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Volumn 352, Issue 1, 2015, Pages 2-13

Epigenetic modifications in fibrotic diseases: Implications for pathogenesis and pharmacological targets

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA METHYLTRANSFERASE 1; HISTONE DEACETYLASE; HISTONE H3; METHYL CPG BINDING PROTEIN 2; MICRORNA; MICRORNA 152; MICRORNA 155; MICRORNA 19B; MICRORNA 21; MICRORNA 29; UNCLASSIFIED DRUG; UNTRANSLATED RNA; HISTONE;

EID: 84919733534     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.219816     Document Type: Article
Times cited : (35)

References (203)
  • 1
    • 84897219596 scopus 로고    scopus 로고
    • CCL2: A link between hepatic inflammation, fibrosis and angiogenesis?
    • published ahead of print
    • Affo S and Sancho-Bru P (2014) CCL2: a link between hepatic inflammation, fibrosis and angiogenesis? Gut DOI: 10.1136/gutjnl-2014-306905 [published ahead of print]
    • (2014) Gut
    • Affo, S.1    Sancho-Bru, P.2
  • 4
    • 84886228790 scopus 로고    scopus 로고
    • Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: Functional and mechanistic implications
    • Azrak SS, Ginel-Picardo A, Drosten M, Barbacid M, and Santos E (2013) Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. BMC Genomics 14:731.
    • (2013) BMC Genomics , vol.436 , pp. 1103-1106
    • Azrak, S.S.1    Ginel-Picardo, A.2    Drosten, M.3    Barbacid, M.4    Santos, E.5
  • 5
    • 24144475284 scopus 로고    scopus 로고
    • Reversing histone methylation
    • Bannister AJ and Kouzarides T (2005) Reversing histone methylation. Nature 436:1103-1106.
    • (2005) Nature , vol.436 , pp. 1103-1106
    • Bannister, A.J.1    Kouzarides, T.2
  • 6
    • 84894601419 scopus 로고    scopus 로고
    • Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy
    • Bao H, Hu S, Zhang C, Shi S, Qin W, Zeng C, Zen K, and Liu Z (2014) Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy. Biochem Biophys Res Commun 444:455-460.
    • (2014) Biochem Biophys Res Commun , vol.444 , pp. 455-460
    • Bao, H.1    Hu, S.2    Zhang, C.3    Shi, S.4    Qin, W.5    Zeng, C.6    Zen, K.7    Liu, Z.8
  • 9
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 10
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin SB and Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16:168-174.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 12
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor TH (2000) The DNA methyltransferases of mammals. Hum Mol Genet 9:2395-2402.
    • (2000) Hum Mol Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 13
    • 84866000151 scopus 로고    scopus 로고
    • DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats
    • Bian EB, Huang C, Ma TT, Tao H, Zhang H, Cheng C, Lv XW, and Li J (2012) DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats. Toxicol Appl Pharmacol 264:13-22.
    • (2012) Toxicol Appl Pharmacol , vol.264 , pp. 13-22
    • Bian, E.B.1    Huang, C.2    Ma, T.T.3    Tao, H.4    Zhang, H.5    Cheng, C.6    Lv, X.W.7    Li, J.8
  • 15
    • 84871099822 scopus 로고    scopus 로고
    • MicroRNAs, transforming growth factor beta-1, and tissue fibrosis
    • Bowen T, Jenkins RH, and Fraser DJ (2013) MicroRNAs, transforming growth factor beta-1, and tissue fibrosis. J Pathol 229:274-285.
    • (2013) J Pathol , vol.229 , pp. 274-285
    • Bowen, T.1    Jenkins, R.H.2    Fraser, D.J.3
  • 16
    • 78751566393 scopus 로고    scopus 로고
    • Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
    • Calvisi DF, Ladu S, Conner EA, Seo D, Hsieh JT, Factor VM, and Thorgeirsson SS (2011) Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J Hepatol 54:311-319.
    • (2011) J Hepatol , vol.54 , pp. 311-319
    • Calvisi, D.F.1    Ladu, S.2    Conner, E.A.3    Seo, D.4    Hsieh, J.T.5    Factor, V.M.6    Thorgeirsson, S.S.7
  • 18
    • 79958845153 scopus 로고    scopus 로고
    • Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation
    • Chen C, Wu CQ, Zhang ZQ, Yao DK, and Zhu L (2011) Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation. Exp Cell Res 317:1714-1725.
    • (2011) Exp Cell Res , vol.317 , pp. 1714-1725
    • Chen, C.1    Wu, C.Q.2    Zhang, Z.Q.3    Yao, D.K.4    Zhu, L.5
  • 19
    • 84866940776 scopus 로고    scopus 로고
    • The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases
    • Chen CC, Wang KY, and Shen CK (2012) The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases. J Biol Chem 287:33116-33121.
    • (2012) J Biol Chem , vol.287 , pp. 33116-33121
    • Chen, C.C.1    Wang, K.Y.2    Shen, C.K.3
  • 20
    • 84881395137 scopus 로고    scopus 로고
    • Both ERK/MAPK and TGF-Beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation
    • Cheng X, Gao W, Dang Y, Liu X, Li Y, Peng X, and Ye X (2013) Both ERK/MAPK and TGF-Beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation. J Diabetes Res 2013:463740.
    • (2013) J Diabetes Res , vol.2013 , pp. 463740
    • Cheng, X.1    Gao, W.2    Dang, Y.3    Liu, X.4    Li, Y.5    Peng, X.6    Ye, X.7
  • 21
    • 14844307097 scopus 로고    scopus 로고
    • Epigenetic regulation by histone methylation and histone variants
    • Cheung P and Lau P (2005) Epigenetic regulation by histone methylation and histone variants. Mol Endocrinol 19:563-573.
    • (2005) Mol Endocrinol , vol.19 , pp. 563-573
    • Cheung, P.1    Lau, P.2
  • 25
    • 73349122640 scopus 로고    scopus 로고
    • Use of microRNA sponges to explore tissue-specific microRNA functions in vivo
    • Cohen SM (2009) Use of microRNA sponges to explore tissue-specific microRNA functions in vivo. Nat Methods 6:873-874.
    • (2009) Nat Methods , vol.6 , pp. 873-874
    • Cohen, S.M.1
  • 27
    • 67651232689 scopus 로고    scopus 로고
    • Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
    • Coward WR, Watts K, Feghali-Bostwick CA, Knox A, and Pang L (2009) Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol Cell Biol 29:4325-4339.
