Lung alveolar epithelium and interstitial lung disease

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 8-9, 2009, Pages 1643-1651

  Corvol, Harriet ^a,b,c   Flamein, Florence ^a,b,c   Epaud, Ralph ^a,b,c   Clement, Annick ^a,b,c   Guillot, Loic ^a,b  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c ARMAND TROUSSEAU HOSPITAL   (France)

Author keywords

Alveolar epithelial cells; Epithelial mesenchymal transition; Interstitial lung disease; Surfactant; Transforming growth factor

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 1; INTERLEUKIN 1BETA; PROTEIN P53; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; DISEASE COURSE; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; HUMAN; INFLAMMATION; INTERSTITIAL LUNG DISEASE; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; SHORT SURVEY;

ANIMALS; EPITHELIUM; HUMANS; LUNG DISEASES, INTERSTITIAL; PROTEIN CONFORMATION; PULMONARY ALVEOLI;

EID: 67349280231     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.02.009     Document Type: Short Survey

References (98)

1. Adamson I.Y., and Bowden D.H. The pathogenesis of bloemycin-induced pulmonary fibrosis in mice. Am J Pathol 77 (1974) 185-197
2. Adamson I.Y., and Bowden D.H. The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen. Lab Invest 30 (1974) 35-42
3. Alder J.K., Chen J.J., Lancaster L., Danoff S., Su S.C., Cogan J.D., et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci USA 105 (2008) 13051-13056
4. Aluwihare P., and Munger J.S. What the lung has taught us about latent TGF-beta activation. Am J Respir Cell Mol Biol 39 (2008) 499-502
5. Antoniou K.M., Pataka A., Bouros D., and Siafakas N.M. Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis. Pulm Pharmacol Ther 20 (2007) 453-461
6. Armanios M.Y., Chen J.J., Cogan J.D., Alder J.K., Ingersoll R.G., Markin C., et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356 (2007) 1317-1326
7. Ask K., Martin G.E., Kolb M., and Gauldie J. Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls. Proc Am Thorac Soc 3 (2006) 389-393
8. ATS. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 161 (2000) 646-664
9. ATS. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus. Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 165 (2002) 277-304
10. Beers M.F., and Mulugeta S. Surfactant protein C biosynthesis and its emerging role in conformational lung disease. Annu Rev Physiol 67 (2005) 663-696
11. Beggs M.L., Nagarajan R., Taylor-Jones J.M., Nolen G., Macnicol M., and Peterson C.A. Alterations in the TGFbeta signaling pathway in myogenic progenitors with age. Aging Cell 3 (2004) 353-361
12. Bridges J.P., Xu Y., Na C.L., Wong H.R., and Weaver T.E. Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. J Cell Biol 172 (2006) 395-407
13. Bringardner B.D., Baran C.P., Eubank T.D., and Marsh C.B. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal 10 (2008) 287-301
14. Cassel S.L., Eisenbarth S.C., Iyer S.S., Sadler J.J., Colegio O.R., Tephly L.A., et al. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 105 (2008) 9035-9040
15. Chilosi M., Poletti V., Zamo A., Lestani M., Montagna L., Piccoli P., et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162 (2003) 1495-1502
16. Choi J.E., Lee S.S., Sunde D.A., Huizar I., Haugk K.L., Thannickal V.J., et al. Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury. Am J Respir Crit Care Med 179 (2009) 212-219
17. Clement A. Task force on chronic interstitial lung disease in immunocompetent children. Eur Respir J 24 (2004) 686-697
18. Clement A., and Eber E. Interstitial lung diseases in infants and children. Eur Respir J 31 (2008) 658-666
19. Clement A., Henrion-Caude A., and Fauroux B. The pathogenesis of interstitial lung diseases in children. Paediatr Respir Rev 5 (2004) 94-97
20. Colwell A.S., Longaker M.T., and Lorenz H.P. Mammalian fetal organ regeneration. Adv Biochem Eng Biotechnol 93 (2005) 83-100
21. Dostert C., Petrilli V., Van Bruggen R., Steele C., Mossman B.T., and Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320 (2008) 674-677
22. Drakopanagiotakis F., Xifteri A., Polychronopoulos V., and Bouros D. Apoptosis in lung injury and fibrosis. Eur Respir J 32 (2008) 1631-1638
23. Edwards D.R., Handsley M.M., and Pennington C.J. The ADAM metalloproteinases. Mol Aspects Med 29 (2008) 258-289
24. Fadok V.A., and Henson P.M. Apoptosis: giving phosphatidylserine recognition an assist-with a twist. Curr Biol 13 (2003) R655-R657
25. Fattman C.L. Apoptosis in pulmonary fibrosis: too much or not enough?. Antioxid Redox Signal 10 (2008) 379-385
26. Garcia-Alvarez J., Ramirez R., Sampieri C.L., Nuttall R.K., Edwards D.R., Selman M., et al. Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis 23 (2006) 13-21
27. Gasse P., Mary C., Guenon I., Noulin N., Charron S., Schnyder-Candrian S., et al. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117 (2007) 3786-3799
