-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0033551704
-
Apoptosis in proliferating, senescent, and immortalized keratinocytes
-
Chaturvedi V., et al. Apoptosis in proliferating, senescent, and immortalized keratinocytes. J. Biol. Chem. 1999, 274:23358-23367.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23358-23367
-
-
Chaturvedi, V.1
-
3
-
-
8344230643
-
Senescent fibroblasts resist apoptosis by downregulating caspase-3
-
Marcotte R., Lacelle C., Wang E. Senescent fibroblasts resist apoptosis by downregulating caspase-3. Mech. Ageing Dev. 2004, 125:777-783.
-
(2004)
Mech. Ageing Dev.
, vol.125
, pp. 777-783
-
-
Marcotte, R.1
Lacelle, C.2
Wang, E.3
-
4
-
-
84889600900
-
Programmed cell senescence during mammalian embryonic development
-
Munoz-Espin D., et al. Programmed cell senescence during mammalian embryonic development. Cell 2013, 155:1104-1118.
-
(2013)
Cell
, vol.155
, pp. 1104-1118
-
-
Munoz-Espin, D.1
-
5
-
-
0022362448
-
Theories of biological aging
-
Hayflick L. Theories of biological aging. Exp. Gerontol. 1985, 20:145-159.
-
(1985)
Exp. Gerontol.
, vol.20
, pp. 145-159
-
-
Hayflick, L.1
-
6
-
-
0026006294
-
Senescence as a mode of tumor suppression
-
Sager R. Senescence as a mode of tumor suppression. Environ. Health Perspect. 1991, 93:59-62.
-
(1991)
Environ. Health Perspect.
, vol.93
, pp. 59-62
-
-
Sager, R.1
-
7
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001, 11:S27-S31.
-
(2001)
Trends Cell Biol.
, vol.11
, pp. S27-S31
-
-
Campisi, J.1
-
8
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt C.A., et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002, 109:335-346.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
-
9
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele R.H., Okorokov A.L., Jardine L., Cummings J., Joel S.P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 2002, 62:1876-1883.
-
(2002)
Cancer Res.
, vol.62
, pp. 1876-1883
-
-
te Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
10
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson I.B. Tumor cell senescence in cancer treatment. Cancer Res. 2003, 63:2705-2715.
-
(2003)
Cancer Res.
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
11
-
-
16844373387
-
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
-
Roberson R.S., Kussick S.J., Vallieres E., Chen S.Y., Wu D.Y. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res. 2005, 65:2795-2803.
-
(2005)
Cancer Res.
, vol.65
, pp. 2795-2803
-
-
Roberson, R.S.1
Kussick, S.J.2
Vallieres, E.3
Chen, S.Y.4
Wu, D.Y.5
-
12
-
-
23244452684
-
Suppressing cancer: the importance of being senescent
-
Campisi J. Suppressing cancer: the importance of being senescent. Science 2005, 309:886-887.
-
(2005)
Science
, vol.309
, pp. 886-887
-
-
Campisi, J.1
-
13
-
-
70349773104
-
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
-
Adams P.D. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 2009, 36:2-14.
-
(2009)
Mol. Cell
, vol.36
, pp. 2-14
-
-
Adams, P.D.1
-
14
-
-
8444237425
-
Replicative senescence: a critical review
-
Cristofalo V.J., Lorenzini A., Allen R.G., Torres C., Tresini M. Replicative senescence: a critical review. Mech. Ageing Dev. 2004, 125:827-848.
-
(2004)
Mech. Ageing Dev.
, vol.125
, pp. 827-848
-
-
Cristofalo, V.J.1
Lorenzini, A.2
Allen, R.G.3
Torres, C.4
Tresini, M.5
-
15
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri G.P., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 1995, 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
-
16
-
-
34249672067
-
Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures
-
Maier A.B., Westendorp R.G., Van Heemst D. Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures. Ann. N Y Acad. Sci. 2007, 1100:323-332.
-
(2007)
Ann. N Y Acad. Sci.
, vol.1100
, pp. 323-332
-
-
Maier, A.B.1
Westendorp, R.G.2
Van Heemst, D.3
-
17
-
-
33646946746
-
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
-
Lee B.Y., et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 2006, 5:187-195.
-
(2006)
Aging Cell
, vol.5
, pp. 187-195
-
-
Lee, B.Y.1
-
18
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig U., Jobling W.A., Chen B.P., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 2004, 14:501-513.
-
(2004)
Mol. Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.3
Chen, D.J.4
Sedivy, J.M.5
-
19
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
20
-
-
33748327046
-
P16INK4A is a robust in vivo biomarker of cellular aging in human skin
-
Ressler S., et al. p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 2006, 5:379-389.
-
(2006)
Aging Cell
, vol.5
, pp. 379-389
-
-
Ressler, S.1
-
21
-
-
0032485213
-
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
-
Robles S.J., Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 1998, 16:1113-1123.
