The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathway

Genes and Development

Volumn 19, Issue 2, 2005, Pages 196-201

  Chan, Ho Man ^a   Narita, Masako ^b   Lowe, Scott W ^b   Livingston, David M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

E1A; myc; p21; p400; p53; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; E1A PROTEIN; PROTEIN; PROTEIN P21; PROTEIN P400; PROTEIN P53; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; FIBROBLAST; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENESCENCE; STAINING;

CELL AGING; CELL CYCLE PROTEINS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA HELICASES; DNA-BINDING PROTEINS; FIBROBLASTS; G1 PHASE; HUMANS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

ADENOVIRIDAE;

EID: 12144283456     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1280205     Document Type: Article

References (35)

1. Brown, J.P., Wei, W., and Sedivy, J.M. 1997. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277: 831-834.
2. Cai, Y., Jin, J., Tomomori-Sato, C., Sato, S., Sorokina, I., Parmely, T.J., Conaway, R.C., and Conaway, J.W. 2003. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J. Biol. Chem. 278: 42733-42736.
3. Deleu, L., Shellard, S., Alevizopoulos, K., Amati, B., and Land, H. 2001. Recruitment of TRRAP required for oncogenic transformation by E1A. Oncogene 20: 8270-8275.
4. Doyon, Y., Selleck, W., Lane, W.S., Tan, S., and Cote, J. 2004. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24: 1884-1896.
5. el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W., and Vogelstein, B. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
6. Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., and Lowe, S.W. 2000. PML is induced by oncogenic ras and promotes premature senescence. Genes & Dev. 14: 2015-2027.
7. Frank, S.R., Schroeder, M., Fernandez, P., Taubert, S., and Amati, B. 2001. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes & Dev. 15: 2069-2082.
8. Frank, S.R., Parisi, T., Taubert, S., Fernandez, P., Fuchs, M., Chan, H.M., Livingston, D.M., and Amati, B. 2003. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep. 4: 575-580.
9. Fuchs, M., Gerber, J., Drapkin, R., Sif, S., Ikura, T., Ogryzko, V., Lane, W.S., Nakatani, Y., and Livingston, D.M. 2001. The p400 complex is an essential E1A transformation target. Cell 106: 297-307.
10. Ganesan, S., Silver, D.P., Greenberg, R.A., Avni, D., Drapkin, R., Miron, A., Mok, S.C., Randrianarison, V., Brodie, S., Salstrom, J., et al. 2002. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111: 393-405.
11. Goodwin, E.C. and DiMaio, D. 2001. Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth Differ. 12: 525-534.
12. Hall, A.R., Dix, B.R., O'Carroll, S.J., and Braithwaite, A.W. 1998. p53-dependent cell death/apoptosis is required for a productive adenovirus infection. Nat. Med. 4: 1068-1072.
13. Hanahan, D. and Weinberg, R.A. 2000. The hallmarks of cancer. Cell 100: 57-70.
14. Herbig, U., Jobling, W.A., Chen, B.P., Chen, D.J., and Sedivy, J.M. 2004. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but Not p16(INK4a). Mol. Cell 14: 501-513.
15. Ikura, T., Ogryzko, V.V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., and Nakatani, Y. 2000. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102: 463-473.
16. Kaeser, M.D. and Iggo, R.D. 2002. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl. Acad. Sci. 99: 95-100.
17. Lill, N.L., Grossman, S.R., Ginsberg, D., DeCaprio, J., and Livingston, D.M. 1997a. Binding and modulation of p53 by p300/CBP coactivators. Nature 387: 823-827.
18. Lill, N.L., Tevethia, M.J., Eckner, R., Livingston, D.M., and Modjtahedi, N. 1997b. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J. Virol. 71: 129-137.
19. Macleod, K.F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B., and Jacks, T. 1995. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes & Dev. 9: 935-944.
20. McConnell, B.B., Starborg, M., Brookes, S., and Peters, G. 1998. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr. Biol. 8: 351-354.
21. Narita, M., Nunez, S., Heard, E., Narita, M., Lin, A.W., Hearn, S.A., Spector, D.L., Hannon, G.J., and Lowe, S.W. 2003. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703-716.
22. Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M., and Smith, J.R. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell. Res. 211: 90-98.
23. Rane, S.G., Cosenza, S.C., Mettus, R.V., and Reddy, E.P. 2002. Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol. Cell. Biol. 22: 644-656.
24. Resnick-Silverman, L., St Clair, S., Maurer, M., Zhao, K., and Manfredi, J.J. 1998. Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes & Dev. 12: 2102-2107.
25. Sager, R. 1991. Senescence as a mode of tumor suppression. Environ. Health Perspect 93: 59-62.
26. Seger, Y.R., Garcia-Cao, M., Piccinin, S., Cunsolo, C.L., Doglioni, C., Blasco, M.A., Hannon, G.J., and Maestro, R. 2002. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2: 401-413.
27. Seoane, J., Le, H.V., and Massague, J. 2002. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734.
28. Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D., and Lowe, S.W. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602.
29. Shang, Y., Hu, X., DiRenzo, J., Lazar, M.A., and Brown, M. 2000. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852.
30. Shaulian, E., Zauberman, A., Ginsberg, D., and Oren, M. 1992. Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding. Mol. Cell. Biol. 12:5581-5592.
31. Sherr, C.J. and Roberts, J.M. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes & Dev. 13: 1501-1512.
32. Taubert, S., Gorrini, C., Frank, S.R., Parisi, T., Fuchs, M., Chan, H.M., Livingston, D.M., and Amati, B. 2004. E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G(1). Mol. Cell. Biol. 24: 4546-4556.
33. Vogelstein, B., Lane, D., and Levine, A.J. 2000. Surfing the p53 network. Nature 408: 307-310.
34. Voorhoeve, P.M. and Agami, R. 2003. The tumor-suppressive functions of the human INK4A locus. Cancer Cell 4: 311-319.
35. Wu, S., Cetinkaya, C., Munoz-Alonso, M.J., von der Lehr, N., Bahram, F., Beuger, V., Eilers, M., Leon, J., and Larsson, L.G. 2003. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22: 351-360.