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Volumn 6, Issue JUL, 2014, Pages

Systemic inflammation, blood-brain barrier vulnerability and cognitive / non-cognitive symptoms in Alzheimer disease: Relevance to pathogenesis and therapy

Author keywords

Alzheimer disease; Blood brain barrier; Pathogenesis; Systemic inflammation; Therapy

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DEMENTIA; DEMENTIA ASSOCIATED BEHAVIORAL DISTURBANCE; DISEASE ASSOCIATION; HUMAN; INFLAMMATION; MENTAL DETERIORATION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; SYSTEMIC INFLAMMATION;

EID: 84904654930     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00171     Document Type: Article
Times cited : (192)

References (105)
  • 1
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer's disease facts and figures
    • Thies W, Bleiler L. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. Mar 2013;9(2):208-245.
    • (2013) Alzheimers Dement. Mar. , vol.9 , Issue.2 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 2
    • 84880185976 scopus 로고    scopus 로고
    • Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective
    • Iqbal K, Grundke-Iqbal I. Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective. J Alzheimers Dis. 2006;9(3 Suppl):219-242.
    • (2006) J Alzheimers Dis. , vol.9 , Issue.3 SUPPL , pp. 219-242
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 3
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Jul 19
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. Jul 19 2002;297(5580):353-356.
    • (2002) Science. , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 4
    • 84655160770 scopus 로고    scopus 로고
    • 'Clinical trials in Alzheimer's disease': immunotherapy approaches
    • Jan
    • Delrieu J, Ousset PJ, Caillaud C, Vellas B. 'Clinical trials in Alzheimer's disease': immunotherapy approaches. J Neurochem. Jan 2012;120 Suppl 1:186-193.
    • (2012) J Neurochem. , vol.120 , Issue.SUPPL 1 , pp. 186-193
    • Delrieu, J.1    Ousset, P.J.2    Caillaud, C.3    Vellas, B.4
  • 6
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Jun
    • Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. May-Jun 2000;21(3):383-421.
    • (2000) Neurobiol Aging. May- , vol.21 , Issue.3 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 7
    • 79960887486 scopus 로고    scopus 로고
    • Systemic inflammation and Alzheimer's disease
    • Holmes C, Butchart J. Systemic inflammation and Alzheimer's disease. Biochem Soc Trans. Aug 2011;39(4):898-901.
    • (2011) Biochem Soc Trans. Aug , vol.39 , Issue.4 , pp. 898-901
    • Holmes, C.1    Butchart, J.2
  • 9
    • 84878655531 scopus 로고    scopus 로고
    • Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease
    • Jun
    • Serrano-Pozo A, Muzikansky A, Gomez-Isla T, et al. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. J Neuropathol Exp Neurol. Jun 2013;72(6):462-471.
    • (2013) J Neuropathol Exp Neurol. , vol.72 , Issue.6 , pp. 462-471
    • Serrano-Pozo, A.1    Muzikansky, A.2    Gomez-Isla, T.3
  • 10
    • 84878433339 scopus 로고    scopus 로고
    • Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
    • May 22
    • Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. May 22 2013;78(4):631-643.
    • (2013) Neuron. , vol.78 , Issue.4 , pp. 631-643
    • Griciuc, A.1    Serrano-Pozo, A.2    Parrado, A.R.3
  • 11
    • 84891706947 scopus 로고    scopus 로고
    • CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
    • Jul
    • Bradshaw EM, Chibnik LB, Keenan BT, et al. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci. Jul 2013;16(7):848-850.
    • (2013) Nat Neurosci. , vol.16 , Issue.7 , pp. 848-850
    • Bradshaw, E.M.1    Chibnik, L.B.2    Keenan, B.T.3
  • 12
    • 79951754336 scopus 로고    scopus 로고
    • Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential
    • Jul
    • Sato N, Takeda S, Uchio-Yamada K, et al. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Curr Aging Sci. Jul 2011;4(2):118-127.
    • (2011) Curr Aging Sci. , vol.4 , Issue.2 , pp. 118-127
    • Sato, N.1    Takeda, S.2    Uchio-Yamada, K.3
  • 13
    • 38449092192 scopus 로고    scopus 로고
    • The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new therapeutic potential
    • Takeda S, Sato N, Ogihara T, Morishita R. The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new therapeutic potential. Front Biosci. 2008;13:2253-2265.
    • (2008) Front Biosci. , vol.13 , pp. 2253-2265
    • Takeda, S.1    Sato, N.2    Ogihara, T.3    Morishita, R.4
  • 14
    • 84895799382 scopus 로고    scopus 로고
    • Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors
    • Sato N, Morishita R. Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors. Front Aging Neurosci. 2013;5:64.