28. Gharaee-Kermani M., Gyetko M.R., Hu B., and Phan S.H. New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy. Pharm Res 24 (2007) 819-841
29. Griese M., Schumacher S., Tredano M., Steinecker M., Braun A., Guttentag S., et al. Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease. Respir Res 6 (2005) 80
30. Gurtner G.C., Callaghan M.J., and Longaker M.T. Progress and potential for regenerative medicine. Annu Rev Med 58 (2007) 299-312
31. Henson P.M. Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis. Am J Respir Cell Mol Biol 29 (2003) S70-S76
32. Horowitz J.C., and Limper A.H. Stress in the ER (endoplasmic reticulum): a matter of life and death for epithelial cells. Am J Respir Crit Care Med 178 (2008) 782-783
33. Horowitz J.C., and Thannickal V.J. Epithelial-mesenchymal interactions in pulmonary fibrosis. Semin Respir Crit Care Med 27 (2006) 600-612
34. Horowitz J.C., and Thannickal V.J. Idiopathic pulmonary fibrosis: new concepts in pathogenesis and implications for drug therapy. Treat Respir Med 5 (2006) 325-342
35. Hostettler K.E., Roth M., Burgess J.K., Gencay M.M., Gambazzi F., Black J.L., et al. Airway epithelium-derived transforming growth factor-beta is a regulator of fibroblast proliferation in both fibrotic and normal subjects. Clin Exp Allergy 38 (2008) 1309-1317
36. Huber M.A., Kraut N., and Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17 (2005) 548-558
37. Ikegami M., Weaver T.E., Conkright J.J., Sly P.D., Ross G.F., Whitsett J.A., et al. Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury. J Appl Physiol 92 (2002) 519-526
38. Jain R., Shaul P.W., Borok Z., and Willis B.C. Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1. Am J Respir Cell Mol Biol 37 (2007) 38-47
39. Kasai H., Allen J.T., Mason R.M., Kamimura T., and Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 6 (2005) 56
40. Kim K.K., and Chapman H.A. Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis. Am J Respir Cell Mol Biol 37 (2007) 1-2
41. Kim K.K., Kugler M.C., Wolters P.J., Robillard L., Galvez M.G., Brumwell A.N., et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 103 (2006) 13180-13185
42. Kim K.K., Wei Y., Szekeres C., Kugler M.C., Wolters P.J., Hill M.L., et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119 (2009) 213-224
43. Koli K., Myllarniemi M., Keski-Oja J., and Kinnula V.L. Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 10 (2008) 333-342
44. Komi-Kuramochi A., Kawano M., Oda Y., Asada M., Suzuki M., Oki J., et al. Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol 186 (2005) 273-289
45. Korfei M., Ruppert C., Mahavadi P., Henneke I., Markart P., Koch M., et al. Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 178 (2008) 838-846
46. Koth L.L., Alex B., Hawgood S., Nead M.A., Sheppard D., Erle D.J., et al. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol 37 (2007) 651-659
47. Kuwano K. Epithelial cell apoptosis and lung remodeling. Cell Mol Immunol 4 (2007) 419-429
48. Kuwano K. Involvement of epithelial cell apoptosis in interstitial lung diseases. Int Med 47 (2008) 345-353
49. Lawless M.W., Mankan A.K., Gray S.G., and Norris S. Endoplasmic reticulum stress-a double edged sword for Z alpha-1 antitrypsin deficiency hepatoxicity. Int J Biochem Cell Biol 40 (2008) 1403-1414
50. Lawson W.E., Crossno P.F., Polosukhin V.V., Roldan J., Cheng D.S., Lane K.B., et al. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol 294 (2008) L1119-L1126
51. Leask A., Parapuram S.K., Shi-Wen X., and Abraham D.J. Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?. J Cell Commun Signal (2009)
52. Lee J.M., Dedhar S., Kalluri R., and Thompson E.W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172 (2006) 973-981
53. Ley K., and Zarbock A. From lung injury to fibrosis. Nat Med 14 (2008) 20-21
54. Liu X. Inflammatory cytokines augments TGF-beta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I. Cell Motil Cytoskeleton 65 (2008) 935-944
55. Maher T.M., Wells A.U., and Laurent G.J. Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?. Eur Respir J 30 (2007) 835-839
56. Marciniak S.J., and Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86 (2006) 1133-1149
57. Martin L., Fluhrer R., Reiss K., Kremmer E., Saftig P., and Haass C. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J Biol Chem 283 (2008) 1644-1652
58. Martinon F. Detection of immune danger signals by NALP3. J Leukoc Biol 83 (2008) 507-511
59. Mimura N., Hamada H., Kashio M., Jin H., Toyama Y., Kimura K., et al. Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP. Cell Death Differ 14 (2007) 1475-1485
60. Moore K.A., and Lemischka I.R. Stem cells and their niches. Science 311 (2006) 1880-1885
61. Mulugeta S., Maguire J.A., Newitt J.L., Russo S.J., Kotorashvili A., and Beers M.F. Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms. Am J Physiol Lung Cell Mol Physiol 293 (2007) L720-L729
