메뉴 건너뛰기




Volumn 12, Issue 12, 2011, Pages 861-874

Non-coding RNAs in human disease

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MICRORNA; PIWI INTERACTING RNA; PROTEIN P53; SMALL NUCLEOLAR RNA; UNTRANSLATED RNA;

EID: 81355142141     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg3074     Document Type: Review
Times cited : (4097)

References (148)
  • 2
  • 3
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. Nature Rev. Genet. 5, 522-531 (2004).
    • (2004) NatureRev. Genet. , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 4
    • 25444457833 scopus 로고    scopus 로고
    • MicroRNAs: Critical regulators of development cellular physiology and malignancy
    • Mendell, J. T. MicroRNAs: critical regulators of development, cellular physiology and malignancy. Cell Cycle 4, 1179-1184 (2005).
    • (2005) CellCycle , vol.4 , pp. 1179-1184
    • Mendell, J.T.1
  • 5
    • 33645294070 scopus 로고    scopus 로고
    • OncomiRs - MicroRNAs with a role in cancer
    • Esquela-Kerscher, A. & Slack, F. J. OncomiRs - microRNAs with a role in cancer. Nature Rev. Cancer 6, 259-269 (2006).
    • (2006) NatureRev. Cancer , vol.6 , pp. 29-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 6
    • 34247555491 scopus 로고    scopus 로고
    • MicroRNAs as tumor suppressors
    • Hammond, S. M. MicroRNAs as tumor suppressors. Nature Genet. 39, 582-583 (2007).
    • (2007) NatureGenet. , vol.39 , pp. 582-583
    • Hammond, S.M.1
  • 7
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce, C. M. Causes and consequences of microRNA dysregulation in cancer. Nature Rev. Genet. 10, 704-714 (2009).
    • (2009) NatureRev. Genet. , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 9
    • 24644519490 scopus 로고    scopus 로고
    • The transcriptional landscape of the mammalian genome
    • Carninci, P. et al. The transcriptional landscape of the mammalian genome. Science 309, 1559-1563 (2005).
    • (2005) Science , vol.309 , pp. 1559-1563
    • Carninci, P.1
  • 10
    • 34250160256 scopus 로고    scopus 로고
    • RNA maps reveal new RNA classes and a possible function for pervasive transcription
    • Kapranov, P. et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316, 1484-1488 (2007).
    • (2007) Science , vol.316 , pp. 1484-1488
    • Kapranov, P.1
  • 11
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis function and decay
    • Krol, J., Loedige, I. & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nature Rev. Genet. 11, 597-610 (2010).
    • (2010) NatureRev. Genet. , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 12
    • 78650306521 scopus 로고    scopus 로고
    • Small RNA sorting: Matchmaking for argonautes
    • Czech, B. & Hannon, G. J. Small RNA sorting: matchmaking for Argonautes. Nature Rev. Genet. 12, 19-31 (2011).
    • (2011) NatureRev. Genet. , vol.12 , pp. 19-31
    • Czech, B.1    Hannon, G.J.2
  • 13
    • 34248160438 scopus 로고    scopus 로고
    • Developmentally regulated piRNA clusters implicate MILI in transposon control
    • Aravin, A. A., Sachidanandam, R., Girard, A., Fejes-Toth, K. & Hannon, G. J. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316, 744-747 (2007).
    • (2007) Science , vol.316 , pp. 744-747
    • Aravin, A.A.1    Sachidanandam, R.2    Girard, A.3    Fejes-Toth, K.4    Hannon, G.J.5
  • 14
    • 33947273235 scopus 로고    scopus 로고
    • Discrete small RNA-generating loci as master regulators of transposon activity in drosophila
    • Brennecke, J. et al. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128, 1089-1103 (2007).
    • (2007) Cell , vol.128 , pp. 1089-1103
    • Brennecke, J.1
  • 15
    • 33947390781 scopus 로고    scopus 로고
    • A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in drosophila
    • Gunawardane, L. S. et al. A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila. Science 315, 1587-1590 (2007).
    • (2007) Science , vol.315 , pp. 1587-1590
    • Gunawardane, L.S.1
  • 16
    • 0942279615 scopus 로고    scopus 로고
    • Heterochromatic silencing and HP1 localization in drosophila are dependent on the rnai machinery
    • Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303, 669-672 (2004).
    • (2004) Science , vol.303 , pp. 669-672
    • Pal-Bhadra, M.1
  • 17
    • 33947720638 scopus 로고    scopus 로고
    • MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
    • Carmell, M. A. et al. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev. Cell 12, 503-514 (2007).
    • (2007) Dev. Cell , vol.12 , pp. 503-514
    • Carmell, M.A.1
  • 18
    • 77951804331 scopus 로고    scopus 로고
    • MVH in piRNA processing and gene silencing of retrotransposons
    • Kuramochi-Miyagawa, S. et al. MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 24, 887-892 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 887-892
    • Kuramochi-Miyagawa, S.1
  • 19
    • 79956052873 scopus 로고    scopus 로고
    • Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse rasgrf1 locus
    • Watanabe, T. et al. Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332, 848-852 (2011).
    • (2011) Science , vol.332 , pp. 848-852
    • Watanabe, T.1
  • 20
    • 0030604698 scopus 로고    scopus 로고
    • Site-specific ribose methylation of preribosomal RNA: A novel function for small nucleolar RNAs
    • Kiss-László, Z., Henry, Y., Bachellerie, J. P., Caizergues-Ferrer, M. & Kiss, T. Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85, 1077-1088 (1996).
    • (1996) Cell , vol.85 , pp. 1077-1088
    • Kiss-László, Z.1    Henry, Y.2    Bachellerie, J.P.3    Caizergues-Ferrer, M.4    Kiss, T.5
  • 21
    • 0030771087 scopus 로고    scopus 로고
    • Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA
    • Ni, J., Tien, A. L. & Fournier, M. J. Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA. Cell 89, 565-573 (1997).