    • (2013) Front Aging Neurosci. , vol.5 , pp. 64
    • Sato, N.1    Morishita, R.2
  • 15
    • 84888019151 scopus 로고    scopus 로고
    • The pathobiology of vascular dementia
    • Nov 20
    • Iadecola C. The pathobiology of vascular dementia. Neuron. Nov 20 2013;80(4):844-866.
    • (2013) Neuron. , vol.80 , Issue.4 , pp. 844-866
    • Iadecola, C.1
  • 16
    • 77956231757 scopus 로고    scopus 로고
    • The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
    • Sep
    • Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. Sep 2010; 120(3):287-296.
    • (2010) Acta Neuropathol. , vol.120 , Issue.3 , pp. 287-296
    • Iadecola, C.1
  • 18
    • 77951028451 scopus 로고    scopus 로고
    • Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
    • Apr 13
    • Takeda S, Sato N, Uchio-Yamada K, et al. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A. Apr 13 2010;107(15):7036-7041.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.15 , pp. 7036-7041
    • Takeda, S.1    Sato, N.2    Uchio-Yamada, K.3
  • 19
    • 84877586983 scopus 로고    scopus 로고
    • Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model
    • Aug
    • Takeda S, Sato N, Ikimura K, Nishino H, Rakugi H, Morishita R. Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model. Neurobiol Aging. Aug 2013;34(8):2064-2070.
    • (2013) Neurobiol Aging. , vol.34 , Issue.8 , pp. 2064-2070
    • Takeda, S.1    Sato, N.2    Ikimura, K.3    Nishino, H.4    Rakugi, H.5    Morishita, R.6
  • 20
    • 62349114515 scopus 로고    scopus 로고
    • Screening of innate immune receptors in neurodegenerative diseases: a similar pattern
    • May
    • Letiembre M, Liu Y, Walter S, et al. Screening of innate immune receptors in neurodegenerative diseases: a similar pattern. Neurobiol Aging. May 2009;30(5):759-768.
    • (2009) Neurobiol Aging. , vol.30 , Issue.5 , pp. 759-768
    • Letiembre, M.1    Liu, Y.2    Walter, S.3
  • 21
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Jan
    • Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia. Jan 1993;7(1):75-83.
    • (1993) Glia. , vol.7 , Issue.1 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 22
    • 0024573330 scopus 로고
    • Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody.
    • Haga S, Akai K, Ishii T. Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol. 1989;77(6):569-575.
    • (1989) Acta Neuropathol. , vol.77 , Issue.6 , pp. 569-575
    • Haga, S.1    Akai, K.2    Ishii, T.3
  • 23
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Feb 16
    • Simard AR, Soulet D, Gowing G, Julien JP, Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron. Feb 16 2006;49(4):489-502.
    • (2006) Neuron. , vol.49 , Issue.4 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 24
    • 0029670066 scopus 로고    scopus 로고
    • Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease
    • Mar
    • Mrak RE, Sheng JG, Griffin WS. Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease. J Neuropathol Exp Neurol. Mar 1996;55(3):273-279.
    • (1996) J Neuropathol Exp Neurol. , vol.55 , Issue.3 , pp. 273-279
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.3
  • 25
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution
    • Mar
    • Griffin WS, Sheng JG, Roberts GW, Mrak RE. Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol. Mar 1995;54(2):276-281.
    • (1995) J Neuropathol Exp Neurol. , vol.54 , Issue.2 , pp. 276-281
    • Griffin, W.S.1    Sheng, J.G.2    Roberts, G.W.3    Mrak, R.E.4
  • 26
    • 0025763298 scopus 로고
    • Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
    • Jul 8
    • Bauer J, Strauss S, Schreiter-Gasser U, et al. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett. Jul 8 1991;285(1):111-114.
    • (1991) FEBS Lett. , vol.285 , Issue.1 , pp. 111-114
    • Bauer, J.1    Strauss, S.2    Schreiter-Gasser, U.3
  • 27
    • 0032868874 scopus 로고    scopus 로고
    • Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia
    • Jul
    • Tarkowski E, Blennow K, Wallin A, Tarkowski A. Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia. J Clin Immunol. Jul 1999;19(4):223-230.
    • (1999) J Clin Immunol. , vol.19 , Issue.4 , pp. 223-230
    • Tarkowski, E.1    Blennow, K.2    Wallin, A.3    Tarkowski, A.4
  • 28
    • 0027450057 scopus 로고
    • Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies
    • Jan
    • van der Wal EA, Gomez-Pinilla F, Cotman CW. Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport. Jan 1993;4(1):69-72.
