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Volumn 35, Issue 3, 2014, Pages 119-126

FibromiRs: Translating molecular discoveries into new anti-fibrotic drugs

Author keywords

drug design; fibrosis; gene targeting; miRNA; therapeutics

Indexed keywords

ANTIFIBROTIC AGENT; FIBROMIR; MICRORNA; MICRORNA 1; MICRORNA 101; MICRORNA 15; MICRORNA 192; MICRORNA 199B; MICRORNA 200B; MICRORNA 208; MICRORNA 21; MICRORNA 24; MICRORNA 29B; MICRORNA 34A; MIRAVIRSEN; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

EID: 84896727760     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.01.003     Document Type: Review
Times cited : (78)

References (55)
  • 1
    • 84872338388 scopus 로고    scopus 로고
    • Therapy for fibrotic diseases: Nearing the starting line
    • S.L. Friedman et al. Therapy for fibrotic diseases: nearing the starting line Sci. Transl. Med. 5 2013 167sr1
    • (2013) Sci. Transl. Med. , vol.5
    • Friedman, S.L.1
  • 2
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • T.A. Wynn Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases J. Clin. Invest. 117 2007 524 529
    • (2007) J. Clin. Invest. , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 3
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: Therapeutic translation for fibrotic disease
    • T.A. Wynn, and T.R. Ramalingam Mechanisms of fibrosis: therapeutic translation for fibrotic disease Nat. Med. 18 2012 1028 1040
    • (2012) Nat. Med. , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 4
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • V. Ambros The functions of animal microRNAs Nature 431 2004 350 355
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 5
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 6
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • R.C. Friedman et al. Most mammalian mRNAs are conserved targets of microRNAs Genome Res. 19 2009 92 105
    • (2009) Genome Res. , vol.19 , pp. 92-105
    • Friedman, R.C.1
  • 7
    • 84856751210 scopus 로고    scopus 로고
    • Developing microRNA therapeutics
    • E. van Rooij et al. Developing microRNA therapeutics Circ. Res. 110 2012 496 507
    • (2012) Circ. Res. , vol.110 , pp. 496-507
    • Van Rooij, E.1
  • 8
    • 84877258007 scopus 로고    scopus 로고
    • Treatment of HCV infection by targeting microRNA
    • H.L. Janssen et al. Treatment of HCV infection by targeting microRNA N. Engl. J. Med. 368 2013 1685 1694
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1685-1694
    • Janssen, H.L.1
  • 9
    • 34247589595 scopus 로고    scopus 로고
    • Control of stress-dependent cardiac growth and gene expression by a microRNA
    • E. van Rooij et al. Control of stress-dependent cardiac growth and gene expression by a microRNA Science 316 2007 575 579
    • (2007) Science , vol.316 , pp. 575-579
    • Van Rooij, E.1
  • 10
    • 67650085171 scopus 로고    scopus 로고
    • TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
    • M. Kato et al. TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN Nat. Cell Biol. 11 2009 881 889
    • (2009) Nat. Cell Biol. , vol.11 , pp. 881-889
    • Kato, M.1
  • 11
    • 84857979740 scopus 로고    scopus 로고
    • Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy
    • S. Putta et al. Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy J. Am. Soc. Nephrol. 23 2012 458 469
    • (2012) J. Am. Soc. Nephrol. , vol.23 , pp. 458-469
    • Putta, S.1
  • 12
    • 84880816481 scopus 로고    scopus 로고
    • Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling
    • I. Karakikes et al. Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling J. Am. Heart Assoc. 2 2013 e000078
    • (2013) J. Am. Heart Assoc. , vol.2 , pp. 000078
    • Karakikes, I.1
  • 13
    • 84878425125 scopus 로고    scopus 로고
    • Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
    • C.A. Gebeshuber et al. Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1 Nat. Med. 19 2013 481 487
    • (2013) Nat. Med. , vol.19 , pp. 481-487
    • Gebeshuber, C.A.1
  • 14
    • 84879902677 scopus 로고    scopus 로고
    • MiR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1
