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Volumn 63, Issue 11, 2003, Pages 2705-2715

Tumor cell senescence in cancer treatment

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR; DOXORUBICIN; PROTEIN P21; RETINOID;

EID: 0038277105     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (569)

References (112)
  • 1
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol., 11: S27-S31, 2001.
    • (2001) Trends Cell Biol. , vol.11
    • Campisi, J.1
  • 3
    • 0033730616 scopus 로고    scopus 로고
    • Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    • Kurz, D. J., Decary, S., Hong, Y., and Erusalimsky, J. D. Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J. Cell Sci., 113: 3613-3622, 2000.
    • (2000) J. Cell Sci. , vol.113 , pp. 3613-3622
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Erusalimsky, J.D.4
  • 5
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. Y., and Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. USA, 98: 12072-12077, 2001.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 6
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L., and Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res., 37: 585-621, 1961.
    • (1961) Exp. Cell Res. , vol.37 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 7
    • 0035754079 scopus 로고    scopus 로고
    • Cell senescence and cancer
    • Mathon, N. F., and Lloyd, A. C. Cell senescence and cancer. Nat. Rev. Cancer, 1: 203-213, 2001.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 203-213
    • Mathon, N.F.1    Lloyd, A.C.2
  • 8
    • 0030761351 scopus 로고    scopus 로고
    • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly(ADP-ribose) polymerase
    • Vaziri, H., West, M. D., Allsopp, R. C., Davison, T. S., Wu, Y. S., Arrowsmith, C. H., Poirier, G. G., and Benchimol, S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J., 16: 6018-6033, 1997.
    • (1997) EMBO J. , vol.16 , pp. 6018-6033
    • Vaziri, H.1    West, M.D.2    Allsopp, R.C.3    Davison, T.S.4    Wu, Y.S.5    Arrowsmith, C.H.6    Poirier, G.G.7    Benchimol, S.8
  • 9
    • 0035954831 scopus 로고    scopus 로고
    • Telomeres and replicative senescence: Is it only length that counts?
    • von Zglinicki, T. Telomeres and replicative senescence: Is it only length that counts? Cancer Lett., 168: 111-116, 2001.
    • (2001) Cancer Lett. , vol.168 , pp. 111-116
    • Von Zglinicki, T.1
  • 11
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88: 593-602, 1997.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 12
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu, J., Woods, D., McMahon, M., and Bishop, J. M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev., 12: 2997-3007, 1998.
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 13
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Xiong, Y., and Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell, 92: 725-734, 1998.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 16
    • 0034738420 scopus 로고    scopus 로고
    • p21(WAF1/Cip1): More than a break to the cell cycle?
    • Dotto, G. P. p21(WAF1/Cip1): more than a break to the cell cycle? Biochim. Biophys. Acta, 1471: M43-M56, 2000.
    • (2000) Biochim. Biophys. Acta , vol.1471
    • Dotto, G.P.1
  • 17
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., and Smith, J. R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res., 211: 90-98, 1994.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 18
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J. C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA, 93: 13742-13747, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 19
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • Stein, G. H., Drullinger, L. F., Soulard, A., and Dulic, V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol., 19: 2109-2117, 1999.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 21
    • 0035966101 scopus 로고    scopus 로고
    • Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts
    • Wang, W., Wu, J., Zhang, Z., and Tong, T. Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts. J. Biol. Chem., 276: 48655-48661, 2001.
    • (2001) J. Biol. Chem. , vol.276 , pp. 48655-48661
    • Wang, W.1    Wu, J.2    Zhang, Z.3    Tong, T.4
  • 22
    • 0034028836 scopus 로고    scopus 로고
    • Tumor suppressors and oncogenes in cellular senescence
    • Bringold, F., and Serrano, M. Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol., 35: 317-329, 2000.
