309
    • 0026670221 scopus 로고
    • Specific transcellular staining of microglia in the adult rat after traumatic degeneration of carbocyanine-filled retinal ganglion cells
    • Thanos S., Pavlidis C., Mey J., Thiel H.J. Specific transcellular staining of microglia in the adult rat after traumatic degeneration of carbocyanine-filled retinal ganglion cells. Exp. Eye Res. 1992, 55:101-117.
    • (1992) Exp. Eye Res. , vol.55 , pp. 101-117
    • Thanos, S.1    Pavlidis, C.2    Mey, J.3    Thiel, H.J.4
  • 310
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay M.E., Lowery R.L., Majewska A.K. Microglial interactions with synapses are modulated by visual experience. PLoS Biol. 2010, 8:e1000527.
    • (2010) PLoS Biol. , vol.8 , pp. e1000527
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 311
    • 84856756074 scopus 로고    scopus 로고
    • Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    • Tremblay M.E., Zettel M.L., Ison J.R., Allen P.D., Majewska A.K. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia 2012, 60:541-558.
    • (2012) Glia , vol.60 , pp. 541-558
    • Tremblay, M.E.1    Zettel, M.L.2    Ison, J.R.3    Allen, P.D.4    Majewska, A.K.5
  • 312
    • 0034861948 scopus 로고    scopus 로고
    • Autoantibodies to complement components
    • Trouw L.A., Roos A., Daha M.R. Autoantibodies to complement components. Mol. Immunol. 2001, 38:199-206.
    • (2001) Mol. Immunol. , vol.38 , pp. 199-206
    • Trouw, L.A.1    Roos, A.2    Daha, M.R.3
  • 313
    • 0029938895 scopus 로고    scopus 로고
    • The lectin pathway of complement activation
    • Turner M.W. The lectin pathway of complement activation. Res. Immunol. 1996, 147:110-115.
    • (1996) Res. Immunol. , vol.147 , pp. 110-115
    • Turner, M.W.1
  • 319
    • 84893718930 scopus 로고    scopus 로고
    • Hyperreflective intraretinal spots in diabetics without and with nonproliferative diabetic retinopathy: an invivo study using spectral domain OCT
    • Vujosevic S., Bini S., Midena G., Berton M., Pilotto E., Midena E. Hyperreflective intraretinal spots in diabetics without and with nonproliferative diabetic retinopathy: an invivo study using spectral domain OCT. J.Diabetes Res. 2013, 2013:491835.
    • (2013) J.Diabetes Res. , vol.2013 , pp. 491835
    • Vujosevic, S.1    Bini, S.2    Midena, G.3    Berton, M.4    Pilotto, E.5    Midena, E.6
  • 320
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses invivo and determine the fate of ischemic terminals
    • Wake H., Moorhouse A.J., Jinno S., Kohsaka S., Nabekura J. Resting microglia directly monitor the functional state of synapses invivo and determine the fate of ischemic terminals. J.Neurosci. 2009, 29:3974-3980.
    • (2009) J.Neurosci. , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 321
    • 65549156409 scopus 로고    scopus 로고
    • Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: another mechanism of complement activation in age-related macular degeneration
    • Wang J., Ohno-Matsui K., Yoshida T., Shimada N., Ichinose S., Sato T., Mochizuki M., Morita I. Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: another mechanism of complement activation in age-related macular degeneration. J.Cell. Physiol. 2009, 220:119-128.
    • (2009) J.Cell. Physiol. , vol.220 , pp. 119-128
    • Wang, J.1    Ohno-Matsui, K.2    Yoshida, T.3    Shimada, N.4    Ichinose, S.5    Sato, T.6    Mochizuki, M.7    Morita, I.8
  • 322
    • 82755167822 scopus 로고    scopus 로고
    • Adaptive Muller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina
    • Wang M., Ma W., Zhao L., Fariss R.N., Wong W.T. Adaptive Muller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina. J.Neuroinflamm. 2011, 8:173.
    • (2011) J.Neuroinflamm. , vol.8 , pp. 173
    • Wang, M.1    Ma, W.2    Zhao, L.3    Fariss, R.N.4    Wong, W.T.5
  • 323
    • 84895456869 scopus 로고    scopus 로고
    • Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina
    • Wang M., Wang X., Zhao L., Ma W., Rodriguez I.R., Fariss R.N., Wong W.T. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J.Neurosci. 2014, 34:3793-3806.
    • (2014) J.Neurosci. , vol.34 , pp. 3793-3806
    • Wang, M.1    Wang, X.2    Zhao, L.3    Ma, W.4    Rodriguez, I.R.5    Fariss, R.N.6    Wong, W.T.7
  • 324
    • 84903740738 scopus 로고    scopus 로고
    • Microglia-Muller cell interactions in the retina
    • Wang M., Wong W.T. Microglia-Muller cell interactions in the retina. Adv. Exp. Med. Biol. 2014, 801:333-338.
