메뉴 건너뛰기




Volumn 8, Issue 4, 2009, Pages 268-276

The role of epigenetics in aging and age-related diseases

Author keywords

Aging; Chromatin; DNA methylation; Epigenetics; Histone modification

Indexed keywords

5 METHYLCYTOSINE; AGOUTI PROTEIN; HISTONE; SIRTUIN;

EID: 68149100569     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2009.03.004     Document Type: Short Survey
Times cited : (278)

References (113)
  • 1
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • Ahuja N., Li Q., Mohan A.L., Baylin S.B., and Issa J.P. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res. 58 (1998) 5489-5494
    • (1998) Cancer Res. , vol.58 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.P.5
  • 2
    • 33751533712 scopus 로고    scopus 로고
    • Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
    • Anway M.D., Leathers C., and Skinner M.K. Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease. Endocrinology 147 (2006) 5515-5523
    • (2006) Endocrinology , vol.147 , pp. 5515-5523
    • Anway, M.D.1    Leathers, C.2    Skinner, M.K.3
  • 5
    • 69049112187 scopus 로고
    • Nucleotide composition of DNA and RNA from somatic tissues of humpback salmon and its changes during spawning
    • Berdyshev G.D., Korotaev G.K., Boyarskikh G.V., and Vanyushin B.F. Nucleotide composition of DNA and RNA from somatic tissues of humpback salmon and its changes during spawning. Biokhimia (1967) 32
    • (1967) Biokhimia , pp. 32
    • Berdyshev, G.D.1    Korotaev, G.K.2    Boyarskikh, G.V.3    Vanyushin, B.F.4
  • 6
    • 9944228800 scopus 로고    scopus 로고
    • Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development
    • Biron V.L., McManus K.J., Hu N., Hendzel M.J., and Underhill D.A. Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development. Dev. Biol. 276 (2004) 337-351
    • (2004) Dev. Biol. , vol.276 , pp. 337-351
    • Biron, V.L.1    McManus, K.J.2    Hu, N.3    Hendzel, M.J.4    Underhill, D.A.5
  • 7
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson H.T., Fallin M.D., and Feinberg A.P. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 20 (2004) 350-358
    • (2004) Trends Genet. , vol.20 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 10
    • 27144475816 scopus 로고    scopus 로고
    • Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
    • Bradbury C.A., Khanim F.L., Hayden R., Bunce C.M., White D.A., Drayson M.T., Craddock C., and Turner B.M. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 19 (2005) 1751-1759
    • (2005) Leukemia , vol.19 , pp. 1751-1759
    • Bradbury, C.A.1    Khanim, F.L.2    Hayden, R.3    Bunce, C.M.4    White, D.A.5    Drayson, M.T.6    Craddock, C.7    Turner, B.M.8
  • 12
    • 0037371674 scopus 로고    scopus 로고
    • Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect
    • Buiting K., Gross S., Lich C., Gillessen-Kaesbach G., el-Maarri O., and Horsthemke B. Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect. Am. J. Hum. Genet. 72 (2003) 571-577
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 571-577
    • Buiting, K.1    Gross, S.2    Lich, C.3    Gillessen-Kaesbach, G.4    el-Maarri, O.5    Horsthemke, B.6
  • 13
    • 29244437192 scopus 로고    scopus 로고
    • From immature lamin to premature aging: molecular pathways and therapeutic opportunities
    • Cadinanos J., Varela I., Lopez-Otin C., and Freije J.M. From immature lamin to premature aging: molecular pathways and therapeutic opportunities. Cell Cycle 4 (2005) 1732-1735
    • (2005) Cell Cycle , vol.4 , pp. 1732-1735
    • Cadinanos, J.1    Varela, I.2    Lopez-Otin, C.3    Freije, J.M.4
  • 14
    • 33746407333 scopus 로고    scopus 로고
    • The emerging science of epigenomics
    • Callinan P.A., and Feinberg A.P. The emerging science of epigenomics. Hum. Mol. Genet. 15 Spec. No. 1 (2006) R95-101
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.Spec. 1