    • (2000) Exp. Gerontol. , vol.35 , pp. 317-329
    • Bringold, F.1    Serrano, M.2
  • 23
    • 0035858987 scopus 로고    scopus 로고
    • Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
    • Munro, J., Steeghs, K., Morrison, V., Ireland, H., and Parkinson, E. K. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene, 20: 3541-3552, 2001.
    • (2001) Oncogene , vol.20 , pp. 3541-3552
    • Munro, J.1    Steeghs, K.2    Morrison, V.3    Ireland, H.4    Parkinson, E.K.5
  • 24
    • 0343293944 scopus 로고    scopus 로고
    • Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)
    • Malumbres, M., Perez, d. C., I, Hernandez, M. I., Jimenez, M., Corral, T., and Pellicer, A. Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b). Mol. Cell. Biol., 20: 2915-2925, 2000.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2915-2925
    • Malumbres, M.1    Perez, D.C.2    Hernandez, M.I.3    Jimenez, M.4    Corral, T.5    Pellicer, A.6
  • 29
    • 0035020826 scopus 로고    scopus 로고
    • Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence
    • Alexander, K., and Hinds, P. W. Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence. Mol. Cell. Biol., 21: 3616-3631, 2001.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3616-3631
    • Alexander, K.1    Hinds, P.W.2
  • 30
    • 0030886015 scopus 로고    scopus 로고
    • Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
    • Sugrue, M. M., Shin, D. Y., Lee, S. W., and Aaronson, S. A. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl. Acad. Sci. USA, 94: 9648-9653, 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9648-9653
    • Sugrue, M.M.1    Shin, D.Y.2    Lee, S.W.3    Aaronson, S.A.4
  • 31
  • 32
    • 0033528830 scopus 로고    scopus 로고
    • Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
    • Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene, 18: 2789-2797, 1999.
    • (1999) Oncogene , vol.18 , pp. 2789-2797
    • Fang, L.1    Igarashi, M.2    Leung, J.3    Sugrue, M.M.4    Lee, S.W.5    Aaronson, S.A.6
  • 33
    • 0034704848 scopus 로고    scopus 로고
    • p16 INK4a can initiate an autonomous senescence program
    • Dai, C. Y., and Enders, G. H. p16 INK4a can initiate an autonomous senescence program. Oncogene, 19: 1613-1622, 2000.
    • (2000) Oncogene , vol.19 , pp. 1613-1622
    • Dai, C.Y.1    Enders, G.H.2
  • 34
    • 0034689774 scopus 로고    scopus 로고
    • Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
    • Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene, 19: 2165-2170, 2000.
    • (2000) Oncogene , vol.19 , pp. 2165-2170
    • Chang, B.D.1    Broude, E.V.2    Fang, J.3    Kalinichenko, T.V.4    Abdryashitov, R.5    Poole, J.C.6    Roninson, I.B.7
  • 38
    • 0034331178 scopus 로고    scopus 로고
    • Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways
    • Wells, S. I., Francis, D. A., Karpova, A. Y., Dowhanick, J. J., Benson, J. D., and Howley, P. M. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J., 5762-5771, 2000.
    • (2000) EMBO J. , pp. 5762-5771
    • Wells, S.I.1    Francis, D.A.2    Karpova, A.Y.3    Dowhanick, J.J.4    Benson, J.D.5    Howley, P.M.6
  • 39
    • 0035178727 scopus 로고    scopus 로고
    • Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres
    • Goodwin, E. C., and DiMaio, D. Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth Differ., 12: 525-534, 2001.