    • (1997) Cell , vol.89 , pp. 565-573
    • Ni, J.1    Tien, A.L.2    Fournier, M.J.3
  • 22
    • 0037292453 scopus 로고    scopus 로고
    • Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center
    • King, T. H., Liu, B., McCully, R. R. & Fournier, M. J. Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center. Mol. Cell 11, 425-435 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 425-435
    • King, T.H.1    Liu, B.2    McCully, R.R.3    Fournier, M.J.4
  • 23
    • 33751114695 scopus 로고    scopus 로고
    • Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program
    • Navarro, P., Page, D. R., Avner, P. & Rougeulle, C. Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program. Genes Dev. 20, 2787-2792 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 2787-2792
    • Navarro, P.1    Page, D.R.2    Avner, P.3    Rougeulle, C.4
  • 24
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • Gupta, R. A. et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464, 1071-1076 (2010).
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1
  • 25
    • 34250729138 scopus 로고    scopus 로고
    • Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    • Rinn, J. L. et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129, 1311-1323 (2007).
    • (2007) Cell , vol.129 , pp. 1311-1323
    • Rinn, J.L.1
  • 26
    • 0242668706 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in X inactivation
    • Plath. K. et al. Role of histone H3 lysine 27 methylation in X inactivation. Science 300, 131-135 (2003).
    • (2003) Science , vol.300 , pp. 131-135
    • Plath, K.1
  • 27
    • 62249133709 scopus 로고    scopus 로고
    • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    • Guttman, M., Amit, I., Garber, M., French, C. & Lin, M. F. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458, 223-227 (2009).
    • (2009) Nature , vol.458 , pp. 223-227
    • Guttman, M.1    Amit, I.2    Garber, M.3    French, C.4    Lin, M.F.5
  • 28
    • 77955323879 scopus 로고    scopus 로고
    • A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    • Huarte, M. et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142, 409-419 (2010).
    • (2010) Cell , vol.142 , pp. 409-419
    • Huarte, M.1
  • 29
    • 80052869283 scopus 로고    scopus 로고
    • LincRNAs act in the circuitry controlling pluripotency and differentiation
    • Guttman, M. et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 477, 295-300 (2011).
    • (2011) Nature , vol.477 , pp. 295-300
    • Guttman, M.1
  • 31
    • 2542542256 scopus 로고    scopus 로고
    • Ultraconserved elements in the human genome
    • Bejerano, G. et al. Ultraconserved elements in the human genome. Science 304, 1321-1325 (2004).
    • (2004) Science , vol.304 , pp. 1321-1325
    • Bejerano, G.1
  • 32
    • 33646928347 scopus 로고    scopus 로고
    • A distal enhancer and an ultraconserved exon are derived from a novel retroposon
    • Bejerano, G. et al. A distal enhancer and an ultraconserved exon are derived from a novel retroposon. Nature 441, 87-90 (2006).
    • (2006) Nature , vol.441 , pp. 87-90
    • Bejerano, G.1
  • 33
    • 34548230885 scopus 로고    scopus 로고
    • Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas
    • Calin, G. A. et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12, 215-229 (2007).
    • (2007) Cancer Cell , vol.12 , pp. 215-229
    • Calin, G.A.1
  • 34
    • 78649881517 scopus 로고    scopus 로고
    • CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
    • Lujambio, A. et al. CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene 29, 6390-6401 (2010).
    • (2010) Oncogene , vol.29 , pp. 6390-6401
    • Lujambio, A.1
  • 35
    • 57849140661 scopus 로고    scopus 로고
    • Divergent transcription from active promoters
    • Seila, A. C. et al. Divergent transcription from active promoters. Science 322, 1849-1851 (2008).
    • (2008) Science , vol.322 , pp. 1849-1851
    • Seila, A.C.1
  • 36
    • 57849123049 scopus 로고    scopus 로고
    • RNA exosome depletion reveals transcription upstream of active human promoters
    • Preker, P. et al. RNA exosome depletion reveals transcription upstream of active human promoters. Science 322, 1851-1854 (2008).
    • (2008) Science , vol.322 , pp. 1851-1854
    • Preker, P.1
  • 37
    • 67349157682 scopus 로고    scopus 로고
    • Tiny RNAs associated with transcription start sites in animals
    • Taft, R. J. et al. Tiny RNAs associated with transcription start sites in animals. Nature Genet. 41, 572-578 (2009).
    • (2009) NatureGenet. , vol.41 , pp. 572-578
    • Taft, R.J.1
  • 38
    • 77955844757 scopus 로고    scopus 로고
    • TERRA biogenesis turnover and implications for function
    • Feuerhahn, S., Iglesias, N., Panza, A., Porro, A. & Lingner, J. TERRA biogenesis, turnover and implications for function. FEBS Lett. 584, 3812-3818 (2010).
    • (2010) FEBS Lett. , vol.584 , pp. 3812-3818
    • Feuerhahn, S.1    Iglesias, N.2    Panza, A.3    Porro, A.4    Lingner, J.5
  • 39
    • 84859911725 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    • 29 Aug 10.1038/onc. 2011. 383
    • Davalos, V. et al. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 29 Aug 2011 (10.1038/onc.2011.383).
    • (2011) Oncogene
    • Davalos, V.1
  • 40
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • USA
    • Calin, G. A. et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 99, 15524-15529 (2002).
    • (2002) Proc. Natl Acad. Sci. , vol.99 , pp. 15524-15529
    • Calin, G.A.1
  • 41
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • USA
    • Calin, G. A. et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl Acad. Sci. USA 101, 2999-3004 (2004).