62. Nakashima N., Kuwano K., Maeyama T., Hagimoto N., Yoshimi M., Hamada N., et al. The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. J Clin Pathol 58 (2005) 583-589
63. Nogee L.M., Dunbar III A.E., Wert S., Askin F., Hamvas A., and Whitsett J.A. Mutations in the surfactant protein C gene associated with interstitial lung disease. Chest 121 (2002) 20S-1S
64. Orlandi A., Francesconi A., Marcellini M., Ferlosio A., and Spagnoli L.G. Role of ageing and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit. Cardiovasc Res 64 (2004) 544-552
65. Pardo A., and Selman M. Matrix metalloproteases in aberrant fibrotic tissue remodeling. Proc Am Thorac Soc 3 (2006) 383-388
66. Plataki M., Koutsopoulos A.V., Darivianaki K., Delides G., Siafakas N.M., and Bouros D. Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis. Chest 127 (2005) 266-274
67. Pomerantz J., and Blau H.M. Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nat Cell Biol 6 (2004) 810-816
68. Psathakis K., Mermigkis D., Papatheodorou G., Loukides S., Panagou P., Polychronopoulos V., et al. Exhaled markers of oxidative stress in idiopathic pulmonary fibrosis. Eur J Clin Invest 36 (2006) 362-367
69. Rahman I., Biswas S.K., and Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 533 (2006) 222-239
70. Schock F., and Perrimon N. Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol 18 (2002) 463-493
71. Scotton C.J., and Chambers R.C. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 132 (2007) 1311-1321
72. Selman M., and Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc 3 (2006) 364-372
73. Selman M., Pardo A., Barrera L., Estrada A., Watson S.R., Wilson K., et al. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med 173 (2006) 188-198
74. Selman M., Pardo A., and Kaminski N. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?. PLoS Med 5 (2008) e62
75. Shannon J.M., and Hyatt B.A. Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 66 (2004) 625-645
76. Shukla M.N., Rose J.L., Ray R., Lathrop K.L., Ray A., and Ray P. Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol (2008)
77. Soltermann A., Tischler V., Arbogast S., Braun J., Probst-Hensch N., Weder W., et al. Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer. Clin Cancer Res 14 (2008) 7430-7437
78. Strieter R.M. What differentiates normal lung repair and fibrosis? Inflammation, resolution of repair, and fibrosis. Proc Am Thorac Soc 5 (2008) 305-310
79. Studer S.M., and Kaminski N. Towards systems biology of human pulmonary fibrosis. Proc Am Thorac Soc 4 (2007) 85-91
80. Szegezdi E., Logue S.E., Gorman A.M., and Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7 (2006) 880-885
81. Thannickal V.J., and Horowitz J.C. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 3 (2006) 350-356
82. Thannickal V.J., Toews G.B., White E.S., Lynch III J.P., and Martinez F.J. Mechanisms of pulmonary fibrosis. Annu Rev Med 55 (2004) 395-417
83. Thiery J.P., and Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7 (2006) 131-142
84. Tsuji T., Ibaragi S., Shima K., Hu M.G., Katsurano M., Sasaki A., et al. Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res 68 (2008) 10377-10386
85. Uhal B.D. Cell cycle kinetics in the alveolar epithelium. Am J Physiol 272 (1997) L1031-L1045
86. Wang W.J., Russo S.J., Mulugeta S., and Beers M.F. Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain. J Biol Chem 277 (2002) 19929-19937
87. Warburton D., Perin L., Defilippo R., Bellusci S., Shi W., and Driscoll B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc 5 (2008) 703-706
88. Wells A.U., and Hogaboam C.M. Update in diffuse parenchymal lung disease 2007. Am J Respir Crit Care Med 177 (2008) 580-584
89. Whitsett J.A. Genetic basis of familial interstitial lung disease: misfolding or function of surfactant protein C?. Am J Respir Crit Care Med 165 (2002) 1201-1202
90. Whitsett J.A., and Weaver T.E. Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 347 (2002) 2141-2148
91. Willis B.C., and Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293 (2007) L525-L534
92. Wynn T.A. Cellular and molecular mechanisms of fibrosis. J Pathol 214 (2008) 199-210
93. Xu J., Lamouille S., and Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19 (2009) 156-172
94. Yamasaki M., Kang H.R., Homer R.J., Chapoval S.P., Cho S.J., Lee B.J., et al. P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway. Am J Respir Cell Mol Biol 38 (2008) 346-353
95. Yoshida H. ER stress and diseases. FEBS J 274 (2007) 630-658
96. Zeisberg M., Shah A.A., and Kalluri R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem 280 (2005) 8094-8100
97. Zhang F., Nielsen L.D., Lucas J.J., and Mason R.J. Transforming growth factor-beta antagonizes alveolar type II cell proliferation induced by keratinocyte growth factor. Am J Respir Cell Mol Biol 31 (2004) 679-686
98. Zuo F., Kaminski N., Eugui E., Allard J., Yakhini Z., Ben-Dor A., et al. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci USA 99 (2002) 6292-6297