    • (2014) Adv. Exp. Med. Biol. , vol.801 , pp. 333-338
    • Wang, M.1    Wong, W.T.2
  • 326
    • 84883886303 scopus 로고    scopus 로고
    • Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome
    • Wang N.K., Lai C.C., Liu C.H., Yeh L.K., Chou C.L., Kong J., Nagasaki T., Tsang S.H., Chien C.L. Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. Dis. Models Mech. 2013, 6:1113-1122.
    • (2013) Dis. Models Mech. , vol.6 , pp. 1113-1122
    • Wang, N.K.1    Lai, C.C.2    Liu, C.H.3    Yeh, L.K.4    Chou, C.L.5    Kong, J.6    Nagasaki, T.7    Tsang, S.H.8    Chien, C.L.9
  • 327
    • 77749324852 scopus 로고    scopus 로고
    • Alleviation of neurotoxicity by microglial human Siglec-11
    • Wang Y., Neumann H. Alleviation of neurotoxicity by microglial human Siglec-11. J.Neurosci. 2010, 30:3482-3488.
    • (2010) J.Neurosci. , vol.30 , pp. 3482-3488
    • Wang, Y.1    Neumann, H.2
  • 328
    • 53149110451 scopus 로고    scopus 로고
    • Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats
    • Wasserman J.K., Yang H., Schlichter L.C. Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats. Eur. J. Neurosci. 2008, 28:1316-1328.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 1316-1328
    • Wasserman, J.K.1    Yang, H.2    Schlichter, L.C.3
  • 329
    • 64249089968 scopus 로고    scopus 로고
    • Immunoregulation of retinal ganglion cell fate in glaucoma
    • Wax M.B., Tezel G. Immunoregulation of retinal ganglion cell fate in glaucoma. Exp. Eye Res. 2009, 88:825-830.
    • (2009) Exp. Eye Res. , vol.88 , pp. 825-830
    • Wax, M.B.1    Tezel, G.2
  • 330
    • 58149345559 scopus 로고    scopus 로고
    • Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand
    • Wax M.B., Tezel G., Yang J., Peng G., Patil R.V., Agarwal N., Sappington R.M., Calkins D.J. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J.Neurosci. 2008, 28:12085-12096.
    • (2008) J.Neurosci. , vol.28 , pp. 12085-12096
    • Wax, M.B.1    Tezel, G.2    Yang, J.3    Peng, G.4    Patil, R.V.5    Agarwal, N.6    Sappington, R.M.7    Calkins, D.J.8
  • 333
    • 11144273817 scopus 로고    scopus 로고
    • Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration
    • Wenzel A., Grimm C., Samardzija M., Reme C.E. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog. Retin. Eye Res. 2005, 24:275-306.
    • (2005) Prog. Retin. Eye Res. , vol.24 , pp. 275-306
    • Wenzel, A.1    Grimm, C.2    Samardzija, M.3    Reme, C.E.4
  • 334
    • 84864708177 scopus 로고    scopus 로고
    • Regulation of microglia by ionotropic glutamatergic and GABAergic neurotransmission
    • Wong W.T., Wang M., Li W. Regulation of microglia by ionotropic glutamatergic and GABAergic neurotransmission. Neuron Glia Biol. 2011, 7:41-46.
    • (2011) Neuron Glia Biol. , vol.7 , pp. 41-46
    • Wong, W.T.1    Wang, M.2    Li, W.3
  • 335
  • 336
    • 0033681191 scopus 로고    scopus 로고
    • Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function
    • Wright G.J., Puklavec M.J., Willis A.C., Hoek R.M., Sedgwick J.D., Brown M.H., Barclay A.N. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 2000, 13:233-242.
    • (2000) Immunity , vol.13 , pp. 233-242
    • Wright, G.J.1    Puklavec, M.J.2    Willis, A.C.3    Hoek, R.M.4    Sedgwick, J.D.5    Brown, M.H.6    Barclay, A.N.7
  • 338
    • 38349116263 scopus 로고    scopus 로고
    • Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice
    • Xu H., Chen M., Manivannan A., Lois N., Forrester J.V. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 2008, 7:58-68.
    • (2008) Aging Cell. , vol.7 , pp. 58-68
    • Xu, H.1    Chen, M.2    Manivannan, A.3    Lois, N.4    Forrester, J.V.5
  • 339
    • 34547645633 scopus 로고    scopus 로고
    • Turnover of resident retinal microglia in the normal adult mouse
    • Xu H., Chen M., Mayer E.J., Forrester J.V., Dick A.D. Turnover of resident retinal microglia in the normal adult mouse. Glia 2007, 55:1189-1198.
    • (2007) Glia , vol.55 , pp. 1189-1198
    • Xu, H.1    Chen, M.2    Mayer, E.J.3    Forrester, J.V.4    Dick, A.D.5
  • 341
    • 35748953451 scopus 로고    scopus 로고
    • Role of NF-kappaB and MAPKs in light-induced photoreceptor apoptosis
    • Yang L.P., Zhu X.A., Tso M.O. Role of NF-kappaB and MAPKs in light-induced photoreceptor apoptosis. Investig. Ophthalmol. Vis. Sci. 2007, 48:4766-4776.