    • (1993) Neuroreport. , vol.4 , Issue.1 , pp. 69-72
    • van der Wal, E.A.1    Gomez-Pinilla, F.2    Cotman, C.W.3
  • 29
    • 0031974406 scopus 로고    scopus 로고
    • Microglial response to amyloid plaques in APPsw transgenic mice
    • Jan
    • Frautschy SA, Yang F, Irrizarry M, et al. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. Jan 1998;152(1):307-317.
    • (1998) Am J Pathol. , vol.152 , Issue.1 , pp. 307-317
    • Frautschy, S.A.1    Yang, F.2    Irrizarry, M.3
  • 30
    • 27744482552 scopus 로고    scopus 로고
    • Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
    • Oct 18
    • Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. Oct 18 2005;2:23.
    • (2005) J Neuroinflammation. , vol.2 , pp. 23
    • Janelsins, M.C.1    Mastrangelo, M.A.2    Oddo, S.3    LaFerla, F.M.4    Federoff, H.J.5    Bowers, W.J.6
  • 31
    • 0035067311 scopus 로고    scopus 로고
    • Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease
    • Apr
    • Matsuoka Y, Picciano M, Malester B, et al. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. Apr 2001;158(4):1345-1354.
    • (2001) Am J Pathol. , vol.158 , Issue.4 , pp. 1345-1354
    • Matsuoka, Y.1    Picciano, M.2    Malester, B.3
  • 32
    • 0033983967 scopus 로고    scopus 로고
    • Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice
    • Jan
    • Sheng JG, Mrak RE, Bales KR, et al. Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice. J Neurochem. Jan 2000;74(1):295-301.
    • (2000) J Neurochem. , vol.74 , Issue.1 , pp. 295-301
    • Sheng, J.G.1    Mrak, R.E.2    Bales, K.R.3
  • 33
    • 58149391968 scopus 로고    scopus 로고
    • Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies
    • Nov 19
    • Ji B, Maeda J, Sawada M, et al. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. J Neurosci. Nov 19 2008;28(47):12255-12267.
    • (2008) J Neurosci. , vol.28 , Issue.47 , pp. 12255-12267
    • Ji, B.1    Maeda, J.2    Sawada, M.3
  • 34
    • 35348821915 scopus 로고    scopus 로고
    • Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    • Oct 10
    • Maeda J, Ji B, Irie T, et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci. Oct 10 2007;27(41):10957-10968.
    • (2007) J Neurosci. , vol.27 , Issue.41 , pp. 10957-10968
    • Maeda, J.1    Ji, B.2    Irie, T.3
  • 35
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • Sep-Oct
    • Sheng JG, Ito K, Skinner RD, et al. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging. Sep-Oct 1996;17(5):761-766.
    • (1996) Neurobiol Aging. , vol.17 , Issue.5 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3
  • 36
    • 27344441062 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid
    • Jun 20
    • Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid. J Neuroinflammation. Jun 20 2005;2:15.
    • (2005) J Neuroinflammation. , vol.2 , pp. 15
    • Craft, J.M.1    Watterson, D.M.2    Hirsch, E.3    Van Eldik, L.J.4
  • 37
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • Jun
    • Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest. Jun 2007;117(6):1595-1604.
    • (2007) J Clin Invest. , vol.117 , Issue.6 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Miller, J.N.4    Johnson, R.E.5    O'Banion, M.K.6
  • 38
    • 76149092520 scopus 로고    scopus 로고
    • Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
    • Feb
    • Chakrabarty P, Jansen-West K, Beccard A, et al. Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. Feb 2010;24(2):548-559.
    • (2010) FASEB J , vol.24 , Issue.2 , pp. 548-559
    • Chakrabarty, P.1    Jansen-West, K.2    Beccard, A.3
  • 39
    • 84874882726 scopus 로고    scopus 로고
    • Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model
    • Mar 13
    • Ghosh S, Wu MD, Shaftel SS, et al. Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci. Mar 13 2013;33(11):5053-5064.
    • (2013) J Neurosci. , vol.33 , Issue.11 , pp. 5053-5064
    • Ghosh, S.1    Wu, M.D.2    Shaftel, S.S.3
  • 40
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies
    • Aug
    • McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology. Aug 1996;47(2):425-432.
    • (1996) Neurology. , vol.47 , Issue.2 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 41
    • 0034254924 scopus 로고    scopus 로고
    • Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
    • Aug 1
    • Lim GP, Yang F, Chu T, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. Aug 1 2000; 20(15):5709-5714.
    • (2000) J Neurosci. , vol.20 , Issue.15 , pp. 5709-5714
    • Lim, G.P.1    Yang, F.2    Chu, T.3
  • 42
    • 0035691115 scopus 로고    scopus 로고
    • Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
    • Nov-Dec
    • Lim GP, Yang F, Chu T, et al. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. Nov-Dec 2001;22(6):983-991.
