Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo

GLIA

Volumn 62, Issue 9, 2014, Pages 1463-1475

  Neher, Jonas J ^a   Neniskyte, Urte ^a   Hornik, Tamara ^a   Brown, Guy C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Amyloid ; Neuroinflammation; Phagoptosis; Uridine diphosphate

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); APYRASE; CIBACRON BLUE F3GA; ISOTHIOCYANIC ACID DERIVATIVE; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; N,N''-1,4-BUTANEDIYLBIS(N'-(3-ISOTHIOCYANATOPHENYL))THIOUREA; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PEROXYNITROUS ACID; PURINERGIC P2 RECEPTOR; PURINERGIC P2 RECEPTOR ANTAGONIST; PURINERGIC P2Y6 RECEPTOR; TEICHOIC ACID; THIOUREA; TRIAZINE DERIVATIVE; URIDINE DIPHOSPHATE;

ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CELL DEATH; CORPUS STRIATUM; DRUG EFFECTS; IMMUNOLOGY; MALE; METABOLISM; MICROGLIA; NERVE CELL; PHAGOCYTOSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; APYRASE; CELL DEATH; CELLS, CULTURED; CORPUS STRIATUM; ISOTHIOCYANATES; LIPOPOLYSACCHARIDES; MALE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PEROXYNITROUS ACID; PHAGOCYTOSIS; PURINERGIC P2 RECEPTOR ANTAGONISTS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; TEICHOIC ACIDS; THIOUREA; TRIAZINES; URIDINE DIPHOSPHATE;

EID: 84904388188     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22693     Document Type: Article

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