Neuroprotection by tetracyclines

Trends in Pharmacological Sciences

Volumn 25, Issue 12, 2004, Pages 609-612

  Domercq, María ^a   Matute, Carlos ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MINOCYCLINE; TETRACYCLINE DERIVATIVE;

AMYOTROPHIC LATERAL SCLEROSIS; CELL ACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DRUG EFFICACY; HUMAN; HUNTINGTON CHOREA; ISCHEMIA; MOLECULAR DYNAMICS; MULTIPLE SCLEROSIS; NERVE CELL; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY;

EID: 7644242460     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2004.10.001     Document Type: Short Survey

References (30)

1. W.M. Clark Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment Stroke 25 1994 1411 1415
2. J. Yrjanheikki Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia Proc. Natl. Acad. Sci. U. S. A. 95 1998 15769 15774
3. P.H. Gordon Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis Neurology 62 2004 1845 1847
4. M. Thomas Minocycline in Huntington's disease: a pilot study Mov. Disord. 19 2004 692 695
5. Huntington Study Group Minocycline safety and tolerability in Huntington disease Neurology 63 2004 547 549
6. L.M. Metz Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis Ann. Neurol. 55 2004 756
7. J. Yrjanheikki A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc. Natl. Acad. Sci. U. S. A. 96 1999 13496 13500
8. Y. Du Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 98 2001 14669 14674
9. T. Tikka Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia J. Neurosci. 21 2001 2580 2588
10. D.C. Wu Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease J. Neurosci. 22 2002 1763 1771
11. N. Popovic Inhibition of autoimmune encephalomyelitis by a tetracycline Ann. Neurol. 51 2002 215 223
12. V. Brundula Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis Brain 125 2002 1297 1308
13. S. Zhu Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Nature 417 2002 74 78
14. X. Wang Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 10483 10487
15. J. Wang Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria J. Biol. Chem. 279 2004 19948 19954
16. L. Xu Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats BMC Neurol. 4 2004 1 7
17. K.L. Arvin Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury Ann. Neurol. 52 2002 54 61
18. M. Tsuji Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model Exp. Neurol. 189 2004 58 65
19. C. Matute The link between excitotoxic oligodendroglial death and demyelinating diseases Trends Neurosci. 24 2001 224 230
20. J.E.A. Wells Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice Brain 126 2003 1628 1637
21. D.P. Stirling Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury J. Neurosci. 24 2004 2182 2190
22. Y.D. Teng Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury Proc. Natl. Acad. Sci. U. S. A. 101 2004 3071 3076
23. J. Kriz Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis Neurobiol. Dis. 10 2002 268 278
24. C.L. Hunter Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning Eur. J. Neurosci. 19 2004 3305 3316
25. M. Chen Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease Nat. Med. 6 2000 797 801
26. D.L. Smith Minocycline and doxycycline are not beneficial in a model of Huntington's disease Ann. Neurol. 54 2003 186 196
27. E. Diguet Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease Eur. J. Neurosci. 19 2004 3266 3276
28. L. Yang Minocycline enhances MPTP toxicity to dopaminergic neurons J. Neurosci. Res. 74 2003 278 285
29. M.H. Barnet, and J.W. Prineas Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion Ann. Neurol. 55 2004 458 468
30. S.C. Fagan Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection Exp. Neurol. 186 2004 248 251