    • H. Zhou et al. miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1 J. Am. Soc. Nephrol. 24 2013 1073 1087
    • (2013) J. Am. Soc. Nephrol. , vol.24 , pp. 1073-1087
    • Zhou, H.1
  • 15
    • 84871099822 scopus 로고    scopus 로고
    • MicroRNAs, transforming growth factor beta-1, and tissue fibrosis
    • T. Bowen et al. MicroRNAs, transforming growth factor beta-1, and tissue fibrosis J. Pathol. 229 2013 274 285
    • (2013) J. Pathol. , vol.229 , pp. 274-285
    • Bowen, T.1
  • 16
    • 77955399498 scopus 로고    scopus 로고
    • Inhibition and role of let-7d in idiopathic pulmonary fibrosis
    • K.V. Pandit et al. Inhibition and role of let-7d in idiopathic pulmonary fibrosis Am. J. Respir. Crit. Care Med. 182 2010 220 229
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , pp. 220-229
    • Pandit, K.V.1
  • 17
    • 84870508377 scopus 로고    scopus 로고
    • Profibrotic role of miR-154 in pulmonary fibrosis
    • J. Milosevic et al. Profibrotic role of miR-154 in pulmonary fibrosis Am. J. Respir. Cell Mol. Biol. 47 2012 879 887
    • (2012) Am. J. Respir. Cell Mol. Biol. , vol.47 , pp. 879-887
    • Milosevic, J.1
  • 18
    • 84859720170 scopus 로고    scopus 로고
    • 2+ overload and cell death
    • 2+ overload and cell death J. Clin. Invest. 122 2012 1222 1232
    • (2012) J. Clin. Invest. , vol.122 , pp. 1222-1232
    • Aurora, A.B.1
  • 19
    • 84867903854 scopus 로고    scopus 로고
    • Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
    • B.C. Bernardo et al. Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function Proc. Natl. Acad. Sci. U.S.A. 109 2012 17615 17620
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 17615-17620
    • Bernardo, B.C.1
  • 20
    • 57749121689 scopus 로고    scopus 로고
    • MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    • N. Liu et al. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart Genes Dev. 22 2008 3242 3254
    • (2008) Genes Dev. , vol.22 , pp. 3242-3254
    • Liu, N.1
  • 21
    • 78649843756 scopus 로고    scopus 로고
    • MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling
    • P.A. da Costa Martins et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling Nat. Cell Biol. 12 2010 1220 1227
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1220-1227
    • Da Costa Martins, P.A.1
  • 22
    • 80053567152 scopus 로고    scopus 로고
    • Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure
    • R.L. Montgomery et al. Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure Circulation 124 2011 1537 1547
    • (2011) Circulation , vol.124 , pp. 1537-1547
    • Montgomery, R.L.1
  • 23
    • 84865206803 scopus 로고    scopus 로고
    • MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-beta1 pathway
    • Z. Pan et al. MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-beta1 pathway Circulation 126 2012 840 850
    • (2012) Circulation , vol.126 , pp. 840-850
    • Pan, Z.1
  • 24
    • 84855350458 scopus 로고    scopus 로고
    • Inhibition of miR-15 protects against cardiac ischemic injury
    • T.G. Hullinger et al. Inhibition of miR-15 protects against cardiac ischemic injury Circ. Res. 110 2012 71 81
    • (2012) Circ. Res. , vol.110 , pp. 71-81
    • Hullinger, T.G.1
  • 25
    • 84865963313 scopus 로고    scopus 로고
    • MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition
    • D. Macconi et al. MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition J. Am. Soc. Nephrol. 23 2012 1496 1505
    • (2012) J. Am. Soc. Nephrol. , vol.23 , pp. 1496-1505
    • Macconi, D.1
  • 26
    • 84863532308 scopus 로고    scopus 로고
    • Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis
    • A.M. Lakner et al. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis Hepatology 56 2012 300 310
    • (2012) Hepatology , vol.56 , pp. 300-310
    • Lakner, A.M.1
  • 27
    • 84873978112 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-17∼92 contributes to the pathogenesis of pulmonary fibrosis
    • D. Dakhlallah et al. Epigenetic regulation of miR-17∼92 contributes to the pathogenesis of pulmonary fibrosis Am. J. Respir. Crit. Care Med. 187 2013 397 405
    • (2013) Am. J. Respir. Crit. Care Med. , vol.187 , pp. 397-405