    • (2001) Neurobiol Aging. , vol.22 , Issue.6 , pp. 983-991
    • Lim, G.P.1    Yang, F.2    Chu, T.3
  • 43
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Aug 20
    • Yan Q, Zhang J, Liu H, et al. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci. Aug 20 2003;23(20):7504-7509.
    • (2003) J Neurosci. , vol.23 , Issue.20 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3
  • 45
    • 0028289083 scopus 로고
    • Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study
    • Feb
    • Breitner JC, Gau BA, Welsh KA, et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology. Feb 1994;44(2):227-232.
    • (1994) Neurology , vol.44 , Issue.2 , pp. 227-232
    • Breitner, J.C.1    Gau, B.A.2    Welsh, K.A.3
  • 46
    • 78650452885 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy?
    • Trepanier CH, Milgram NW. Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy? J Alzheimers Dis. 2010;21(4):1089-1099.
    • (2010) J Alzheimers Dis. , vol.21 , Issue.4 , pp. 1089-1099
    • Trepanier, C.H.1    Milgram, N.W.2
  • 47
    • 0033927533 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 inhibitors: rationale and therapeutic potential for Alzheimer's disease
    • Jul
    • McGeer PL. Cyclo-oxygenase-2 inhibitors: rationale and therapeutic potential for Alzheimer's disease. Drugs Aging. Jul 2000;17(1):1-11.
    • (2000) Drugs Aging. , vol.17 , Issue.1 , pp. 1-11
    • McGeer, P.L.1
  • 48
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimer's disease
    • Aug
    • Rogers J, Kirby LC, Hempelman SR, et al. Clinical trial of indomethacin in Alzheimer's disease. Neurology. Aug 1993;43(8):1609-1611.
    • (1993) Neurology. , vol.43 , Issue.8 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 49
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • Jul 13
    • Scharf S, Mander A, Ugoni A, Vajda F, Christophidis N. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology. Jul 13 1999;53(1):197-201.
    • (1999) Neurology. , vol.53 , Issue.1 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3    Vajda, F.4    Christophidis, N.5
  • 50
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
    • Jun 4
    • Aisen PS, Schafer KA, Grundman M, et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA. Jun 4 2003;289(21):2819-2826.
    • (2003) JAMA. , vol.289 , Issue.21 , pp. 2819-2826
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3
  • 51
    • 0345830739 scopus 로고    scopus 로고
    • Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study
    • Jan 13
    • Reines SA, Block GA, Morris JC, et al. Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology. Jan 13 2004;62(1):66-71.
    • (2004) Neurology. , vol.62 , Issue.1 , pp. 66-71
    • Reines, S.A.1    Block, G.A.2    Morris, J.C.3
  • 53
    • 34347268434 scopus 로고    scopus 로고
    • Brain-immune communication pathways
    • Aug
    • Quan N, Banks WA. Brain-immune communication pathways. Brain Behav Immun. Aug 2007;21(6):727-735.
    • (2007) Brain Behav Immun. , vol.21 , Issue.6 , pp. 727-735
    • Quan, N.1    Banks, W.A.2
  • 54
    • 34247519766 scopus 로고    scopus 로고
    • Course of cerebral amyloid angiopathy-related inflammation
    • Apr 24
    • Kinnecom C, Lev MH, Wendell L, et al. Course of cerebral amyloid angiopathy-related inflammation. Neurology. Apr 24 2007;68(17):1411-1416.
    • (2007) Neurology. , vol.68 , Issue.17 , pp. 1411-1416
    • Kinnecom, C.1    Lev, M.H.2    Wendell, L.3
  • 55
    • 7644219821 scopus 로고    scopus 로고
    • Amyloid angiopathy-related vascular cognitive impairment
    • Nov
    • Greenberg SM, Gurol ME, Rosand J, Smith EE. Amyloid angiopathy-related vascular cognitive impairment. Stroke. Nov 2004;35(11 Suppl 1):2616-2619.
    • (2004) Stroke. , vol.35 , Issue.11 SUPPL 1 , pp. 2616-2619
    • Greenberg, S.M.1    Gurol, M.E.2    Rosand, J.3    Smith, E.E.4
  • 56
    • 23044447002 scopus 로고    scopus 로고
    • Association between dementia and infectious disease: evidence from a case-control study
    • Apr-Jun
    • Dunn N, Mullee M, Perry VH, Holmes C. Association between dementia and infectious disease: evidence from a case-control study. Alzheimer Dis Assoc Disord. Apr-Jun 2005;19(2):91-94.
