Inflammation and apoptosis: Linked therapeutic targets in spinal cord injury

Trends in Molecular Medicine

Volumn 10, Issue 12, 2004, Pages 580-583

  Beattie, Michael S ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RECEPTOR AFFECTING AGENT; FAS ANTIGEN; FAS LIGAND; GLUTAMIC ACID; IONOTROPIC RECEPTOR ANTAGONIST; MINOCYCLINE; NITRIC OXIDE SYNTHASE; PROTEIN DERIVATIVE; TETRACYCLINE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CELL CYCLE; CELL INTERACTION; CELL TRANSPLANTATION; CLINICAL TRIAL; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; HUMAN; MICROGLIA; MYELITIS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN SECRETION; REVIEW; SCHWANN CELL; SPINAL CORD INJURY; TREATMENT PLANNING; UPREGULATION;

RODENTIA;

EID: 9644259008     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.10.006     Document Type: Short Survey

References (23)

1. S. Casha Oligodendoglial apoptosis occursa along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in rats Neuroscience 103 2001 203 218
2. M.S. Beattie Current evidence for apoptosis after spinal cord injury J. Neurotrauma 17 2000 915 926
3. J.R. Bethea Spinal cord injury induced inflammation: a two-edged sword Prog. Brain Res. 128 2000 33 42
4. P.G. Popovich Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord Prog. Brain Res. 128 2000 43 58
5. E.C. Beattie Control of synaptic strength by glial TNFα Science 295 2002 2282 2285
6. D. Liu Neurotoxicity of glutamate at the concentration released upon spinal cord injury Neuroscience 93 1999 1383 1389
7. S.S. Panter Alterations in extracellular amino acids after spinal cord Ann. Neurol. 27 1990 96 99
8. D.W. Choi Excitotoxic cell death J. Neurobiol. 23 1992 1261 1276
9. N.G. Wahlgren, and N. Ahmed Neuroprotection in cerebral ischemia: facts and fancies - the need for new approaches Cerebrovasc. Dis. 17 Suppl. 1 2004 153 166
10. D. Demjen Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury Nat. Med. 10 2004 389 395
11. Y.D. Teng Minocycline inhibits contusion-triggered mtiochondrial cytochrome c release and mitigates functional deficits after spinal cord injury Proc. Natl. Acad. Sci. U. S. A. 101 2004 3071 3076
12. D.P. Stirling Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury J. Neurosci. 24 2004 2182 2190
13. R. Pannu A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-γ-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases J. Neurosci. 24 2004 5942 5954
14. D.D. Pearse cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury Nat. Med. 10 2004 610 616
15. M.J. Crowe Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys Nat. Med. 3 1997 73 76
16. C. Matute The link between excitotoxic oligodendroglial death and demyelinating diseases Trends Neurosci. 24 2001 224 230
17. D.M. Basso A new sensitive locomotor rating scale for locomotor recovery after spinal cord contusion injuries in rats J. Neurotrauma 12 1995 1 21
18. S.L. Shuman Apoptosis of microglia and oligodendrocytes after spinal cord injury in rats J. Neurosci. Res. 50 1997 798 808
19. E. Diguet Rise and fall of minocycline in neuroprotection: need to promote pub,ication of negative results Exp. Neurol. 189 2004 1 4
20. T. Tikka Minocycline, a tehtracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia J. Neurosci. 21 2001 2580 2588
21. S. Lehnardt Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4 pathway Proc. Natl. Acad. Sci. U. S. A. 100 2003 8514 8519
22. M-F. Tsan, and B. Gao Endogenous ligands of Toll-like receptors J. Leukoc. Biol. 76 2004 514 519
23. M.S. Beattie Pro-NGF induces p75-mediated death of oligodendrocytes following spinal cord injury Neuron 36 2002 375 386