-
(1998)
Oncogene
, vol.16
, pp. 1113-1123
-
-
Robles, S.J.1
Adami, G.R.2
-
22
-
-
0030784943
-
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development
-
Zindy F., et al. Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development. Cell Growth Differ. 1997, 8:1139-1150.
-
(1997)
Cell Growth Differ.
, vol.8
, pp. 1139-1150
-
-
Zindy, F.1
-
23
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J., et al. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 2004, 114:1299-1307.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
-
24
-
-
2342438613
-
Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence
-
Herbig U., Wei W., Dutriaux A., Jobling W.A., Sedivy J.M. Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell 2003, 2:295-304.
-
(2003)
Aging Cell
, vol.2
, pp. 295-304
-
-
Herbig, U.1
Wei, W.2
Dutriaux, A.3
Jobling, W.A.4
Sedivy, J.M.5
-
25
-
-
78650243948
-
Impact of cellular senescence signature on ageing research
-
Sikora E., Arendt T., Bennett M., Narita M. Impact of cellular senescence signature on ageing research. Ageing Res. Rev. 2011, 10:146-152.
-
(2011)
Ageing Res. Rev.
, vol.10
, pp. 146-152
-
-
Sikora, E.1
Arendt, T.2
Bennett, M.3
Narita, M.4
-
26
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita M., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003, 113:703-716.
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
-
27
-
-
33847703331
-
Cellular senescence and chromatin organisation
-
Narita M. Cellular senescence and chromatin organisation. Br. J. Cancer 2007, 96:686-691.
-
(2007)
Br. J. Cancer
, vol.96
, pp. 686-691
-
-
Narita, M.1
-
28
-
-
34648816970
-
Cellular senescence and chromatin structure
-
Funayama R., Ishikawa F. Cellular senescence and chromatin structure. Chromosoma 2007, 116:431-440.
-
(2007)
Chromosoma
, vol.116
, pp. 431-440
-
-
Funayama, R.1
Ishikawa, F.2
-
29
-
-
19944427674
-
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
-
Zhang R., et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 2005, 8:19-30.
-
(2005)
Dev. Cell
, vol.8
, pp. 19-30
-
-
Zhang, R.1
-
30
-
-
33646877911
-
Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes
-
Rastogi S., et al. Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol. Cell Biol. 2006, 26:4161-4171.
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 4161-4171
-
-
Rastogi, S.1
-
31
-
-
33749549246
-
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
-
Coppe J.P., Kauser K., Campisi J., Beausejour C.M. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J. Biol. Chem. 2006, 281:29568-29574.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 29568-29574
-
-
Coppe, J.P.1
Kauser, K.2
Campisi, J.3
Beausejour, C.M.4
-
32
-
-
70350125106
-
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
-
Orjalo A.V., Bhaumik D., Gengler B.K., Scott G.K., Campisi J. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc. Natl. Acad. Sci. USA 2009, 106:17031-17036.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 17031-17036
-
-
Orjalo, A.V.1
Bhaumik, D.2
Gengler, B.K.3
Scott, G.K.4
Campisi, J.5
-
33
-
-
68249096784
-
Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion
-
Rodier F., et al. Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
-
34
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
-
35
-
-
60849127227
-
Cellular senescence, ageing and disease
-
Burton D.G. Cellular senescence, ageing and disease. Age (Dordr) 2009, 31:1-9.
-
(2009)
Age (Dordr)
, vol.31
, pp. 1-9
-
-
Burton, D.G.1
-
36
-
-
1542781659
-
When cells get stressed: an integrative view of cellular senescence
-
Ben-Porath I., Weinberg R.A. When cells get stressed: an integrative view of cellular senescence. J. Clin. Invest. 2004, 113:8-13.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 8-13
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
37
-
-
14644410453
-
The signals and pathways activating cellular senescence
-
Ben-Porath I., Weinberg R.A. The signals and pathways activating cellular senescence. Int. J. Biochem. Cell Biol. 2005, 37:961-976.
-
(2005)
Int. J. Biochem. Cell Biol.
, vol.37
, pp. 961-976
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
38
-
-
10944257464
-
Human cell senescence as a DNA damage response
-
von Zglinicki T., Saretzki G., Ladhoff J., d'Adda di Fagagna F., Jackson S.P. Human cell senescence as a DNA damage response. Mech. Ageing Dev. 2005, 126:111-117.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 111-117
-
-
von Zglinicki, T.1
Saretzki, G.2
Ladhoff, J.3
d'Adda di Fagagna, F.4
Jackson, S.P.5
-
39
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
40
-
-
64949135819
-
Does damage to DNA and other macromolecules play a role in aging? If so, how?
-
Campisi J., Vijg J. Does damage to DNA and other macromolecules play a role in aging? If so, how?. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:175-178.
