Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis

Ophthalmic Research

Volumn 40, Issue 3-4, 2008, Pages 160-164

  Saraswathy, Sindhu ^a   Rao, Narsing A ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b DOHENY EYE INSTITUTE   (United States)

Author keywords

Experimental autoimmune uveitis; Mitochondrial oxidative stress; Peroxynitrite; Photoreceptors

Indexed keywords

MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE;

CELL INFILTRATION; HISTOLOGY; IMMUNIZATION; MACROPHAGE; MICROGLIA; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NITRATION; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA; SHORT SURVEY; UVEITIS;

ANIMALS; AUTOIMMUNE DISEASES; CYTOKINES; DISEASE MODELS, ANIMAL; MITOCHONDRIA; OXIDATIVE STRESS; PHOTORECEPTORS, VERTEBRATE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES; UVEITIS;

EID: 42449093785     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000119869     Document Type: Short Survey

References (24)

1. Wu GS, Zhang J, Rao NA: Peroxynitrite and oxidative damage in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 1997;38:1333-1339.
2. Zhang J, Wu LY, Wu GS, Rao NA: Differential expression of nitric oxide synthase in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 1999;40:1899-1905.
3. Goto H, Wu GS, Gritz DC, Atalla LR, Rao NA: Chemotactic activity of the peroxidized retinal membrane lipids in experimental autoimmune uveitis. Curr Eye Res 1991;10:1009-1014.
4. Wu GS, Sevanian A, Rao NA: Detection of retinal lipid hydroperoxides in experimental uveitis. Free Radic Biol Med 1992;12:19-27.
5. Rao NA, Kimoto T, Zamir E, Giri R, Wang R, Ito S, Paarajasegaram G, Read RW, Wu GS: Pathogenic role of retinal microglia in experimental uveoretinitis. Invest Ophthalmol Vis Sci 2003;44:22-31.
6. Ranjendram R, Saraswathy S, Rao NA: Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. Br J Ophthalmol 2007;91:531-537.
7. Wu GS, Lee TD, Moore RE, Rao NA: Photoreceptor mitochondrial tyrosine nitration in experimental uveitis. Invest Ophthalmol Vis Sci 2005;46:2271-2281.
8. Suzukawa K, Miura K, Mitsushita J, Resau J, Hirose K, Crystal R, Kamata T: Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J Biol Chem 2000;275:13175-13178.
9. Sarti P, Giuffrè A, Forte E, Mastronicola D, Barone MC, Brunori M: Nitric oxide and cytochrome c oxidase: mechanisms of inhibition and NO degradation. Biochem Biophys Res Commun 2000;274:183-187.
10. Brown GC: Nitric oxide and mitochondrial respiration. Biochem Biophys Acta 1999;1411:351-369.
11. Swift LM, Sarvazyan N: Localization of dichlorofluorescein in cardiac myocytes: implications for assessment of oxidative stress. Am J Physiol Heart Circ Physiol 2000;278:H982-H990.
12. Crow JP: Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric Oxide 1997;1:145-157.
13. Boveris A, Alvarez S, Navarro A: The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic Biol Med 2002;33:1186-1193.
14. Mizuguchi J, Takeuchi M, Usui M: Type I interferons as immunoregulatory molecules; implications for therapy in experimental autoimmune uveoretinitis. Arch Immunol Ther Exp 2002;50:243-254.
15. Ooi KG, Galatowicz G, Towler HM, Lightman SL, Calder VL: Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10, and IF gamma profiles in uveitis. Invest Ophthalmol Vis Sci 2006;47:272-277.
16. Savion S, Oddo S, Grover S, Caspi RR: Uveitogenic T lymphocytes in the rat: pathogenicity vs. lymphokine production, adhesion molecules and surface antigen expression. J Neuroimmunol 1994;55;35-44.
17. Rao KM: Molecular mechanisms regulating iNOS expression in various cell types. J Toxicol Environ Health B Crit Rev 2000;3:27-58.
18. Dinarello CA: The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002;20(suppl 27):S1-S13.
19. Ischiropoulos H, Zhu L, Beckman JS: Peroxynitrite formation from macrophage-derived nitric oxide. Arch Biochem Biophys 1992;298:446-451.
20. Omura T: Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. J Biochem 1998;123:1010-1016.
21. Fothergill-Gilmore LA, Watson HC: The phosphoglycerate mutases. Adv Enzymol Relat Areas Mol Biol 1989;62:227-313.
22. Greenacre SA, Ischiropoulos H: Tyrosine nitration: localization, quantitation, consequences of protein function and signal transduction. Free Radic Res 2001;34:541-581.
23. Witting L: Lipid peroxidation in vivo. J Am Oil Chem Soc 1965;42:908-913.
24. Saraswathy S, Wu GS, Rao NA: Retinal microglial activation and chemotaxis by docosahexaenoic acid hydroperoxide. Invest Ophthalmol Vis Sci 2006;47:3656-3663.