    • Callinan, P.A.1    Feinberg, A.P.2
  • 16
    • 33646576501 scopus 로고    scopus 로고
    • Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing
    • Chen H., Ke Q., Kluz T., Yan Y., and Costa M. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol. Cell Biol. 26 (2006) 3728-3737
    • (2006) Mol. Cell Biol. , vol.26 , pp. 3728-3737
    • Chen, H.1    Ke, Q.2    Kluz, T.3    Yan, Y.4    Costa, M.5
  • 17
    • 27544434763 scopus 로고    scopus 로고
    • Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    • Chen W.Y., Wang D.H., Yen R.C., Luo J., Gu W., and Baylin S.B. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 (2005) 437-448
    • (2005) Cell , vol.123 , pp. 437-448
    • Chen, W.Y.1    Wang, D.H.2    Yen, R.C.3    Luo, J.4    Gu, W.5    Baylin, S.B.6
  • 19
    • 34249035861 scopus 로고    scopus 로고
    • Environmental effects on gene expression phenotype have regional biases in the human genome
    • Choi J.K., and Kim S.C. Environmental effects on gene expression phenotype have regional biases in the human genome. Genetics 175 (2007) 1607-1613
    • (2007) Genetics , vol.175 , pp. 1607-1613
    • Choi, J.K.1    Kim, S.C.2
  • 20
    • 34548456881 scopus 로고    scopus 로고
    • Dietary histone deacetylase inhibitors: from cells to mice to man
    • Dashwood R.H., and Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man. Semin. Cancer Biol. 17 (2007) 363-369
    • (2007) Semin. Cancer Biol. , vol.17 , pp. 363-369
    • Dashwood, R.H.1    Ho, E.2
  • 21
    • 34249080596 scopus 로고    scopus 로고
    • Theoretical analysis of epigenetic cell memory by nucleosome modification
    • Dodd I.B., Micheelsen M.A., Sneppen K., and Thon G. Theoretical analysis of epigenetic cell memory by nucleosome modification. Cell 129 (2007) 813-822
    • (2007) Cell , vol.129 , pp. 813-822
    • Dodd, I.B.1    Micheelsen, M.A.2    Sneppen, K.3    Thon, G.4
  • 24
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8 (2007) 286-298
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 286-298
    • Esteller, M.1
  • 25
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N. Engl. J. Med. 358 (2008) 1148-1159
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 26
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • Feinberg A.P. Phenotypic plasticity and the epigenetics of human disease. Nature 447 (2007) 433-440
    • (2007) Nature , vol.447 , pp. 433-440
    • Feinberg, A.P.1
  • 27
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg A.P., and Tycko B. The history of cancer epigenetics. Nat. Rev. Cancer 4 (2004) 143-153
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 28
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg A.P., and Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301 (1983) 89-92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 29
    • 34249683635 scopus 로고    scopus 로고
    • Cross-talk between aging and cancer: the epigenetic language
    • Fraga M.F., Agrelo R., and Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann. N Y Acad. Sci. 1100 (2007) 60-74
    • (2007) Ann. N Y Acad. Sci. , vol.1100 , pp. 60-74
    • Fraga, M.F.1    Agrelo, R.2    Esteller, M.3
  • 32
    • 26444573127 scopus 로고    scopus 로고
    • Towards the human cancer epigenome: a first draft of histone modifications
    • Fraga M.F., and Esteller M. Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle 4 (2005) 1377-1381
    • (2005) Cell Cycle , vol.4 , pp. 1377-1381
    • Fraga, M.F.1    Esteller, M.2
  • 33
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: the targets and the marks
    • Fraga M.F., and Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet. 23 (2007) 413-418
    • (2007) Trends Genet. , vol.23 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 35
    • 0025173860 scopus 로고
    • A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?