    • (2009) Mol Cell Biol , vol.29 , pp. 4325-4339
    • Coward, W.R.1    Watts, K.2    Feghali-Bostwick, C.A.3    Knox, A.4    Pang, L.5
  • 28
    • 84903749469 scopus 로고    scopus 로고
    • A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis
    • Coward WR, Feghali-Bostwick CA, Jenkins G, Knox AJ, and Pang L (2014) A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. FASEB J 28:3183-3196.
    • (2014) FASEB J , vol.28 , pp. 3183-3196
    • Coward, W.R.1    Feghali-Bostwick, C.A.2    Jenkins, G.3    Knox, A.J.4    Pang, L.5
  • 32
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • Deaton AM and Bird A (2011) CpG islands and the regulation of transcription. Genes Dev 25:1010-1022.
    • (2011) Genes Dev , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 34
    • 1042286369 scopus 로고    scopus 로고
    • PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats
    • Diep QN, Benkirane K, Amiri F, Cohn JS, Endemann D, and Schiffrin EL (2004) PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats. J Mol Cell Cardiol 36:295-304.
    • (2004) J Mol Cell Cardiol , vol.36 , pp. 295-304
    • Diep, Q.N.1    Benkirane, K.2    Amiri, F.3    Cohn, J.S.4    Endemann, D.5    Schiffrin, E.L.6
  • 35
    • 84894084047 scopus 로고    scopus 로고
    • MicroRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2
    • Dong S, Ma W, Hao B, Hu F, Yan L, Yan X, Wang Y, Chen Z, and Wang Z (2014) microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2. Int J Clin Exp Pathol 7:565-574.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 565-574
    • Dong, S.1    Ma, W.2    Hao, B.3    Hu, F.4    Yan, L.5    Yan, X.6    Wang, Y.7    Chen, Z.8    Wang, Z.9
  • 36
    • 77649270362 scopus 로고    scopus 로고
    • High glucose down-regulates miR-29a to increase collagen IV production in HK-2cells
    • Du B, Ma LM, Huang MB, Zhou H, Huang HL, Shao P, Chen YQ, and Qu LH (2010) High glucose down-regulates miR-29a to increase collagen IV production in HK-2cells. FEBS Lett 584:811-816.
    • (2010) FEBS Lett , vol.584 , pp. 811-816
    • Du, B.1    Ma, L.M.2    Huang, M.B.3    Zhou, H.4    Huang, H.L.5    Shao, P.6    Chen, Y.Q.7    Qu, L.H.8
  • 37
    • 84904668928 scopus 로고    scopus 로고
    • Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro
    • Duan WJ, Yu X, Huang XR, Yu JW, and Lan HY (2014) Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro. Am J Pathol 184:2275-2284.
    • (2014) Am J Pathol , vol.184 , pp. 2275-2284
    • Duan, W.J.1    Yu, X.2    Huang, X.R.3    Yu, J.W.4    Lan, H.Y.5
  • 40
    • 0033953813 scopus 로고    scopus 로고
    • A bird's eye view of global methylation
    • Eng C, Herman JG, and Baylin SB (2000) A bird's eye view of global methylation. Nat Genet 24:101-102.
    • (2000) Nat Genet , vol.24 , pp. 101-102
    • Eng, C.1    Herman, J.G.2    Baylin, S.B.3
  • 41
    • 37349113774 scopus 로고    scopus 로고
    • Inhibition of microRNA with antisense oligonucleotides
    • Esau CC (2008) Inhibition of microRNA with antisense oligonucleotides. Methods 44:55-60.
    • (2008) Methods , vol.44 , pp. 55-60
    • Esau, C.C.1
  • 43
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861-874.
    • (2011) Nat Rev Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 44
    • 84869850999 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors in cancer: A chemical and therapeutic patent overview and selected clinical studies
    • Fahy J, Jeltsch A, and Arimondo PB (2012) DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat 22:1427-1442.
    • (2012) Expert Opin Ther Pat , vol.22 , pp. 1427-1442
    • Fahy, J.1    Jeltsch, A.2    Arimondo, P.B.3
  • 45
    • 84890559595 scopus 로고    scopus 로고
    • Long non-coding RNAs: New players in cell differentiation and development
    • Fatica A and Bozzoni I (2014) Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet 15:7-21.
    • (2014) Nat Rev Genet , vol.15 , pp. 7-21
    • Fatica, A.1    Bozzoni, I.2
  • 47
    • 78149291406 scopus 로고    scopus 로고
    • Role of myofibroblasts in vascular remodelling: Focus on restenosis and aneurysm
    • Forte A, Della Corte A, De Feo M, Cerasuolo F, and Cipollaro M (2010) Role of myofibroblasts in vascular remodelling: focus on restenosis and aneurysm. Cardiovasc Res 88:395-405.
    • (2010) Cardiovasc Res , vol.88 , pp. 395-405
    • Forte, A.1    Della Corte, A.2    De Feo, M.3    Cerasuolo, F.4    Cipollaro, M.5
  • 50
    • 85042951078 scopus 로고    scopus 로고
    • Yin yang 1 and histone methylation are associated with fibroblast differentiation
    • Guo J and Sime PJ (2012) Yin yang 1 and histone methylation are associated with fibroblast differentiation. Am J Respir Crit Care Med 185:A3916.
    • (2012) Am J Respir Crit Care Med , vol.185
    • Guo, J.1    Sime, P.J.2
  • 51
    • 70349783724 scopus 로고    scopus 로고
    • Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells
    • Guo CJ, Pan Q, Jiang B, Chen GY, and Li DG (2009a) Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells. Apoptosis 14:1331-1340.
    • (2009) Apoptosis , vol.14 , pp. 1331-1340
    • Guo, C.J.1    Pan, Q.2    Jiang, B.3    Chen, G.Y.4    Li, D.G.5
  • 52
    • 61849096150 scopus 로고    scopus 로고
    • miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis
    • Guo CJ, Pan Q, Li DG, Sun H, and Liu BW (2009b) miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis. J Hepatol 50:766-778.
    • (2009) J Hepatol , vol.50 , pp. 766-778
    • Guo, C.J.1    Pan, Q.2    Li, D.G.3    Sun, H.4    Liu, B.W.5
  • 53
    • 80054880084 scopus 로고    scopus 로고
    • DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter
    • Han H, Cortez CC, Yang X, Nichols PW, Jones PA, and Liang G (2011) DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet 20:4299-4310.
