Complex antibody profile changes in an experimental autoimmune glaucoma animal model

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 10, 2009, Pages 4734-4742

  Joachim, Stephanie C ^a   Grus, Franz H ^a   Kraft, Daniela ^a   White Farrar, Kisha ^b   Barnes, George ^b   Barbeck, Mike ^c   Ghanaati, Shahram ^c   Cao, Shutong ^b   Li, Byron ^b   Wax, Martin B ^d  

^a Experimental Ophthalmology   (Germany)

^b ALCON RESEARCH LTD   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ENOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 90; AUTOANTIBODY; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE DISEASE; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; DOWN REGULATION; EYE FUNDUS; GLAUCOMA; IMMUNIZATION; IMMUNOREACTIVITY; INTRAOCULAR PRESSURE; MALE; MASS SPECTROMETRY; NONHUMAN; OPTIC DISK; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; RETINA HEMORRHAGE; UPREGULATION; WESTERN BLOTTING; ANIMAL; AUTOIMMUNITY; BLOOD; CELL COUNT; DISEASE MODEL; IMMUNOLOGY; LEWIS RAT; PATHOLOGY;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BLOTTING, WESTERN; CELL COUNT; DISEASE MODELS, ANIMAL; GLAUCOMA; HSP27 HEAT-SHOCK PROTEINS; IMMUNOGLOBULIN G; INTRAOCULAR PRESSURE; MALE; MASS SPECTROMETRY; RATS; RATS, INBRED LEW; RETINAL GANGLION CELLS;

EID: 70349581636     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-3144     Document Type: Article

References (52)