    • (2004) Proc. Natl Acad. Sci. , vol.101 , pp. 2999-3004
    • Calin, G.A.1
  • 42
    • 33745168962 scopus 로고    scopus 로고
    • MicroRNAs exhibit high frequency genomic alterations in human cancer
    • USA
    • Zhang, L. et al. microRNAs exhibit high frequency genomic alterations in human cancer. Proc. Natl Acad. Sci. USA 103, 9136-9141 (2006).
    • (2006) Proc. Natl Acad. Sci. , vol.103 , pp. 9136-9141
    • Zhang, L.1
  • 43
    • 61349127117 scopus 로고    scopus 로고
    • A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
    • Melo, S. A. et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nature Genetics 41, 365-370 (2009).
    • (2009) NatureGenetics , vol.41 , pp. 365-370
    • Melo, S.A.1
  • 44
    • 67749129007 scopus 로고    scopus 로고
    • DICER1 mutations in familial pleuropulmonary blastoma
    • Hill, D. A. et al. DICER1 mutations in familial pleuropulmonary blastoma. Science 325, 965 (2009).
    • (2009) Science , vol.325 , pp. 965
    • Hill, D.A.1
  • 45
    • 77957940475 scopus 로고    scopus 로고
    • A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
    • Melo, S. A. et al. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18, 303-315 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 303-315
    • Melo, S.A.1
  • 46
    • 78649491248 scopus 로고    scopus 로고
    • Identification of piRNAs in HeLa cells by massive parallel sequencing
    • Lu, Y. et al. Identification of piRNAs in HeLa cells by massive parallel sequencing. BMB Rep. 43, 635-641 (2010).
    • (2010) BMB Rep. , vol.43 , pp. 635-641
    • Lu, Y.1
  • 47
    • 78649357109 scopus 로고    scopus 로고
    • Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells
    • Park, C. W., Zeng, Y., Zhang, X., Subramanian, S. & Steer, C. J. Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells. RNA Biol. 7, 606-614 (2010).
    • (2010) RNA Biol. , vol.7 , pp. 606-614
    • Park, C.W.1    Zeng, Y.2    Zhang, X.3    Subramanian, S.4    Steer, C.J.5
  • 48
    • 77956925786 scopus 로고    scopus 로고
    • Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cells
    • Cichocki, F. et al. Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cells. J. Immunol. 185, 2009-2012 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 2009-2012
    • Cichocki, F.1
  • 49
    • 80055071064 scopus 로고    scopus 로고
    • Widespread expression of piRNA-like molecules in somatic tissues
    • Yan, Z. et al. Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. 39, 6596-6607 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6596-6607
    • Yan, Z.1
  • 50
    • 33847044299 scopus 로고    scopus 로고
    • Expression of the stem cell self-renewal gene hiwi and risk of tumour-related death in patients with soft-tissue sarcoma
    • Taubert, H. et al. Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. Oncogene 26, 1098-1100 (2007).
    • (2007) Oncogene , vol.26 , pp. 1098-1100
    • Taubert, H.1
  • 51
    • 79151475344 scopus 로고    scopus 로고
    • Clinical significance of hiwi gene expression in gliomas
    • Sun, G. et al. Clinical significance of Hiwi gene expression in gliomas. Brain Res. 1373, 183-188 (2011).
    • (2011) Brain Res. , vol.1373 , pp. 183-188
    • Sun, G.1
  • 52
    • 31144460828 scopus 로고    scopus 로고
    • Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway
    • Lee, J. H. et al. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Hum. Mol. Genet. 15, 201-211 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 201-211
    • Lee, J.H.1
  • 53
    • 77953371365 scopus 로고    scopus 로고
    • Piwil2 is expressed in various stages of breast cancers and has the potential to be used as a novel biomarker
    • Liu, J. J. et al. Piwil2 is expressed in various stages of breast cancers and has the potential to be used as a novel biomarker. Int. J. Clin. Exp. Pathol. 3, 328-337 (2010).
    • (2010) Int. J. Clin. Exp. Pathol. , vol.3 , pp. 328-337
    • Liu, J.J.1
  • 54
    • 33645226840 scopus 로고    scopus 로고
    • Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells
    • Liu, X. et al. Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int. J. Cancer 118, 1922-1929 (2006).
    • (2006) Int. J. Cancer , vol.118 , pp. 1922-1929
    • Liu, X.1
  • 55
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by polycomb in human embryonic stem cells
    • Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G. & Levine, S. S. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125, 301-313 (2006).
    • (2006) Cell , vol.125 , pp. 301-313
    • Lee, T.I.1    Jenner, R.G.2    Boyer, L.A.3    Guenther, M.G.4    Levine, S.S.5
  • 56
    • 78650631610 scopus 로고    scopus 로고
    • Ectopic expression of germline genes drives malignant brain tumor growth in drosophila
    • Janic, A., Mendizabal, L., Llamazares, S., Rossell, D. & Gonzalez, C. Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science 330, 1824-1827 (2010).
    • (2010) Science , vol.330 , pp. 1824-1827
    • Janic, A.1    Mendizabal, L.2    Llamazares, S.3    Rossell, D.4    Gonzalez, C.5
  • 57
    • 0035863870 scopus 로고    scopus 로고
    • + stem cells express the hiwi gene a human homologue of the drosophila gene piwi
    • + stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood 97, 426-434 (2001).
    • (2001) Blood , vol.97 , pp. 426-434
    • Sharma, A.K.1
  • 58
    • 35649019863 scopus 로고    scopus 로고
    • Precancerous stem cells have the potential for both benign and malignant differentiation
    • Chen, L. et al. Precancerous stem cells have the potential for both benign and malignant differentiation. PLoS ONE 2, e293 (2007).