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.64
, pp. 175-178
-
-
Campisi, J.1
Vijg, J.2
-
41
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson S.P., Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
42
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull T.T., et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 2000, 10:886-895.
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
-
43
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
44
-
-
0034700511
-
A role for Saccharomyces cerevisiae histone H2A in DNA repair
-
Downs J.A., Lowndes N.F., Jackson S.P. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 2000, 408:1001-1004.
-
(2000)
Nature
, vol.408
, pp. 1001-1004
-
-
Downs, J.A.1
Lowndes, N.F.2
Jackson, S.P.3
-
45
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 2001, 276:47759-47762.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
47
-
-
79951974992
-
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks
-
Moyal L., et al. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol. Cell 2011, 41:529-542.
-
(2011)
Mol. Cell
, vol.41
, pp. 529-542
-
-
Moyal, L.1
-
48
-
-
84859895529
-
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
-
Mallette F.A., et al. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 2012, 31:1865-1878.
-
(2012)
EMBO J.
, vol.31
, pp. 1865-1878
-
-
Mallette, F.A.1
-
49
-
-
84879888213
-
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
-
Fradet-Turcotte A., et al. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 2013, 499:50-54.
-
(2013)
Nature
, vol.499
, pp. 50-54
-
-
Fradet-Turcotte, A.1
-
50
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
-
Escribano-Diaz C., et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 2013, 49:872-883.
-
(2013)
Mol. Cell
, vol.49
, pp. 872-883
-
-
Escribano-Diaz, C.1
-
51
-
-
84878893538
-
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
-
Callen E., et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 2013, 153:1266-1280.
-
(2013)
Cell
, vol.153
, pp. 1266-1280
-
-
Callen, E.1
-
52
-
-
84876527317
-
RIF1 counteracts BRCA1-mediated end resection during DNA repair
-
Feng L., Fong K.W., Wang J., Wang W., Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J. Biol. Chem. 2013, 288:11135-11143.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11135-11143
-
-
Feng, L.1
Fong, K.W.2
Wang, J.3
Wang, W.4
Chen, J.5
-
53
-
-
84876855215
-
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
-
Chapman J.R., et al. RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 2013, 49:858-871.
-
(2013)
Mol. Cell
, vol.49
, pp. 858-871
-
-
Chapman, J.R.1
-
54
-
-
84873488846
-
53BP1 regulates DSB repair using Rif1 to control 5' end resection
-
Zimmermann M., Lottersberger F., Buonomo S.B., Sfeir A., de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science 2013, 339:700-704.
-
(2013)
Science
, vol.339
, pp. 700-704
-
-
Zimmermann, M.1
Lottersberger, F.2
Buonomo, S.B.3
Sfeir, A.4
de Lange, T.5
-
55
-
-
84873526612
-
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
-
Di Virgilio M., et al. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 2013, 339:711-715.
-
(2013)
Science
, vol.339
, pp. 711-715
-
-
Di Virgilio, M.1
-
56
-
-
77953166592
-
GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
-
Lobrich M., et al. gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle 2010, 9:662-669.
-
(2010)
Cell Cycle
, vol.9
, pp. 662-669
-
-
Lobrich, M.1
-
57
-
-
77953149691
-
The limitations of the G1-S checkpoint
-
Deckbar D., et al. The limitations of the G1-S checkpoint. Cancer Res. 2010, 70:4412-4421.
-
(2010)
Cancer Res.
, vol.70
, pp. 4412-4421
-
-
Deckbar, D.1
-
58
-
-
55349095456
-
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations
-
Muller M. Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Antioxid. Redox Signal 2009, 11:59-98.
-
(2009)
Antioxid. Redox Signal
, vol.11
, pp. 59-98
-
-
Muller, M.1
-
59
-
-
0034630432
-
Accumulation of short telomeres in human fibroblasts prior to replicative senescence
-
Martens U.M., Chavez E.A., Poon S.S., Schmoor C., Lansdorp P.M. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp. Cell Res. 2000, 256:291-299.
-
(2000)
Exp. Cell Res.
, vol.256
, pp. 291-299
-
-
Martens, U.M.1
Chavez, E.A.2
Poon, S.S.3
Schmoor, C.4
Lansdorp, P.M.5
-
60
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F., et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
-
61
-
-
33646757232
-
The complexity of p53 stabilization and activation
-
Lavin M.F., Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ 2006, 13:941-950.
-
(2006)
Cell Death Differ
, vol.13
, pp. 941-950
-
-
Lavin, M.F.1
Gueven, N.2
-
62
-
-
0026054961
-
A role for both RB and p53 in the regulation of human cellular senescence
-
Shay J.W., Pereira-Smith O.M., Wright W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 1991, 196:33-39.
-
(1991)
Exp. Cell Res.
