SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

Journal of Experimental Medicine

Volumn 199, Issue 12, 2004, Pages 1701-1707

  Yoshida, Takafumi ^a,b   Ogata, Hisanobu ^a   Kamio, Masaki ^a   Joo, Akiko ^a   Shiraishi, Hiroshi ^a   Tokunaga, Yoko ^b   Sata, Michio ^b   Nagai, Hisaki ^c   Yoshimura, Akihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Cytokine; DNA methylation; Hepatitis C virus; STAT; TGF

Indexed keywords

DIMETHYLNITROSAMINE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DNA METHYLATION; GENE DELETION; GENE SILENCING; HEPATITIS C; HEPATITIS C VIRUS; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURVIVAL RATE; WILD TYPE;

ANIMALS; BIOPSY; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CHOLINE DEFICIENCY; DISEASE MODELS, ANIMAL; DNA METHYLATION; DNA, NEOPLASM; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 3042592451     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031675     Document Type: Article

References (26)

1. Hoshida, Y., K. Ikeda, M. Kobayashi, Y. Suzuki, A. Tsubota, S. Saitoh, Y. Arase, N. Murashima, K. Chayama, and H. Kumada. 1999. Chronic liver disease in the extremely elderly of 80 years or more: clinical characteristics, prognosis and patient survival analysis. J. Hepatol. 31:860-866.
2. Ikeda, K., S. Saitoh, Y. Suzuki, M. Kobayashi, A. Tsubota, I. Koida, Y. Arase, M. Fukuda, K. Chayama, N. Murashima, and H. Kumada. 1998. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J. Hepatol. 28:930-938.
3. Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, et al. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature. 387:924-929.
4. Starr, R., T.A. Willson, E.M. Viney, L.J. Murray, J.R. Rayner, B.J. Jenkins, T.J. Gonda, W.S. Alexander, D. Metcalf, N.A. Nicola, and D.J. Hilton. 1997. A family of cytokine-inducible inhibitors of signalling. Nature. 387:917-921.
5. Endo, T.A., M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsubo, H. Misawa, et al. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 387:921-924.
6. Metcalf, D. 1999. The SOCS-1 story. Exp. Hematol. 27: 1715-1723.
7. Naka, T., H. Tsutsui, M. Fujimoto, Y. Kawazoe, H. Kohzaki, Y. Morita, R. Nakagawa, M. Narazaki, K. Adachi, T. Yoshimoto, et al. 2001. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity. 14:535-545.
8. Yoshikawa, H., K. Matsubara, G.S. Qian, P. Jackson, J.D. Groopman, J.E. Manning, C.C. Harris, and J.G. Herman. 2001. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 28:29-35.
9. Bedossa, P., and T. Poynard. 1996. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 24:289-293.
10. Herman, J.G., J.R. Graff, S. Myohanen, B.D. Nelkin, and S.B. Baylin. 1996. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA. 93:9821-9826.
11. Merlo, A., J.G. Herman, L. Mao, D.J. Lee, E. Gabrielson, P.C. Burger, S.B. Baylin, and D. Sidransky. 1995. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1:686-692.
12. Nagai, H., Y.S. Kim, N. Konishi, M. Baba, T. Kubota, A. Yoshimura, and M. Emi. 2002. Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/ SOCS-1/JAB gene in human hepatocellular carcinomas. Cancer Lett. 186:59-65.
13. Marine, J.C., D.J. Topham, C. McKay, D. Wang, E. Parganas, D. Stravopodis, A. Yoshimura, and J.N. Ihle. 1999. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. 98:609-616.
14. Tokuda, A., M. Itakura, N. Onai, H. Kimura, T. Kuriyama, and K. Matsushima. 2000. Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice. J. Immunol. 164:2745-2751.
15. Canbay, A., M.E. Guicciardi, H. Higuchi, A. Feldstein, S.F. Bronk, R. Rydzewski, M. Taniai, and G.J. Gores. 2003. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J. Clin. Invest. 112:152-159.
16. Poole, T.M., and N.R. Drinkwater. 1996. Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones. Proc. Natl. Acad. Sci. USA. 93:5848-5853.
17. Ward, J.M., N. Konishi, and B.A. Diwan. 1990. Renal tubular cell or hepatocyte hyperplasia is not associated with tumor promotion by di(2-ethylhexyl)phthalate in B6C3F1 mice after transplacental initiation with N-nitrosoethylurea. Exp. Pathol. 40:125-138.
18. Yoshida, H., N. Kato, Y. Shiratori, M. Otsuka, S. Maeda, J. Kato, and M. Omata. 2001. Hepatitis C virus core protein activates nuclear factor kappa B-dependent signaling through tumor necrosis factor receptor-associated factor. J. Biol. Chem. 276:16399-16405.
19. El-Serag, H.B. 2002. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology. 36:S74-S83.
20. Chitturi, S., and J. George. 2000. Predictors of liver-related complications in patients with chronic hepatitis C. Ann. Med. 32:588-591.
21. Tanikawa, K. 1994. Serum marker for hepatic fibrosis and related liver pathology. Pathol. Res. Pract. 190:960-968.
22. Schook, L.B., J.F. Lockwood, S.D. Yang, and M.J. Myers. 1992. Dimethylnitrosamine (DMN)-induced IL-1 beta, TNF-alpha, and IL-6 inflammatory cytokine expression. Toxicol. Appl. Pharmacol. 116:110-116.
23. Yasukawa, H., A. Sasaki, and A. Yoshimura. 2000. Negative regulation of cytokine signaling pathways. Annu. Rev. Immunol. 18:143-164.
24. Hong, F., B. Jaruga, W.H. Kim, S. Radaeva, O.N. El-Assal, Z. Tian, V.A. Nguyen, and B. Gao. 2002. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J. Clin. Invest. 110:1503-1513.
25. Liu, R.H., B. Baldwin, B.C. Tennant, and J.H. Hotchkiss. 1991. Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection. Cancer Res. 51: 3925-3929.
26. Kaneto, H., S. Sasaki, H. Yamamoto, F. Itoh, M. Toyota, H. Suzuki, I. Ozeki, N. Iwata, T. Ohmura, T. Satoh, et al. 2001. Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut. 48:372-377.