    • (2007) PLoS ONE , vol.2
    • Chen, L.1
  • 59
    • 79952484238 scopus 로고    scopus 로고
    • Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment
    • Wang, Q., Han, C., Milum, K. & Wani, A. A. Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment. Mutat. Res. 708, 59-68 (2011).
    • (2011) Mutat. Res. , vol.708 , pp. 59-68
    • Wang, Q.1    Han, C.2    Milum, K.3    Wani, A.A.4
  • 60
    • 79959321051 scopus 로고    scopus 로고
    • PiRNA the new non-coding RNA is aberrantly expressed in human cancer cells
    • Cheng, J. et al. piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. Clin. Chim. Acta 412, 1621-1625 (2011).
    • (2011) Clin. Chim. Acta , vol.412 , pp. 1621-1625
    • Cheng, J.1
  • 62
    • 77954869863 scopus 로고    scopus 로고
    • Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer
    • Liao, J., Yu, L., Mei, Y., Guarnera, M. & Shen, J. Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Mol. Cancer 9, 198 (2010).
    • (2010) Mol. Cancer , vol.9 , pp. 198
    • Liao, J.1    Yu, L.2    Mei, Y.3    Guarnera, M.4    Shen, J.5
  • 63
    • 68349143121 scopus 로고    scopus 로고
    • Implication of snoRNA U50 in human breast cancer
    • Dong, X. Y., Guo, P., Boyd, J., Sun, X. & Li, Q. Implication of snoRNA U50 in human breast cancer. J. Genet. Genomics 36, 447-454 (2009).
    • (2009) J. Genet. Genomics , vol.36 , pp. 447-454
    • Dong, X.Y.1    Guo, P.2    Boyd, J.3    Sun, X.4    Li, Q.5
  • 64
    • 41149126821 scopus 로고    scopus 로고
    • SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer
    • Dong, X. Y. et al. snoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum. Mol. Genet. 17, 1031-1042 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 1031-1042
    • Dong, X.Y.1
  • 65
    • 43149098277 scopus 로고    scopus 로고
    • Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 GAS5
    • Mourtada-Maarabouni, M., Hedge, V. L., Kirkham, L., Farzaneh, F. & Williams, G. T. Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). J. Cell Sci. 121, 939-946 (2008).
    • (2008) J. Cell Sci. , vol.121 , pp. 939-946
    • Mourtada-Maarabouni, M.1    Hedge, V.L.2    Kirkham, L.3    Farzaneh, F.4    Williams, G.T.5
  • 66
    • 58249098615 scopus 로고    scopus 로고
    • GAS5 a non-protein-coding RNA controls apoptosis and is downregulated in breast cancer
    • Mourtada-Maarabouni, M., Pickard, M. R., Hedge, V. L., Farzaneh, F. & Williams, G. T. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28, 195-208 (2009).
    • (2009) Oncogene , vol.28 , pp. 195-208
    • Mourtada-Maarabouni, M.1    Pickard, M.R.2    Hedge, V.L.3    Farzaneh, F.4    Williams, G.T.5
  • 68
  • 69
    • 80053574876 scopus 로고    scopus 로고
    • From snoRNA to miRNA: Dual function regulatory non-coding RNAs
    • Scott, M. S. & Ono, M. From snoRNA to miRNA: dual function regulatory non-coding RNAs. Biochimie 93, 1987-1992 (2011).
    • (2011) Biochimie , vol.93 , pp. 1987-1992
    • Scott, M.S.1    Ono, M.2
  • 70
    • 56949096813 scopus 로고    scopus 로고
    • Cancer-associated genomic regions CAGRs and noncoding RNAs: Bioinformatics and therapeutic implications
    • Rossi, S., Sevignani, C., Nnadi, S. C., Siracusa, L. D. & Calin, G. A. Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm. Genome 19, 526-540 (2008).
    • (2008) Mamm. Genome , vol.19 , pp. 526-540
    • Rossi, S.1    Sevignani, C.2    Nnadi, S.C.3    Siracusa, L.D.4    Calin, G.A.5
  • 71
    • 74249097855 scopus 로고    scopus 로고
    • Transcribed-ultra conserved region expression is associated with outcome in high-risk neuroblastoma
    • Scaruffi, P. et al. Transcribed-ultra conserved region expression is associated with outcome in high-risk neuroblastoma. BMC Cancer 9, 441 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 441
    • Scaruffi, P.1
  • 72
    • 77649221027 scopus 로고    scopus 로고
    • Non-coding RNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer
    • Wojcik, S. E. et al. Non-coding RNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer. Carcinogenesis 31, 208-215 (2010).
    • (2010) Carcinogenesis , vol.31 , pp. 208-215
    • Wojcik, S.E.1
  • 73
    • 79551674253 scopus 로고    scopus 로고
    • Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma
    • USA
    • Braconi, C. et al. Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc. Natl Acad. Sci. USA 108, 786-791 (2011).
    • (2011) Proc. Natl Acad. Sci. , vol.108 , pp. 786-791
    • Braconi, C.1
  • 74
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • Yu, W. et al. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451, 202-206 (2010).
    • (2010) Nature , vol.451 , pp. 202-206
    • Yu, W.1
  • 76
    • 34548537573 scopus 로고    scopus 로고
    • A microRNA feedback circuit in midbrain dopamine neurons
    • Kim, J. et al. A microRNA feedback circuit in midbrain dopamine neurons. Science 317, 1220-1224 (2007).
    • (2007) Science , vol.317 , pp. 1220-1224
    • Kim, J.1
  • 77
    • 34447261382 scopus 로고    scopus 로고
    • Cerebellar neurodegeneration in the absence of microRNAs
    • Schaefer, A. et al. Cerebellar neurodegeneration in the absence of microRNAs. J. Exp. Med. 204, 1553-1558 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1553-1558
    • Schaefer, A.1
  • 78
    • 73549104488 scopus 로고    scopus 로고
    • Dicer ablation in oligodendrocytes provokes neuronal impairment in mice
    • Shin, D., Shin, J. Y., McManus, M. T., Ptácek, L. J. & Fu, Y. H. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann. Neurol. 66, 843-857 (2009).
