Both ERK/MAPK and TGF-Beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation

Journal of Diabetes Research

Volumn 2013, Issue , 2013, Pages

  Cheng, Xiaoyun ^a   Gao, Wenke ^b   Dang, Yongyan ^b   Liu, Xia ^b   Li, Yujuan ^b   Peng, Xu ^b   Ye, Xiyun ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; GLUCOSE; INTERSTITIAL COLLAGENASE; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; DIABETIC NEPHROPATHY; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; KIDNEY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD GLUCOSE; COLLAGEN TYPE I; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FIBROSIS; KIDNEY; MALE; MATRIX METALLOPROTEINASE 1; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84881395137     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2013/463740     Document Type: Article

References (26)

1. del Prato S., In search of normoglycaemia in diabetes: controlling postprandial glucose. International Journal of Obesity 2002 26 3 S9 S17 2-s2.0-0036733143 10.1038/sj.ijo.0802172 (Pubitemid 35034477)
2. Ceriello A., The emerging role of post-prandial hyperglycaemic spikes in the pathogenesis of diabetic complications. Diabetic Medicine 1998 15 188 193 (Pubitemid 28126152)
3. Bonora E., Muggeo M., Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence. Diabetologia 2001 44 12 2107 2114 2-s2.0-0035675342 10.1007/s001250100020 (Pubitemid 34015463)
4. Piconi L., Quagliaro L., da Ros R., Assaloni R., Giugliano D., Esposito K., Szabó C., Ceriello A., Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. Journal of Thrombosis and Haemostasis 2004 2 8 1453 1459 2-s2.0-13244262637 10.1111/j.1538-7836.2004. 00835.x (Pubitemid 40186145)
5. Quagliaro L., Piconi L., Assaloni R., Martinelli L., Motz E., Ceriello A., Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003 52 11 2795 2804 2-s2.0-0242300561 10.2337/diabetes.52.11.2795 (Pubitemid 37339710)
6. Quagliaro L., Piconi L., Assaloni R., Da Ros R., Maier A., Zuodar G., Ceriello A., Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005 183 2 259 267 2-s2.0-27644459845 10.1016/j.atherosclerosis. 2005.03.015 (Pubitemid 41579276)
7. Gross J. L., de Azevedo M. J., Silveiro S. P., Canani L. H., Caramori M. L., Zelmanovitz T., Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 2005 28 1 164 176 2-s2.0-11844291920 10.2337/diacare.28.1.164 (Pubitemid 40095801)
8. Liu Y., Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney International 2006 69 2 213 217 2-s2.0-33644638349 10.1038/sj.ki.5000054 (Pubitemid 43323069)
9. Nishida M., Okumura Y., Sato H., Hamaoka K., Delayed inhibition of p38 mitogen-activated protein kinase ameliorates renal fibrosis in obstructive nephropathy. Nephrology Dialysis Transplantation 2008 23 8 2520 2524 2-s2.0-48749112845 10.1093/ndt/gfn309
10. Wang W., Koka V., Lan H. Y., Transforming growth factor- β and Smad signalling in kidney diseases. Nephrology 2005 10 1 48 56 2-s2.0-14844337071 10.1111/j.1440-1797.2005.00334.x (Pubitemid 40349406)
11. Azuma K., Kawamori R., Toyofuku Y., Kitahara Y., Sato F., Shimizu T., Miura K., Mine T., Tanaka Y., Mitsumata M., Watada H., Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta. Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 10 2275 2280 2-s2.0-33749074727 10.1161/01.ATV.0000239488.05069.03 (Pubitemid 44465722)
12. Piconi L., Quagliaro L., Assaloni R., Da Ros R., Maier A., Zuodar G., Ceriello A., Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes/Metabolism Research and Reviews 2006 22 3 198 203 2-s2.0-33744473330 10.1002/dmrr.613 (Pubitemid 43805400)
13. Risso A., Mercuri F., Quagliaro L., Damante G., Ceriello A., Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture. American Journal of Physiology-Endocrinology and Metabolism 2001 281 5 E924 E930 2-s2.0-0035199659