    • (2005) Alzheimer Dis Assoc Disord. , vol.19 , Issue.2 , pp. 91-94
    • Dunn, N.1    Mullee, M.2    Perry, V.H.3    Holmes, C.4
  • 57
    • 70349086077 scopus 로고    scopus 로고
    • Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study
    • Sundelof J, Kilander L, Helmersson J, et al. Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study. J Alzheimers Dis. 2009;18(1):79-87.
    • (2009) J Alzheimers Dis. , vol.18 , Issue.1 , pp. 79-87
    • Sundelof, J.1    Kilander, L.2    Helmersson, J.3
  • 58
    • 84875201745 scopus 로고    scopus 로고
    • The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis
    • Apr
    • Koyama A, O'Brien J, Weuve J, Blacker D, Metti AL, Yaffe K. The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis. J Gerontol A Biol Sci Med Sci. Apr 2013;68(4):433-440.
    • (2013) J Gerontol A Biol Sci Med Sci. , vol.68 , Issue.4 , pp. 433-440
    • Koyama, A.1    O'Brien, J.2    Weuve, J.3    Blacker, D.4    Metti, A.L.5    Yaffe, K.6
  • 59
    • 0034016372 scopus 로고    scopus 로고
    • Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging
    • May
    • Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. May 2000;157(5):708-714.
    • (2000) Am J Psychiatry. , vol.157 , Issue.5 , pp. 708-714
    • Lyketsos, C.G.1    Steinberg, M.2    Tschanz, J.T.3    Norton, M.C.4    Steffens, D.C.5    Breitner, J.C.6
  • 60
    • 0035139773 scopus 로고    scopus 로고
    • Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments
    • Jan
    • Margallo-Lana M, Swann A, O'Brien J, et al. Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments. Int J Geriatr Psychiatry. Jan 2001;16(1):39-44.
    • (2001) Int J Geriatr Psychiatry. , vol.16 , Issue.1 , pp. 39-44
    • Margallo-Lana, M.1    Swann, A.2    O'Brien, J.3
  • 61
    • 33644877955 scopus 로고    scopus 로고
    • Persistence of and changes in neuropsychiatric symptoms in Alzheimer disease over 6 months: the LASER-AD study
    • Nov
    • Ryu SH, Katona C, Rive B, Livingston G. Persistence of and changes in neuropsychiatric symptoms in Alzheimer disease over 6 months: the LASER-AD study. Am J Geriatr Psychiatry. Nov 2005;13(11):976-983.
    • (2005) Am J Geriatr Psychiatry. , vol.13 , Issue.11 , pp. 976-983
    • Ryu, S.H.1    Katona, C.2    Rive, B.3    Livingston, G.4
  • 62
    • 84875859346 scopus 로고    scopus 로고
    • Agitation and aggression in people with Alzheimer's disease
    • May
    • Ballard C, Corbett A. Agitation and aggression in people with Alzheimer's disease. Curr Opin Psychiatry. May 2013;26(3):252-259.
    • (2013) Curr Opin Psychiatry. , vol.26 , Issue.3 , pp. 252-259
    • Ballard, C.1    Corbett, A.2
  • 63
    • 84862792198 scopus 로고    scopus 로고
    • Treatment of behavioral and psychological symptoms of Alzheimer's disease
    • Apr
    • Corbett A, Smith J, Creese B, Ballard C. Treatment of behavioral and psychological symptoms of Alzheimer's disease. Curr Treat Options Neurol. Apr 2012;14(2):113-125.
    • (2012) Curr Treat Options Neurol. , vol.14 , Issue.2 , pp. 113-125
    • Corbett, A.1    Smith, J.2    Creese, B.3    Ballard, C.4
  • 64
    • 77449084057 scopus 로고    scopus 로고
    • Systemic infection and delirium: when cytokines and acetylcholine collide
    • Feb 27
    • van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet. Feb 27 2010;375(9716):773-775.
    • (2010) Lancet. , vol.375 , Issue.9716 , pp. 773-775
    • van Gool, W.A.1    van de Beek, D.2    Eikelenboom, P.3
  • 66
    • 47949125556 scopus 로고    scopus 로고
    • Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years.
    • Kat MG, Vreeswijk R, de Jonghe JF, et al. Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years. Dement Geriatr Cogn Disord. 2008;26(1):1-8.
    • (2008) Dement Geriatr Cogn Disord. , vol.26 , Issue.1 , pp. 1-8
    • Kat, M.G.1    Vreeswijk, R.2    de Jonghe, J.F.3
  • 67
    • 0344701036 scopus 로고    scopus 로고
    • Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats
    • Jan
    • Willard LB, Hauss-Wegrzyniak B, Wenk GL. Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats. Neuroscience. Jan 1999;88(1):193-200.