    • Gartner K. A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?. Lab. Anim. 24 (1990) 71-77
    • (1990) Lab. Anim. , vol.24 , pp. 71-77
    • Gartner, K.1
  • 37
    • 0034193776 scopus 로고    scopus 로고
    • Sir2 links chromatin silencing, metabolism, and aging
    • Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 14 (2000) 1021-1026
    • (2000) Genes Dev. , vol.14 , pp. 1021-1026
    • Guarente, L.1
  • 38
    • 13944253348 scopus 로고    scopus 로고
    • Calorie restriction-the SIR2 connection
    • Guarente L., and Picard F. Calorie restriction-the SIR2 connection. Cell 120 (2005) 473-482
    • (2005) Cell , vol.120 , pp. 473-482
    • Guarente, L.1    Picard, F.2
  • 39
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., and Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25 (1961) 585-621
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 40
    • 34047142805 scopus 로고    scopus 로고
    • Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
    • Heijmans B.T., Kremer D., Tobi E.W., Boomsma D.I., and Slagboom P.E. Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum. Mol. Genet. 16 (2007) 547-554
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 547-554
    • Heijmans, B.T.1    Kremer, D.2    Tobi, E.W.3    Boomsma, D.I.4    Slagboom, P.E.5
  • 41
    • 35649021295 scopus 로고    scopus 로고
    • Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance
    • Hitchins M.P., and Ward R.L. Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance. Nat. Genet. 39 (2007) 1289
    • (2007) Nat. Genet. , vol.39 , pp. 1289
    • Hitchins, M.P.1    Ward, R.L.2
  • 42
    • 0023279926 scopus 로고
    • The inheritance of epigenetic defects
    • Holliday R. The inheritance of epigenetic defects. Science 238 (1987) 163-170
    • (1987) Science , vol.238 , pp. 163-170
    • Holliday, R.1
  • 43
    • 34548138278 scopus 로고    scopus 로고
    • Epigenetics: a historical overview
    • Holliday R. Epigenetics: a historical overview. Epigenetics 1 (2006) 76-80
    • (2006) Epigenetics , vol.1 , pp. 76-80
    • Holliday, R.1
  • 44
    • 0034644187 scopus 로고    scopus 로고
    • Cancer-nature, nurture, or both
    • Hoover R.N. Cancer-nature, nurture, or both. N. Engl. J. Med. 343 (2000) 135-136
    • (2000) N. Engl. J. Med. , vol.343 , pp. 135-136
    • Hoover, R.N.1
  • 46
    • 0142185046 scopus 로고    scopus 로고
    • Age-related epigenetic changes and the immune system
    • Issa J.P. Age-related epigenetic changes and the immune system. Clin. Immunol. 109 (2003) 103-108
    • (2003) Clin. Immunol. , vol.109 , pp. 103-108
    • Issa, J.P.1
  • 48
    • 0029976873 scopus 로고    scopus 로고
    • Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis
    • Issa J.P., Vertino P.M., Boehm C.D., Newsham I.F., and Baylin S.B. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 11757-11762
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 11757-11762
    • Issa, J.P.1    Vertino, P.M.2    Boehm, C.D.3    Newsham, I.F.4    Baylin, S.B.5
  • 49
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 50
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3 (2002) 415-428
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 51
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
    • (1999) Genes Dev. , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 53
    • 53049099107 scopus 로고    scopus 로고
    • Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity
    • Kapoor-Vazirani P., Kagey J.D., Powell D.R., and Vertino P.M. Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity. Cancer Res. 68 (2008) 6810-6821
    • (2008) Cancer Res. , vol.68 , pp. 6810-6821
    • Kapoor-Vazirani, P.1    Kagey, J.D.2    Powell, D.R.3    Vertino, P.M.4
  • 54
    • 40849116456 scopus 로고    scopus 로고
    • Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    • Kuratomi G., Iwamoto K., Bundo M., Kusumi I., Kato N., Iwata N., Ozaki N., and Kato T. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol. Psychiatry 13 (2008) 429-441
    • (2008) Mol. Psychiatry , vol.13 , pp. 429-441
    • Kuratomi, G.1    Iwamoto, K.2    Bundo, M.3    Kusumi, I.4    Kato, N.5    Iwata, N.6    Ozaki, N.7    Kato, T.8
  • 56
    • 0016249048 scopus 로고
    • Changes in histone methylase activity of rat brain and liver with ageing
    • Lee C.T., and Duerre J.A. Changes in histone methylase activity of rat brain and liver with ageing. Nature 251 (1974) 240-242
    • (1974) Nature , vol.251 , pp. 240-242
    • Lee, C.T.1    Duerre, J.A.2
  • 58
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop K.A., Phillips E.S., Jackson A.A., Hanson M.A., and Burdge G.C. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J. Nutr. 135 (2005) 1382-1386
    • (2005) J. Nutr. , vol.135 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 59
    • 33745899960 scopus 로고    scopus 로고
    • Endocrine disruptors and reproductive health: the case of bisphenol-A
    • Maffini M.V., Rubin B.S., Sonnenschein C., and Soto A.M. Endocrine disruptors and reproductive health: the case of bisphenol-A. Mol. Cell. Endocrinol. 254-255 (2006) 179-186
    • (2006) Mol. Cell. Endocrinol. , vol.254-255 , pp. 179-186
    • Maffini, M.V.1    Rubin, B.S.2    Sonnenschein, C.3    Soto, A.M.4
  • 60
    • 33745039815 scopus 로고    scopus 로고
    • Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene
    • Mill J., Dempster E., Caspi A., Williams B., Moffitt T., and Craig I. Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 141B (2006) 421-425
    • (2006) Am. J. Med. Genet. B: Neuropsychiatr. Genet. , vol.141 B , pp. 421-425
    • Mill, J.1    Dempster, E.2    Caspi, A.3    Williams, B.4    Moffitt, T.5    Craig, I.6
  • 65
    • 28044470276 scopus 로고    scopus 로고
    • Granulocyte heterochromatin: defining the epigenome
    • Olins D.E., and Olins A.L. Granulocyte heterochromatin: defining the epigenome. BMC Cell Biol. 6 (2005) 39
    • (2005) BMC Cell Biol. , vol.6 , pp. 39
    • Olins, D.E.1    Olins, A.L.2
  • 67
    • 39649119288 scopus 로고    scopus 로고
    • The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma
    • Pfister S., Rea S., Taipale M., Mendrzyk F., Straub B., Ittrich C., Thuerigen O., Sinn H.P., Akhtar A., and Lichter P. The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. Int. J. Cancer 122 (2008) 1207-1213
    • (2008) Int. J. Cancer , vol.122 , pp. 1207-1213
    • Pfister, S.1    Rea, S.2    Taipale, M.3    Mendrzyk, F.4    Straub, B.5    Ittrich, C.6    Thuerigen, O.7    Sinn, H.P.8    Akhtar, A.9    Lichter, P.10
  • 68
    • 33646142159 scopus 로고    scopus 로고
    • Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats
    • Pogribny I.P., Ross S.A., Tryndyak V.P., Pogribna M., Poirier L.A., and Karpinets T.V. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis 27 (2006) 1180-1186
    • (2006) Carcinogenesis , vol.27 , pp. 1180-1186
    • Pogribny, I.P.1    Ross, S.A.2    Tryndyak, V.P.3    Pogribna, M.4    Poirier, L.A.5    Karpinets, T.V.6
  • 69
    • 34247473478 scopus 로고    scopus 로고
    • The epigenetic basis of twin discordance in age-related diseases
    • Poulsen P., Esteller M., Vaag A., and Fraga M.F. The epigenetic basis of twin discordance in age-related diseases. Pediatr. Res. 61 (2007) 38R-42R
    • (2007) Pediatr. Res. , vol.61
    • Poulsen, P.1    Esteller, M.2    Vaag, A.3    Fraga, M.F.4
  • 70
    • 33748608275 scopus 로고    scopus 로고
    • The nuclear lamina and its proposed roles in tumorigenesis: projection on the hematologic malignancies and future targeted therapy
