Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy

Biochemical and Biophysical Research Communications

Volumn 444, Issue 4, 2014, Pages 455-460

  Bao, Hao ^a   Hu, Shuai ^a   Zhang, Changming ^a   Shi, Shaolin ^a   Qin, Weisong ^a   Zeng, Caihong ^a   Zen, Ke ^a   Liu, Zhihong ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Fibrogenic activation; IgA nephropathy; miRNA 21

Indexed keywords

FIBROGENIC ACTIVATION; IGA NEPHROPATHY; MIRNA-21;

CELL LINE; CYTOKINES; GLOMERULONEPHRITIS, IGA; HUMANS; KIDNEY TUBULES; MESANGIAL CELLS; MICRORNAS; PODOCYTES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84894601419     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.065     Document Type: Article

References (28)

1. G. D'Amico The commonest glomerulonephritis in the world: IgA nephropathy Q. J. Med. 64 1987 709 727
2. H. Lee, S.H. Yi, M.S. Seo, J.N. Hyun, J.S. Jeon, H. Noh, D.C. Han, S.D. Hwang, S.Y. Jin, and S.H. Kwon Validation of the Oxford classification of IgA nephropathy: A single-center study in Korean adults Korean J. Intern. Med. 27 2012 293 300
3. C.H. Zeng, W. Le, Z. Ni, M. Zhang, L. Miao, P. Luo, R. Wang, Z. Lv, J. Chen, J. Tian, N. Chen, X. Pan, P. Fu, Z. Hu, L. Wang, Q. Fan, H. Zheng, D. Zhang, Y. Wang, Y. Huo, H. Lin, S. Chen, S. Sun, Y. Wang, Z. Liu, D. Liu, L. Ma, T. Pan, A. Zhang, X. Jiang, C. Xing, B. Sun, Q. Zhou, W. Tang, F. Liu, Y. Liu, S. Liang, F. Xu, Q. Huang, H. Shen, J. Wang, Y. Shyr, S. Phillips, S. Trojanov, A. Fogo, and Z.H. Liu A multicenter application and evaluation of the oxford classification of IgA nephropathy in adult Chinese patients Am. J. Kidney Dis. 60 2012 812 820
4. K.K. El, G.S. Hill, A. Karras, L. Moulonguet, V. Caudwell, A. Loupy, P. Bruneval, C. Jacquot, and D. Nochy Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies Kidney Int. 79 2011 643 654
5. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, and T. Tuschl Identification of novel genes coding for small expressed RNAs Science 294 2001 853 858
6. K. Bhatt, Q.S. Mi, and Z. Dong MicroRNAs in kidneys: biogenesis, regulation, and pathophysiological roles Am. J. Physiol. Renal Physiol. 300 2011 F602 F610
7. W. Le, S. Liang, Y. Hu, K. Deng, H. Bao, C. Zeng, and Z. Liu Long-term renal survival and related risk factors in patients with IgA nephropathy: results from a cohort of 1155 cases in a Chinese adult population Nephrol. Dial. Transplant. 27 2012 1479 1485
8. G. Wang, B.C. Kwan, F.M. Lai, K.M. Chow, L.P. Kam-Tao, and C.C. Szeto Expression of microRNAs in the urinary sediment of patients with IgA nephropathy Dis. Markers 28 2010 79 86
9. T. Kobayashi, S. Uehara, T. Ikeda, H. Itadani, and H. Kotani Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells Kidney Int. 64 2003 1632 1642
10. A.A. Divekar, S. Dubey, P.R. Gangalum, and R.R. Singh Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: An apparent paradox in the setting of an inflammatory milieu J. Immunol. 186 2011 924 930
11. X. Zhong, A.C. Chung, H.Y. Chen, X.M. Meng, and H.Y. Lan Smad3-mediated upregulation of miR-21 promotes renal fibrosis J. Am. Soc. Nephrol. 22 2011 1668 1681
