Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 35, 2008, Pages 13027-13032

  Van Rooij, Eva ^a   Sutherland, Lillian B ^a   Thatcher, Jeffrey E ^b   DiMaio, J Michael ^b   Naseem, R Haris ^b   Marshall, William S ^c   Hill, Joseph A ^b   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c miRagen Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; MICRORNA; MIR 29; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HEART FAILURE; HEART HYPERTROPHY; HEART INFARCTION; HEART MUSCLE FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COLLAGEN; COS CELLS; DOWN-REGULATION; ENDOMYOCARDIAL FIBROSIS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; MODELS, BIOLOGICAL; MYOCARDIAL INFARCTION; RNA, MESSENGER;

MUS;

EID: 51349141401     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805038105     Document Type: Article

References (32)

1. Fox CS, et al. (2007) Increasing cardiovascular disease burden due to diabetes mellitus: The Framingham Heart Study. Circulation 115:1544-1550.
2. Swynghedauw B (1999) Molecular mechanisms of myocardial remodeling. Physiol Rev 79:215-262.
3. Bouzeghrane F, Reinhardt DP, Reudelhuber TL, Thibault G (2005) Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosis. Am J Physiol Heart Circ Physiol 289:H982-991.
4. Powell DW, et al. (1999) Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 277:C1-C9.
5. Cheng Y, et al. (2007) MicroRNAs are aberrantly expressed in hypertrophic heart: Do they play a role in cardiac hypertrophy? Am J Pathol 170:1831-1840.
6. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M (2007) MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100:416-424.
7. Tatsuguchi M, et al. (2007) Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 42:1137-1141.
8. Thum T, et al. (2007) MicroRNAs in the human heart. A clue to fetal gene reprogramming in heart failure. Circulation 116:258-267.
9. van Rooij E, et al. (2006) A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA 103(48):18255-18260.
10. Ikeda S, et al. (2007) Altered microRNA expression in human heart disease. Physiol Genomics 31:367-373.
11. van Rooij E, Olson EN (2007) MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest 117:2369-2376.
12. van Rooij E, Olson EN (2007) microRNAs put their signatures on the heart. Physiol Genomics 31:365-366.
13. Bartel DP (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297.
14. Ambros V (2003) MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing. Cell 113:673-676.
15. Hammond SM (2006) MicroRNAs as oncogenes. Curr Opin Genet Dev 16:4-9.
16. Berezikov E, et al. (2005) Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120:21-24.
17. McDonald K (2008) Diastolic heart failure in the elderly: Underlying mechanisms and clinical relevance. Int J Cardiol 125:197-202.
18. Border WA, Noble NA (1994) Transforming growth factor beta in tissue fibrosis. N Engl J Med 331:1286-1292.
19. Pillai RS, Bhattacharyya SN, Filipowicz W (2007) Repression of protein synthesis by miRNAs: How many mechanisms? Trends Cell Biol 17:118-126.
20. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R (2006) Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20:515-524.
21. Krutzfeldt J, et al. (2007) Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res 35:2885-2892.
22. Krutzfeldt J, et al. (2005) Silencing of microRNAs in vivo with "antagomirs." Nature 438:685-689.
23. Lijnen PJ, Petrov VV, Fagard RH (2000) Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol Genet Metab 71:418-435.
24. Kapoun AM, et al. (2004) B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: Fibrosis, myofibroblast conversion, proliferation, and inflammation. Circ Res 94:453-461.
25. He A, Zhu L, Gupta N, Chang Y, Fang F (2007) Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol 21:2785-2794.
26. Fabbri M, et al. (2007) MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 104:15805-15810.
27. Leung AK, Sharp PA (2007) microRNAs: A safeguard against turmoil? Cell 130:581-585.
28. Diez J (2007) Mechanisms of cardiac fibrosis in hypertension. J Clin Hypertens (Greenwich) 9:546-550.
29. Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214:199-210.
30. Sengupta S, et al. (2008) MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci USA 105:5874-5878.
31. Shelton JM, Lee MH, Richardson JA, Patel SB (2000) Microsomal triglyceride transfer protein expression during mouse development. J Lipid Res 41:532-537.
32. Simpson P, Savion S (1982) Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res 50:101-116.