    • Prokocimer M., Margalit A., and Gruenbaum Y. The nuclear lamina and its proposed roles in tumorigenesis: projection on the hematologic malignancies and future targeted therapy. J. Struct. Biol. 155 (2006) 351-360
    • (2006) J. Struct. Biol. , vol.155 , pp. 351-360
    • Prokocimer, M.1    Margalit, A.2    Gruenbaum, Y.3
  • 72
    • 33750942982 scopus 로고    scopus 로고
    • Epigenetic variation and inheritance in mammals
    • Rakyan V.K., and Beck S. Epigenetic variation and inheritance in mammals. Curr. Opin. Genet. Dev. 16 (2006) 573-577
    • (2006) Curr. Opin. Genet. Dev. , vol.16 , pp. 573-577
    • Rakyan, V.K.1    Beck, S.2
  • 73
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447 (2007) 425-432
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 74
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W., Dean W., and Walter J. Epigenetic reprogramming in mammalian development. Science 293 (2001) 1089-1093
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 75
    • 0023340731 scopus 로고
    • Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
    • Rine J., and Herskowitz I. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116 (1987) 9-22
    • (1987) Genetics , vol.116 , pp. 9-22
    • Rine, J.1    Herskowitz, I.2
  • 78
    • 0015518651 scopus 로고
    • Histone acetylation during aging of human cells in culture
    • Ryan J.M., and Cristofalo V.J. Histone acetylation during aging of human cells in culture. Biochem. Biophys. Res. Commun. 48 (1972) 735-742
    • (1972) Biochem. Biophys. Res. Commun. , vol.48 , pp. 735-742
    • Ryan, J.M.1    Cristofalo, V.J.2
  • 80
    • 0037131426 scopus 로고    scopus 로고
    • Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
    • Sarg B., Koutzamani E., Helliger W., Rundquist I., and Lindner H.H. Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. J. Biol. Chem. 277 (2002) 39195-39201
    • (2002) J. Biol. Chem. , vol.277 , pp. 39195-39201
    • Sarg, B.1    Koutzamani, E.2    Helliger, W.3    Rundquist, I.4    Lindner, H.H.5
  • 81
    • 33748331132 scopus 로고    scopus 로고
    • Progressive loss of SIRT1 with cell cycle withdrawal
    • Sasaki T., Maier B., Bartke A., and Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 5 (2006) 413-422
    • (2006) Aging Cell , vol.5 , pp. 413-422
    • Sasaki, T.1    Maier, B.2    Bartke, A.3    Scrable, H.4
  • 82
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • Seligson D.B., Horvath S., Shi T., Yu H., Tze S., Grunstein M., and Kurdistani S.K. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 435 (2005) 1262-1266
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 83
    • 21244465079 scopus 로고    scopus 로고
    • Assessing natural variations in gene expression in humans by comparing with monozygotic twins using microarrays
    • Sharma A., Sharma V.K., Horn-Saban S., Lancet D., Ramachandran S., and Brahmachari S.K. Assessing natural variations in gene expression in humans by comparing with monozygotic twins using microarrays. Physiol. Genomics 21 (2005) 117-123
    • (2005) Physiol. Genomics , vol.21 , pp. 117-123
    • Sharma, A.1    Sharma, V.K.2    Horn-Saban, S.3    Lancet, D.4    Ramachandran, S.5    Brahmachari, S.K.6
  • 84
    • 19444367952 scopus 로고    scopus 로고
    • Allele-specific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure
    • Shiao Y.H., Crawford E.B., Anderson L.M., Patel P., and Ko K. Allele-specific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure. Toxicol. Appl. Pharmacol. 205 (2005) 290-296
    • (2005) Toxicol. Appl. Pharmacol. , vol.205 , pp. 290-296
    • Shiao, Y.H.1    Crawford, E.B.2    Anderson, L.M.3    Patel, P.4    Ko, K.5
  • 86
    • 33847638915 scopus 로고    scopus 로고
    • Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics