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
63
-
-
0033989829
-
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
-
Dimri G.P., Itahana K., Acosta M., Campisi J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol. Cell Biol. 2000, 20:273-285.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 273-285
-
-
Dimri, G.P.1
Itahana, K.2
Acosta, M.3
Campisi, J.4
-
64
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein G.H., Drullinger L.F., Soulard A., Dulic V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell Biol. 1999, 19:2109-2117.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
65
-
-
0033528830
-
P21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
-
Fang L., et al. p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene 1999, 18:2789-2797.
-
(1999)
Oncogene
, vol.18
, pp. 2789-2797
-
-
Fang, L.1
-
66
-
-
0030609861
-
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
-
Brown J.P., Wei W., Sedivy J.M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 1997, 277:831-834.
-
(1997)
Science
, vol.277
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
67
-
-
84899098006
-
ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets
-
Carlos A.R., et al. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets. Nat. Commun. 2013, 4:2697.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2697
-
-
Carlos, A.R.1
-
68
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello S., et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 2003, 5:741-747.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
-
69
-
-
7044231343
-
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
-
Ohtani N., Yamakoshi K., Takahashi A., Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J. Med. Invest. 2004, 51:146-153.
-
(2004)
J. Med. Invest.
, vol.51
, pp. 146-153
-
-
Ohtani, N.1
Yamakoshi, K.2
Takahashi, A.3
Hara, E.4
-
70
-
-
0345932931
-
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
-
Iwasa H., Han J., Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003, 8:131-144.
-
(2003)
Genes Cells
, vol.8
, pp. 131-144
-
-
Iwasa, H.1
Han, J.2
Ishikawa, F.3
-
71
-
-
1842483852
-
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
-
Bulavin D.V., et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 2004, 36:343-350.
-
(2004)
Nat. Genet.
, vol.36
, pp. 343-350
-
-
Bulavin, D.V.1
-
72
-
-
0346463059
-
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
-
Deng Q., Liao R., Wu B.L., Sun P. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J. Biol. Chem. 2004, 279:1050-1059.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1050-1059
-
-
Deng, Q.1
Liao, R.2
Wu, B.L.3
Sun, P.4
-
73
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
74
-
-
0041966056
-
Reversal of human cellular senescence: roles of the p53 and p16 pathways
-
Beausejour C.M., et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 2003, 22:4212-4222.
-
(2003)
EMBO J.
, vol.22
, pp. 4212-4222
-
-
Beausejour, C.M.1
-
75
-
-
77950486542
-
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence
-
Chicas A., et al. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell 2010, 17:376-387.
-
(2010)
Cancer Cell
, vol.17
, pp. 376-387
-
-
Chicas, A.1
-
76
-
-
11144268164
-
Significant role for p16INK4a in p53-independent telomere-directed senescence
-
Jacobs J.J., de Lange T. Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr. Biol. 2004, 14:2302-2308.
-
(2004)
Curr. Biol.
, vol.14
, pp. 2302-2308
-
-
Jacobs, J.J.1
de Lange, T.2
-
77
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith J.D., et al. Mammalian telomeres end in a large duplex loop. Cell 1999, 97:503-514.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
-
78
-
-
84885580087
-
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation
-
Doksani Y., Wu J.Y., de Lange T., Zhuang X. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell 2013, 155:345-356.
-
(2013)
Cell
, vol.155
, pp. 345-356
-
-
Doksani, Y.1
Wu, J.Y.2
de Lange, T.3
Zhuang, X.4
-
79
-
-
0037148277
-
Protection of mammalian telomeres
-
de Lange T. Protection of mammalian telomeres. Oncogene 2002, 21:532-540.
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
de Lange, T.1
-
80
-
-
33947317206
-
The epigenetic regulation of mammalian telomeres
-
Blasco M.A. The epigenetic regulation of mammalian telomeres. Nat. Rev. Genet. 2007, 8:299-309.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 299-309
-
-
Blasco, M.A.1
-
81
-
-
24944460598
-
Shelterin: the protein complex that shapes and safeguards human telomeres
-
de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19:2100-2110.
-
(2005)
Genes Dev.
, vol.19
, pp. 2100-2110
-
-
de Lange, T.1
-
82
-
-
69749092744
-
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
-
Martinez P., et al. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 2009, 23:2060-2075.
-
(2009)
Genes Dev.
, vol.23
, pp. 2060-2075
-
-
Martinez, P.1
-
83
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai H., Smogorzewska A., de Lange T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 2003, 13:1549-1556.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
de Lange, T.3
-
84
-
-
0035844082
-
Pot1, the putative telomere end-binding protein in fission yeast and humans
-
Baumann P., Cech T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 2001, 292:1171-1175.
-
(2001)
Science
, vol.292
, pp. 1171-1175
-
-
Baumann, P.1
Cech, T.R.2
-
85
-
-
3242680818
-
PTOP interacts with POT1 and regulates its localization to telomeres
-
Liu D., et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. 2004, 6:673-680.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 673-680
-
-
Liu, D.1
-
86
-
-
22144490491
-
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
-
Celli G.B., de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 2005, 7:712-718.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 712-718
-
-
Celli, G.B.1
de Lange, T.2
-
87
-
-
77950196212
-
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal
-
Sfeir A., Kabir S., van Overbeek M., Celli G.B., de Lange T. Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 2010, 327:1657-1661.