    • (2011) Hum Mol Genet , vol.20 , pp. 4299-4310
    • Han, H.1    Cortez, C.C.2    Yang, X.3    Nichols, P.W.4    Jones, P.A.5    Liang, G.6
  • 54
    • 62249118461 scopus 로고    scopus 로고
    • CpG islands or CpG clusters: How to identify functional GC-rich regions in a genome?
    • Han L and Zhao Z (2009) CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome? BMC Bioinformatics 10:65.
    • (2009) BMC Bioinformatics , vol.10 , pp. 65
    • Han, L.1    Zhao, Z.2
  • 56
    • 84864011802 scopus 로고    scopus 로고
    • MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4
    • He Y, Huang C, Sun X, Long XR, Lv XW, and Li J (2012) MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal 24:1923-1930.
    • (2012) Cell Signal , vol.24 , pp. 1923-1930
    • He, Y.1    Huang, C.2    Sun, X.3    Long, X.R.4    Lv, X.W.5    Li, J.6
  • 57
    • 77954234485 scopus 로고    scopus 로고
    • Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
    • Huang J, Wang Y, Guo Y, and Sun S (2010a) Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 52:60-70.
    • (2010) Hepatology , vol.52 , pp. 60-70
    • Huang, J.1    Wang, Y.2    Guo, Y.3    Sun, S.4
  • 60
    • 84902011530 scopus 로고    scopus 로고
    • Role of miR-208 in cardiac fibrosis: Prevention or promotion?
    • Huang Y, Xu T, and Li J (2014b) Role of miR-208 in cardiac fibrosis: prevention or promotion? Arch Med Res 45:356.
    • (2014) Arch Med Res , vol.45 , pp. 356
    • Huang, Y.1    Xu, T.2    Li, J.3
  • 61
    • 0033983168 scopus 로고    scopus 로고
    • Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study
    • Hubbard R, Venn A, Lewis S, and Britton J (2000) Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med 161:5-8.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 5-8
    • Hubbard, R.1    Venn, A.2    Lewis, S.3    Britton, J.4
  • 64
    • 0032482318 scopus 로고    scopus 로고
    • Transcription: Gene control by targeted histone acetylation
    • Imhof A and Wolffe AP (1998) Transcription: gene control by targeted histone acetylation. Curr Biol 8:R422-R424.
    • (1998) Curr Biol , vol.8 , pp. R422-R424
    • Imhof, A.1    Wolffe, A.P.2
  • 65
    • 15744389164 scopus 로고    scopus 로고
    • Effects of methylation of non-CpG sequence in the promoter region on the expression of human synaptotagmin XI (syt11)
    • Inoue S and Oishi M (2005) Effects of methylation of non-CpG sequence in the promoter region on the expression of human synaptotagmin XI (syt11). Gene 348:123-134.
    • (2005) Gene , vol.348 , pp. 123-134
    • Inoue, S.1    Oishi, M.2
  • 66
  • 68
    • 84856006723 scopus 로고    scopus 로고
    • Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol
    • James TT, Aroor AR, Lim RW, and Shukla SD (2012) Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol. J Pharmacol Exp Ther 340:237-247.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 237-247
    • James, T.T.1    Aroor, A.R.2    Lim, R.W.3    Shukla, S.D.4
  • 69
    • 59849084351 scopus 로고    scopus 로고
    • Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation
    • Ji J, Zhang J, Huang G, Qian J, Wang X, and Mei S (2009) Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 583:759-766.
    • (2009) FEBS Lett , vol.583 , pp. 759-766
    • Ji, J.1    Zhang, J.2    Huang, G.3    Qian, J.4    Wang, X.5    Mei, S.6
  • 70
    • 84873528392 scopus 로고    scopus 로고
    • MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism
    • Ji W, Yang L, Yuan J, Yang L, Zhang M, Qi D, Duan X, Xuan A, Zhang W, and Lu J, et al. (2013) MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism. Carcinogenesis 34:446-453.
    • (2013) Carcinogenesis , vol.34 , pp. 446-453
    • Ji, W.1    Yang, L.2    Yuan, J.3    Yang, L.4    Zhang, M.5    Qi, D.6    Duan, X.7    Xuan, A.8    Zhang, W.9    Lu, J.10
  • 72
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones PA (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13:484-492.
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 73
    • 79960905171 scopus 로고    scopus 로고
    • Epigenetic modifications: Novel therapeutic strategies for systemic sclerosis?
    • Jüngel A, Distler JH, Gay S, and Distler O (2011) Epigenetic modifications: novel therapeutic strategies for systemic sclerosis? Expert Rev Clin Immunol 7:475-480.
    • (2011) Expert Rev Clin Immunol , vol.7 , pp. 475-480
    • Jüngel, A.1    Distler, J.H.2    Gay, S.3    Distler, O.4
  • 74
    • 84865280797 scopus 로고    scopus 로고
    • H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells
    • Karmodiya K, Krebs AR, Oulad-Abdelghani M, Kimura H, and Tora L (2012) H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells. BMC Genomics 13:424.
    • (2012) BMC Genomics , vol.13 , pp. 424
    • Karmodiya, K.1    Krebs, A.R.2    Oulad-Abdelghani, M.3    Kimura, H.4    Tora, L.5
  • 76
    • 80053561101 scopus 로고    scopus 로고
    • Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132
    • Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, Fortunato O, Avolio E, Cesselli D, and Beltrami AP, et al. (2011) Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res 109:894-906.
    • (2011) Circ Res , vol.109 , pp. 894-906
    • Katare, R.1    Riu, F.2    Mitchell, K.3    Gubernator, M.4    Campagnolo, P.5    Cui, Y.6    Fortunato, O.7    Avolio, E.8    Cesselli, D.9    Beltrami, A.P.10
  • 77
    • 33847682663 scopus 로고    scopus 로고
    • MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors
    • Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi JJ, and Natarajan R (2007) MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci USA 104:3432-3437.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3432-3437
    • Kato, M.1    Zhang, J.2    Wang, M.3    Lanting, L.4    Yuan, H.5    Rossi, J.J.6    Natarajan, R.7
  • 79
    • 58149127646 scopus 로고    scopus 로고
    • PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta
    • Kawai T, Masaki T, Doi S, Arakawa T, Yokoyama Y, Doi T, Kohno N, and Yorioka N (2009) PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Lab Invest 89:47-58.
    • (2009) Lab Invest , vol.89 , pp. 47-58
    • Kawai, T.1    Masaki, T.2    Doi, S.3    Arakawa, T.4    Yokoyama, Y.5    Doi, T.6    Kohno, N.7    Yorioka, N.8
  • 80
    • 84901502081 scopus 로고    scopus 로고
    • From gene action to reactive genomes
    • Keller EF (2014) From gene action to reactive genomes. J Physiol 592:2423-2429.
