Disruption of Smad4 impairs TGF-Β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

Kidney International

Volumn 81, Issue 3, 2012, Pages 266-279

  Meng, Xiao Ming ^a   Huang, Xiao Ru ^a   Xiao, Jun ^a   Chung, Arthur C K ^a   Qin, Wei ^a   Chen, Hai Yong ^a   Lan, Hui Yao ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

fibrosis; inflammation; Smad4; TGF b1 signaling

Indexed keywords

CD45 ANTIGEN; COLLAGEN TYPE 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; FIBROBLAST; FIBROGENESIS; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION REGULATION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; KNOCKOUT MOUSE; LEUKOCYTE; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NEPHRITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; URETER OBSTRUCTION;

EID: 84856691720     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.327     Document Type: Article

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