The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 12, 2009, Pages 5934-5943

  Luhmann, Ulrich F O ^a   Robbie, Scott ^a   Munro, Peter M G ^a   Barker, Susie E ^a   Duran, Yanai ^a   Luong, Vy ^a   Fitzke, Frederick W ^a   Bainbridge, James W B ^a   Ali, Robin R ^a   Maclaren, Robert E ^a,b,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD68 ANTIGEN; LIPOFUSCIN; VISUAL PIGMENT; CCL2 PROTEIN, MOUSE; CD68 PROTEIN, MOUSE; DIFFERENTIATION ANTIGEN; EMR4 PROTEIN, MOUSE; EPIDERMAL GROWTH FACTOR; LEUKOCYTE ANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN 1;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CCL2 MOUSE; CONTROLLED STUDY; DRUSEN; ELECTRORETINOGRAPHY; IN VIVO STUDY; KNOCKOUT MOUSE; MACROPHAGE MIGRATION; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PHAGOSOME; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SCANNING LASER OPHTHALMOSCOPY; SENESCENCE; AGING; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENZYME IMMUNOASSAY; FLUORESCENCE ANGIOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE; MACROPHAGE; METABOLISM; MOUSE MUTANT; OPHTHALMOSCOPY; PATHOLOGY; PHYSIOLOGY; RETINA MACULA DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

AGING; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CHEMOKINE CCL2; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; EPIDERMAL GROWTH FACTOR; FLUORESCEIN ANGIOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNOENZYME TECHNIQUES; LIPOFUSCIN; MACROPHAGES; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OPHTHALMOSCOPY; RETINAL DRUSEN;

EID: 73349097249     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3462     Document Type: Article

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