    • (2014) J Physiol , vol.592 , pp. 2423-2429
    • Keller, E.F.1
  • 81
    • 24044474409 scopus 로고    scopus 로고
    • Histone h3 modifications in rat hepatic stellate cells by ethanol
    • Kim JS and Shukla SD (2005) Histone h3 modifications in rat hepatic stellate cells by ethanol. Alcohol Alcohol 40:367-372.
    • (2005) Alcohol Alcohol , vol.40 , pp. 367-372
    • Kim, J.S.1    Shukla, S.D.2
  • 82
    • 84904763727 scopus 로고    scopus 로고
    • Protective role of 5-azacytidine on myocardial infarction is associated with modulation of macrophage phenotype and inhibition of fibrosis
    • Kim YS, Kang WS, Kwon JS, Hong MH, Jeong HY, Jeong HC, Jeong MH, and Ahn Y (2014) Protective role of 5-azacytidine on myocardial infarction is associated with modulation of macrophage phenotype and inhibition of fibrosis. J Cell Mol Med 18:1018-1027.
    • (2014) J Cell Mol Med , vol.18 , pp. 1018-1027
    • Kim, Y.S.1    Kang, W.S.2    Kwon, J.S.3    Hong, M.H.4    Jeong, H.Y.5    Jeong, H.C.6    Jeong, M.H.7    Ahn, Y.8
  • 85
    • 78651293534 scopus 로고    scopus 로고
    • miRBase: Integrating microRNA annotation and deep-sequencing data
    • Kozomara A and Griffiths-Jones S (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39:D152-D157.
    • (2011) Nucleic Acids Res , vol.39 , pp. D152-D157
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 87
    • 78650470110 scopus 로고    scopus 로고
    • MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: A novel role of miR-382
    • Kriegel AJ, Fang Y, Liu Y, Tian Z, Mladinov D, Matus IR, Ding X, Greene AS, and Liang M (2010) MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. Nucleic Acids Res 38:8338-8347.
    • (2010) Nucleic Acids Res , vol.38 , pp. 8338-8347
    • Kriegel, A.J.1    Fang, Y.2    Liu, Y.3    Tian, Z.4    Mladinov, D.5    Matus, I.R.6    Ding, X.7    Greene, A.S.8    Liang, M.9
  • 88
    • 84863229877 scopus 로고    scopus 로고
    • MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis
    • Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, and Liang M (2012) MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. Physiol Genomics 44:259-267.
    • (2012) Physiol Genomics , vol.44 , pp. 256-267
    • Kriegel, A.J.1    Liu, Y.2    Cohen, B.3    Usa, K.4    Liu, Y.5    Liang, M.6
  • 90
    • 79251563128 scopus 로고    scopus 로고
    • PPAR-g ligands repress TGFb-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: Implications for therapy of fibrosis
    • Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, and Sime PJ (2011) PPAR-g ligands repress TGFb-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS ONE 6:e15909.
    • (2011) PLoS ONE , vol.6
    • Kulkarni, A.A.1    Thatcher, T.H.2    Olsen, K.C.3    Maggirwar, S.B.4    Phipps, R.P.5    Sime, P.J.6
  • 91
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microRNA processing enhances cellular transformation and tumorigenesis
    • Kumar MS, Lu J, Mercer KL, Golub TR, and Jacks T (2007) Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39:673-677.
    • (2007) Nat Genet , vol.39 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3    Golub, T.R.4    Jacks, T.5
  • 92
    • 84911414400 scopus 로고    scopus 로고
    • Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease
    • published ahead of print
    • Kwon KD, Choi MJ, Park JM, Song KM, Kwon MH, Batbold D, Yin GN, Kim WJ, Ryu JK, and Suh JK (2014) Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease. BJU Int DOI: 10.1111/bju.12812 [published ahead of print].
    • (2014) BJU Int
    • Kwon, K.D.1    Choi, M.J.2    Park, J.M.3    Song, K.M.4    Kwon, M.H.5    Batbold, D.6    Yin, G.N.7    Kim, W.J.8    Ryu, J.K.9    Suh, J.K.10
  • 94
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelialmesenchymal transition
    • Lamouille S, Xu J, and Derynck R (2014) Molecular mechanisms of epithelialmesenchymal transition. Nat Rev Mol Cell Biol 15:178-196.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 95
    • 80052754775 scopus 로고    scopus 로고
    • Diverse roles of TGF-b/Smads in renal fibrosis and inflammation
    • Lan HY (2011) Diverse roles of TGF-b/Smads in renal fibrosis and inflammation. Int J Biol Sci 7:1056-1067.
    • (2010) Int J Biol Sci , vol.7 , pp. 1056-1067
    • Lan, H.Y.1
  • 97
    • 78649669329 scopus 로고    scopus 로고
    • Mechanistic connection between inflammation and fibrosis
    • Lee SB and Kalluri R (2010) Mechanistic connection between inflammation and fibrosis. Kidney Int Suppl 78:S22-S26.
    • (2010) Kidney Int Suppl , vol.78 , pp. S22-S26
    • Lee, S.B.1    Kalluri, R.2
  • 98
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, and Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 100
    • 79955065145 scopus 로고    scopus 로고
    • The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    • Li WQ, Chen C, Xu MD, Guo J, Li YM, Xia QM, Liu HM, He J, Yu HY, and Zhu L (2011) The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS J 278:1522-1532.
    • (2011) FEBS J , vol.278 , pp. 1522-1532
    • Li, W.Q.1    Chen, C.2    Xu, M.D.3    Guo, J.4    Li, Y.M.5    Xia, Q.M.6    Liu, H.M.7    He, J.8    Yu, H.Y.9    Zhu, L.10
  • 101
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin SL, Kisseleva T, Brenner DA, and Duffield JS (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173:1617-1627.
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 105
    • 77950500403 scopus 로고    scopus 로고
    • Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes
    • Liu Y, Taylor NE, Lu L, Usa K, Cowley AW, Jr, Ferreri NR, Yeo NC, and Liang M (2010b) Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes. Hypertension 55:974-982.