    • (2009) Ann. Neurol. , vol.66 , pp. 843-857
    • Shin, D.1    Shin, J.Y.2    McManus, M.T.3    Ptácek, L.J.4    Fu, Y.H.5
  • 79
    • 77957735016 scopus 로고    scopus 로고
    • Genetic ablation of dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    • Hébert, S. S. et al. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum. Mol. Genet. 19, 3959-3969 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3959-3969
    • Hébert, S.S.1
  • 80
    • 77955784599 scopus 로고    scopus 로고
    • ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
    • USA
    • Ling, S. C, Albuquerque, C. P., Han, J. S., Lagier-Tourenne, C. & Tokunaga, S. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc. Natl Acad. Sci. USA 107, 13318-13323 (2010).
    • (2010) Proc. Natl Acad. Sci. , vol.107 , pp. 13318-13323
    • Ling, S.C.1    Albuquerque, C.P.2    Han, J.S.3    Lagier-Tourenne, C.4    Tokunaga, S.5
  • 81
    • 75949101467 scopus 로고    scopus 로고
    • Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132
    • Edbauer, D., Neilson, J. R., Foster, K. A., Wang, C. F. & Seeburg, D. P. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 65, 373-384 (2010).
    • (2010) Neuron , vol.65 , pp. 373-384
    • Edbauer, D.1    Neilson, J.R.2    Foster, K.A.3    Wang, C.F.4    Seeburg, D.P.5
  • 82
    • 77955152366 scopus 로고    scopus 로고
    • Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    • Gehrke, S. et al. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466, 637-641 (2010).
    • (2010) Nature , vol.466 , pp. 637-641
    • Gehrke, S.1
  • 83
    • 74049098309 scopus 로고    scopus 로고
    • Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human down syndrome brains
    • Kuhn, D. E., Nuovo, G. J., Terry, A. V. Jr, Martin, M. M. & Malana, G. E. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J. Biol. Chem. 285, 1529-1543 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 1529-1543
    • Kuhn, D.E.1    Nuovo, G.J.2    Terry Jr., A.V.3    Martin, M.M.4    Malana, G.E.5
  • 84
    • 49749133954 scopus 로고    scopus 로고
    • An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway
    • Glinsky, G. V. An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway. Cell Cycle 7, 2570-2583 (2008).
    • (2008) CellCycle , vol.7 , pp. 2570-2583
    • Glinsky, G.V.1
  • 85
    • 40749145370 scopus 로고    scopus 로고
    • Variation in the miRNA-433 binding site of FGF20 confers risk for parkinson disease by overexpression of a-synuclein
    • Wang, G., van der Walt, J. M., Mayhew, G., Li, Y. J. & Z?chner, S. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of a-synuclein. Am. J. Hum. Genet. 82, 283-289 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 283-289
    • Wang, G.1    Van Der Walt, J.M.2    Mayhew, G.3    Li, Y.J.4    Züchner, S.5
  • 86
    • 72149131804 scopus 로고    scopus 로고
    • MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
    • Williams, A. H. et al. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326, 1549-1554 (2009).
    • (2009) Science , vol.326 , pp. 1549-1554
    • Williams, A.H.1
  • 87
    • 77955599311 scopus 로고    scopus 로고
    • MiRNA malfunction causes spinal motor neuron disease
    • USA
    • Haramati, S. et al. miRNA malfunction causes spinal motor neuron disease. Proc. Natl Acad. Sci. USA 107, 13111-13116 (2010).
    • (2010) Proc. Natl Acad. Sci. , vol.107 , pp. 13111-13116
    • Haramati, S.1
  • 88
    • 52949137369 scopus 로고    scopus 로고
    • MiR-19 miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
    • Lee, Y. et al. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nature Neurosci. 11, 1137-1139 (2008).
    • (2008) NatureNeurosci. , vol.11 , pp. 1137-1139
    • Lee, Y.1
  • 89
    • 44049108170 scopus 로고    scopus 로고
    • Loss of microRNA cluster miR-29a/b-1 in sporadic alzheimers disease correlates with increased BACE1/β-secretase expression
    • USA
    • Hbert, S. S., Horr, K., Nicola, L., Papadopoulou, A. S. & Mandemakers, W. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. Proc. Natl Acad. Sci. USA 105, 6415-6420 (2008).
    • (2008) Proc. Natl Acad. Sci. , vol.105 , pp. 6415-6420
    • Hbert, S.S.1    Horr, K.2    Nicola, L.3    Papadopoulou, A.S.4    Mandemakers, W.5
  • 90
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in alzheimers disease and may accelerate disease progression through regulation of b-site amyloid precursor protein-cleaving enzyme 1
    • Wang, W. X., Rajeev, B. W., Stromberg, A. J., Ren, N. & Tang, G. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of b-site amyloid precursor protein-cleaving enzyme 1. J. Neurosci. 28, 1213-1223 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5
  • 91
    • 59049087888 scopus 로고    scopus 로고
    • MicroRNA-298 and microRNA-328 regulate expression of mouse β-amyloid precursor protein-converting enzyme 1
    • Boissonneault, V., Plante, I., Rivest, S. & Provost, P. MicroRNA-298 and microRNA-328 regulate expression of mouse β-amyloid precursor protein-converting enzyme 1. J. Biol. Chem. 284, 1971-1981 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 1971-1981
    • Boissonneault, V.1    Plante, I.2    Rivest, S.3    Provost, P.4
  • 93
    • 77957888270 scopus 로고    scopus 로고
    • MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood
    • Cox, M. B., Cairns, M. J., Gandhi, K. S., Carroll, A. P. & Moscovis, S. MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood. PLoS ONE 5, e12132 (2010).
