Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

Annals of the Rheumatic Diseases

Volumn 72, Issue 4, 2013, Pages 614-620

  Krämer, Marlene ^a   Dees, Clara ^a   Huang, Jingang ^a   Schlottmann, Inga ^a   Palumbo Zerr, Katrin ^a   Zerr, Pawel ^a   Gelse, Kolja ^a   Beyer, Christian ^a   Distler, Alfiya ^a   Marquez, Victor E ^b   Distler, Oliver ^c   Schett, Georg ^a   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEAZANEPLANOCIN A; BLEOMYCIN; COLLAGEN; HISTONE H3; HYDROXYPROLINE; LYSINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FRA 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; FIBROBLAST CULTURE; HISTONE METHYLATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SKIN FIBROSIS; WESTERN BLOTTING;

ADULT; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELLS, CULTURED; COLLAGEN; DERMIS; DISEASE MODELS, ANIMAL; DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; FIBROBLASTS; FIBROSIS; FOS-RELATED ANTIGEN-2; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MALE; MICE; MICE, INBRED DBA; MIDDLE AGED; SCLERODERMA, DIFFUSE; YOUNG ADULT;

EID: 84874432715     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-201615     Document Type: Article

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