    • (2010) Hypertension , vol.55 , pp. 974-982
    • Liu, Y.1    Taylor, N.E.2    Lu, L.3    Usa, K.4    Cowley, A.W.5    Ferreri, N.R.6    Yeo, N.C.7    Liang, M.8
  • 106
    • 84872475091 scopus 로고    scopus 로고
    • Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling
    • Liu N, He S, Ma L, Ponnusamy M, Tang J, Tolbert E, Bayliss G, Zhao TC, Yan H, and Zhuang S (2013a) Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling. PLoS ONE 8:e54001.
    • (2013) PLoS ONE , vol.8
    • Liu, N.1    He, S.2    Ma, L.3    Ponnusamy, M.4    Tang, J.5    Tolbert, E.6    Bayliss, G.7    Zhao, T.C.8    Yan, H.9    Zhuang, S.10
  • 107
    • 84875052732 scopus 로고    scopus 로고
    • A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling
    • Liu Y, Wang Z, Wang J, Lam W, Kwong S, Li F, Friedman SL, Zhou S, Ren Q, and Xu Z, et al. (2013b) A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling. Liver Int 33:504-515.
    • (2013) Liver Int , vol.33 , pp. 504-515
    • Liu, Y.1    Wang, Z.2    Wang, J.3    Lam, W.4    Kwong, S.5    Li, F.6    Friedman, S.L.7    Zhou, S.8    Ren, Q.9    Xu, Z.10
  • 110
    • 84900540815 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis
    • Lu D and Insel PA (2014) Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. Am J Physiol Cell Physiol 306:C779-C788.
    • (2014) Am J Physiol Cell Physiol , vol.306 , pp. C779-C788
    • Lu, D.1    Insel, P.A.2
  • 111
    • 63349085394 scopus 로고    scopus 로고
    • A single antimicroRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple micro-RNAs offers an improved approach for microRNA interference
    • Lu Y, Xiao J, Lin H, Bai Y, Luo X, Wang Z, and Yang B (2009) A single antimicroRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple micro-RNAs offers an improved approach for microRNA interference. Nucleic Acids Res 37:e24.
    • (2009) Nucleic Acids Res , vol.37 , pp. e24
    • Lu, Y.1    Xiao, J.2    Lin, H.3    Bai, Y.4    Luo, X.5    Wang, Z.6    Yang, B.7
  • 112
    • 78650004201 scopus 로고    scopus 로고
    • MicroRNA: Biogenesis, function and role in cancer
    • Macfarlane LA and Murphy PR (2010) MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics 11:537-561.
    • (2010) Curr Genomics , vol.11 , pp. 537-561
    • Macfarlane, L.A.1    Murphy, P.R.2
  • 113
    • 75149141045 scopus 로고    scopus 로고
    • MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
    • Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, and Mann DA (2010) MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology 138:705-714.
    • (2010) Gastroenterology , vol.138 , pp. 705-714
    • Mann, J.1    Chu, D.C.2    Maxwell, A.3    Oakley, F.4    Zhu, N.L.5    Tsukamoto, H.6    Mann, D.A.7
  • 114
    • 27644589675 scopus 로고    scopus 로고
    • The diverse functions of histone lysine methylation
    • Martin C and Zhang Y (2005) The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 6:838-849.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 838-849
    • Martin, C.1    Zhang, Y.2
  • 118
    • 84856691720 scopus 로고    scopus 로고
    • Disruption of Smad4 impairs TGF-b/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
    • Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, and Lan HY (2012) Disruption of Smad4 impairs TGF-b/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81:266-279.
    • (2012) Kidney Int , vol.81 , pp. 266-279
    • Meng, X.M.1    Huang, X.R.2    Xiao, J.3    Chung, A.C.4    Qin, W.5    Chen, H.Y.6    Lan, H.Y.7
  • 121
    • 77950523785 scopus 로고    scopus 로고
    • Hypoxiainduced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - A mechanism involved in SERPINE1 (PAI-1) overexpression
    • Muth M, Theophile K, Hussein K, Jacobi C, Kreipe H, and Bock O (2010) Hypoxiainduced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression. J Transl Med 8:33.
    • (2010) J Transl Med , vol.8 , pp. 33
    • Muth, M.1    Theophile, K.2    Hussein, K.3    Jacobi, C.4    Kreipe, H.5    Bock, O.6
  • 122
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, and Bird A (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 124
    • 84904555188 scopus 로고    scopus 로고
    • Angiotensin II upregulated the expression of microRNA-224 but not microRNA-21 in adult rat cardiac fibroblasts
    • Ning Q and Jiang X (2013) Angiotensin II upregulated the expression of microRNA-224 but not microRNA-21 in adult rat cardiac fibroblasts. Biomed Rep 1:776-780.
    • (2013) Biomed Rep , vol.1 , pp. 776-780
    • Ning, Q.1    Jiang, X.2
  • 127
    • 84865206803 scopus 로고    scopus 로고
    • MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway
    • Pan Z, Sun X, Shan H, Wang N, Wang J, Ren J, Feng S, Xie L, Lu C, and Yuan Y, et al. (2012) MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway. Circulation 126:840-850.
    • (2012) Circulation , vol.126 , pp. 840-850
    • Pan, Z.1    Sun, X.2    Shan, H.3    Wang, N.4    Wang, J.5    Ren, J.6    Feng, S.7    Xie, L.8    Lu, C.9    Yuan, Y.10
  • 130
    • 84901796479 scopus 로고    scopus 로고
    • The evidence for functional non-CpG methylation in mammalian cells
    • Patil V, Ward RL, and Hesson LB (2014) The evidence for functional non-CpG methylation in mammalian cells. Epigenetics 9:823-828.
    • (2014) Epigenetics , vol.9 , pp. 823-828
    • Patil, V.1    Ward, R.L.2    Hesson, L.B.3
  • 132
    • 77957259450 scopus 로고    scopus 로고
    • Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
    • Pogribny IP, Starlard-Davenport A, Tryndyak VP, Han T, Ross SA, Rusyn I, and Beland FA (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90:1437-1446.
    • (2010) Lab Invest , vol.90 , pp. 1437-1446
    • Pogribny, I.P.1    Starlard-Davenport, A.2    Tryndyak, V.P.3    Han, T.4    Ross, S.A.5    Rusyn, I.6    Beland, F.A.7
  • 134
    • 84896727760 scopus 로고    scopus 로고
    • FibromiRs: Translating molecular discoveries into new anti-fibrotic drugs
    • Pottier N, Cauffiez C, Perrais M, Barbry P, and Mari B (2014) FibromiRs: translating molecular discoveries into new anti-fibrotic drugs. Trends Pharmacol Sci 35:119-126.
