Assessment and In Vivo Scoring of Murine Experimental Autoimmune Uveoretinitis Using Optical Coherence Tomography

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Chu, Colin J ^a   Herrmann, Philipp ^a   Carvalho, Livia S ^a   Liyanage, Sidath E ^a   Bainbridge, James W B ^a,b   Ali, Robin R ^a,b   Dick, Andrew D ^b,c   Luhmann, Ulrich F O ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL INFILTRATION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING EQUIPMENT; DIAGNOSTIC VALUE; DISEASE SEVERITY; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; FEMALE; FLUORESCENCE ANGIOGRAPHY; FUNDUS FLUORESCEIN ANGIOGRAPHY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROGLIA; MOUSE; NONHUMAN; OPTIC DISK; OPTICAL COHERENCE TOMOGRAPHY; RETINA FOLD; SCORING SYSTEM; T LYMPHOCYTE; THREE DIMENSIONAL IMAGING; TOPICAL ENDOSCOPIC FUNDAL IMAGING; UVEORETINITIS; VASCULITIS; VITREOUS OPACITY;

ANIMALS; AUTOIMMUNE DISEASES; BLOOD VESSELS; CALIBRATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HUMANS; MICE; OPTIC DISK; RETINITIS; TOMOGRAPHY, OPTICAL COHERENCE; UVEITIS;

EID: 84877744077     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063002     Document Type: Article

References (29)

1. Caspi RR, Silver PB, Luger D, Tang J, Cortes LM, et al. (2008) Mouse models of experimental autoimmune uveitis. Ophthalmic Res 40: 169-174.
2. Schewitz-Bowers LP, Lee RW, Dick AD, (2010) Immune mechanisms of intraocular inflammation. Ex Rev Op 5: 43-58.
3. Horai R, Caspi RR (2011) Cytokines in Autoimmune Uveitis. Journal of Interferon & Cytokine Research. doi:10.1089/jir.2011.0042.
4. Calder CJ, Nicholson LB, Dick AD, (2005) A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol 175: 6286-6293.
5. Raveney BJE, Copland DA, Dick AD, Nicholson LB, (2009) TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. J Immunol 183: 2321-2329.
6. Caspi RR (2003) Experimental autoimmune uveoretinitis in the rat and mouse. Curr Protoc Immunol Chapter 15: Unit 15.6. doi:10.1002/0471142735.im1506s53.
7. Dick AD, Cheng YF, Liversidge J, Forrester JV, (1994) Immunomodulation of experimental autoimmune uveoretinitis: a model of tolerance induction with retinal antigens. Eye (Lond) 8 (Pt 1): 52-59.
8. Jiang HR, Lumsden L, Forrester JV, (1999) Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice. Invest Ophthalmol Vis Sci 40: 3177-3185.
9. Xu H, Koch P, Chen M, Lau A, Reid DM, et al. (2008) A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res 87: 319-326.
10. Copland DA, Wertheim MS, Armitage WJ, Nicholson LB, Raveney BJE, et al. (2008) The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci 49: 5458-5465.
11. Kerr EC, Raveney BJE, Copland DA, Dick AD, Nicholson LB, (2008) Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J Autoimmun 31: 354-361.
12. Copland DA, Liu J, Schewitz-Bowers LP, Brinkmann V, Anderson K, et al. (2012) Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-Ocular Barrier. Am J Pathol 180: 672-681.
13. Wenzel A, Grimm C, Samardzija M, Remé CE, (2005) Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res 24: 275-306.
14. Drexler W, Fujimoto JG, (2008) State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res 27: 45-88.
15. Gabriele ML, Wollstein G, Ishikawa H, Kagemann L, Xu J, et al. (2011) Optical coherence tomography: history, current status, and laboratory work. Invest Ophthalmol Vis Sci 52: 2425-2436.
16. Keane PA, Patel PJ, Liakopoulos S, Heussen FM, Sadda SR, et al. (2012) Evaluation of age-related macular degeneration with optical coherence tomography. Surv Ophthalmol 57: 389-414.
17. Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, et al. (2009) Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS ONE 4: e7507.
18. Luhmann UFO, Lange CA, Robbie S, Munro PMG, Cowing JA, et al. (2012) Differential modulation of retinal degeneration by ccl2 and cx3cr1 chemokine signalling. PLoS ONE 7: e35551.
19. Petryniak J, Huard TK, Nordblom GD, Goldstein IJ, (1986) Lectin binding studies on murine peritoneal cells: physicochemical characterization of the binding of lectins from Datura stramonium, Evonymus europaea, and Griffonia simplicifolia to murine peritoneal cells. Arch Biochem Biophys 244: 57-66.
20. Maddox DE, Shibata S, Goldstein IJ, (1982) Stimulated macrophages express a new glycoprotein receptor reactive with Griffonia simplicifolia I-B4 isolectin. Proc Natl Acad Sci USA 79: 166-170.
21. National Centre for the Replacement, Refinement and Reduction of Animals in Research (2008) Responsibility in the use of animals in bioscience research: expectations of the major research councils and charitable funding bodies. nc3rsorguk. Available: http://www.nc3rs.org.uk. Accessed 28 November 2012.
22. Chen M, Copland DA, Zhao J, Liu J, Forrester JV, et al. (2012) Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligation. Am J Pathol 180: 235-245.
23. Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, et al. (2010) Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol 248: 1063-1070.
24. Caspi RR, Grubbs BG, Chan CC, Chader GJ, Wiggert B, (1992) Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes. J Immunol 148: 2384-2389.
25. Gadjanski I, Williams SK, Hein K, Sättler MB, Bähr M, et al. (2011) Correlation of optical coherence tomography with clinical and histopathological findings in experimental autoimmune uveoretinitis. Exp Eye Res 93: 82-90.
26. Wojtkowski M, Kaluzny B, Zawadzki RJ, (2012) New directions in ophthalmic optical coherence tomography. Optom Vis Sci 89: 524-542.
27. Forooghian F, Gulati N, Jabs DA, (2010) Restoration of retinal architecture following systemic immunosuppression in birdshot chorioretinopathy. Ocul Immunol Inflamm 18: 470-471.
28. Vance SK, Khan S, Klancnik JM, Freund KB, (2011) Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. Retina (Philadelphia, Pa) 31: 717-723.
29. Gallagher MJ, Yilmaz T, Cervantes-Castañeda RA, Foster CS, (2007) The characteristic features of optical coherence tomography in posterior uveitis. Br J Ophthalmol 91: 1680-1685.