    • (2001) Cell Growth Differ. , vol.12 , pp. 525-534
    • Goodwin, E.C.1    DiMaio, D.2
  • 40
    • 17444388849 scopus 로고    scopus 로고
    • A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
    • Chang, B. D., Broude, E. V., Dokmanovic, M., Zhu, H., Ruth, A., Xuan, Y., Kandel, E. S., Lausch, E., Christov, K., and Roninson, I. B. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res., 59: 3761-3767, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 3761-3767
    • Chang, B.D.1    Broude, E.V.2    Dokmanovic, M.3    Zhu, H.4    Ruth, A.5    Xuan, Y.6    Kandel, E.S.7    Lausch, E.8    Christov, K.9    Roninson, I.B.10
  • 41
    • 0032533504 scopus 로고    scopus 로고
    • Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells
    • Wang, X., Wong, S. C., Pan, J., Tsao, S. W., Fung, K. H., Kwong, D. L., Sham, J. S., and Nicholls, J. M. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells. Cancer Res., 58: 5019-5022, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 5019-5022
    • Wang, X.1    Wong, S.C.2    Pan, J.3    Tsao, S.W.4    Fung, K.H.5    Kwong, D.L.6    Sham, J.S.7    Nicholls, J.M.8
  • 43
    • 0036731380 scopus 로고    scopus 로고
    • Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence
    • Haq, R., Brenton, J. D., Takahashi, M., Finan, D., Rottapel, R., and Zanke, B. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res., 62: 5076-5082, 2002.
    • (2002) Cancer Res. , vol.62 , pp. 5076-5082
    • Haq, R.1    Brenton, J.D.2    Takahashi, M.3    Finan, D.4    Rottapel, R.5    Zanke, B.6
  • 44
    • 0037086268 scopus 로고    scopus 로고
    • DNA damage is able to induce senescence in tumor cells in vitro and in vivo
    • te Poele, R. H., Okorokov, A. L., Jardine, L., Cummings, J., and Joel, S. P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res., 62: 1876-1883, 2002.
    • (2002) Cancer Res. , vol.62 , pp. 1876-1883
    • Te Poele, R.H.1    Okorokov, A.L.2    Jardine, L.3    Cummings, J.4    Joel, S.P.5
  • 45
    • 0037144595 scopus 로고    scopus 로고
    • Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction
    • Elmore, L. W., Rehder, C. W., Di, X., McChesney, P. A., Jackson-Cook, C. K., Gewirtz, D. A., and Holt, S. E. Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. J. Biol. Chem., 277: 35509-35515, 2002.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35509-35515
    • Elmore, L.W.1    Rehder, C.W.2    Di, X.3    McChesney, P.A.4    Jackson-Cook, C.K.5    Gewirtz, D.A.6    Holt, S.E.7
  • 49
    • 0037039381 scopus 로고    scopus 로고
    • Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic drug
    • Chang, B. D., Swift, M. E., Shen, M., Fang, J., Broude, E. V., and Roninson, I. B. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic drug. Proc. Natl. Acad. Sci. USA, 99: 389-394, 2002.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 389-394
    • Chang, B.D.1    Swift, M.E.2    Shen, M.3    Fang, J.4    Broude, E.V.5    Roninson, I.B.6
  • 50
    • 0024968476 scopus 로고
    • Stable cell membrane labelling
    • Horan, P. K., and Slezak, S. E. Stable cell membrane labelling. Nature (Lond.), 340: 167-168, 1989.
    • (1989) Nature (Lond.) , vol.340 , pp. 167-168
    • Horan, P.K.1    Slezak, S.E.2
  • 51
    • 0034657818 scopus 로고    scopus 로고
    • Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation
    • Ruth, A. C., and Roninson, I. B. Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res., 60: 2576-2578, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 2576-2578
    • Ruth, A.C.1    Roninson, I.B.2
  • 53
    • 0033525019 scopus 로고    scopus 로고
    • Transforming growth factor β triggers two independent-senescence programs in cancer cells
    • Katakura, Y., Nakata, E., Miura, T., and Shirahata, S. Transforming growth factor β triggers two independent-senescence programs in cancer cells. Biochem. Biophys. Res. Commun., 255: 110-115, 1999.
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 110-115
    • Katakura, Y.1    Nakata, E.2    Miura, T.3    Shirahata, S.4
  • 55
    • 0037214472 scopus 로고    scopus 로고
    • Induction of senescence-associated growth inhibitors in the tumor-suppressive function of retinoids
    • Roninson, I. B., and Dokmanovic, M. Induction of senescence-associated growth inhibitors in the tumor-suppressive function of retinoids. J. Cell Biochem., 88: 83-94, 2003.