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 119-126
    • Pottier, N.1    Cauffiez, C.2    Perrais, M.3    Barbry, P.4    Mari, B.5
  • 137
    • 4143070452 scopus 로고    scopus 로고
    • Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-kappaB and proinflammatory gene expression
    • Rahman I, Marwick J, and Kirkham P (2004) Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and proinflammatory gene expression. Biochem Pharmacol 68:1255-1267.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1255-1267
    • Rahman, I.1    Marwick, J.2    Kirkham, P.3
  • 140
    • 84867183192 scopus 로고    scopus 로고
    • Histone phosphorylation: A chromatin modification involved in diverse nuclear events
    • Rossetto D, Avvakumov N, and Côté J (2012) Histone phosphorylation: a chromatin modification involved in diverse nuclear events. Epigenetics 7:1098-1108.
    • (2012) Epigenetics , vol.7 , pp. 1098-1108
    • Rossetto, D.1    Avvakumov, N.2    Côté, J.3
  • 141
    • 84875538389 scopus 로고    scopus 로고
    • miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease
    • Rossi M, Pitari MR, Amodio N, Di Martino MT, Conforti F, Leone E, Botta C, Paolino FM, Del Giudice T, and Iuliano E, et al. (2013) miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol 228:1506-1515.
    • (2013) J Cell Physiol , vol.228 , pp. 1506-1515
    • Rossi, M.1    Pitari, M.R.2    Amodio, N.3    Di Martino, M.T.4    Conforti, F.5    Leone, E.6    Botta, C.7    Paolino, F.M.8    Del Giudice, T.9    Iuliano, E.10
  • 144
    • 84899785349 scopus 로고    scopus 로고
    • Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice
    • Sanders YY, Hagood JS, Liu H, Zhang W, Ambalavanan N, and Thannickal VJ (2014) Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J 43:1448-1458.
    • (2014) Eur Respir J , vol.43 , pp. 1448-1458
    • Sanders, Y.Y.1    Hagood, J.S.2    Liu, H.3    Zhang, W.4    Ambalavanan, N.5    Thannickal, V.J.6
  • 145
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed D, Hong C, Chen IY, Lypowy J, and Abdellatif M (2007) MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100:416-424.
    • (2007) Circ Res , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Chen, I.Y.3    Lypowy, J.4    Abdellatif, M.5
  • 147
    • 84901495661 scopus 로고    scopus 로고
    • Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life
    • Sela M, Kloog Y, and Rechavi O (2014) Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life. J Physiol 592:2369-2373.
    • (2014) J Physiol , vol.592 , pp. 2369-2373
    • Sela, M.1    Kloog, Y.2    Rechavi, O.3
  • 148
    • 67651111989 scopus 로고    scopus 로고
    • Downregulation of miR-133 and miR-590 contributes to nicotineinducedatrial remodelling in canines
    • Shan H, Zhang Y, Lu Y, Zhang Y, Pan Z, Cai B, Wang N, Li X, Feng T, and Hong Y, et al. (2009) Downregulation of miR-133 and miR-590 contributes to nicotineinducedatrial remodelling in canines. Cardiovasc Res 83:465-472.
    • (2009) Cardiovasc Res , vol.83 , pp. 465-472
    • Shan, H.1    Zhang, Y.2    Lu, Y.3    Zhang, Y.4    Pan, Z.5    Cai, B.6    Wang, N.7    Li, X.8    Feng, T.9    Hong, Y.10
  • 149
    • 84908165234 scopus 로고    scopus 로고
    • Epigenomic programing: A future way to health?
    • Shenderov BA and Midtvedt T (2014) Epigenomic programing: a future way to health? Microb Ecol Health Dis 25:24145-24152.
    • (2014) Microb Ecol Health Dis , vol.25 , pp. 24145-24152
    • Shenderov, B.A.1    Midtvedt, T.2
  • 150
    • 84876952651 scopus 로고    scopus 로고
    • SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis
    • Simic P, Williams EO, Bell EL, Gong JJ, Bonkowski M, and Guarente L (2013) SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Reports 3:1175-1186.
    • (2013) Cell Reports , vol.3 , pp. 1175-1186
    • Simic, P.1    Williams, E.O.2    Bell, E.L.3    Gong, J.J.4    Bonkowski, M.5    Guarente, L.6
  • 153
    • 84889077185 scopus 로고    scopus 로고
    • Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2
    • Stefanska B, Suderman M, Machnes Z, Bhattacharyya B, Hallett M, and Szyf M (2013) Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2. Carcinogenesis 34: 2738-2749.
    • (2013) Carcinogenesis , vol.34 , pp. 2738-2749
    • Stefanska, B.1    Suderman, M.2    Machnes, Z.3    Bhattacharyya, B.4    Hallett, M.5    Szyf, M.6
  • 154
    • 34247179606 scopus 로고    scopus 로고
    • The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair
    • Stramer BM, Mori R, and Martin P (2007) The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J Invest Dermatol 127: 1009-1017.
    • (2007) J Invest Dermatol , vol.127 , pp. 1009-1017
    • Stramer, B.M.1    Mori, R.2    Martin, P.3
  • 155
    • 70350738517 scopus 로고    scopus 로고
    • The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    • Strieter RM, Keeley EC, Hughes MA, Burdick MD, and Mehrad B (2009) The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol 86:1111-1118.
    • (2009) J Leukoc Biol , vol.86 , pp. 1111-1118
    • Strieter, R.M.1    Keeley, E.C.2    Hughes, M.A.3    Burdick, M.D.4    Mehrad, B.5
  • 156
    • 84904647822 scopus 로고    scopus 로고
    • DNA methyltransferases: A novel target for prevention and therapy
    • Subramaniam D, Thombre R, Dhar A, and Anant S (2014) DNA methyltransferases: a novel target for prevention and therapy. Front Oncol 4:80.
    • (2014) Front Oncol , vol.4 , pp. 80
    • Subramaniam, D.1    Thombre, R.2    Dhar, A.3    Anant, S.4
  • 158
    • 84879251931 scopus 로고    scopus 로고
    • The epigenetic feedback loop between DNA methylation and microRNAs in fibrotic disease with an emphasis on DNA methyltransferases
    • Sun X, He Y, Huang C, Ma TT, and Li J (2013) The epigenetic feedback loop between DNA methylation and microRNAs in fibrotic disease with an emphasis on DNA methyltransferases. Cell Signal 25:1870-1876.
