Complement factor H variant increases the risk of age-related macular degeneration

Science

Volumn 308, Issue 5720, 2005, Pages 419-421

  Haines, Jonathan L ^a   Hauser, Michael A ^b   Schmidt, Silke ^b   Scott, William K ^b   Olson, Lana M ^a   Gallins, Paul ^b   Spencer, Kylee L ^a   Shu, Ying Kwan ^b   Noureddine, Maher ^b   Gilbert, John R ^b   Schnetz Boutaud, Nathalie ^a   Agarwal, Anita ^c   Postel, Eric A ^b   Pericak Vance, Margaret A ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; DISEASES; DNA; GENES; GENETIC ENGINEERING;

AGE-RELATED MACULAR DEGENERATION (AMD); COMPLEMENT FACTOR H VARIANTS; HALOPHYTES; SINGLE-NUCLEOTIDE POLYMORPHISM;

VISION;

COMPLEMENT FACTOR H;

AGING;

ARTICLE; DNA SEQUENCE; GENETIC CODE; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ALLELES; BINDING SITES; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 1; COMPLEMENT ACTIVATION; COMPLEMENT FACTOR H; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HEPARIN; HUMANS; LINKAGE DISEQUILIBRIUM; MACULAR DEGENERATION; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEQUENCE ANALYSIS, DNA; SMOKING; VARIATION (GENETICS);

EID: 20244388812     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1110359     Document Type: Article

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24. We thank all of the study participants and their relatives; M. de la Paz, M. Klein, J. Caldwell, R. Domurath, K. Haynes, V. Mitchell, M. Shaw, and J. Galloway for participant ascertainment; K. Abramson, J. Benton, W. Lambert, B. Love, T. Skelly, E. Tegnell, M. Allen, C. Haynes, R. Chung, and J. Bunch for valuable technical assistance; J. M. Vance and M. Summar for critical reading of the manuscript; and D. J. M. Gass for patient ascertainment and clinical expertise. We also thank the following clinics and clinicians for referring individuals to the study: Southern Retina, LLC (C Harris); Vitreo-Retinal Surgeons (M. Duan and C. Devine); Georgia Retina, P.C.; and The Retina Group of Washington. Supported by grants EY12118 (to M.A.P.-V. and J.L.H.) and EY015216 (to S.S.) from the NIH/National Eye Institute, grant AG11268 from the NIH/National Institute on Aging (to H. Cohen), and grant M01 RR-00095 from the NIH/National Center for Research Resources (to Vanderbilt University).