    • (2003) J. Cell Biochem. , vol.88 , pp. 83-94
    • Roninson, I.B.1    Dokmanovic, M.2
  • 56
    • 0036052395 scopus 로고    scopus 로고
    • Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growthinhibitory genes
    • Dokmanovic, M., Chang, B. D., Fang, J., and Roninson, I. B. Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growthinhibitory genes. Cancer Biol. Ther., 1: 24-27, 2002.
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 24-27
    • Dokmanovic, M.1    Chang, B.D.2    Fang, J.3    Roninson, I.B.4
  • 57
    • 0035979249 scopus 로고    scopus 로고
    • Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells
    • Wainwright, L. J., Lasorella, A., and Iavarone, A. Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells. Proc. Natl. Acad. Sci. USA, 98: 9396-9400, 2001.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9396-9400
    • Wainwright, L.J.1    Lasorella, A.2    Iavarone, A.3
  • 58
    • 0031214617 scopus 로고    scopus 로고
    • Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells
    • Zhu, W. Y., Jones, C. S., Kiss, A., Matsukuma, K., Amin, S., and De Luca, L. M. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp. Cell Res., 234: 293-299, 1997.
    • (1997) Exp. Cell Res. , vol.234 , pp. 293-299
    • Zhu, W.Y.1    Jones, C.S.2    Kiss, A.3    Matsukuma, K.4    Amin, S.5    De Luca, L.M.6
  • 59
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson, I. B., Broude, E. V., and Chang, B. D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Updat., 4: 303-313, 2001.
    • (2001) Drug Resist. Updat. , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 60
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., and Lowe, S. W. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell, 109: 335-346, 2002.
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3    Lee, S.4    Baranov, E.5    Hoffman, R.M.6    Lowe, S.W.7
  • 61
    • 0029664942 scopus 로고    scopus 로고
    • Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival
    • Lock, R. B., and Stribinskiene, L. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res., 56: 4006-4012, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4006-4012
    • Lock, R.B.1    Stribinskiene, L.2
  • 62
    • 0036047982 scopus 로고    scopus 로고
    • Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase I and topoisomerase IIα genes by p21(WAF1/CIP1/SDI1)
    • Zhu, H., Chang, B. D., Uchiumi, T., and Roninson, I. B. Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase I and topoisomerase IIα genes by p21(WAF1/CIP1/SDI1). Cell Cycle, 1: 59-66, 2002.
    • (2002) Cell Cycle , vol.1 , pp. 59-66
    • Zhu, H.1    Chang, B.D.2    Uchiumi, T.3    Roninson, I.B.4
  • 64
    • 0025970571 scopus 로고
    • Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts
    • Adler, M. J., Coronel, C., Shelton, E., Seegmiller, J. E., and Dewji, N. N. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc. Natl. Acad. Sci. USA, 88: 16-20, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 16-20
    • Adler, M.J.1    Coronel, C.2    Shelton, E.3    Seegmiller, J.E.4    Dewji, N.N.5
  • 65
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas, B., and Weinberg, R. A. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp. Cell Res., 264: 169-184, 2001.
    • (2001) Exp. Cell Res. , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 66
  • 67
    • 0034051249 scopus 로고    scopus 로고
    • Expression of senescence-associated β-galactosidase in enlarged prostates from men with benign prostatic hyperplasia
    • Choi, J., Shendrik, I., Peacocke, M., Peehl, D., Buttyan, R., Ikeguchi, E. F., Katz, A. E., and Benson, M. C. Expression of senescence-associated β-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. Urology, 56: 160-166, 2000.