    • (2013) Cell Signal , vol.25 , pp. 1870-1876
    • Sun, X.1    He, Y.2    Huang, C.3    Ma, T.T.4    Li, J.5
  • 159
    • 0037133565 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG islands in human chromosomes 21 and 22
    • Takai D and Jones PA (2002) Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA 99:3740-3745.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3740-3745
    • Takai, D.1    Jones, P.A.2
  • 161
    • 0035891265 scopus 로고    scopus 로고
    • A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
    • Tamaru H and Selker EU (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414:277-283.
    • (2001) Nature , vol.414 , pp. 277-283
    • Tamaru, H.1    Selker, E.U.2
  • 164
    • 84874958737 scopus 로고    scopus 로고
    • Function and fate of myofibroblasts after myocardial infarction
    • Turner NA and Porter KE (2013) Function and fate of myofibroblasts after myocardial infarction. Fibrogenesis Tissue Repair 6:5.
    • (2013) Fibrogenesis Tissue Repair , vol.6 , pp. 5
    • Turner, N.A.1    Porter, K.E.2
  • 168
    • 73549111067 scopus 로고    scopus 로고
    • Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation
    • Venugopal SK, Jiang J, Kim TH, Li Y, Wang SS, Torok NJ, Wu J, and Zern MA (2010) Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol 298:G101-G106.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G101-G106
    • Venugopal, S.K.1    Jiang, J.2    Kim, T.H.3    Li, Y.4    Wang, S.S.5    Torok, N.J.6    Wu, J.7    Zern, M.A.8
  • 169
    • 84900541013 scopus 로고    scopus 로고
    • Hepatic fibrosis and the microenvironment: Fertile soil for hepatocellular carcinoma development
    • Wallace MC and Friedman SL (2014) Hepatic fibrosis and the microenvironment: fertile soil for hepatocellular carcinoma development. Gene Expr 16:77-84.
    • (2014) Gene Expr , vol.16 , pp. 77-84
    • Wallace, M.C.1    Friedman, S.L.2
  • 170
    • 77954274715 scopus 로고    scopus 로고
    • E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta
    • Wang B, Herman-Edelstein M, Koh P, Burns W, Jandeleit-Dahm K, Watson A, Saleem M, Goodall GJ, Twigg SM, and Cooper ME, et al. (2010) E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta. Diabetes 59:1794-1802.
    • (2010) Diabetes , vol.59 , pp. 1794-1802
    • Wang, B.1    Herman-Edelstein, M.2    Koh, P.3    Burns, W.4    Jandeleit-Dahm, K.5    Watson, A.6    Saleem, M.7    Goodall, G.J.8    Twigg, S.M.9    Cooper, M.E.10
  • 172
    • 84894252009 scopus 로고    scopus 로고
    • MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart
    • Wang BW, Wu GJ, Cheng WP, and Shyu KG (2014) MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart. PLoS ONE 9:e84188.
    • (2014) PLoS ONE , vol.9
    • Wang, B.W.1    Wu, G.J.2    Cheng, W.P.3    Shyu, K.G.4
  • 174
    • 34247277178 scopus 로고    scopus 로고
    • Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma
    • Wang L, Wang WL, Zhang Y, Guo SP, Zhang J, and Li QL (2007) Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. Hepatol Res 37:389-396.
    • (2007) Hepatol Res , vol.37 , pp. 389-396
    • Wang, L.1    Wang, W.L.2    Zhang, Y.3    Guo, S.P.4    Zhang, J.5    Li, Q.L.6
  • 175
    • 57349186092 scopus 로고    scopus 로고
    • MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
    • Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X, and Quigg RJ (2008a) MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J 22:4126-4135.
    • (2008) FASEB J , vol.22 , pp. 4126-4135
    • Wang, Q.1    Wang, Y.2    Minto, A.W.3    Wang, J.4    Shi, Q.5    Li, X.6    Quigg, R.J.7
  • 176
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y, Fan PS, and Kahaleh B (2006) Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 54:2271-2279.
    • (2006) Arthritis Rheum , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.S.2    Kahaleh, B.3
  • 179
    • 33744944779 scopus 로고    scopus 로고
    • Epithelial origin of myofibroblasts during fibrosis in the lung
    • Willis BC, duBois RM, and Borok Z (2006) Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc 3:377-382.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 377-382
    • Willis, B.C.1    Du Bois, R.M.2    Borok, Z.3
  • 181
    • 84864100255 scopus 로고    scopus 로고
    • Nickel-induced epithelialmesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation
    • Wu CH, Tang SC, Wang PH, Lee H, and Ko JL (2012) Nickel-induced epithelialmesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem 287:25292-25302.
    • (2012) J Biol Chem , vol.287 , pp. 25292-25302
    • Wu, C.H.1    Tang, S.C.2    Wang, P.H.3    Lee, H.4    Ko, J.L.5
  • 183
    • 84862909357 scopus 로고    scopus 로고
    • The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression
    • Xiong M, Jiang L, Zhou Y, Qiu W, Fang L, Tan R, Wen P, and Yang J (2012) The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression. Am J Physiol Renal Physiol 302:F369-F379.
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F369-F379
    • Xiong, M.1    Jiang, L.2    Zhou, Y.3    Qiu, W.4    Fang, L.5    Tan, R.6    Wen, P.7    Yang, J.8
  • 184
    • 84884494821 scopus 로고    scopus 로고
    • The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells
    • Yamada M, Kubo H, Ota C, Takahashi T, Tando Y, Suzuki T, Fujino N, Makiguchi T, Takagi K, and Suzuki T, et al. (2013) The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells. Respir Res 14:95.
    • (2013) Respir Res , vol.14 , pp. 14-95
    • Yamada, M.1    Kubo, H.2    Ota, C.3    Takahashi, T.4    Tando, Y.5    Suzuki, T.6    Fujino, N.7    Makiguchi, T.8    Takagi, K.9    Suzuki, T.10
  • 187
    • 79951974174 scopus 로고    scopus 로고
    • Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction
    • Yao Q, Cao S, Li C, Mengesha A, Kong B, and Wei M (2011) Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction. Int J Cancer 128:1783-1792.
    • (2011) Int J Cancer , vol.128 , pp. 1783-1792
    • Yao, Q.1    Cao, S.2    Li, C.3    Mengesha, A.4    Kong, B.5    Wei, M.6
  • 189
    • 77953806617 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro
    • Yu J, Zhang S, Chu ES, Go MY, Lau RH, Zhao J, Wu CW, Tong L, Zhao J, and Poon TC, et al. (2010) Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. Int J Biochem Cell Biol 42:948-957.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 948-957
    • Yu, J.1    Zhang, S.2    Chu, E.S.3    Go, M.Y.4    Lau, R.H.5    Zhao, J.6    Wu, C.W.7    Tong, L.8    Zhao, J.9    Poon, T.C.10
  • 190
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, and Kalluri R (2003) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9:964-968.