    • Siddiqui H., Fox S.R., Gunawardena R.W., and Knudsen E.S. Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics. J. Cell. Physiol. 211 (2007) 131-137
    • (2007) J. Cell. Physiol. , vol.211 , pp. 131-137
    • Siddiqui, H.1    Fox, S.R.2    Gunawardena, R.W.3    Knudsen, E.S.4
  • 87
    • 25144482413 scopus 로고    scopus 로고
    • Developmental origins of adult metabolic disease: concepts and controversies
    • Simmons R. Developmental origins of adult metabolic disease: concepts and controversies. Trends Endocrinol. Metab. 16 (2005) 390-394
    • (2005) Trends Endocrinol. Metab. , vol.16 , pp. 390-394
    • Simmons, R.1
  • 89
    • 33748867063 scopus 로고    scopus 로고
    • Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray
    • So K., Tamura G., Honda T., Homma N., Endoh M., Togawa N., Nishizuka S., and Motoyama T. Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray. Pathol. Int. 56 (2006) 571-575
    • (2006) Pathol. Int. , vol.56 , pp. 571-575
    • So, K.1    Tamura, G.2    Honda, T.3    Homma, N.4    Endoh, M.5    Togawa, N.6    Nishizuka, S.7    Motoyama, T.8
  • 90
    • 33748948208 scopus 로고    scopus 로고
    • DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
    • Sommer M., Poliak N., Upadhyay S., Ratovitski E., Nelkin B.D., Donehower L.A., and Sidransky D. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle 5 (2006) 2005-2011
    • (2006) Cell Cycle , vol.5 , pp. 2005-2011
    • Sommer, M.1    Poliak, N.2    Upadhyay, S.3    Ratovitski, E.4    Nelkin, B.D.5    Donehower, L.A.6    Sidransky, D.7
  • 91
    • 2442424419 scopus 로고    scopus 로고
    • Germline epimutation of MLH1 in individuals with multiple cancers
    • Suter C.M., Martin D.I., and Ward R.L. Germline epimutation of MLH1 in individuals with multiple cancers. Nat. Genet. 36 (2004) 497-501
    • (2004) Nat. Genet. , vol.36 , pp. 497-501
    • Suter, C.M.1    Martin, D.I.2    Ward, R.L.3
  • 92
    • 0037960155 scopus 로고    scopus 로고
    • Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
    • Takiguchi M., Achanzar W.E., Qu W., Li G., and Waalkes M.P. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp. Cell Res. 286 (2003) 355-365
    • (2003) Exp. Cell Res. , vol.286 , pp. 355-365
    • Takiguchi, M.1    Achanzar, W.E.2    Qu, W.3    Li, G.4    Waalkes, M.P.5
  • 93
    • 0033052929 scopus 로고    scopus 로고
    • Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex
    • Tohgi H., Utsugisawa K., Nagane Y., Yoshimura M., Genda Y., and Ukitsu M. Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Brain Res. Mol. Brain Res. 70 (1999) 288-292
    • (1999) Brain Res. Mol. Brain Res. , vol.70 , pp. 288-292
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3    Yoshimura, M.4    Genda, Y.5    Ukitsu, M.6
  • 94
    • 32544452237 scopus 로고    scopus 로고
    • Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1 Suv4-20h2 histone methyltransferase and methyl-binding proteins
    • Tryndyak V.P., Kovalchuk O., and Pogribny I.P. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1 Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol. Ther. 5 (2006) 65-70
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 65-70
    • Tryndyak, V.P.1    Kovalchuk, O.2    Pogribny, I.P.3
  • 95
    • 33845877732 scopus 로고    scopus 로고
    • Defining an epigenetic code
    • Turner B.M. Defining an epigenetic code. Nat. Cell Biol. 9 (2007) 2-6
    • (2007) Nat. Cell Biol. , vol.9 , pp. 2-6
    • Turner, B.M.1
  • 98
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., and Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 (2004) 93-105
    • (2004) Mol. Cell , vol.16 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5    Reinberg, D.6
  • 99
    • 23844487725 scopus 로고    scopus 로고
    • The history of DES, lessons to be learned
