Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 9, 2002, Pages 2962-2968

  Naskar, Rita ^a   Wissing, Mechthild ^a   Thanos, Solon ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CALCIUM BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; FLUORESCENCE MICROSCOPY; GLAUCOMA; IMMUNOCYTOCHEMISTRY; MICROGLIA; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA GANGLION CELL;

ANIMALS; CELL DEATH; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; GLAUCOMA; INTRAOCULAR PRESSURE; MICROSCOPY, FLUORESCENCE; NERVE DEGENERATION; NEUROGLIA; PYRIDINIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS;

EID: 0036727499     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Nitric oxide: A potential mediator of retinal ganglion cell damage in glaucoma
2. Programmed cell death of retinal ganglion cells during experimental glaucoma
3. Laser energy levels for trabecular meshwork damage in the primate eye
4. TUNEL-positive ganglion cells in human primary open-angle glaucoma
5. Potential treatment modalities for glaucoma neuropathy: Neuroprotection and neuroregeneration
6. A proposed role for excitotoxicity in glaucoma
7. Noninvasive measurement of rat intraocular pressure with the tono-pen
8. Chronic ocular hypertension following episcleral venous occlusion in rats
9. Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink
10. Glioanatomy assessed by cell-cell interactions and phagocytic labelling
11. Electroretinographic abnormalities in a rat glaucoma model with chronic elevated intraocular pressure
12. Using conventional fluorescence microscopy to monitor retinal neuronal death in vivo (in vivo FM)
13. An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma
14. Role of macrophages and microglia in the injured CNS
15. Activated microglia in the human glaucomatous optic nerve head
16. Activated human retinal microglia under pathological conditions
17. Halothane anesthesia and aqueous humor dynamics in laboratory animals
18. Comparison of the effects of isoflurane and halothane on intraocular pressure
19. Regenerating ganglion cells in the adult rat establish retinofugal topography and restore visual function
20. The patterns of retinal ganglion cell death in hypertensive eyes
21. Long-term non-invasive measurement of intraocular pressure in the rat eye
22. Clinical comparison of the oculab tonopen to the goldmann applanation tonometer
23. The tonopen: A manometric and clinical study
24. Variability of intraocular pressure after auditory stimulation in rabbits
25. Comparative anaesthetic effects on aqueous humor dynamics in the cynomolgus monkey
26. Specific transcellular staining of microglia in the adult rat after traumatic degeneration of carbocyanine-filled retinal ganglion cells
27. Ultrastructural changes in the aqueous outflow apparatus of beagles with inherited glaucoma
28. Optic nerve head axonal transport in rabbits with hereditary glaucoma
29. Sick photoreceptors attract activated microglia from the ganglion cell layer: A model to study the inflammatory cascades in rats with inherited retinal dystrophy
30. Confirmation of the rat model of chronic, moderately elevated intraocular pressure
31. The neuronal naturalist: Watching neurons in their native habitat
32. Immunohistologic evidence for retinal glial cell changes in human glaucoma
33. Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model
34. Morphological studies on neuroglia. III: Macrophage response and "microgliocytosis" in kainic acid-induced lesions
35. Glial reactivity, an early feature of diabetic retinopathy
36. Microglia, the first line of defence in brain pathologies
37. Glutamate receptor subunit GluR2 and NMDAR1 immunoreactivity in the retina of macaque monkeys with experimental glaucoma does not identify vulnerable neurons
38. Neuroprotection in relation to retinal ischemia and relevance to glaucoma
39. Microglia-specific localization of a novel, calcium binding protein, Iba1
40. Iba1 is an actin-cross-linking protein in macrophages/microglia
41. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia
42. Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain
43. Nitric oxide, microglial activities and neuronal cell death in the lateral geniculate nucleus of glaucomatous rats