    • (1999) Neuroscience. , vol.88 , Issue.1 , pp. 193-200
    • Willard, L.B.1    Hauss-Wegrzyniak, B.2    Wenk, G.L.3
  • 68
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout JP, Chen J, Abraham J, et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. Aug 2005;19(10):1329-1331.
    • (2005) FASEB J. Aug , vol.19 , Issue.10 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3
  • 69
    • 64649100658 scopus 로고    scopus 로고
    • Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
    • May
    • Godbout JP, Johnson RW. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Immunol Allergy Clin North Am. May 2009;29(2):321-337.
    • (2009) Immunol Allergy Clin North Am. , vol.29 , Issue.2 , pp. 321-337
    • Godbout, J.P.1    Johnson, R.W.2
  • 70
    • 34248394268 scopus 로고    scopus 로고
    • Mood and male sexual behaviour in the APP23 model of Alzheimer's disease
    • Jun 18
    • Vloeberghs E, Van Dam D, Franck F, Staufenbiel M, De Deyn PP. Mood and male sexual behaviour in the APP23 model of Alzheimer's disease. Behav Brain Res. Jun 18 2007;180(2):146-151.
    • (2007) Behav Brain Res. , vol.180 , Issue.2 , pp. 146-151
    • Vloeberghs, E.1    Van Dam, D.2    Franck, F.3    Staufenbiel, M.4    De Deyn, P.P.5
  • 72
    • 84897564199 scopus 로고    scopus 로고
    • Capillary pericytes regulate cerebral blood flow in health disease.
    • Mar 26
    • Hall CN, Reynell C, Gesslein B, et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. Mar 26 2014.
    • (2014) Nature.
    • Hall, C.N.1    Reynell, C.2    Gesslein, B.3
  • 73
    • 79951922143 scopus 로고    scopus 로고
    • Engaging neuroscience to advance translational research in brain barrier biology
    • Mar
    • Neuwelt EA, Bauer B, Fahlke C, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. Mar 2011;12(3):169-182.
    • (2011) Nat Rev Neurosci. , vol.12 , Issue.3 , pp. 169-182
    • Neuwelt, E.A.1    Bauer, B.2    Fahlke, C.3
  • 74
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Dec
    • Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. Dec 2011;12(12):723-738.
    • (2011) Nat Rev Neurosci. , vol.12 , Issue.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 75
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Jul
    • Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. Jul 2009;118(1):103-113.
    • (2009) Acta Neuropathol. , vol.118 , Issue.1 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 76
    • 33745032028 scopus 로고    scopus 로고
    • Delivering drugs to the central nervous system: a medicinal chemistry or a pharmaceutical technology issue?
    • Ricci M, Blasi P, Giovagnoli S, Rossi C. Delivering drugs to the central nervous system: a medicinal chemistry or a pharmaceutical technology issue? Curr Med Chem. 2006;13(15):1757-1775.
    • (2006) Curr Med Chem. , vol.13 , Issue.15 , pp. 1757-1775
    • Ricci, M.1    Blasi, P.2    Giovagnoli, S.3    Rossi, C.4
  • 77
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Jan
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. Jan 2006;7(1):41-53.
    • (2006) Nat Rev Neurosci. , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 78
    • 0025265046 scopus 로고
    • An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro
    • May
    • Dehouck MP, Meresse S, Delorme P, Fruchart JC, Cecchelli R. An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro. J Neurochem. May 1990;54(5):1798-1801.
    • (1990) J Neurochem. , vol.54 , Issue.5 , pp. 1798-1801
    • Dehouck, M.P.1    Meresse, S.2    Delorme, P.3    Fruchart, J.C.4    Cecchelli, R.5
  • 79
    • 0035876286 scopus 로고    scopus 로고
    • Mechanisms of glucose transport at the blood-brain barrier: an in vitro study
    • Jun 15
    • McAllister MS, Krizanac-Bengez L, Macchia F, et al. Mechanisms of glucose transport at the blood-brain barrier: an in vitro study. Brain Res. Jun 15 2001;904(1):20-30.
    • (2001) Brain Res. , vol.904 , Issue.1 , pp. 20-30
    • McAllister, M.S.1    Krizanac-Bengez, L.2    Macchia, F.3
  • 80
    • 80053504148 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function in neurodegenerative disease
    • Bartels AL. Blood-brain barrier P-glycoprotein function in neurodegenerative disease. Curr Pharm Des. 2011;17(26):2771-2777.