    • Dakhlallah, D.1
  • 28
    • 69249202575 scopus 로고    scopus 로고
    • Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: Implication in epithelial-mesenchymal interactions
    • N. Pottier et al. Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial- mesenchymal interactions PLoS ONE 4 2009 e6718
    • (2009) PLoS ONE , vol.4 , pp. 6718
    • Pottier, N.1
  • 29
    • 84874779817 scopus 로고    scopus 로고
    • MiR-199a-5p is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1
    • C.L. Lino Cardenas et al. miR-199a-5p is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1 PLoS Genet. 9 2013 e1003291
    • (2013) PLoS Genet. , vol.9 , pp. 1003291
    • Lino Cardenas, C.L.1
  • 30
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • T. Thum et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts Nature 456 2008 980 984
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1
  • 31
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    • E. van Rooij et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis Proc. Natl. Acad. Sci. U.S.A. 105 2008 13027 13032
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 13027-13032
    • Van Rooij, E.1
  • 32
    • 84864773072 scopus 로고    scopus 로고
    • MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
    • W.C. Tsai et al. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis J. Clin. Invest. 122 2012 2884 2897
    • (2012) J. Clin. Invest. , vol.122 , pp. 2884-2897
    • Tsai, W.C.1
  • 33
    • 84878758490 scopus 로고    scopus 로고
    • MiR-145 regulates myofibroblast differentiation and lung fibrosis
    • S. Yang et al. miR-145 regulates myofibroblast differentiation and lung fibrosis FASEB J. 27 2013 2382 2391
    • (2013) FASEB J. , vol.27 , pp. 2382-2391
    • Yang, S.1
  • 34
    • 84863116324 scopus 로고    scopus 로고
    • MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways
    • B.N. Chau et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways Sci. Transl. Med. 4 2012 121ra18
    • (2012) Sci. Transl. Med. , vol.4
    • Chau, B.N.1
  • 35
    • 84865439215 scopus 로고    scopus 로고
    • MicroRNA-24 regulates cardiac fibrosis after myocardial infarction
    • J. Wang et al. MicroRNA-24 regulates cardiac fibrosis after myocardial infarction J. Cell. Mol. Med. 16 2012 2150 2160
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 2150-2160
    • Wang, J.1
  • 36
    • 78149459698 scopus 로고    scopus 로고
    • MiR-200b precursor can ameliorate renal tubulointerstitial fibrosis
    • S. Oba et al. miR-200b precursor can ameliorate renal tubulointerstitial fibrosis PLoS ONE 5 2010 e13614
    • (2010) PLoS ONE , vol.5 , pp. 13614
    • Oba, S.1
  • 37
    • 84874700585 scopus 로고    scopus 로고
    • MicroRNA-34a regulates cardiac ageing and function
    • R.A. Boon et al. MicroRNA-34a regulates cardiac ageing and function Nature 495 2013 107 110
    • (2013) Nature , vol.495 , pp. 107-110
    • Boon, R.A.1
  • 38
    • 77952946050 scopus 로고    scopus 로고
    • MicroRNA-29, a key regulator of collagen expression in systemic sclerosis
    • B. Maurer et al. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Arthritis Rheum. 62 2010 1733 1743
    • (2010) Arthritis Rheum. , vol.62 , pp. 1733-1743
    • Maurer, B.1
  • 39
    • 79960946532 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29
    • W. Qin et al. TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29 J. Am. Soc. Nephrol. 22 2011 1462 1474
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 1462-1474
    • Qin, W.1
  • 40
    • 80051655553 scopus 로고    scopus 로고
    • MiR-29 is a major regulator of genes associated with pulmonary fibrosis
    • L. Cushing et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis Am. J. Respir. Cell Mol. Biol. 45 2011 287 294
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.45 , pp. 287-294
    • Cushing, L.1
  • 41
    • 78751476297 scopus 로고    scopus 로고
    • Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
    • C. Roderburg et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis Hepatology 53 2011 209 218
    • (2011) Hepatology , vol.53 , pp. 209-218
    • Roderburg, C.1
