Microglia in human retina: A heterogeneous population with distinct ontogenies

Perspectives on Developmental Neurobiology

Volumn 3, Issue 3, 1996, Pages 213-222

  Provis, J M ^a   Diaz, C M ^a   Penfold, P L ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Blood brain barrier; Dendritic cells; Glia limitons; Immunocompetent cells; Macrophages; Major histocompatability complex

Indexed keywords

CD45 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; HLA ANTIGEN; LEUKOCYTE ANTIGEN;

ADULT; CELL LINEAGE; CLASSIFICATION; CYTOLOGY; HUMAN; MICROGLIA; PHYSIOLOGY; PRENATAL DEVELOPMENT; RETINA; RETINA BLOOD VESSEL; REVIEW;

ADULT; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL LINEAGE; HLA ANTIGENS; HUMANS; MICROGLIA; RETINA; RETINAL VESSELS;

EID: 0030330923     PISSN: 10640517     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Graeber, M. B., and Streit, W. J. (1990). Microglia - immune network in the CNS. Brain Pathol. 1, 2-5.
2. Gehrmann, J., Banati, R. B., and Kreutzberg, G. W. (1993). Microglia in the immune surveillance of the brain: Human microglia constitutively express HLA-DR molecules. J. Neuroimmunol. 48, 189-198.
3. Graeber, M. B. (1993). Microglia, macrophages and the blood-brain barrier. Clin. Neuropathol. 12, 196-297.
4. Penfold, P. L., Provis, J. M., and Liew, S. C. K. (1993). Human retinal microglia express phenotypic characteristics in common with dendritic antigen-presenting cells. J. Neuroimmunol. 45, 183-192.
5. Liew, S. C. K., Penfold, P. L., Provis, J. M., Madigan, M. C., and Billson, F. A. (1994). Modulation of MHC class II expression in the absence of leucocytic infiltrates in Alzheimer's disease. J. Neuropathol. Exp. Neural. 54, 150-157.
6. Esiri, W., and McGee, J. O. (1986). Monoclonal antibody to macrophages (EBM/11) labels macrophages and microglial cells in human brain. J. Clin. Pathol. 39, 615-621.
7. Graeber, M. B., Streit, W. J., and Kreutzberg, G. W. (1989). Identity of ED-2 positive perivascular cells in rat bran. J. Neurosci. Res. 22, 103-106.
8. Penfold, P. L., Madigan, M. C., and Provis, J. M. (1991). Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina. Vis. Neurosci. 7, 383-388.
9. Graeber, M. B., Streit, W. J., Büringer, D., Sparks, D. L., and Kreutzberg, G. W. (1992). Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain. J. Neuropath. Exp. Neural. 51, 303-311.
10. Honda, H., Kimura, H., Silvers, W. K., and Rostami, A. (1990). Perivascular location and phenotypic heterogeneity of microglial cells in the rat brain. J. Neuroimmunol. 29, 183-191.
11. Sedgwick, J. D., Schwender, S., Gregersen, R., Domes, R., and ter Meulen, V. (1993). Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive. J. Exp. Med. 177, 1145-1152.
12. Penfold, P. L., Provis, J. M., Edwards, A. J., and van Driel, D. (1994). Microglia and the glia limitans in the human retina. Proc. Aust. Neurosci. Soc. 5, 254.
13. Diaz-Araya, C. M., Provis, J. M., and Penfold, P. L. (1994). Ontogeny of leucocyte antigens in foetal human retinae: Expression of MHC Class I, Class II and macrophage antigens by microglia. Proc. Aust. Neurosci. Soc. 5, 119.
14. Provis, J. M., Penfold, P. L., Edwards, A. J., and van Driel, D. (1995). Human retinal microglia: Expression of immune markers and relationship to the glia limitans. Glia 14, 243-256..
15. Sadegh-Nasseri, S., and Germain, R. N. (1992). How MHC class II molecules work: Peptide-dependent completion of protein folding. Immunol. Today 13, 173-179.
16. Monaco, J. J. (1992). A molecular model of MHC class-I-restricted antigen presentation. Immunol. Today 13, 173-179.
17. Wood, G. S., Freudenthal, P. S., Edinger, A., Steinman, R. M., and Warnke, R. A. (1991). CD45 mapping of human CD1a+ dendritic cells and peripheral blood dendritic cells. Am. J. Pathol. 138, 1451-1459.
18. Streit, W. J., Graeber, M. B., and Kreutzberg, G. W. (1989). Expression of la antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury. Exp. Neural. 105, 115-126.
