Neuronal 'On' and 'Off' signals control microglia

Trends in Neurosciences

Volumn 30, Issue 11, 2007, Pages 596-602

  Biber, Knut ^a   Neumann, Harald ^b   Inoue, Kazuhide ^c   Boddeke, Hendrikus W G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF BONN   (Germany)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CD200 ANTIGEN; CD22 ANTIGEN; CD47 ANTIGEN; CHEMOKINE; CX3C CHEMOKINE; GLUTAMIC ACID; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; NEUROTOXIN; NEUROTRANSMITTER; PURINE DERIVATIVE; SECONDARY LYMPHOID TISSUE CHEMOKINE; TRANSFORMING GROWTH FACTOR BETA; URIDINE TRIPHOSPHATE;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; CELL FUNCTION; CELL MIGRATION; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HOST RESISTANCE; IMMUNE FUNCTION TEST; IMMUNOMODULATION; INFLAMMATION; MICROGLIA; NERVE CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMMUNICATION; CHEMOKINES; MICROGLIA; MODELS, NEUROLOGICAL; NEURONS; SIGNAL TRANSDUCTION;

EID: 35748939409     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2007.08.007     Document Type: Review

References (73)

1. Kreutzberg G.W. Microglia: A sensor for pathological event is the CNS. Trends Neurosci. 19 (1996) 312-318
2. Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40 (2002) 133-139
3. Nimmerjahn A., et al. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308 (2005) 1314-1318
4. Davalos D., et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8 (2005) 752-758
5. Haynes S.E., et al. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 9 (2006) 1512-1519
6. Fetler L., and Amigorena S. Brain under surveillance: the microglia patrol. Science 309 (2005) 392-393
7. van Rossum D., and Hanisch U.K. Microglia. Metab. Brain Dis. 19 (2004) 393-411
8. Schwartz M., et al. Microglial phenotype: is the commitment reversible?. Trends Neurosci. 29 (2006) 68-74
9. Hanisch U.K. Microglia as a source and target of cytokines. Glia 40 (2002) 140-155
10. Butovsky O., et al. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol. Cell. Neurosci. 29 (2005) 381-393
11. Turrin N.P., and Rivest S. Tumor necrosis factor a but not interleukin 1b mediates neuroprotection in response to acute nitric oxide excitotoxicity. J. Neurosci. 26 (2006) 143-151
12. Lalancette-Hebert M., et al. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J. Neurosci. 27 (2007) 2596-2605
13. Biollée S., et al. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312 (2006) 1389-1392
14. El Khoury J., et al. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13 (2007) 432-438
15. Cardona A.E., et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat. Neurosci. 9 (2006) 917-924
16. Streit W.J. Microglial senescence: does the brain's immune system have an expiration date?. Trends Neurosci. 29 (2006) 506-510
17. Neumann H., and Takahashi K. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J. Neuroimmunol. 184 (2007) 92-99
18. Banati R.B. Brain plasticity and microglia: is transsynaptic glial activation in the thalamus after limb denervation linked to cortical plasticity and central sensitisation? J. Physiol. (Paris) 96 (2002) 289-299
19. Galea I., et al. What is immune privilege (not)?. Trends Immunol. 28 (2007) 12-18
20. Volterra A., and Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat. Rev. Neurosci. 6 (2005) 626-640
21. Majed H.H., et al. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J. Neurosci. 26 (2006) 1730-1738
22. Wright G.J., et al. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Immunology 102 (2001) 173-179
23. Hoek R.M., et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290 (2000) 1768-1771
24. Wright G.J., et al. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13 (2000) 233-242
25. Broderick C., et al. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am. J. Pathol. 161 (2002) 1669-1677
26. Deckert M., et al. Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction. Acta Neuropathol. (Berl.) 111 (2006) 548-559
27. Tan J., et al. CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway. J. Biol. Chem. 275 (2000) 37224-37231
28. Mott R.T., et al. Neuronal expression of CD22: Novel mechanism for inhibitory microglial preinflammatory cytokine production. Glia 46 (2004) 369-379
29. Ohnishi H., et al. Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons. J. Neurosci. 25 (2005) 2702-2711
30. Biber K., et al. Chemokines and their receptors in central nervous system disease. Curr. Drug Targets 7 (2006) 29-46
31. Zujovic V., et al. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 29 (2000) 305-315
32. Mizuno T., et al. Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res. 979 (2003) 65-70