    • (2011) Curr Pharm Des. , vol.17 , Issue.26 , pp. 2771-2777
    • Bartels, A.L.1
  • 81
    • 77953501722 scopus 로고    scopus 로고
    • The role of neuroinflammation on the pathogenesis of Parkinson's disease
    • Apr
    • Chung YC, Ko HW, Bok E, et al. The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Rep. Apr 2010;43(4):225-232.
    • (2010) BMB Rep. , vol.43 , Issue.4 , pp. 225-232
    • Chung, Y.C.1    Ko, H.W.2    Bok, E.3
  • 82
    • 84873103309 scopus 로고    scopus 로고
    • Neuroinflammatory imaging biomarkers: relevance to multiple sclerosis and its therapy
    • Jan
    • Tourdias T, Dousset V. Neuroinflammatory imaging biomarkers: relevance to multiple sclerosis and its therapy. Neurotherapeutics. Jan 2013;10(1):111-123.
    • (2013) Neurotherapeutics. , vol.10 , Issue.1 , pp. 111-123
    • Tourdias, T.1    Dousset, V.2
  • 83
    • 84868535759 scopus 로고    scopus 로고
    • Progressive multiple sclerosis: pathology and pathogenesis
    • Nov 5
    • Lassmann H, van Horssen J, Mahad D. Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol. Nov 5 2012;8(11):647-656.
    • (2012) Nat Rev Neurol. , vol.8 , Issue.11 , pp. 647-656
    • Lassmann, H.1    van Horssen, J.2    Mahad, D.3
  • 84
    • 84864434405 scopus 로고    scopus 로고
    • Oligodendrocytes and the early multiple sclerosis lesion
    • Jul
    • Prineas JW, Parratt JD. Oligodendrocytes and the early multiple sclerosis lesion. Ann Neurol. Jul 2012;72(1):18-31.
    • (2012) Ann Neurol. , vol.72 , Issue.1 , pp. 18-31
    • Prineas, J.W.1    Parratt, J.D.2
  • 85
    • 84896520534 scopus 로고    scopus 로고
    • Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice.
    • Mar 3
    • Winkler EA, Sengillo JD, Sagare AP, et al. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. Mar 3 2014.
    • (2014) Proc Natl Acad Sci U S A.
    • Winkler, E.A.1    Sengillo, J.D.2    Sagare, A.P.3
  • 86
    • 84893257209 scopus 로고    scopus 로고
    • Blood-CNS Barrier Impairment in ALS patients versus an animal model
    • Garbuzova-Davis S, Sanberg PR. Blood-CNS Barrier Impairment in ALS patients versus an animal model. Front Cell Neurosci. 2014;8:21.
    • (2014) Front Cell Neurosci. , vol.8 , pp. 21
    • Garbuzova-Davis, S.1    Sanberg, P.R.2
  • 88
    • 0037338557 scopus 로고    scopus 로고
    • Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    • Mar
    • Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke. Mar 2003;34(3):806-812.
    • (2003) Stroke , vol.34 , Issue.3 , pp. 806-812
    • Wardlaw, J.M.1    Sandercock, P.A.2    Dennis, M.S.3    Starr, J.4
  • 89
    • 0042888745 scopus 로고    scopus 로고
    • Hypertension, hypertension-clustering factors and Alzheimer's disease
    • Sep
    • Skoog I, Gustafson D. Hypertension, hypertension-clustering factors and Alzheimer's disease. Neurol Res. Sep 2003;25(6):675-680.
    • (2003) Neurol Res. , vol.25 , Issue.6 , pp. 675-680
    • Skoog, I.1    Gustafson, D.2
  • 91
    • 57749116386 scopus 로고    scopus 로고
    • Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension
    • Feb
    • Gentile MT, Poulet R, Di Pardo A, et al. Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension. Neurobiol Aging. Feb 2009;30(2):222-228.
    • (2009) Neurobiol Aging , vol.30 , Issue.2 , pp. 222-228
    • Gentile, M.T.1    Poulet, R.2    Di Pardo, A.3
  • 92
    • 73349097900 scopus 로고    scopus 로고
    • Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling
    • Dec
    • Takeda S, Sato N, Takeuchi D, et al. Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension. Dec 2009;54(6):1345-1352.
    • (2009) Hypertension. , vol.54 , Issue.6 , pp. 1345-1352
    • Takeda, S.1    Sato, N.2    Takeuchi, D.3
  • 93
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
    • May
    • Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci. May 2009;10(5):333-344.
    • (2009) Nat Rev Neurosci. , vol.10 , Issue.5 , pp. 333-344
    • Bu, G.1
  • 94
    • 77649314191 scopus 로고    scopus 로고
    • APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    • Morris JC, Roe CM, Xiong C, et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of Neurology. 2010;67(1):122-131.