-
(2010)
Science
, vol.327
, pp. 1657-1661
-
-
Sfeir, A.1
Kabir, S.2
van Overbeek, M.3
Celli, G.B.4
de Lange, T.5
-
88
-
-
81355150876
-
Telomere protection by TPP1/POT1 requires tethering to TIN2
-
Takai K.K., Kibe T., Donigian J.R., Frescas D., de Lange T. Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol. Cell 2011, 44:647-659.
-
(2011)
Mol. Cell
, vol.44
, pp. 647-659
-
-
Takai, K.K.1
Kibe, T.2
Donigian, J.R.3
Frescas, D.4
de Lange, T.5
-
89
-
-
84860456242
-
Removal of shelterin reveals the telomere end-protection problem
-
Sfeir A., de Lange T. Removal of shelterin reveals the telomere end-protection problem. Science 2012, 336:593-597.
-
(2012)
Science
, vol.336
, pp. 593-597
-
-
Sfeir, A.1
de Lange, T.2
-
90
-
-
34548317418
-
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
-
Denchi E.L., de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 2007, 448:1068-1071.
-
(2007)
Nature
, vol.448
, pp. 1068-1071
-
-
Denchi, E.L.1
de Lange, T.2
-
91
-
-
0033605145
-
P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J., Broccoli D., Dai Y., Hardy S., de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999, 283:1321-1325.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
de Lange, T.5
-
92
-
-
0037341373
-
Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung
-
Nakanishi K., et al. Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Clin. Cancer Res. 2003, 9:1105-1111.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1105-1111
-
-
Nakanishi, K.1
-
93
-
-
11144227269
-
Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis
-
Oh B.K., Kim Y.J., Park C., Park Y.N. Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am. J. Pathol. 2005, 166:73-80.
-
(2005)
Am. J. Pathol.
, vol.166
, pp. 73-80
-
-
Oh, B.K.1
Kim, Y.J.2
Park, C.3
Park, Y.N.4
-
94
-
-
27144515686
-
XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
-
Munoz P., Blanco R., Flores J.M., Blasco M.A. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat. Genet. 2005, 37:1063-1071.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1063-1071
-
-
Munoz, P.1
Blanco, R.2
Flores, J.M.3
Blasco, M.A.4
-
95
-
-
79957880976
-
Detailed analysis of DNA repair and senescence marker kinetics over the life span of a human fibroblast cell line
-
Endt H., et al. Detailed analysis of DNA repair and senescence marker kinetics over the life span of a human fibroblast cell line. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66:367-375.
-
(2011)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.66
, pp. 367-375
-
-
Endt, H.1
-
96
-
-
0015844590
-
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
-
Olovnikov A.M. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 1973, 41:181-190.
-
(1973)
J. Theor. Biol.
, vol.41
, pp. 181-190
-
-
Olovnikov, A.M.1
-
97
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
98
-
-
0037382414
-
Erosion of the telomeric single-strand overhang at replicative senescence
-
Stewart S.A., et al. Erosion of the telomeric single-strand overhang at replicative senescence. Nat. Genet. 2003, 33:492-496.
-
(2003)
Nat. Genet.
, vol.33
, pp. 492-496
-
-
Stewart, S.A.1
-
99
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann M.T., Strong M.A., Hao L.Y., Greider C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001, 107:67-77.
-
(2001)
Cell
, vol.107
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
Hao, L.Y.3
Greider, C.W.4
-
100
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn E.H. Switching and signaling at the telomere. Cell 2001, 106:661-673.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
101
-
-
13944261190
-
Dysfunctional telomeres at senescence signal cell cycle arrest via Chk2
-
Gire V. Dysfunctional telomeres at senescence signal cell cycle arrest via Chk2. Cell Cycle 2004, 3:1217-1220.
-
(2004)
Cell Cycle
, vol.3
, pp. 1217-1220
-
-
Gire, V.1
-
102
-
-
77951976271
-
Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
-
Nakamura A.J., Redon C.E., Bonner W.M., Sedelnikova O.A. Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells. Aging (Albany NY) 2009, 1:212-218.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 212-218
-
-
Nakamura, A.J.1
Redon, C.E.2
Bonner, W.M.3
Sedelnikova, O.A.4
-
103
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U., Ferreira M., Condel L., Carey D., Sedivy J.M. Cellular senescence in aging primates. Science 2006, 311:1257.
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
104
-
-
0037178761
-
Connecting chromosomes, crisis, and cancer
-
Maser R.S., DePinho R.A. Connecting chromosomes, crisis, and cancer. Science 2002, 297:565-569.