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6    Kalluri, R.7
  • 191
    • 84953886622 scopus 로고    scopus 로고
    • Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
    • published ahead of print
    • Zerr P, Palumbo-Zerr K, Huang J, Tomcik M, Sumova B, Distler O, Schett G, and Distler JH (2014) Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis. Ann Rheum Dis DOI: 10.1136/annrheumdis-2014-205740 [published ahead of print].
    • (2014) Ann Rheum Dis
    • Zerr, P.1    Palumbo-Zerr, K.2    Huang, J.3    Tomcik, M.4    Sumova, B.5    Distler, O.6    Schett, G.7    Distler, J.H.8
  • 192
    • 77955419042 scopus 로고    scopus 로고
    • Tectorigenin inhibits the in vitro proliferation and enhances miR-338∗ expression of pulmonary fibroblasts in rats with idiopathic pulmonary fibrosis
    • Zhang H, Liu X, Chen S, Wu J, Ye X, Xu L, Chen H, Zhang D, Tan R, and Wang Y (2010) Tectorigenin inhibits the in vitro proliferation and enhances miR-338∗ expression of pulmonary fibroblasts in rats with idiopathic pulmonary fibrosis. J Ethnopharmacol 131:165-173.
    • (2010) J Ethnopharmacol , vol.131 , pp. 165-173
    • Zhang, H.1    Liu, X.2    Chen, S.3    Wu, J.4    Ye, X.5    Xu, L.6    Chen, H.7    Zhang, D.8    Tan, R.9    Wang, Y.10
  • 193
    • 79957892087 scopus 로고    scopus 로고
    • The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice
    • Zhang QJ, Chen HZ, Wang L, Liu DP, Hill JA, and Liu ZP (2011) The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest 121:2447-2456.
    • (2011) J Clin Invest , vol.121 , pp. 2447-2456
    • Zhang, Q.J.1    Chen, H.Z.2    Wang, L.3    Liu, D.P.4    Hill, J.A.5    Liu, Z.P.6
  • 194
    • 84884852643 scopus 로고    scopus 로고
    • Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblasts
    • Zhang X, Liu H, Hock T, Thannickal VJ, and Sanders YY (2013a) Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblasts. Int J Mol Sci 14: 19605-19617.
    • (2013) Int J Mol Sci , vol.14 , pp. 19605-19617
    • Zhang, X.1    Liu, H.2    Hock, T.3    Thannickal, V.J.4    Sanders, Y.Y.5
  • 195
    • 84899982846 scopus 로고    scopus 로고
    • miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGFβ/Smad3 signaling
    • Zhang Y, Huang XR, Wei LH, Chung AC, Yu CM, and Lan HY (2014) miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGFβ/Smad3 signaling. Mol Ther 22:974-985.
    • (2014) Mol Ther , vol.22 , pp. 974-985
    • Zhang, Y.1    Huang, X.R.2    Wei, L.H.3    Chung, A.C.4    Yu, C.M.5    Lan, H.Y.6
  • 196
    • 0035883954 scopus 로고    scopus 로고
    • Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails
    • Zhang Y and Reinberg D (2001) Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 15:2343-2360.
    • (2001) Genes Dev , vol.15 , pp. 2343-2360
    • Zhang, Y.1    Reinberg, D.2
  • 197
    • 84891387376 scopus 로고    scopus 로고
    • The autoregulatory feedback loop of microRNA-21/programmed cell death protein4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development
    • Zhang Z, Zha Y, Hu W, Huang Z, Gao Z, Zang Y, Chen J, Dong L, and Zhang J (2013b) The autoregulatory feedback loop of microRNA-21/programmed cell death protein4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development. J Biol Chem 288:37082-37093.
    • (2013) J Biol Chem , vol.288 , pp. 37082-37093
    • Zhang, Z.1    Zha, Y.2    Hu, W.3    Huang, Z.4    Gao, Z.5    Zang, Y.6    Chen, J.7    Dong, L.8    Zhang, J.9
  • 198
    • 84877578496 scopus 로고    scopus 로고
    • DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B
    • Zhao Q, Fan YC, Zhao J, Gao S, Zhao ZH, and Wang K (2013a) DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B. J Viral Hepat 20: 430-437.
    • (2013) J Viral Hepat , vol.20 , pp. 430-437
    • Zhao, Q.1    Fan, Y.C.2    Zhao, J.3    Gao, S.4    Zhao, Z.H.5    Wang, K.6
  • 199
    • 84873036497 scopus 로고    scopus 로고
    • Epigenetic modifications in hepatic stellate cells contribute to liver fibrosis
    • Zhao Q, Qin CY, Zhao ZH, Fan YC, and Wang K (2013b) Epigenetic modifications in hepatic stellate cells contribute to liver fibrosis. Tohoku J Exp Med 229: 35-43.
    • (2013) Tohoku J Exp Med , vol.229 , pp. 35-43
    • Zhao, Q.1    Qin, C.Y.2    Zhao, Z.H.3    Fan, Y.C.4    Wang, K.5
  • 200
    • 84869426437 scopus 로고    scopus 로고
    • Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal
    • Zheng L, Chen X, Guo J, Sun H, Liu L, Shih DQ, and Zhang X (2012) Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal. Int J Mol Med 30:1424-1430.
    • (2012) Int J Mol Med , vol.30 , pp. 1424-1430
    • Zheng, L.1    Chen, X.2    Guo, J.3    Sun, H.4    Liu, L.5    Shih, D.Q.6    Zhang, X.7
  • 201
  • 202
    • 84863389824 scopus 로고    scopus 로고
    • Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts
    • Zhou L, Wang L, Lu L, Jiang P, Sun H, and Wang H (2012) Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts. PLoS ONE 7:e33766.
    • (2012) PLoS ONE , vol.7
    • Zhou, L.1    Wang, L.2    Lu, L.3    Jiang, P.4    Sun, H.5    Wang, H.6
  • 203
    • 84885100164 scopus 로고    scopus 로고
    • MicroRNAs: Their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma
    • Zhu H, Luo H, and Zuo X (2013) MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma. Exp Mol Med 45:e41.
    • (2013) Exp Mol Med , vol.45 , pp. e41
    • Zhu, H.1    Luo, H.2    Zuo, X.3


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