14. Monnier L., Mas E., Ginet C., Michel F., Villon L., Cristol J.-P., Colette C., Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. Journal of the American Medical Association 2006 295 14 1681 1687 2-s2.0-33645745733 10.1001/jama.295.14.1681
15. Ye X., Tong Z., Dang Y., Tu Q., Weng Y., Liu J., Zhang Z., Effects of blood glucose fluctuation on skin biophysical properties, structure and antioxidant status in an animal model. Clinical and Experimental Dermatology 2010 35 1 78 82 2-s2.0-71949128285 10.1111/j.1365-2230.2009.03361.x
16. González-Avila G., Iturria C., Vadillo-Ortega F., Ovalle C., Montaño M., Changes in matrix metalloproteinases during the evolution of interstitial renal fibrosis in a rat experimental model. Pathobiology 1998 66 5 196 204 2-s2.0-0031716581 (Pubitemid 28404331)
17. Polhill T. S., Saad S., Poronnik P., Fulcher G. R., Pollock C. A., Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure. American Journal of Physiology-Renal Physiology 2004 287 2 F268 F273 2-s2.0-3242675272 10.1152/ajprenal.00084.2004 (Pubitemid 38943943)
18. Stambe C., Atkins R. C., Tesch G. H., Masaki T., Schreiner G. F., Nikolic-Paterson D. J., The role of p38 α mitogen-activated protein kinase activation in renal fibrosis. Journal of the American Society of Nephrology 2004 15 2 370 379 2-s2.0-0942287102 10.1097/01.ASN.0000109669.23650.56 (Pubitemid 38140777)
19. Sugaru E., Sakai M., Horigome K., Tokunaga T., Kitoh M., Hume W. E., Nagata R., Nakagawa T., Taiji M., SMP-534 inhibits TGF- β -induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis. American Journal of Physiology-Renal Physiology 2005 289 5 F998 F1004 2-s2.0-26844573361 10.1152/ajprenal.00065.2005 (Pubitemid 41447054)
20. Chen R., Huang C., Morinelli T. A., Trojanowska M., Paul R. V., Blockade of the effects of TGF- β 1 on mesangial cells by overexpression of Smad7. Journal of the American Society of Nephrology 2002 13 4 887 893 2-s2.0-0036205654 (Pubitemid 34274084)
21. Kalo E., Buganim Y., Shapira K. E., Besserglick H., Goldfinger N., Weisz L., Stambolsky P., Henis Y. I., Rotter V., Mutant p53 attenuates the SMAD-dependent transforming growth factor β 1 (TGF- β 1) signaling pathway by repressing the expression of TGF- β receptor type II. Molecular and Cellular Biology 2007 27 23 8228 8242 2-s2.0-36849093364 10.1128/MCB.00374-07 (Pubitemid 350234236)
22. Heldin C.-H., Miyazono K., Ten Dijke P., TGF- β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997 390 6659 465 471 2-s2.0-0031438047 10.1038/37284 (Pubitemid 28013118)
23. Ebisawa T., Fukuchi M., Murakami G., Chiba T., Tanaka K., Imamura T., Miyazono K., Smurf1 interacts with transforming growth factor- β type I receptor through smad7 and induces receptor degradation. Journal of Biological Chemistry 2001 276 16 12477 12480 2-s2.0-0035918274 10.1074/jbc.C100008200
24. Chen H. Y., Huang X. R., Wang W., Li J. H., Heuchel R. L., Chung A. C. K., Lan H. Y., The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 2011 60 2 590 601 2-s2.0-79551599216 10.2337/db10-0403
25. Ka S. M., Yeh Y. C., Huang X. R., Chao T. K., Hung Y. J., Yu C. P., Lin T. J., Wu C. C., Lan H. Y., Chen A., Kidney-targeting Smad7 gene transfer inhibits renal TGF- β /MAD homologue (SMAD) and nuclear factor b (NF- B) signalling pathways, and improves diabetic nephropathy in mice. Diabetologia 2012 55 2 509 519 2-s2.0-84856718373 10.1007/s00125-011-2364-5
26. Kattla J. J., Carew R. M., Heljić M., Godson C., Brazil D. P., Protein kinase B/Akt activity is involved in renal TGF- β 1-driven epithelial-mesenchymal transition in vitro and in vivo. American Journal of Physiology-Renal Physiology 2008 295 1 F215 F225 2-s2.0-49949114895 10.1152/ajprenal.00548.2007