Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 7, 2009, Pages 3404-3409

  van Dijk, Hille W ^a   Kok, Pauline H B ^a   Garvin, Mona ^b   Sonka, Milan ^b,c   Hans Devries, J ^a   Michels, Robert P J ^a   van Velthoven, Mirjam E J ^a   Schlingemann, Reinier O ^a   Verbraak, Frank D ^a   Abràmoff, Michael D ^b,c,d  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; GLYCOSYLATED HEMOGLOBIN;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE DURATION; EYE PHOTOGRAPHY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NERVE DEGENERATION; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA FOVEA; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; RETINA MACULA LUTEA; THICKNESS; VISUAL SYSTEM EXAMINATION; ALGORITHM; PATHOLOGY; PHOTOGRAPHY; RETINA DEGENERATION; RETINA NERVE CELL;

ADULT; ALGORITHMS; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; PHOTOGRAPHY; RETINAL DEGENERATION; RETINAL NEURONS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 67649977021     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-3143     Document Type: Article

References (40)

1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-820.
2. Abu-El-Asrar AM, Dralands L, Missotten L, et al. Expression of apoptosis markers in the retinas of human subjects with diabetes. Invest Ophthalmol Vis Sci. 2004;45:2760-2766.
3. Barber AJ, Lieth E, Khin SA, et al. Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J Clin Invest. 1998;102:783-791.
4. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:283-290.
5. Bloodworth JM Jr. Diabetic retinopathy. Diabetes. 1962;11:1-22.
6. Gastinger MJ, Singh RS, Barber AJ. Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci. 2006; 47:3143-3150.
7. Gastinger MJ, Kunselman AR, Conboy EE, et al. Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice. Invest Ophthalmol Vis Sci. 2008;49:2635-2642.
8. Li Q, Puro DG. Diabetes-induced dysfunction of the glutamate transporter in retinal Muller cells. Invest Ophthalmol Vis Sci. 2002;43:3109-3116.
9. Lieth E, Barber AJ, Xu B, et al. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy: Penn State Retina Research Group. Diabetes. 1998;47:815-820.
10. Lieth E, Gardner TW, Barber AJ, et al. Retinal neurodegeneration: early pathology in diabetes. Clin Exp Ophthalmol. 2000;28:3-8.
11. Martin PM, Roon P, Van Ells TK, et al. Death of retinal neurons in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci. 2004;45:3330-3336.
12. Mizutani M, Gerhardinger C, Lorenzi M. Muller cell changes in human diabetic retinopathy. Diabetes. 1998;47:445-449.
13. Park SH, Park JW, Park SJ, et al. Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia. 2003;46:1260-1268.
14. Rungger-Brandle E, Dosso AA, Leuenberger PM. Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2000;41:1971-1980.
15. Zeng XX, Ng YK, Ling EA. Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats. Vis Neurosci. 2000; 17:463-471.
16. Barber AJ, Antonetti DA, Kern TS, et al. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci. 2005;46:2210-2218.
17. Biallosterski C, van Velthoven ME, Michels RP, et al. Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy. Br J Ophthalmol. 2007;91:1135-1138.
18. Browning DJ, Fraser CM, Clark S. The relationship of macular thickness to clinically graded diabetic retinopathy severity in eyes without clinically detected diabetic macular edema. Ophthalmology. 2008;115:533-539.
19. Nilsson M, von Wendt G, Wanger P, Martin L. Early detection of macular changes in patients with diabetes using Rarebit Fovea Test and optical coherence tomography. Br J Ophthalmol. 2007;91: 1596-1598.
20. Oshitari T, Hanawa K, Adachi-Usami E. Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes. Eye. 2009;23(4):884-889.
21. Fernandez DC, Salinas M, Puliafito A. Automated detection of retinal layer structures on optical coherence tomography images. Opt Expr. 2008;13:10200-10216.
22. Garvin MK, Abramoff MD, Kardon R, et al. Intraretinal layer segmentation of macular optical coherence tomography images using optimal 3D graph search. IEEE Trans Med Imaging. 2008;27: 1495-1505.
23. Haeker M, Wu X, Abramoff M, et al. Incorporation of regional information in optimal 3D graph search with application for intraretinal layer segmentation of optical coherence tomography images. Inf Process Med Imaging. 2007;20:607-618.
24. Haeker M, Abramoff MD, Wu X, et al. Use of varying constraints in optimal 3D graph search for segmentation of macular optical coherence tomography images. Med Image Comput Comput Assist Interv Int Conf. 2007;10:244-251.
25. Haeker M, Sonka M, Kardon R, et al. Automated segmentation of intraretinal layers from macular optical coherence tomography images. Proc SPIE Med Imag. 2007;6512.
26. Ishikawa H, Stein DM, Wollstein G, et al. Macular segmentation with optical coherence tomography. Invest Ophthalmol Vis Sci. 2005;46:2012-2017.
27. Wilkinson CP, Ferris FL III, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110:1677-1682.
28. Bearse MA Jr, Han Y, Schneck ME, et al. Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthalmol Vis Sci. 2004;45:3259-3265.
29. Fortune B, Schneck ME, Adams AJ. Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy. Invest Ophthalmol Vis Sci. 1999;40:2638-2651.
30. Greenstein VC, Shapiro A, Zaidi Q, et al. Psychophysical evidence for post-receptoral sensitivity loss in diabetics. Invest Ophthalmol Vis Sci. 1992;33:2781-2790.
31. Han Y, Adams AJ, Bearse MA Jr, et al. Multifocal electroretinogram and short-wavelength automated perimetry measures in diabetic eyes with little or no retinopathy. Arch Ophthalmol. 2004;122: 1809-1815.
32. Hardy KJ, Lipton J, Scase MO, et al. Detection of colour vision abnormalities in uncomplicated type 1 diabetic patients with angiographically normal retinas. Br J Ophthalmol. 1992;76:461-464.
33. Kurtenbach A, Flogel W, Erb C. Anomaloscope matches in patients with diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 2002; 240:79-84.
34. Realini T, Lai MQ, Barber L. Impact of diabetes on glaucoma screening using frequency-doubling perimetry. Ophthalmology. 2004;111:2133-2136.
35. Shimada Y, Li Y, Bearse MA Jr, et al. Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol. 2001;85:414-419.
36. Antonetti DA, Barber AJ, Bronson SK, et al. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 2006;55:2401-2411.
37. Barber AJ, Nakamura M, Wolpert EB, et al. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Aktmediated mechanism that reduces the activation of caspase-3. J Biol Chem. 2001;276:32814-32821.
38. Nakamura M, Barber AJ, Antonetti DA, et al. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem. 2001;276:43748-43755.
39. King GL, Brownlee M. The cellular and molecular mechanisms of diabetic complications. Endocrinol Metab Clin North Am. 1996; 25:255-270.
40. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification: ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98:786-806.