12. L. Qi, J. Bart, L.P. Tan, I. Platteel, T. Sluis, S. Huitema, G. Harms, L. Fu, H. Hollema, and A. Berg Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma BMC Cancer 9 2009 163
13. J.C. Leung, L.Y. Chan, S.C. Tang, M.F. Lam, C.W. Chow, A.I. Lim, and K.N. Lai Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone J. Transl. Med. 9 2011 169
14. Y. Xu, J. Kulkosky, E. Acheampong, G. Nunnari, J. Sullivan, and R.J. Pomerantz HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy Proc. Natl. Acad. Sci. USA 101 2004 7070 7075
15. R. Gong, A. Rifai, Y. Ge, S. Chen, and L.D. Dworkin Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells J. Biol. Chem. 283 2008 7401 7410
16. V. Jazbutyte, and T. Thum MicroRNA-21: from cancer to cardiovascular disease Curr. Drug Targets 11 2010 926 935
17. A. Zarjou, S. Yang, E. Abraham, A. Agarwal, and G. Liu Identification of a microRNA signature in renal fibrosis: role of miR-21 Am. J. Physiol. Renal Physiol. 301 2011 F793 F801
18. A.P. Kong, K. Xiao, K.C. Choi, G. Wang, M.H. Chan, C.S. Ho, I. Chan, C.K. Wong, J.C. Chan, and C.C. Szeto Associations between microRNA (miR-21, 126, 155 and 221), albuminuria and heavy metals in Hong Kong Chinese adolescents Clin. Chim. Acta. 413 2012 1053 1057
19. L.Y. Chan, J.C. Leung, A.W. Tsang, S.C. Tang, and K.N. Lai Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy Kidney Int. 67 2005 602 612
20. K.N. Lai, J.C. Leung, L.Y. Chan, M.A. Saleem, P.W. Mathieson, F.M. Lai, and S.C. Tang Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy Am. J. Physiol. Renal Physiol. 294 2008 F945 F955
21. Y. Li, Y.S. Kang, C. Dai, L.P. Kiss, X. Wen, and Y. Liu Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria Am. J. Pathol. 172 2008 299 308
22. B. Wang, R. Komers, R. Carew, C.E. Winbanks, B. Xu, M. Herman-Edelstein, P. Koh, M. Thomas, K. Jandeleit-Dahm, P. Gregorevic, M.E. Cooper, and P. Kantharidis Suppression of microRNA-29 expression by TGF-beta1 promotes collagen expression and renal fibrosis J. Am. Soc. Nephrol. 23 2012 252 265
23. Y. Liu New insights into epithelial-mesenchymal transition in kidney fibrosis J. Am. Soc. Nephrol. 21 2010 212 222
24. B.H. Jiang, and L.Z. Liu PI3K/PTEN signaling in angiogenesis and tumorigenesis Adv. Cancer Res. 102 2009 19 65
25. K.A. Bowen, H.Q. Doan, B.P. Zhou, Q. Wang, Y. Zhou, P.G. Rychahou, and B.M. Evers PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells Anticancer Res. 29 2009 4439 4449
26. F. Meng, R. Henson, M. Lang, H. Wehbe, S. Maheshwari, J.T. Mendell, J. Jiang, T.D. Schmittgen, and T. Patel Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines Gastroenterology 130 2006 2113 2129
27. Y. Yao, H. Wei, L. Liu, L. Liu, S. Bai, C. Li, Y. Luo, R. Zeng, M. Han, S. Ge, and G. Xu Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation J. Huazhong Univ. Sci. Technol. Med. Sci. 31 2011 469 475
28. M.D. Jamie Lin, M.D. Jing Xu, W.E.M. PhD, F. MD, M.D. Zhaoyong Hu. PTEN Deletion in Podocytes: A Potential General Mechanism Causing Foot Processes Effacement and Proteinuria, ASN, FR-PO688, 2012.