19. Gehrmann, J., and Kreutzberg, G. W. (1993). Monoclonal antibodies against macrophages/microglia: Immunocytochemical studies of early microglial activation in experimental neuropathology. Clin. Neuropathol. 12, 301-306.
20. Streit, W. J., and Graeber, M. B. (1993). Heterogeneity of microglial and perivascular cell population: Insights gained form the facial nucleus paradigm. Glia 7, 68-74.
21. Holt, P. G., Degebrodt, A., O'Leary, C., Krska, K., and Plozza, T. (1985). T cell activation by antigen presenting cells from lung tissue digests: Suppression be endogenous macrophages. Clin. Exp. Immunol. 62, 586-593.
22. Pavli, P., Hume, D. A., Van der Pol, E., and Doe, W. F. (1993). Dendritic cells, the major antigen-presenting cells of the colonie lamina propria. Immunology 78, 132-141.
23. Isaacson, P. G., and Jones, D. B. (1983). Immunohistochemical differentiation between histocytic and lymphoid neoplasms. Histochem. J. 15, 621-635.
24. Hume, D. A., Perry, V. H., and Gordon, S. (1983). The immunohistochemical localisation of a macrophage-specific antigen in the developing mouse retina. Phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J. Cell Biol. 97, 253-257.
25. Graeber, M. B., and Streit, W. J. (1990). Perivascular microglia defined. Trends Neurosci. 13, 366.
26. Lassmann, H., Zimprich, F., Vass, K., and Hickey, W. F. (1991). Microglial cells are a component of the perivascular glia limitans. J. Neurosci. Res. 28, 236-243.
27. Ling, E.-A., and Wong, W.-C. (1993). The origin and nature of ramified and amoeboid microglia: A historical review and current concepts, Glia 7, 9-18.
28. Diaz-Araya, C. M., Provis, J. M., and Penfold, P. L. (1993). Distribution of HLA-DR and CD45 reactive microglia in developing human retinae. Proc. Aust. Neurosci. Soc. 4, 33.
29. Diaz-Araya, C. M., Provis, J. M., Penfold, P. L., and Billson, F. A. (1996). Development of microglial topography in human retina. J. Comp. Neural. 363, 53-68.
30. Diaz-Araya, C. M., Madigan, M. C., Provis, J. M., and Penfold, P. L. (1995). Immunohistochemical and topographical studies of dendritic cells and macrophages in human fetal cornea. Invest. Ophthalmol. Vis. Sci. 36, 644-656.
31. Hendrickson, A. E., and Yuodelis, C. (1984). The morphological development of the human fovea. Ophthalmology 91, 603-612.
32. Penfold, P. L., Provis, J. M., Madigan, M. C., van Driel, D., and Bill-son, F. A. (1991). Angiogenesis in normal human retinal development: The involvement of astrocytes and macrophages. Graef's Arch. Clin. Exp. Ophthalmol. 228, 255-263.
33. Steinman, R. M., and Nussenzweig, M. C. (1980). Dendritic cells: Features and functions. Immunol. Rev. 53, 127-147.
34. King, P. D., and Katz, D. R. (1990). Mechanisms of dendritic cell function. Immunol. Today 11, 206-211.
35. Kettenmann, H., Hoppe, D., Gottmann, K., Banati, R., and Kreutzberg, G. W. (1990). Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages. J. Neurosci. Res. 26, 278-287.
36. Martin, F. C., Charles, A. C., Sanderson, M. J., and Merrill, J. E. (1992). Substance P stimulates IL-1 production by astrocytes via intracellular calcium. Brain Res. 599, 13-18.
37. Sacerdote, P., Denis-Donini, S., Paglia, P., Granucci, F., Panerai, A., and Ricciardie-Castagnoli, P. (1993). Cloned microglial cells but not macrophages synthesize β-endorphin in response to CRH activation. Glia 9, 305-310.
38. Banati, R. B., Rothe, G., Valet, G., and Kreutzberg, G. W. (1991). A subpopulation of bone marrow-derived macrophage-like cells share a unique ion channel pattern with microglia. J. Neurosci. Res. 30, 593-600.
39. Penfold, P. L., Liew, S. C. K., Madigan, M. C., and Provis, J. M. (1996). Modulation of MHC Class II expression on retinal microglia and endothelial cells in age related macular degeneration. (Submitted.)
40. Dickson, D. W., Mattiace, L. A., Kure, K., Hutchins, K., Lyman, W. D., and Brosman, C. F. (1991). Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab. Invest. 64, 135-156.