BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

Nature Medicine

Volumn 9, Issue 7, 2003, Pages 964-968

  Zeisberg, Michael ^a   Hanai, Jun Ichi ^a   Sugimoto, Hikaru ^a   Mammoto, Tadanori ^a   Charytan, David ^a   Strutz, Frank ^a   Kalluri, Raghu ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOGENIC PROTEIN 1; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BREAST EPITHELIUM; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; EYE DEVELOPMENT; GENE DELETION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY DEVELOPMENT; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY TUBULE EPITHELIUM; MESENCHYME CELL; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BONE MORPHOGENETIC PROTEINS; CADHERINS; CELL DIFFERENTIATION; CELLS, CULTURED; CHRONIC DISEASE; DNA-BINDING PROTEINS; EPITHELIAL CELLS; KIDNEY TUBULES; MESODERM; MICE; MICE, INBRED STRAINS; NEPHRITIS; PHOSPHOPROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD5 PROTEIN; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 0038717407     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm888     Document Type: Article

References (28)

1. Ozkaynak, E. et al. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J. 9, 2085-2093 (1990).
2. Hogan, B.L. Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6, 432-438 (1996).
3. Cano, A. et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2, 76-83 (2000).
4. Iwano, M. et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110, 341-350 (2002).
5. Thiery, J.P. Epithelial-mesenchymal transitions in tumor progression. Nat. Rev. Cancer 2, 442-454 (2002).
6. Hay, E.D. & Zuk, A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am. J. Kidney Dis. 26, 678-690 (1995).
7. Strutz, F. et al. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int. 61, 1714-1728 (2002).
8. Behrens, J., Lowrick, O., Klein-Hitpass, L. & Birchmeier, W. The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc. Natl. Acad. Sci. USA 88, 11495-11499 (1991).
9. Heldin, C.H., Miyazono, K. & ten Dijke, P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471 (1997).
10. Wrana, J.L. Regulation of Smad activity. Cell 100, 189-192 (2000).
11. Derynck, R., Zhang, Y. & Feng, X.H. Smads: transcriptional activators of TGF-beta responses. Cell 95, 737-740 (1998).
12. Massague, J. How cells read TGF-beta signals. Nat. Rev. Mol. Cell. Biol. 1, 169-178 (2000).
13. Attisano, L. & Wrana, J.L. Signal transduction by the TGF-beta superfamily. Science 296, 1646-1647 (2002).
14. Chen, Y.G. et al. Determinants of specificity in TGF-beta signal transduction. Genes Dev. 12, 2144-2152 (1998).
15. Ishida, W. et al. Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem. 275, 6075-6079 (2000).
16. Candia, A.F. et al. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 124, 4467-4480 (1997).
17. Comijn, J. et al. The two-handed E box binding zinc finger protein SIP1 downregulates E- cadherin and induces invasion. Mol. Cell 7, 1267-1278 (2001).
18. Lloyd, C.M. et al. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med. 185, 1371-1380 (1997).
19. Hruska, K.A. et al. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am. J. Physiol. Renal Physiol. 279, F130-F143 (2000).
20. Border, W.A. et al. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 360, 361-364 (1992).
21. Remuzzi, G. & Bertani, T. Pathophysiology of progressive nephropathies. N. Engl. J. Med. 339, 1448-1456 (1998).
22. Hennig, G., Lowrick, O., Birchmeier, W. & Behrens, J. Mechanisms identified in the transcriptional control of epithelial gene expression. J. Biol. Chem. 271, 595-602 (1996).
23. Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. & Miyazono, K. Smad proteins exist as monomers in vivo and undergo homo- and hetero- oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17, 4056-4065 (1998).
24. Imamura, T. et al. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 389, 622-626 (1997).
25. Okada, H., Danoff, T.M., Kalluri, R. & Neilson, E.G. Early role of Fsp1 in epithelial-mesenchymal transformation. Am. J. Physiol. 273, F563-F574 (1997).
26. Zeisberg, M. et al. Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am. J. Pathol. 159, 1313-1321 (2001).
27. Hanai, J. et al. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline C alpha promoter. J. Biol. Chem. 274, 31577-31582 (1999).
28. Zeisberg, M., Maeshima, Y., Mosterman, B. & Kalluri, R. Renal fibrosis: extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am. J. Pathol. 160, 2001-2008 (2002).