    • (2010) PLoS ONE , vol.5
    • Cox, M.B.1    Cairns, M.J.2    Gandhi, K.S.3    Carroll, A.P.4    Moscovis, S.5
  • 94
    • 69149102628 scopus 로고    scopus 로고
    • Repression of a-synuclein expression and toxicity by microRNA-7
    • USA
    • Junn, E., Lee, K. W., Jeong, B. S., Chan, T. W. & Im, J. Y. Repression of a-synuclein expression and toxicity by microRNA-7. Proc. Natl Acad. Sci. USA 106, 13052-13057 (2009).
    • (2009) Proc. Natl Acad. Sci. , vol.106 , pp. 13052-13057
    • Junn, E.1    Lee, K.W.2    Jeong, B.S.3    Chan, T.W.4    Im, J.Y.5
  • 95
    • 51449100794 scopus 로고    scopus 로고
    • SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology
    • Chen, W. L., Lin, J. W. & Huang, H. J. SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology. Brain Res. 1233, 176-184 (2008).
    • (2008) Brain Res. , vol.1233 , pp. 176-184
    • Chen, W.L.1    Lin, J.W.2    Huang, H.J.3
  • 96
    • 77952885217 scopus 로고    scopus 로고
    • MicroRNAs are necessary for vascular smooth muscle growth differentiation and function
    • Albinsson, S. et al. MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler. Thromb. Vasc. Biol. 6, 1118-1126 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.6 , pp. 1118-1126
    • Albinsson, S.1
  • 97
    • 34147153781 scopus 로고    scopus 로고
    • Dysregulation of cardiogenesis cardiac conduction and cell cycle in mice lacking miRNA-1-2
    • Zhao, Y. et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129, 303-317 (2007).
    • (2007) Cell , vol.129 , pp. 303-317
    • Zhao, Y.1
  • 98
    • 34147095310 scopus 로고    scopus 로고
    • The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    • Yang, B. et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nature Med. 13, 486-491 (2007).
    • (2007) NatureMed. , vol.13 , pp. 486-491
    • Yang, B.1
  • 99
    • 33845317603 scopus 로고    scopus 로고
    • A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    • USA
    • Van Rooij, E. et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc. Natl Acad. Sci. USA 103, 18255-18260 (2006).
    • (2006) Proc. Natl Acad. Sci. , vol.103 , pp. 18255-18260
    • Van Rooij, E.1
  • 100
    • 77955795714 scopus 로고    scopus 로고
    • MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro
    • USA
    • Fang, Y., Shi, C., Manduchi, E., Civelek, M. & Davies, P. F. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc. Natl Acad. Sci. USA 107, 13450-13455 (2010).
    • (2010) Proc. Natl Acad. Sci. , vol.107 , pp. 13450-13455
    • Fang, Y.1    Shi, C.2    Manduchi, E.3    Civelek, M.4    Davies, P.F.5
  • 101
    • 68449097267 scopus 로고    scopus 로고
    • MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity
    • Cordes, K. R. et al. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460, 705-710 (2009).
    • (2009) Nature , vol.460 , pp. 705-710
    • Cordes, K.R.1
  • 102
    • 77951621138 scopus 로고    scopus 로고
    • MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
    • Nicoli, S. et al. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature 464, 1196-1200 (2010).
    • (2010) Nature , vol.464 , pp. 1196-1200
    • Nicoli, S.1
  • 103
    • 34250172419 scopus 로고    scopus 로고
    • MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    • Ji, R. et al. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ. Res. 100, 1579-1588 (2007).
    • (2007) Circ. Res. , vol.100 , pp. 1579-1588
    • Ji, R.1
  • 104
    • 33745577150 scopus 로고    scopus 로고
    • A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    • Clop, A. et al. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nature Genet. 38, 813-818 (2006).
    • (2006) NatureGenet. , vol.38 , pp. 813-818
    • Clop, A.1
  • 105
    • 34547727263 scopus 로고    scopus 로고
    • Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: A mechanism for functional single-nucleotide polymorphisms related to phenotypes
    • Sethupathy, P. et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am. J. Hum. Genet. 81, 405-413 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 405-413
    • Sethupathy, P.1
  • 106
    • 73849121794 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
    • Starczynowski, D. T. et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature Med. 16, 49-58 (2010).
    • (2010) NatureMed. , vol.16 , pp. 49-58
    • Starczynowski, D.T.1
  • 107
    • 77954682167 scopus 로고    scopus 로고
    • Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome
    • Gatto, S., Della Ragione, F., Cimmino, A., Strazzullo, M. & Fabbri, M. Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome. Epigenetics 5, 427-443 (2010).
    • (2010) Epigenetics , vol.5 , pp. 427-443
    • Gatto, S.1    Della Ragione, F.2    Cimmino, A.3    Strazzullo, M.4    Fabbri, M.5
  • 108
    • 77957958411 scopus 로고    scopus 로고
    • Disrupted microRNA expression caused by Mecp2 loss in a mouse model of rett syndrome
    • Urdinguio, R. G. et al. Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome. Epigenetics 5, 656-663 (2010).
    • (2010) Epigenetics , vol.5 , pp. 656-663
    • Urdinguio, R.G.1
  • 109
    • 78149248751 scopus 로고    scopus 로고
    • Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome
    • USA
    • Wu, H. et al. Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome. Proc. Natl Acad. Sci. USA 107, 18161-18166 (2010).
    • (2010) Proc. Natl Acad. Sci. , vol.107 , pp. 18161-18166
    • Wu, H.1
  • 110
    • 79952134938 scopus 로고    scopus 로고
    • A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in crohns disease
    • Brest, P. et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nature Genet. 43, 242-245 (2011).
