Microglial activation in human diabetic retinopathy

Archives of Ophthalmology

Volumn 126, Issue 2, 2008, Pages 227-232

  Zeng, Hui Yang ^a,b   Green, William Richard ^a   Tso, Mark O M ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD68 ANTIGEN; HLA DR ANTIGEN;

ADULT; AGED; ANTIBODY LABELING; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; EPIRETINAL MEMBRANE; HUMAN; HUMAN TISSUE; HYPERTROPHY; MICROANEURYSM; MICROGLIA; OPTIC NERVE; PRIORITY JOURNAL; RETINA BLOOD VESSEL; RETINA HEMORRHAGE; RETINA NEOVASCULARIZATION; VITREOUS DISEASE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; DIABETIC RETINOPATHY; HLA-DR ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; MICROGLIA; MIDDLE AGED; RETINAL VASCULITIS;

EID: 39049127031     PISSN: 00039950     EISSN: 00039950     Source Type: Journal    
DOI: 10.1001/archophthalmol.2007.65     Document Type: Article

References (21)

1. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW. Diabetic retinopathy: more than meets the eye. Surv Ophthalmol. 2002;47(suppl 2):S253-S262.
2. Zeng XX, Ng YK, Ling EA. Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats. Vis Neurosci. 2000;17(3):463-471.
3. Rungger-Brändle E, Dosso AA, Leuenberger PM. Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2000;41(7):1971-1980.
4. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19(8):312-318.
5. Krady JK, Basu A, Allen CM, et al. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes. 2005;54(5):1559-1565.
6. Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol. 2001;158(1):147-152.
7. Funatsu H, Yamashita H, Noma H, Mimura T, Yamashita T, Hori S. Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol. 2002;133(1):70-77.
8. Provis JM, Penfold PL, Edwards AJ, van Driel D. Human retinal microglia: expression of immune markers and relationship to the glia limitans. Glia. 1995;14(4):243-256.
9. Meleth AD, Agron E, Chan CC, et al. Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2005;46(11):4295-4301.
10. Funatsu H, Yamashita H, Noma H, Mimura T, Yamashita T, Hori S. Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol. 2002;133(1):70-77.
11. Nakamura Y. Regulating factors for microglial activation. Biol Pharm Bull. 2002;25(8):945-953.
12. Hughes EH, Dick A. The pathology and pathogenesis of retinal vasculitis. Neuropathol Appl Neurobiol. 2003;29(4):325-340.
13. Cunha-Vaz JG. The blood-retinal barriers. Doc Ophthalmol. 1976;41(2):287-327.
14. Lipton SA. Molecular mechanisms of trauma-induced neuronal degeneration. Curr Opin Neurol Neurosurg. 1993;6(4):588-596.
15. Harada C, Mitamura Y, Harada T. The role of cytokines and trophic factors inepiretinal membranes: involvement of signal transduction in glial cells. Prog Retin Eye Res. 2006;25(2):149-164.
16. Zhang C, Lam TT, Tso MO. Heterogeneous populations of microglia/macrophages in the retina and their activation after retinal ischemia and reperfusion injury. Exp Eye Res. 2005;81(6):700-709.
17. del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 2000;10(1):95-112.
18. Aiello LP. Vascular endothelial growth factor: 20th-century mechanisms, 21stcentury therapies. Invest Ophthalmol Vis Sci. 1997;38(9):1647-1652.
19. Adamis AP, Miller JW, Bernal MT, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994;118(4):445-450.
20. Tran KC, Ryu JK, McLarnon JG. Induction of angiogenesis by platelet-activating factor in the rat striatum. Neuroreport. 2005;16(14):1579-1583.
21. Moster ML. Neuro-ophthalmology of diabetes. Curr Opin Ophthalmol. 1999;10 (6):376-381.