-
(2002)
Science
, vol.297
, pp. 565-569
-
-
Maser, R.S.1
DePinho, R.A.2
-
105
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
-
Sedelnikova O.A., et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 2004, 6:168-170.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
-
106
-
-
66149167336
-
DNA damage response and cellular senescence in tissues of aging mice
-
Wang C., et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009, 8:311-323.
-
(2009)
Aging Cell
, vol.8
, pp. 311-323
-
-
Wang, C.1
-
107
-
-
45849117573
-
Activation of the cellular DNA damage response in the absence of DNA lesions
-
Soutoglou E., Misteli T. Activation of the cellular DNA damage response in the absence of DNA lesions. Science 2008, 320:1507-1510.
-
(2008)
Science
, vol.320
, pp. 1507-1510
-
-
Soutoglou, E.1
Misteli, T.2
-
108
-
-
42949130159
-
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
-
Bonilla C.Y., Melo J.A., Toczyski D.P. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell 2008, 30:267-276.
-
(2008)
Mol. Cell
, vol.30
, pp. 267-276
-
-
Bonilla, C.Y.1
Melo, J.A.2
Toczyski, D.P.3
-
109
-
-
38949124412
-
ATR signaling can drive cells into senescence in the absence of DNA breaks
-
Toledo L.I., Murga M., Gutierrez-Martinez P., Soria R., Fernandez-Capetillo O. ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev. 2008, 22:297-302.
-
(2008)
Genes Dev.
, vol.22
, pp. 297-302
-
-
Toledo, L.I.1
Murga, M.2
Gutierrez-Martinez, P.3
Soria, R.4
Fernandez-Capetillo, O.5
-
110
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
Pospelova T.V., et al. Pseudo-DNA damage response in senescent cells. Cell Cycle 2009, 8:4112-4118.
-
(2009)
Cell Cycle
, vol.8
, pp. 4112-4118
-
-
Pospelova, T.V.1
-
111
-
-
0036860225
-
Replicative senescence and senescence-like state induced in cancer-derived cells
-
Hwang E.S. Replicative senescence and senescence-like state induced in cancer-derived cells. Mech. Ageing Dev. 2002, 123:1681-1694.
-
(2002)
Mech. Ageing Dev.
, vol.123
, pp. 1681-1694
-
-
Hwang, E.S.1
-
112
-
-
11144290236
-
Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts
-
Zhao W., Lin Z.X., Zhang Z.Q. Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts. Cell Res. 2004, 14:60-66.
-
(2004)
Cell Res.
, vol.14
, pp. 60-66
-
-
Zhao, W.1
Lin, Z.X.2
Zhang, Z.Q.3
-
113
-
-
58149327460
-
Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells
-
Sliwinska M.A., et al. Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells. Mech. Ageing Dev. 2009, 130:24-32.
-
(2009)
Mech. Ageing Dev.
, vol.130
, pp. 24-32
-
-
Sliwinska, M.A.1
-
114
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
-
Di Leonardo A., Linke S.P., Clarkin K., Wahl G.M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 1994, 8:2540-2551.
-
(1994)
Genes Dev.
, vol.8
, pp. 2540-2551
-
-
Di Leonardo, A.1
Linke, S.P.2
Clarkin, K.3
Wahl, G.M.4
-
115
-
-
0033732110
-
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
-
Toussaint O., Medrano E.E., von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 2000, 35:927-945.
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 927-945
-
-
Toussaint, O.1
Medrano, E.E.2
von Zglinicki, T.3
-
116
-
-
20144362952
-
Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway
-
Debacq-Chainiaux F., et al. Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J. Cell Sci. 2005, 118:743-758.
-
(2005)
J. Cell Sci.
, vol.118
, pp. 743-758
-
-
Debacq-Chainiaux, F.1
-
117
-
-
84859372986
-
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
-
Fumagalli M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012, 14:355-365.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 355-365
-
-
Fumagalli, M.1
-
118
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson M., et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 2000, 406:207-210.
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
-
119
-
-
75449097024
-
Oncogene-induced cellular senescence
-
Chandeck C., Mooi W.J. Oncogene-induced cellular senescence. Adv. Anat. Pathol. 2010, 17:42-48.
-
(2010)
Adv. Anat. Pathol.
, vol.17
, pp. 42-48
-
-
Chandeck, C.1
Mooi, W.J.2
-
120
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova J., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
-
121
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee A.C., et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 1999, 274:7936-7940.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
-
122
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco R., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006, 444:638-642.
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di Micco, R.1
-
123
-
-
36048965126
-
Breaking news: high-speed race ends in arrest - how oncogenes induce senescence
-
Di Micco R., Fumagalli M., d'Adda di Fagagna F. Breaking news: high-speed race ends in arrest - how oncogenes induce senescence. Trends Cell Biol. 2007, 17:529-536.
-
(2007)
Trends Cell Biol.
