DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

Toxicology and Applied Pharmacology

Volumn 264, Issue 1, 2012, Pages 13-22

  Bian, Er Bao ^a   Huang, Cheng ^a   Ma, Tao Tao ^a   Tao, Hui ^a   Zhang, Hui ^a   Cheng, Chang ^a   Lv, Xiong Wen ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

DNA methylation; DNA methyltransferase 1 (DNMT1); Hepatic stellate cell (HSC); Liver fibrosis; Phosphatase and tension homolog deleted on chromosome 10 (PTEN)

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FIBROGENESIS; GENE EXPRESSION; GENE SILENCING; LIVER FIBROGENESIS; MALE; NONHUMAN; PROMOTER REGION; PROTEIN METHYLATION; RAT; RECEPTOR UPREGULATION; STELLATE CELL;

ANIMALS; AZACITIDINE; CELL LINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

RATTUS;

EID: 84866000151     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.06.022     Document Type: Article

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