    • Veurink M., Koster M., and Berg L.T. The history of DES, lessons to be learned. Pharm. World Sci. 27 (2005) 139-143
    • (2005) Pharm. World Sci. , vol.27 , pp. 139-143
    • Veurink, M.1    Koster, M.2    Berg, L.T.3
  • 100
    • 41149176108 scopus 로고    scopus 로고
    • Production of different phenotypes from the same genotype in the same environment by developmental variation
    • Vogt G., Huber M., Thiemann M., van den Boogaart G., Schmitz O.J., and Schubart C.D. Production of different phenotypes from the same genotype in the same environment by developmental variation. J. Exp. Biol. 211 (2008) 510-523
    • (2008) J. Exp. Biol. , vol.211 , pp. 510-523
    • Vogt, G.1    Huber, M.2    Thiemann, M.3    van den Boogaart, G.4    Schmitz, O.J.5    Schubart, C.D.6
  • 101
    • 0002947085 scopus 로고
    • The epigenotype
    • Waddington C. The epigenotype. Endeavour 1 (1942) 18-20
    • (1942) Endeavour , vol.1 , pp. 18-20
    • Waddington, C.1
  • 102
    • 33646790538 scopus 로고    scopus 로고
    • Assessing the effects of high methionine intake on DNA methylation
    • Waterland R.A. Assessing the effects of high methionine intake on DNA methylation. J. Nutr. 136 (2006) 1706S-1710S
    • (2006) J. Nutr. , vol.136
    • Waterland, R.A.1
  • 103
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    • Waterland R.A., and Jirtle R.L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol. 23 (2003) 5293-5300
    • (2003) Mol. Cell Biol. , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 105
    • 33749022748 scopus 로고    scopus 로고
    • How lifetimes shape epigenotype within and across generations
    • Whitelaw N.C., and Whitelaw E. How lifetimes shape epigenotype within and across generations. Hum. Mol. Genet. 15 Spec. No. 2 (2006) R131-R137
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.Spec. 2
    • Whitelaw, N.C.1    Whitelaw, E.2
  • 106
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Wilson V.L., and Jones P.A. DNA methylation decreases in aging but not in immortal cells. Science 220 (1983) 1055-1057
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 107
    • 0023664725 scopus 로고
    • Genomic 5-methyldeoxycytidine decreases with age
    • Wilson V.L., Smith R.A., Ma S., and Cutler R.G. Genomic 5-methyldeoxycytidine decreases with age. J. Biol. Chem. 262 (1987) 9948-9951
    • (1987) J. Biol. Chem. , vol.262 , pp. 9948-9951
    • Wilson, V.L.1    Smith, R.A.2    Ma, S.3    Cutler, R.G.4
  • 108
    • 0031873353 scopus 로고    scopus 로고
    • Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice
    • Wolff G.L., Kodell R.L., Moore S.R., and Cooney C.A. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 12 (1998) 949-957
    • (1998) FASEB J. , vol.12 , pp. 949-957
    • Wolff, G.L.1    Kodell, R.L.2    Moore, S.R.3    Cooney, C.A.4
  • 109
    • 40549127104 scopus 로고    scopus 로고
    • Capturing epigenetic dynamics during pre-implantation development using live cell imaging
    • Yamagata K. Capturing epigenetic dynamics during pre-implantation development using live cell imaging. J. Biochem. 143 (2008) 279-286
    • (2008) J. Biochem. , vol.143 , pp. 279-286
    • Yamagata, K.1
  • 110
    • 0032401895 scopus 로고    scopus 로고
    • Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen-induced mammary tumorigenesis in the rat
    • Yenbutr P., Hilakivi-Clarke L., and Passaniti A. Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen-induced mammary tumorigenesis in the rat. Mech. Ageing Dev. 106 (1998) 93-102
    • (1998) Mech. Ageing Dev. , vol.106 , pp. 93-102
    • Yenbutr, P.1    Hilakivi-Clarke, L.2    Passaniti, A.3
  • 111
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., and Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23 (2004) 2369-2380
    • (2004) EMBO J. , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.