1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262-267.
2. Quigley HA. Open-angle glaucoma. N Engl J Med. 1993;328:1097-1106.
3. Foster PJ. The epidemiology of primary angle closure and associated glaucomatous optic neuropathy. Semin Ophthalmol. 2002; 17:50-58.
4. Tezel G, Hernandez R, Wax MB. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol. 2000;118:511-518.
5. Maruyama I, Ohguro H, Ikeda Y. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest Ophthalmol Vis Sci. 2000;41:1657-1665.
6. Yang J, Tezel G, Patil RV, Romano C, Wax MB. Serum autoantibody against glutathione S-transferase in patients with glaucoma. Invest Ophthalmol Vis Sci. 2001;42:1273-1276.
7. Tezel G, Edward DP, Wax MB. Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. Arch Ophthalmol. 1999;117:917-924.
8. Grus FH, Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Wax MB. Serum autoantibodies to α-fodrin are present in glaucoma patients from Germany and the United States. Invest Ophthalmol Vis Sci. 2006;47:968-976.
9. Joachim SC, Pfeiffer N, Grus FH. Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens. Graefes Arch Clin Exp Ophthalmol. 2005;243:817-823.
10. Grus FH, Joachim SC, Hoffmann EM, Pfeiffer N. Complex autoantibody repertoires in patients with glaucoma. Mol Vis. 2004;10: 132-137.
11. Guo L, Tsatourian V, Luong V, et al. En face optical coherence tomography: a new method to analyse structural changes of the optic nerve head in rat glaucoma. Br J Ophthalmol. 2005;89: 1210-1216.
12. Neufeld AH, Sawada A, Becker B. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc Natl Acad Sci U S A. 1999;96:9944-9948.
13. Morrison JC. Elevated intraocular pressure and optic nerve injury models in the rat. J Glaucoma. 2005;14:315-317.
14. Morrison JC, Moore CG, Deppmeier LM, Gold BG, Meshul CK, Johnson EC. A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res. 1997;64:85-96.
15. Li B, Pang IH, Barnes G, McLaughlin M, Holt W. A new method and device to induce transient retinal ischemia in the rat. Curr Eye Res. 2002;24:458-464.
16. Buchi ER, Suivaizdis I, Fu J. Pressure-induced retinal ischemia in rats: an experimental model for quantitative study. Ophthalmologica. 1991;203:138-147.
17. Schwartz M. Optic nerve crush: protection and regeneration. Brain Res Bull. 2004;62:467-471.
18. Levkovitch-Verbin H, Harris-Cerruti C, Groner Y, Wheeler LA, Schwartz M, Yoles E. RGC death in mice after optic nerve crush injury: oxidative stress and neuroprotection. Invest Ophthalmol Vis Sci. 2000;41:4169-4174.
19. Jakob U, Gaestel M, Engel K, Buchner J. Small heat shock proteins are molecular chaperones. J Biol Chem. 1993;268:1517-1520.
20. Hawkes EL, Krueger-Naug AM, Nickerson PE, Myers TL, Currie RW, Clarke DB. Expression of Hsp27 in retinal ganglion cells of the rat during postnatal development. J Comp Neurol. 2004;478:143-148.
21. Krueger-Naug AM, Emsley JG, Myers TL, Currie RW, Clarke DB. Injury to retinal ganglion cells induces expression of the small heat shock protein Hsp27 in the rat visual system. Neuroscience. 2002; 110:653-665.
22. Strunnikova N, Baffi J, Gonzalez A, Silk W, Cousins SW, Csaky KG. Regulated heat shock protein 27 expression in human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2001;42:2130-2138.
23. Costigan M, Mannion RJ, Kendall G, et al. Heat shock protein 27: developmental regulation and expression after peripheral nerve injury. J Neurosci. 1998;18:5891-5900.
24. Tezel G, Seigel GM, Wax MB. Autoantibodies to small heat shock proteins in glaucoma. Invest Ophthalmol Vis Sci. 1998;39:2277-2287.
25. Tezel G, Wax MB. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci. 2000;20:3552-3562.
26. Raijmakers R, Vogelzangs J, Raats J, et al. Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice. J Comp Neurol. 2006;498:217-226.
27. Zhu B, Guleria I, Khosroshahi A, et al. Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. J Immunol. 2006;176:3480-3489.
28. Augustin AJ, Loeffler KU, Sekundo W, Grus FH, Lutz J. Effects of systemically applied allopurinol and prednisolone on experimental autoimmune uveitis. Graefes Arch Clin Exp Ophthalmol. 1999; 237:508-512.
29. Grus FH, Augustin AJ, Loeffler K, Dick B, Lutz J, Pfeiffer N. Allopurinol has immunomodulating activity following topical and systemic application in experimental autoimmune uveitis. Eur J Ophthalmol. 2001;11:252-260.
30. Sakai T, Kohno H, Ishihara T, et al. Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate. Exp Eye Res. 2006;82:657-663.
31. Kuhn KA, Kulik L, Tomooka B, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest. 2006;116:961-973.
32. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980;283:666-668.
33. Schenk D, Barbour R, Dunn W, et al. Immunization with amyloidbeta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999;400:173-177.
34. Wax MB, Tezel G, Yang J, et al. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci. 2008; 28:12085-12096.
35. Moore CG, Milne ST, Morrison JC. Noninvasive measurement of rat intraocular pressure with the Tono-Pen. Invest Ophthalmol Vis Sci. 1993;34:363-369.
36. Goldblum D, Kontiola AI, Mittag T, Chen B, Danias J. Non-invasive determination of intraocular pressure in the rat eye: comparison of an electronic tonometer (TonoPen), and a rebound (impact probe) tonometer. Graefes Arch Clin Exp Ophthalmol. 2002;240:942-946.
37. Quina LA, Pak W, Lanier J, et al. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci. 2005;25:11595-11604.
38. Gerrero MR, McEvilly RJ, Turner E, et al. Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. Proc Natl Acad Sci U S A. 1993;90:10841-10845.
39. Xiang M, Zhou L, Macke JP, et al. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci. 1995;15:4762-4785.
40. Joachim SC, Grus FH, Pfeiffer N. Analysis of autoantibody repertoires in sera of patients with glaucoma. Eur J Ophthalmol. 2003; 13:752-758.
41. Joachim SC, Reichelt J, Berneiser S, Pfeiffer N, Grus FH. Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens. Graefes Arch Clin Exp Ophthalmol. 2008;246:573-580.
42. Mahalanobis PC. On the generalized distance in statistics. Proceedings National Institute of Science, India. 1936;II:48-55.
43. Barcikowski RS, Stevens JP. A Monte Carlo study of the stability of canonical correlations, canonical weights and canonical variatevariable correlations. J Multivariate Behav Res. 1975;10:353-364.
44. Olsson T, Henriksson A, Link H, Kristensson K. IgM and IgG responses during chronic relapsing experimental allergic encephalomyelitis (r-EAE). J Neuroimmunol. 1984;6:265-281.
45. Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H, Mizusawa H. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun. 2003;312:1342-1348.
46. Yang Y, Gehrke S, Haque ME, et al. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphati-dylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A. 2005; 102:13670-13675.
47. Joachim SC, Wuenschig D, Pfeiffer N, Grus FH. IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma. Mol Vis. 2007;13:1573-1579.
48. Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003;299:256-259.
49. Zephir H, Almeras L, El Behi M, et al. Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006;179:53-64.
50. Schluesener HJ, Sobel RA, Linington C, Weiner HL. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol. 1987;139:4016-4021.
51. Willenborg DO, Sjollema P, Danta G. Immunoglobulin deficient rats as donors and recipients of effector cells of allergic encephalomyelitis. J Neuroimmunol. 1986;11:93-103.
52. Suzuki I, Takahashi S, Fujii Y, Fuyama S, Arai S. Experimental autoimmune uveoretinitis (EAU) in rats: abrogation of resistance to the induction and augmentation of the inflammation by pertussis toxin. Jpn J Ophthalmol. 1989;33:27-35.