33. Limatola C., et al. Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. J. Neuroimmunol 166 (2005) 19-28
34. Erichsen D., et al. Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia. J. Neuroimmunol. 138 (2003) 144-155
35. Farber K., and Kettenmann H. Physiology of microglia cells. Brain Res. Brain Res. Rev. 48 (2005) 133-143
36. Inoue K. The function of microglia through purinergic receptors: Neuropathic pain and cytokine release. Pharmacol. Ther. 109 (2006) 210-226
37. Pannasch U., et al. The potassium channels Kv1.5 and Kv1.3 modulate distinct functions of microglia. Mol. Cell. Neurosci. 33 (2006) 401-411
38. Farber K., et al. Dopamine and noradrenaline control distinct functions in rodent microglial cells. Mol. Cell. Neurosci. 29 (2005) 128-138
39. Neumann H., et al. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 5779-5784
40. Pocock J.M., and Kettenmann H. Neurotransmitter receptors on microglia. Trends Neurosci. 30 (2007) 527-535
41. Brionne T.C., et al. Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40 (2003) 1133-1145
42. Wang X., et al. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 10 (2004) 821-827
43. Koizumi S., et al. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446 (2007) 1091-1095
44. Suzuki T., et al. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J. Neurosci. 24 (2004) 1-7
45. Honda S., et al. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21 (2001) 1975-1982
46. Ohsawa K., et al. Involvement of P2X(4) and P2Y(12) receptors in ATP-induced microglial chemotaxis. Glia 55 (2007) 604-616
47. Kettenmann H. Neuroscience: the brain's garbage man. Nature 446 (2007) 987-989
48. Tsuda M., et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424 (2003) 778-783
49. Tsuda M., et al. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci. 28 (2005) 101-107
50. de Jong E.K., et al. Vesicle-mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia activation remote from a primary lesion. J. Neurosci. 25 (2005) 7548-7557
51. Klein R.S., et al. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J. Virol. 79 (2005) 11457-11466
52. Dijkstra I.M., et al. Cutting edge: activity of human adult microglia in response to CC chemokine ligand 21. J. Immunol. 172 (2004) 2744-2747
53. Rappert A., et al. Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia. J. Immunol. 168 (2002) 3221-3226
54. Rappert A., et al. CXCR3-dependent microglial recruitment is essential for dendritic loss after brain lesion. J. Neurosci. 24 (2004) 8500-8509
55. Hagino Y., et al. Heterogeneity and potentiation of AMPA type glutamate receptors in rat cultured microglia. Glia 47 (2004) 68-77
56. Taylor D.L., et al. Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease. J. Neurochem. 82 (2002) 1179-1191
57. Taylor D.L., et al. Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity. J. Neurosci. 23 (2003) 2150-2160
58. Biber K., et al. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. J. Neurochem. 72 (1999) 1671-1680
59. Noda M., et al. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J. Neurosci. 20 (2000) 251-258
60. Taylor D.L., et al. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. J. Neurosci. 25 (2005) 2952-2964
61. Venero J.L., et al. DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury. Neuroscience 113 (2002) 857-869
62. Rosenberg G.A. Matrix metalloproteinases in neuroinflammation. Glia 39 (2002) 279-291
63. Sole S., et al. Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion. J. Neuropathol. Exp. Neurol. 63 (2004) 338-349
64. Helbecque N., et al. Impact of the matrix metalloproteinase MMP-3 on dementia. Neurobiol. Aging 28 (2006) 1215-1220
65. Kanesaka T., et al. Serum matrix metalloproteinase-3 levels correlate with disease activity in relapsing-remitting multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 77 (2006) 185-188
66. Kim Y.S., et al. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. J. Neurosci. 25 (2005) 3701-3711
67. Kim Y.S., et al. A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration vie microglial activation. FASEB J. 21 (2007) 179-187
68. Colonna M., et al. TREMs in the immune system and beyond. Nat. Rev. Immunol. 3 (2003) 445-453
69. Kaifu T., et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111 (2003) 323-332
70. Roumier A., et al. Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24 (2004) 11421-11428
71. Takahashi K., et al. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201 (2005) 647-657
72. Hamerman J.A., et al. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J. Immunol. 177 (2006) 2051-2055
73. Turrin N.P., and Rivest S. Molecular and cellular immune mediators of neuroprotection. Mol. Neurobiol. 34 (2006) 221-242