  • 42
    • 79952790398 scopus 로고    scopus 로고
    • MicroRNAs in idiopathic pulmonary fibrosis
    • K.V. Pandit et al. MicroRNAs in idiopathic pulmonary fibrosis Transl. Res. 157 2011 191 199
    • (2011) Transl. Res. , vol.157 , pp. 191-199
    • Pandit, K.V.1
  • 43
    • 77955373730 scopus 로고    scopus 로고
    • MiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    • G. Liu et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis J. Exp. Med. 207 2010 1589 1597
    • (2010) J. Exp. Med. , vol.207 , pp. 1589-1597
    • Liu, G.1
  • 44
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: A potential new class of pharmaceutical drugs
    • D. Bumcrot et al. RNAi therapeutics: a potential new class of pharmaceutical drugs Nat. Chem. Biol. 2 2006 711 719
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 711-719
    • Bumcrot, D.1
  • 45
    • 77949512140 scopus 로고    scopus 로고
    • RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    • C.F. Bennett, and E.E. Swayze RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform Annu. Rev. Pharmacol. Toxicol. 50 2010 259 293
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 259-293
    • Bennett, C.F.1    Swayze, E.E.2
  • 46
    • 84869011885 scopus 로고    scopus 로고
    • RNAi joins the 'Singles Club'
    • V.J. Peschansky et al. RNAi joins the 'Singles Club' Mol. Ther. 20 2012 2010 2011
    • (2012) Mol. Ther. , vol.20 , pp. 2010-2011
    • Peschansky, V.J.1
  • 47
    • 84865688581 scopus 로고    scopus 로고
    • Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression
    • D. Yu et al. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression Cell 150 2012 895 908
    • (2012) Cell , vol.150 , pp. 895-908
    • Yu, D.1
  • 48
    • 71549132206 scopus 로고    scopus 로고
    • Adeno-associated viral vectors and their redirection to cell-type specific receptors
    • S. Michelfelder, and M. Trepel Adeno-associated viral vectors and their redirection to cell-type specific receptors Adv. Genet. 67 2009 29 60
    • (2009) Adv. Genet. , vol.67 , pp. 29-60
    • Michelfelder, S.1    Trepel, M.2
  • 49
    • 84861916258 scopus 로고    scopus 로고
    • MiR-29 inhibits bleomycin-induced pulmonary fibrosis in mice
    • J. Xiao et al. miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice Mol. Ther. 20 2012 1251 1260
    • (2012) Mol. Ther. , vol.20 , pp. 1251-1260
    • Xiao, J.1
  • 50
    • 79953202455 scopus 로고    scopus 로고
    • Silencing of microRNA families by seed-targeting tiny LNAs
    • S. Obad et al. Silencing of microRNA families by seed-targeting tiny LNAs Nat. Genet. 43 2011 371 378
    • (2011) Nat. Genet. , vol.43 , pp. 371-378
    • Obad, S.1
  • 51
    • 80255137053 scopus 로고    scopus 로고
    • MicroRNA-29 in aortic dilation: Implications for aneurysm formation
    • R.A. Boon et al. MicroRNA-29 in aortic dilation: implications for aneurysm formation Circ. Res. 109 2011 1115 1119
    • (2011) Circ. Res. , vol.109 , pp. 1115-1119
    • Boon, R.A.1
  • 52
    • 0035942332 scopus 로고    scopus 로고
    • Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism
    • J.P. Sheehan, and T.M. Phan Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism Biochemistry 40 2001 4980 4989
    • (2001) Biochemistry , vol.40 , pp. 4980-4989
    • Sheehan, J.P.1    Phan, T.M.2
  • 53
    • 78049432896 scopus 로고    scopus 로고
    • Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice
    • D.M. Patrick et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice J. Clin. Invest. 120 2010 3912 3916
    • (2010) J. Clin. Invest. , vol.120 , pp. 3912-3916
    • Patrick, D.M.1
  • 54
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • B.N. Davis et al. SMAD proteins control DROSHA-mediated microRNA maturation Nature 454 2008 56 61
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1
  • 55
    • 77955484492 scopus 로고    scopus 로고
    • Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha
    • B.N. Davis et al. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha Mol. Cell 39 2010 373 384
    • (2010) Mol. Cell , vol.39 , pp. 373-384
    • Davis, B.N.1


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