, vol.17
, pp. 529-536
-
-
Di Micco, R.1
Fumagalli, M.2
d'Adda di Fagagna, F.3
-
124
-
-
0033941559
-
Evidence for a telomere-independent clock limiting RAS oncogene-driven proliferation of human thyroid epithelial cells
-
Jones C.J., et al. Evidence for a telomere-independent clock limiting RAS oncogene-driven proliferation of human thyroid epithelial cells. Mol. Cell Biol. 2000, 20:5690-5699.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 5690-5699
-
-
Jones, C.J.1
-
125
-
-
77953625822
-
The central role of chromatin maintenance in aging
-
Pegoraro G., Misteli T. The central role of chromatin maintenance in aging. Aging (Albany NY) 2009, 1:1017-1022.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 1017-1022
-
-
Pegoraro, G.1
Misteli, T.2
-
126
-
-
34147182401
-
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
-
Adams P.D. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 2007, 397:84-93.
-
(2007)
Gene
, vol.397
, pp. 84-93
-
-
Adams, P.D.1
-
127
-
-
79851493300
-
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a)
-
Kosar M., et al. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle 2011, 10:457-468.
-
(2011)
Cell Cycle
, vol.10
, pp. 457-468
-
-
Kosar, M.1
-
128
-
-
33845687060
-
Loss of linker histone H1 in cellular senescence
-
Funayama R., Saito M., Tanobe H., Ishikawa F. Loss of linker histone H1 in cellular senescence. J. Cell Biol. 2006, 175:869-880.
-
(2006)
J. Cell Biol.
, vol.175
, pp. 869-880
-
-
Funayama, R.1
Saito, M.2
Tanobe, H.3
Ishikawa, F.4
-
129
-
-
68149100569
-
The role of epigenetics in aging and age-related diseases
-
Calvanese V., Lara E., Kahn A., Fraga M.F. The role of epigenetics in aging and age-related diseases. Ageing Res. Rev. 2009, 8:268-276.
-
(2009)
Ageing Res. Rev.
, vol.8
, pp. 268-276
-
-
Calvanese, V.1
Lara, E.2
Kahn, A.3
Fraga, M.F.4
-
130
-
-
0037131426
-
Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
-
Sarg B., Koutzamani E., Helliger W., Rundquist I., Lindner H.H. Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. J. Biol. Chem. 2002, 277:39195-39201.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39195-39201
-
-
Sarg, B.1
Koutzamani, E.2
Helliger, W.3
Rundquist, I.4
Lindner, H.H.5
-
131
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig M., et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005, 436:660-665.
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
-
132
-
-
23944523926
-
A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain
-
Krouwels I.M., et al. A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. J. Cell. Biol. 2005, 170:537-549.
-
(2005)
J. Cell. Biol.
, vol.170
, pp. 537-549
-
-
Krouwels, I.M.1
-
133
-
-
84896863739
-
The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence
-
Talluri S., Dick F.A. The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence. Cell Cycle 2014, 13:641-651.
-
(2014)
Cell Cycle
, vol.13
, pp. 641-651
-
-
Talluri, S.1
Dick, F.A.2
-
134
-
-
84899145875
-
The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence
-
Munch S., et al. The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence. Mol. Cell Biol. 2014, 34:1733-1746.
-
(2014)
Mol. Cell Biol.
, vol.34
, pp. 1733-1746
-
-
Munch, S.1
-
135
-
-
33746752125
-
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
-
Narita M., et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 2006, 126:503-514.
-
(2006)
Cell
, vol.126
, pp. 503-514
-
-
Narita, M.1
-
136
-
-
2942596544
-
Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin
-
Catez F., et al. Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol. Cell Biol. 2004, 24:4321-4328.
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 4321-4328
-
-
Catez, F.1
-
137
-
-
84882269557
-
Rb protein is essential to the senescence-associated heterochromatic foci formation induced by HMGA2 in primary WI38 cells
-
Shi X., et al. Rb protein is essential to the senescence-associated heterochromatic foci formation induced by HMGA2 in primary WI38 cells. J. Genet. Genomics 2013, 40:391-398.
-
(2013)
J. Genet. Genomics
, vol.40
, pp. 391-398
-
-
Shi, X.1
-
138
-
-
34147143631
-
Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
-
Ye X., et al. Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol. Cell Biol. 2007, 27:2452-2465.
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 2452-2465
-
-
Ye, X.1
-
139
-
-
59249106280
-
Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells
-
Banumathy G., et al. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol. Cell Biol. 2009, 29:758-770.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 758-770
-
-
Banumathy, G.1
-
140
-
-
84864297655
-
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
-
Chandra T., et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol. Cell 2012, 47:203-214.
-
(2012)
Mol. Cell
, vol.47
, pp. 203-214
-
-
Chandra, T.1
-
141
-
-
84882642434
-
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
-
Sadaie M., et al. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 2013, 27:1800-1808.