    • (2011) NatureGenet. , vol.43 , pp. 242-245
    • Brest, P.1
  • 111
    • 67349132265 scopus 로고    scopus 로고
    • An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice
    • Lewis, M. A. et al. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nature Genet. 41, 614-618 (2009).
    • (2009) NatureGenet. , vol.41 , pp. 614-618
    • Lewis, M.A.1
  • 112
    • 46749083733 scopus 로고    scopus 로고
    • Expression of a noncoding RNA is elevated in alzheimers disease and drives rapid feed-forward regulation of beta-secretase
    • Faghihi, M. A. et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nature Med. 14, 723-730 (2008).
    • (2008) NatureMed. , vol.14 , pp. 723-730
    • Faghihi, M.A.1
  • 113
    • 78549267206 scopus 로고    scopus 로고
    • Enrichment of ultraconserved elements among genomic imbalances causing mental delay and congenital anomalies
    • Martínez, F. et al. Enrichment of ultraconserved elements among genomic imbalances causing mental delay and congenital anomalies. BMC Med. Genomics 3, 54 (2010).
    • (2010) BMC Med. Genomics , vol.3 , pp. 54
    • Martínez, F.1
  • 114
    • 49449111926 scopus 로고    scopus 로고
    • Mechanisms of imprinting of the prader-willi/angelman region
    • Horsthemke, B. & Wagstaff, J. Mechanisms of imprinting of the Prader-Willi/Angelman region. Am. J. Med. Genet. A. 146 A, 2041-2052 (2008).
    • (2008) Am. J. Med. Genet. A. , vol.146 A , pp. 2041-2052
    • Horsthemke, B.1    Wagstaff, J.2
  • 115
    • 30844442607 scopus 로고    scopus 로고
    • The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C
    • Kishore, S. & Stamm, S. The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 311, 230-232 (2006).
    • (2006) Science , vol.311 , pp. 230-232
    • Kishore, S.1    Stamm, S.2
  • 116
    • 44349191455 scopus 로고    scopus 로고
    • Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster
    • Sahoo, T. et al. Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster. Nature Genet. 40, 719-721 (2008).
    • (2008) NatureGenet. , vol.40 , pp. 719-721
    • Sahoo, T.1
  • 117
    • 10744223519 scopus 로고    scopus 로고
    • Mili a mammalian member of piwi family gene is essential for spermatogenesis
    • Kuramochi-Miyagawa, S. et al. Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131, 839-849 (2004).
    • (2004) Development , vol.131 , pp. 839-849
    • Kuramochi-Miyagawa, S.1
  • 118
    • 78649518098 scopus 로고    scopus 로고
    • Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population
    • Gu, A. et al. Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. Hum. Reprod. 25, 2955-2961 (2010).
    • (2010) Hum. Reprod. , vol.25 , pp. 2955-2961
    • Gu, A.1
  • 119
    • 78650696753 scopus 로고    scopus 로고
    • Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
    • Burd, C. E. et al. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 6, e1001233 (2010).
    • (2010) PLoS Genet. , vol.6
    • Burd, C.E.1
  • 121
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with antagomirs
    • Krutzfeldt, J., Rajewsky, N. & Braich R. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438, 685-689 (2005).
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 122
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • Elmen, J., Lindow, M. & Schutz, S. LNA-mediated microRNA silencing in non-human primates. Nature 452, 896-899 (2008).
    • (2008) Nature , vol.452 , pp. 896-899
    • Elmen, J.1    Lindow, M.2    Schutz, S.3
  • 123
    • 37349113774 scopus 로고    scopus 로고
    • Inhibition of microRNA with antisense oligonucleotides
    • Esau, C. C. Inhibition of microRNA with antisense oligonucleotides. Methods 44, 55-60 (2008).
    • (2008) Methods , vol.44 , pp. 55-60
    • Esau, C.C.1
  • 124
    • 77950665077 scopus 로고    scopus 로고
    • Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
    • Ma, L. et al. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nature Biotech. 28, 341-347 (2010).
    • (2010) NatureBiotech. , vol.28 , pp. 341-347
    • Ma, L.1
  • 125
    • 63349085394 scopus 로고    scopus 로고
    • A single anti-microRNA antisense oligodeoxyribonucleotide AMO targeting multiple microRNAs offers an improved approach for microRNA interference
    • Lu, Y., Xiao, J. & Lin, H. A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res. 37, e24 (2009).
    • (2009) Nucleic Acids Res. , vol.37
    • Lu, Y.1    Xiao, J.2    Lin, H.3
  • 126
    • 73349122640 scopus 로고    scopus 로고
    • Use of microRNA sponges to explore tissue-specific microRNA functions in vivo
    • Cohen, S. M. Use of microRNA sponges to explore tissue-specific microRNA functions in vivo. Nature Methods 6, 873-874 (2009).
    • (2009) NatureMethods , vol.6 , pp. 873-874
    • Cohen, S.M.1
  • 127
    • 77649275464 scopus 로고    scopus 로고
    • MiR-9 a MYC/MYCN-activated microRNA regulates E-cadherin and cancer metastasis
    • Ma, L. et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nature Cell Biol. 12, 247-256 (2010).
    • (2010) NatureCell Biol. , vol.12 , pp. 247-256
    • Ma, L.1
  • 128
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota, J. et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137, 1005-1017 (2009).
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1
  • 129
    • 79954650563 scopus 로고    scopus 로고
    • State-of-the-art gene-based therapies: The road ahead
    • Kay, M. A. State-of-the-art gene-based therapies: the road ahead. Nature Rev. Genet. 12, 316-328 (2011).
    • (2011) NatureRev. Genet. , vol.12 , pp. 316-328
    • Kay, M.A.1
  • 130
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microRNA processing enhances cellular transformation and tumorigenesis
    • Kumar, M. S., Lu, J., Mercer, K. L., Golub, T. R. & Jacks, T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genet. 39, 673-677 (2007).