    • (2010) Annals of Neurology. , vol.67 , Issue.1 , pp. 122-131
    • Morris, J.C.1    Roe, C.M.2    Xiong, C.3
  • 95
    • 66149084048 scopus 로고    scopus 로고
    • Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's diseas
    • April 21, 2009
    • Reiman EM, Chen K, Liu X, et al. Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease. Proceedings of the National Academy of Sciences. April 21, 2009 2009;106(16):6820-6825.
    • (2009) Proceedings of the National Academy of Sciences. , vol.106 , Issue.16 , pp. 6820-6825
    • Reiman, E.M.1    Chen, K.2    Liu, X.3
  • 96
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
    • May 24
    • Bell RD, Winkler EA, Singh I, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. May 24 2012;485(7399):512-516.
    • (2012) Nature. , vol.485 , Issue.7399 , pp. 512-516
    • Bell, R.D.1    Winkler, E.A.2    Singh, I.3
  • 97
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • Dec
    • Ujiie M, Dickstein DL, Carlow DA, Jefferies WA. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation. Dec 2003;10(6):463-470.
    • (2003) Microcirculation. , vol.10 , Issue.6 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 98
    • 33645816954 scopus 로고    scopus 로고
    • Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease
    • Mar
    • Dickstein DL, Biron KE, Ujiie M, Pfeifer CG, Jeffries AR, Jefferies WA. Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease. FASEB J. Mar 2006;20(3):426-433.
    • (2006) FASEB J. , vol.20 , Issue.3 , pp. 426-433
    • Dickstein, D.L.1    Biron, K.E.2    Ujiie, M.3    Pfeifer, C.G.4    Jeffries, A.R.5    Jefferies, W.A.6
  • 99
    • 0037112201 scopus 로고    scopus 로고
    • Cerebral hemorrhage after passive anti-Abeta immunotherapy
    • Nov 15
    • Pfeifer M, Boncristiano S, Bondolfi L, et al. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science. Nov 15 2002;298(5597):1379.
    • (2002) Science. , vol.298 , Issue.5597 , pp. 1379
    • Pfeifer, M.1    Boncristiano, S.2    Bondolfi, L.3
  • 100
    • 19944431509 scopus 로고    scopus 로고
    • Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
    • Jan 19
    • Racke MM, Boone LI, Hepburn DL, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J Neurosci. Jan 19 2005;25(3):629-636.
    • (2005) J Neurosci. , vol.25 , Issue.3 , pp. 629-636
    • Racke, M.M.1    Boone, L.I.2    Hepburn, D.L.3
  • 101
    • 33845426936 scopus 로고    scopus 로고
    • Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage
    • Feb
    • Burbach GJ, Vlachos A, Ghebremedhin E, et al. Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage. Neurobiol Aging. Feb 2007;28(2):202-212.
    • (2007) Neurobiol Aging , vol.28 , Issue.2 , pp. 202-212
    • Burbach, G.J.1    Vlachos, A.2    Ghebremedhin, E.3
  • 102
    • 78649555789 scopus 로고    scopus 로고
    • Magnetic resonance imaging detection time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice.
    • Luo F, Rustay NR, Seifert T, et al. Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice. J Pharmacol Exp Ther. Dec;335(3):580-588.
    • J Pharmacol Exp Ther. Dec , vol.335 , Issue.3 , pp. 580-588
    • Luo, F.1    Rustay, N.R.2    Seifert, T.3
  • 103
    • 0037442177 scopus 로고    scopus 로고
    • Alzheimer's disease and angiogenesis
    • Feb 15
    • Vagnucci AH, Jr., Li WW. Alzheimer's disease and angiogenesis. Lancet. Feb 15 2003;361(9357):605-608.
    • (2003) Lancet. , vol.361 , Issue.9357 , pp. 605-608
    • Vagnucci Jr., A.H.1    Li, W.W.2
  • 104
    • 0037404666 scopus 로고    scopus 로고
    • Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism
    • May-Jun
    • Suhara T, Magrane J, Rosen K, et al. Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism. Neurobiol Aging. May-Jun 2003;24(3):437-451.
    • (2003) Neurobiol Aging. , vol.24 , Issue.3 , pp. 437-451
    • Suhara, T.1    Magrane, J.2    Rosen, K.3
  • 105
    • 73949133110 scopus 로고    scopus 로고
    • Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy
    • Nov
    • Hayashi S, Sato N, Yamamoto A, et al. Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. Arterioscler Thromb Vasc Biol. Nov 2009;29(11):1909-1915.
    • (2009) Arterioscler Thromb Vasc Biol. , vol.29 , Issue.11 , pp. 1909-1915
    • Hayashi, S.1    Sato, N.2    Yamamoto, A.3


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