-
(2013)
Genes Dev.
, vol.27
, pp. 1800-1808
-
-
Sadaie, M.1
-
142
-
-
84876431455
-
BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss
-
Tu Z., Zhuang X., Yao Y.G., Zhang R. BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol. Cell Biol. 2013, 33:1819-1829.
-
(2013)
Mol. Cell Biol.
, vol.33
, pp. 1819-1829
-
-
Tu, Z.1
Zhuang, X.2
Yao, Y.G.3
Zhang, R.4
-
143
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C., et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005, 436:720-724.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
-
144
-
-
12144283456
-
The p400 E1A-associated protein is a novel component of the p53 - > p21 senescence pathway
-
Chan H.M., Narita M., Lowe S.W., Livingston D.M. The p400 E1A-associated protein is a novel component of the p53 - > p21 senescence pathway. Genes Dev. 2005, 19:196-201.
-
(2005)
Genes Dev.
, vol.19
, pp. 196-201
-
-
Chan, H.M.1
Narita, M.2
Lowe, S.W.3
Livingston, D.M.4
-
145
-
-
79952268809
-
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
-
Di Micco R., et al. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat. Cell Biol. 2011, 13:292-302.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 292-302
-
-
Di Micco, R.1
-
146
-
-
64049094851
-
Epigenetic therapies in haematological malignancies: searching for true targets
-
Altucci L., Minucci S. Epigenetic therapies in haematological malignancies: searching for true targets. Eur. J. Cancer 2009, 45:1137-1145.
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 1137-1145
-
-
Altucci, L.1
Minucci, S.2
-
147
-
-
84891542755
-
Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence
-
Swanson E.C., Manning B., Zhang H., Lawrence J.B. Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence. J. Cell Biol. 2013, 203:929-942.
-
(2013)
J. Cell Biol.
, vol.203
, pp. 929-942
-
-
Swanson, E.C.1
Manning, B.2
Zhang, H.3
Lawrence, J.B.4
-
148
-
-
34447532525
-
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals
-
Kim J.A., Kruhlak M., Dotiwala F., Nussenzweig A., Haber J.E. Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J. Cell Biol. 2007, 178:209-218.
-
(2007)
J. Cell Biol.
, vol.178
, pp. 209-218
-
-
Kim, J.A.1
Kruhlak, M.2
Dotiwala, F.3
Nussenzweig, A.4
Haber, J.E.5
-
149
-
-
42249102663
-
GammaH2AX foci form preferentially in euchromatin after ionising-radiation
-
Cowell I.G., et al. gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One 2007, 2:e1057.
-
(2007)
PLoS One
, vol.2
, pp. e1057
-
-
Cowell, I.G.1
-
150
-
-
47349107760
-
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
-
Goodarzi A.A., et al. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 2008, 31:167-177.
-
(2008)
Mol. Cell
, vol.31
, pp. 167-177
-
-
Goodarzi, A.A.1
-
151
-
-
79952314830
-
Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
-
Chiolo I., et al. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 2011, 144:732-744.
-
(2011)
Cell
, vol.144
, pp. 732-744
-
-
Chiolo, I.1
-
152
-
-
79961207835
-
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
-
Jakob B., et al. DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res. 2011, 39:6489-6499.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 6489-6499
-
-
Jakob, B.1
-
153
-
-
83055167028
-
Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells
-
Drissi R., Wu J., Hu Y., Bockhold C., Dome J.S. Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells. Cancer Prev. Res. (Phila) 2011, 4:1973-1981.
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 1973-1981
-
-
Drissi, R.1
Wu, J.2
Hu, Y.3
Bockhold, C.4
Dome, J.S.5
-
154
-
-
38349134829
-
Delayed kinetics of DNA double-strand break processing in normal and pathological aging
-
Sedelnikova O.A., et al. Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell 2008, 7:89-100.
-
(2008)
Aging Cell
, vol.7
, pp. 89-100
-
-
Sedelnikova, O.A.1
-
155
-
-
78651104478
-
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
-
Rodier F., et al. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J. Cell Sci. 2011, 124:68-81.
-
(2011)
J. Cell Sci.
, vol.124
, pp. 68-81
-
-
Rodier, F.1
-
156
-
-
84886946145
-
CHD chromatin remodelling enzymes and the DNA damage response
-
Stanley F.K., Moore S., Goodarzi A.A. CHD chromatin remodelling enzymes and the DNA damage response. Mutat. Res. 2013, 750:31-44.
-
(2013)
Mutat. Res.
, vol.750
, pp. 31-44
-
-
Stanley, F.K.1
Moore, S.2
Goodarzi, A.A.3
-
157
-
-
80053589357
-
Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest
-
Brunton H., et al. Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest. Mol. Cell Biol. 2011, 31:4022-4035.
-
(2011)
Mol. Cell Biol.
, vol.31
, pp. 4022-4035
-
-
Brunton, H.1
|