    • (2007) Investig. Ophthalmol. Vis. Sci. , vol.48 , pp. 4766-4776
    • Yang, L.P.1    Zhu, X.A.2    Tso, M.O.3
  • 342
    • 0034533814 scopus 로고    scopus 로고
    • Localization and characterization of immunocompetent cells in the human retina
    • Yang P., Das P.K., Kijlstra A. Localization and characterization of immunocompetent cells in the human retina. Ocul. Immunol. Inflamm. 2000, 8:149-157.
    • (2000) Ocul. Immunol. Inflamm. , vol.8 , pp. 149-157
    • Yang, P.1    Das, P.K.2    Kijlstra, A.3
  • 345
    • 0033781980 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head
    • Yuan L., Neufeld A.H. Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 2000, 32:42-50.
    • (2000) Glia , vol.32 , pp. 42-50
    • Yuan, L.1    Neufeld, A.H.2
  • 346
    • 0035370336 scopus 로고    scopus 로고
    • Activated microglia in the human glaucomatous optic nerve head
    • Yuan L., Neufeld A.H. Activated microglia in the human glaucomatous optic nerve head. J.Neurosci. Res. 2001, 64:523-532.
    • (2001) J.Neurosci. Res. , vol.64 , pp. 523-532
    • Yuan, L.1    Neufeld, A.H.2
  • 347
    • 1542637007 scopus 로고    scopus 로고
    • Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse
    • Zeiss C.J., Johnson E.A. Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse. Investig. Ophthalmol. Vis. Sci. 2004, 45:971-976.
    • (2004) Investig. Ophthalmol. Vis. Sci. , vol.45 , pp. 971-976
    • Zeiss, C.J.1    Johnson, E.A.2
  • 348
    • 39049127031 scopus 로고    scopus 로고
    • Microglial activation in human diabetic retinopathy
    • Zeng H.Y., Green W.R., Tso M.O. Microglial activation in human diabetic retinopathy. Arch. Ophthalmol. 2008, 126:227-232.
    • (2008) Arch. Ophthalmol. , vol.126 , pp. 227-232
    • Zeng, H.Y.1    Green, W.R.2    Tso, M.O.3
  • 349
    • 24644480719 scopus 로고    scopus 로고
    • Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice
    • Zeng H.Y., Zhu X.A., Zhang C., Yang L.P., Wu L.M., Tso M.O. Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Investig. Ophthalmol. Vis. Sci. 2005, 46:2992-2999.
    • (2005) Investig. Ophthalmol. Vis. Sci. , vol.46 , pp. 2992-2999
    • Zeng, H.Y.1    Zhu, X.A.2    Zhang, C.3    Yang, L.P.4    Wu, L.M.5    Tso, M.O.6
  • 351
    • 3242877090 scopus 로고    scopus 로고
    • Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration
    • Zhang C., Lei B., Lam T.T., Yang F., Sinha D., Tso M.O. Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration. Investig. Ophthalmol. Vis. Sci. 2004, 45:2753-2759.
    • (2004) Investig. Ophthalmol. Vis. Sci. , vol.45 , pp. 2753-2759
    • Zhang, C.1    Lei, B.2    Lam, T.T.3    Yang, F.4    Sinha, D.5    Tso, M.O.6
  • 352
    • 39549094749 scopus 로고    scopus 로고
    • Murine cytomegalovirus infection and apoptosis in organotypic retinal cultures
    • Zhang M., Marshall B., Atherton S.S. Murine cytomegalovirus infection and apoptosis in organotypic retinal cultures. Investig. Ophthalmol. Vis. Sci. 2008, 49:295-303.
    • (2008) Investig. Ophthalmol. Vis. Sci. , vol.49 , pp. 295-303
    • Zhang, M.1    Marshall, B.2    Atherton, S.S.3
  • 353
    • 67349151290 scopus 로고    scopus 로고
    • Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy
    • Zhao L., Ma W., Fariss R.N., Wong W.T. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Exp. Eye Res. 2009, 88:1004-1013.
    • (2009) Exp. Eye Res. , vol.88 , pp. 1004-1013
    • Zhao, L.1    Ma, W.2    Fariss, R.N.3    Wong, W.T.4
  • 354
    • 80052863472 scopus 로고    scopus 로고
    • Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial: inhibition as a potential therapeutic strategy
    • Zhao L., Ma W., Fariss R.N., Wong W.T. Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial: inhibition as a potential therapeutic strategy. Am. J. Pathol. 2011, 179:1265-1277.
    • (2011) Am. J. Pathol. , vol.179 , pp. 1265-1277
    • Zhao, L.1    Ma, W.2    Fariss, R.N.3    Wong, W.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.