    • (2007) NatureGenet. , vol.39 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3    Golub, T.R.4    Jacks, T.5
  • 131
    • 49449096792 scopus 로고    scopus 로고
    • A small molecule enhances RNA interference and promotes microRNA processing
    • Shan, G. et al. A small molecule enhances RNA interference and promotes microRNA processing. Nature Biotech. 26, 933-940 (2008).
    • (2008) NatureBiotech. , vol.26 , pp. 933-940
    • Shan, G.1
  • 132
    • 79952717616 scopus 로고    scopus 로고
    • The small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
    • USA
    • Melo, S. et al. The small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc. Natl Acad. Sci. USA 108, 4394-4399 (2011).
    • (2011) Proc. Natl Acad. Sci. , vol.108 , pp. 4394-4399
    • Melo, S.1
  • 133
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito, Y. et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9, 435-443 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1
  • 134
    • 33847763576 scopus 로고    scopus 로고
    • Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    • Lujambio, A. et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 67, 1424-1429 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 1424-1429
    • Lujambio, A.1
  • 135
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodríguez-Paredes, M. & Esteller, M. Cancer epigenetics reaches mainstream oncology. Nature Med. 17, 330-339 (2011).
    • (2011) NatureMed. , vol.17 , pp. 33-339
    • Rodríguez-Paredes, M.1    Esteller, M.2
  • 136
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as a modular scaffold of histone modification complexes
    • Tsai, M. C. et al. Long noncoding RNA as a modular scaffold of histone modification complexes. Science 329, 689-693 (2010).
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1
  • 137
    • 78651390167 scopus 로고    scopus 로고
    • Long intergenic noncoding RNAs: New links in cancer progression
    • Tsai, M. C., Spitale, R. C. & Chang, H. Y. Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res. 71, 3-7 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3-7
    • Tsai, M.C.1    Spitale, R.C.2    Chang, H.Y.3
  • 138
    • 77953930273 scopus 로고    scopus 로고
    • An aptamer targeting the apical-loop domain modulates pri-miRNA processing
    • Lunse, C. E., Michlewski, G. & Hopp, C. S. An aptamer targeting the apical-loop domain modulates pri-miRNA processing. Angew. Chem. Int. Ed. Engl. 49, 4674-4677 (2010).
    • (2010) Angew. Chem. Int. Ed. Engl. , vol.49 , pp. 4674-4677
    • Lunse, C.E.1    Michlewski, G.2    Hopp, C.S.3
  • 139
    • 67349260751 scopus 로고    scopus 로고
    • Non-coding RNAs and new opportunities for the private sector
    • Costa, F. F. Non-coding RNAs and new opportunities for the private sector. Drug Discov. Today 14, 446-452 (2009).
    • (2009) Drug Discov. Today , vol.14 , pp. 446-452
    • Costa, F.F.1
  • 140
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • The ENCODE Project Consortium
    • The ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816 (2007).
    • (2007) Nature , vol.447 , pp. 799-816
  • 141
    • 34248162440 scopus 로고    scopus 로고
    • Functionality or transcriptional noise evidence for selection within long noncoding RNAs
    • Ponjavic, J., Ponting, C. P. & Lunter, G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res. 17, 556-565 (2007).
    • (2007) Genome Res. , vol.17 , pp. 556-565
    • Ponjavic, J.1    Ponting, C.P.2    Lunter, G.3
  • 142
    • 77956339881 scopus 로고    scopus 로고
    • OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
    • Medina, P. P., Nolde, M. & Slack, F. J. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467, 86-90 (2010).
    • (2010) Nature , vol.467 , pp. 86-90
    • Medina, P.P.1    Nolde, M.2    Slack, F.J.3
  • 143
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    • Voorhoeve, P. M. et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169-1181 (2006).
    • (2006) Cell , vol.124 , pp. 1169-1181
    • Voorhoeve, P.M.1
  • 144
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum, T. et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456, 980-984 (2008).
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1
  • 145
    • 66749154227 scopus 로고    scopus 로고
    • Silver-russell and Beckwith- Wiedemann syndromes: Opposite epi mutations in 11p15 result in opposite clinical pictures
    • Eggermann, T. Silver-Russell and Beckwith- Wiedemann syndromes: opposite (epi)mutations in 11p15 result in opposite clinical pictures. Horm. Res. 71, (Suppl. 2), 30-35 (2009).
    • (2009) Horm. Res. , vol.71 , Issue.2 , pp. 30-35
    • Eggermann, T.1
  • 146
    • 79953733907 scopus 로고    scopus 로고
    • Uncoupling antisense-mediated silencing and DNA methylation in the imprinted gnas cluster
    • Williamson, C. M. et al. Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster. PLoS Genet. 7, e1001347 (2011).
    • (2011) PLoS Genet. , vol.7
    • Williamson, C.M.1
  • 147
    • 79960480764 scopus 로고    scopus 로고
    • MiRNA-146a in rheumatoid arthritis: A new therapeutic strategy
    • Pauley, K. M. & Cha, S. miRNA-146a in rheumatoid arthritis: a new therapeutic strategy. Immunotherapy 3, 829-831 (2011).
    • (2011) Immunotherapy , vol.3 , pp. 829-831
    • Pauley, K.M.1    Cha, S.2
  • 148
    • 0036918736 scopus 로고    scopus 로고
    • Transient neonatal diabetes a disorder of imprinting
    • Temple, I. K. & Shield, J. P. Transient neonatal diabetes, a disorder of imprinting. J. Med. Genet. 39, 872-875 (2002).
    • (2002) J. Med. Genet. , vol.39 , pp. 872-875
    • Temple, I.K.1    Shield, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.