In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

Journal of Pathology

Volumn 227, Issue 3, 2012, Pages 275-285

  Fornari, Francesca ^a   Milazzo, Maddalena ^a   Chieco, Pasquale ^a   Negrini, Massimo ^b   Marasco, Elena ^a   Capranico, Giovanni ^c   Mantovani, Vilma ^a   Marinello, Jessica ^c   Sabbioni, Silvia ^b   Callegari, Elisa ^b   Cescon, Matteo ^a   Ravaioli, Matteo ^a   Croce, Carlo M ^d   Bolondi, Luigi ^a   Gramantieri, Laura ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

AKT3; C19MC; CDKN1A p21; HCC; Methylation; microRNA; PTEN; TIMP2

Indexed keywords

MICRORNA; PROTEIN P53;

ADULT; AGED; AKT 3 GENE; ARTICLE; C19MC GENE; CARCINOGENICITY; CDKN 1A GENE; CHROMOSOME 19; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; GENE; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; MIR 591D GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PTEN GENE; TIMP 3 GENE; TUMOR SUPPRESSOR GENE; UPREGULATION;

AGED; AGED, 80 AND OVER; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA METHYLATION; DOXORUBICIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84862009479     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3995     Document Type: Article

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