Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

Oncogene

Volumn 25, Issue 17, 2006, Pages 2520-2530

  Ogata, H ^a,b   Chinen, T ^a   Yoshida, T ^a,c   Kinjyo, I ^a   Takaesu, G ^a   Shiraishi, H ^a   Iida, M ^b   Kobayashi, T ^a   Yoshimura, A ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Liver fibrosis; SOCS; STAT; TGF 1

Indexed keywords

CHEMICAL AGENT; CONCANAVALIN A; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYTOKINE PRODUCTION; DISEASE SEVERITY; DNA METHYLATION; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; GENE EXPRESSION REGULATION; GENE SILENCING; GENES, DOMINANT; HUMANS; INTEGRASES; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 33646146734     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209281     Document Type: Article

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