CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis

Immunology

Volumn 128, Issue 1, 2009, Pages 25-33

  Dagkalis, Athanasios ^a,b   Wallace, Carol ^a   Hing, Benjamin ^a   Liversidge, Janet ^a   Crane, Isabel J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Autoimmunity; Cell trafficking; Chemokine receptor; Chemokines; Inflammation; Monocytes

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; INFLAMMATION; MICROGLIA; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; UVEITIS;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; KILLER CELLS, NATURAL; MACROPHAGE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MONOCYTES; RECEPTORS, CHEMOKINE; RETINA; UVEITIS;

EID: 68249095210     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03046.x     Document Type: Article

References (47)

1. Kim SU, de Vellis J. Microglia in health and disease. J Neurosci Res 2005 81 : 302 13.
2. Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004 22 : 891 928.
3. Sunderkotter C, Nikolic T, Dillon MJ et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 2004 172 : 4410 7.
4. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005 5 : 953 64.
5. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003 19 : 71 82.
6. Boring L, Gosling J, Chensue SW et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 1997 100 : 2552 61.
7. Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. Journal Exp Med 2000 192 : 1075 80.
8. Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2001 98 : 7958 63.
9. Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol 2006 7 : 311 7.
10. Tsou CL, Peters W, Si Y et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 2007 117 : 902 9.
11. Tacke F, Alvarez D, Kaplan TJ et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 2007 117 : 185 94.
12. Quinones MP, Ahuja SK, Jimenez F et al. Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. J Clin Invest 2004 113 : 856 66.
13. Lesnik P, Haskell CA, Charo IF. Decreased atherosclerosis in CX3CR1-\- mice reveals a role for fractalkine in atherogenesis. J Clin Invest 2003 111 : 333 40.
14. Combadiere C, Potteaux S, Gao JL et al. Decreased atherosclerotic lesion formation in CX3CR1\apolipoprotein E double knockout mice. Circulation 2003 107 : 1009 16.
15. 3CR1. Kidney Int 1999 56 : 612 20.
16. Soriano SG, Amaravadi LS, Wang YF et al. Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol 2002 125 : 59 65.
17. Auffray C, Fogg D, Garfa M et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 2007 317 : 666 70.
18. 3CR1- expressing microglia. Proc Natl Acad Sci USA 1998 95 : 10896 901.
19. Cardona AE, Pioro EP, Sasse ME et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 2006 9 : 917 24.
20. Mizuno T, Kawanokuchi J, Numata K, Suzumura A. Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res 2003 979 : 65 70.
21. Zujovic V, Benavides J, Vige X, Carter C, Taupin V. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 2000 29 : 305 15.
22. Meucci O, Fatatis A, Simen AA, Miller RJ. Expression of CX(3)CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A 2000 97 : 8075 80.
23. 3CR-1-expressing microglia. J Immunol 1999 163 : 1628 35.
24. Cross AK, Woodroofe MN. Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. Glia 1999 28 : 183 9.
25. Boehme SA, Lio FM, Maciejewski-Lenoir D, Bacon KB, Conlon PJ. The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia. J Immunol 2000 165 : 397 403.
26. Combadiere C, Feumi C, Raoul W et al. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest 2007 117 : 2920 8.
27. 3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 2000 20 : 4106 14.
28. Davalos D, Grutzendler J, Yang G et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005 8 : 752 8.
29. Forrester JV, Huitinga I, Lumsden L, Dijkstra CD. Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats. Curr Eye Res 1998 17 : 426 37.
30. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick J, Dick AD. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002 161 : 1669 77.
31. Calder CJ, Nicholson LB, Dick AD. Mechanisms for inducing nasal mucosal tolerance in experimental autoimmune uveoretinitis. Methods 2006 38 : 69 76.
32. Jiang H-R, Lumsden L, Forrester JV. Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice. Invest Ophthalmol Vis Sci 1999 40 : 3177 85.
33. Chan-Ling T. Glial, vascular, and neuronal cytogenesis in whole-mounted cat retina. Microsc Res Tech 1997 36 : 1 16.
34. Abràmoff MD, Magelhaes PJ, Ram SJ. Image processing with ImageJ. Biophotonics Int 2004 11 : 36 42.
35. Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 2001 33 : 256 66.
36. Quinones MP, Estrada CA, Kalkonde Y et al. The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis. J Mol Med 2005 83 : 672 81.
37. Crane IJ, McKillop-Smith S, Wallace CA, Lamont GR, Forrester JV. Expression of the chemokines MIP-1α, MCP-1 and RANTES in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 2001 42 : 1547 52.
38. Foxman EF, Zhang MF, Hurst SD et al. Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation. J Immunol 2002 168 : 2483 92.
39. Crane IJ, Xu H, Wallace C et al. Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis. J Leukoc Biol 2006 79 : 435 43.
40. Crane IJ, Xu H, Manivannan A et al. Effect of anti-macrophage inflammatory protein-1α on leukocyte trafficking and disease progression in experimental autoimmune uveoretinitis. Eur J Immunol 2003 33 : 402 10.
41. Rao NA, Kimoto T, Zamir E et al. Pathogenic role of retinal microglia in experimental uveoretinitis. Invest Ophthalmol Vis Sci 2003 44 : 22 31.
42. Brockhaus J, Moller T, Kettenmann H. Phagocytozing ameboid microglial cells studied in a mouse corpus callosum slice preparation. Glia 1996 16 : 81 90.
43. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005 308 : 1314 8.
44. Silverman MD, Zamora DO, Pan YZ et al. Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells. Invest Ophthalmol Vis Sci 2003 44 : 1608 15.
45. Huang D, Shi FD, Jung S et al. The neuronal chemokine CX3CL1\fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J 2006 20 : 896 905.
46. Campbell JJ, Qin SX, Unutmaz D et al. Unique subpopulations of CD56(+) NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol 2001 166 : 6477 82.
47. Kitaichi N, Kotake S, Morohashi T, Onoe K, Ohno S, Taylor AW. Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells. J Leukoc Biol 2002 72 : 1117 21.