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Volumn 9, Issue 12, 2006, Pages 1512-1519

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE; PURINE P2Y12 RECEPTOR; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; MEMBRANE PROTEIN; PURINE P2 RECEPTOR;

EID: 33845259342     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1805     Document Type: Article
Times cited : (1178)

References (34)
  • 1
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8, 752-758 (2005).
    • (2005) Nat. Neurosci. , vol.8 , pp. 752-758
    • Davalos, D.1
  • 2
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005).
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 3
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: A confocal time-lapse analysis in hippocampal slices
    • Stence, N., Waite, M. & Dailey, M.E. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33, 256-266 (2001).
    • (2001) Glia , vol.33 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 4
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao, C.C., Hu, S., Molitor, T.W., Shaskan, E.G. & Peterson, P.K. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149, 2736-2741 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 5
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg, G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318 (1996).
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 6
    • 0036848882 scopus 로고    scopus 로고
    • Microglial activation by purines and pyrimidines
    • Inoue, K. Microglial activation by purines and pyrimidines. Glia 40, 156-163 (2002).
    • (2002) Glia , vol.40 , pp. 156-163
    • Inoue, K.1
  • 7
    • 0344013132 scopus 로고    scopus 로고
    • Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain
    • Sasaki, Y. et al. Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Glia 44, 242-250 (2003).
    • (2003) Glia , vol.44 , pp. 242-250
    • Sasaki, Y.1
  • 8
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • Coull, J.A. et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438, 1017-1021 (2005).
    • (2005) Nature , vol.438 , pp. 1017-1021
    • Coull, J.A.1
  • 10
    • 0035869474 scopus 로고    scopus 로고
    • Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors
    • Honda, S. et al. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21, 1975-1982 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 1975-1982
    • Honda, S.1
  • 12
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter, G. et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409, 202-207 (2001).
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1
  • 13
    • 0035896562 scopus 로고    scopus 로고
    • ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999
    • Zhang, F.L. et al. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. J. Biol. Chem. 276, 8608-8615 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 8608-8615
    • Zhang, F.L.1
  • 14
    • 85047694005 scopus 로고    scopus 로고
    • P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
    • Andre, P. et al. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J. Clin. Invest. 112, 398-406 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 398-406
    • Andre, P.1
  • 15
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster, C.J. et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J. Clin. Invest. 107, 1591-1598 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1591-1598
    • Foster, C.J.1
  • 16
    • 0035843161 scopus 로고    scopus 로고
    • Cardiovascular biology. Small cells, big issues
    • Brass, S. Cardiovascular biology. Small cells, big issues. Nature 409, 145-147 (2001).
    • (2001) Nature , vol.409 , pp. 145-147
    • Brass, S.1
  • 17
    • 0042976076 scopus 로고    scopus 로고
    • P2Y12, a new platelet ADP receptor, target of clopidogrel
    • Herbert, J.M. & Savi, P. P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin. Vasc. Med. 3, 113-122 (2003).
    • (2003) Semin. Vasc. Med. , vol.3 , pp. 113-122
    • Herbert, J.M.1    Savi, P.2
  • 18
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung, S. et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106-4114 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4106-4114
    • Jung, S.1
  • 20
    • 0024199439 scopus 로고
    • Functional plasticity of microglia: A review
    • Streit, W.J., Graeber, M.B. & Kreutzberg, G.W. Functional plasticity of microglia: a review. Glia 1, 301-307 (1988).
    • (1988) Glia , vol.1 , pp. 301-307
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 21
    • 18244410166 scopus 로고    scopus 로고
    • Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum
    • Lee, J.C. et al. Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum. Glia 50, 168-181 (2005).
    • (2005) Glia , vol.50 , pp. 168-181
    • Lee, J.C.1
  • 22
    • 0141769473 scopus 로고    scopus 로고
    • Activation of mouse microglial cells affects P2 receptor signaling
    • Moller, T., Kann, O., Verkhratsky, A. & Kettenmann, H. Activation of mouse microglial cells affects P2 receptor signaling. Brain Res. 853, 49-59 (2000).
    • (2000) Brain Res. , vol.853 , pp. 49-59
    • Moller, T.1    Kann, O.2    Verkhratsky, A.3    Kettenmann, H.4
  • 23
    • 18244389451 scopus 로고    scopus 로고
    • P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
    • Hardy, A.R. et al. P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood 105, 3552-3560 (2005).
    • (2005) Blood , vol.105 , pp. 3552-3560
    • Hardy, A.R.1
  • 24
    • 0037118947 scopus 로고    scopus 로고
    • Down-regulation of complement receptor 3 and major histocompatibility complex I and II antigen-like immunoreactivity accompanies ramification in isolated rat microglia
    • Salimi, K. & Humpel, C. Down-regulation of complement receptor 3 and major histocompatibility complex I and II antigen-like immunoreactivity accompanies ramification in isolated rat microglia. Brain Res. 946, 283-289 (2002).
    • (2002) Brain Res. , vol.946 , pp. 283-289
    • Salimi, K.1    Humpel, C.2
  • 25
    • 33745548105 scopus 로고    scopus 로고
    • Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis
    • Kurpius, D., Wilson, N., Fuller, L., Hoffman, A. & Dailey, M.E. Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis. Glia 54, 58-70 (2006).
    • (2006) Glia , vol.54 , pp. 58-70
    • Kurpius, D.1    Wilson, N.2    Fuller, L.3    Hoffman, A.4    Dailey, M.E.5
  • 26
    • 0036149221 scopus 로고    scopus 로고
    • Cell damage excites nociceptors through release of cytosolic ATP
    • Cook, S.P. & McCleskey, E.W. Cell damage excites nociceptors through release of cytosolic ATP. Pain 95, 41-47 (2002).
    • (2002) Pain , vol.95 , pp. 41-47
    • Cook, S.P.1    McCleskey, E.W.2
  • 27
    • 0042968804 scopus 로고    scopus 로고
    • P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • Tsuda, M. et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424, 778-783 (2003).
    • (2003) Nature , vol.424 , pp. 778-783
    • Tsuda, M.1
  • 28
    • 0037092429 scopus 로고    scopus 로고
    • ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels
    • Chakfe, Y. et al. ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. J. Neurosci. 22, 3061-3069 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 3061-3069
    • Chakfe, Y.1
  • 29
    • 0842322759 scopus 로고    scopus 로고
    • Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia
    • Suzuki, T. et al. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J. Neurosci. 24, 1-7 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 1-7
    • Suzuki, T.1
  • 30
    • 0035798576 scopus 로고    scopus 로고
    • Identification of a novel human ADP receptor coupled to G(i)
    • Communi, D. et al. Identification of a novel human ADP receptor coupled to G(i). J. Biol. Chem. 276, 41479-41485 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 41479-41485
    • Communi, D.1
  • 31
    • 0022922108 scopus 로고
    • Characterization of ameboid microglia isolated from developing mammalian brain
    • Giulian, D. & Baker, T.J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6, 2163-2178 (1986).
    • (1986) J. Neurosci. , vol.6 , pp. 2163-2178
    • Giulian, D.1    Baker, T.J.2
  • 33
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina, M.J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1
  • 34
    • 18244381020 scopus 로고    scopus 로고
    • The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression
    • Luecke, H.F. & Yamamoto, K.R. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 19, 1116-1127 (2005).
    • (2005) Genes Dev. , vol.19 , pp. 1116-1127
    • Luecke, H.F.1    Yamamoto, K.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.