    • (2000) Urology , vol.56 , pp. 160-166
    • Choi, J.1    Shendrik, I.2    Peacocke, M.3    Peehl, D.4    Buttyan, R.5    Ikeguchi, E.F.6    Katz, A.E.7    Benson, M.C.8
  • 68
    • 0024395366 scopus 로고
    • Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts
    • Saitoh, T., Sundsmo, M., Roch, J. M., Kimura, N., Cole, G., Schubert, D., Oltersdoff, T., and Schenk, D. B. Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts. Cell, 58: 615-622, 1989.
    • (1989) Cell , vol.58 , pp. 615-622
    • Saitoh, T.1    Sundsmo, M.2    Roch, J.M.3    Kimura, N.4    Cole, G.5    Schubert, D.6    Oltersdoff, T.7    Schenk, D.B.8
  • 71
    • 0037042177 scopus 로고    scopus 로고
    • Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): Association with cell senescence and tumour-promoting activities of stromal fibroblasts
    • Roninson, I. B. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett., 179: 1-14, 2002.
    • (2002) Cancer Lett. , vol.179 , pp. 1-14
    • Roninson, I.B.1
  • 72
    • 0030614504 scopus 로고    scopus 로고
    • Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
    • Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D. H., and Nabel, G. J. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science (Wash. DC), 275: 523-527, 1997.
    • (1997) Science (Wash. DC) , vol.275 , pp. 523-527
    • Perkins, N.D.1    Felzien, L.K.2    Betts, J.C.3    Leung, K.4    Beach, D.H.5    Nabel, G.J.6
  • 73
    • 0034069878 scopus 로고    scopus 로고
    • A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation
    • Snowden, A. W., Anderson, L. A., Webster, G. A., and Perkins, N. D. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. Mol. Cell Biol., 20: 2676-2686, 2000.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 2676-2686
    • Snowden, A.W.1    Anderson, L.A.2    Webster, G.A.3    Perkins, N.D.4
  • 74
    • 85078504862 scopus 로고    scopus 로고
    • Induction of transcription through the p300 CRD1 motif by p21(WAF1/CIP1) is core promoter specific and cyclin dependent kinase independent
    • Gregory, D. J., Garcia-Wilson, E., Poole, J. C., Snowden, A. W., Roninson, I. B., and Perkins, N. D. Induction of transcription through the p300 CRD1 motif by p21(WAF1/CIP1) is core promoter specific and cyclin dependent kinase independent. Cell Cycle, 1: 343-350, 2002.
    • (2002) Cell Cycle , vol.1 , pp. 343-350
    • Gregory, D.J.1    Garcia-Wilson, E.2    Poole, J.C.3    Snowden, A.W.4    Roninson, I.B.5    Perkins, N.D.6
  • 76
    • 0020579353 scopus 로고
    • Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, Stage III, predict long-term survival?
    • Cox, J. D., and Kline, R. W. Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, Stage III, predict long-term survival? Int. J. Radiat. Oncol. Biol. Phys., 9: 299-303, 1983.
    • (1983) Int. J. Radiat. Oncol. Biol. Phys. , vol.9 , pp. 299-303
    • Cox, J.D.1    Kline, R.W.2
  • 78
    • 0031978025 scopus 로고    scopus 로고
    • Analysis of the p16 tumor suppressor gene in early-stage prostate cancer
    • Gu, K., Mes-Masson, A. M., Gauthier, J., and Saad, F. Analysis of the p16 tumor suppressor gene in early-stage prostate cancer. Mol. Carcinog., 21: 164-170, 1998.
    • (1998) Mol. Carcinog. , vol.21 , pp. 164-170
    • Gu, K.1    Mes-Masson, A.M.2    Gauthier, J.3    Saad, F.4
  • 79
    • 0032948380 scopus 로고    scopus 로고
    • Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer
    • Lee, C. T., Capodieci, P., Osman, I., Fazzari, M., Ferrara, J., Scher, H. I., and Cordon-Cardo, C. Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer. Clin. Cancer Res., 5: 977-983, 1999.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 977-983
    • Lee, C.T.1    Capodieci, P.2    Osman, I.3    Fazzari, M.4    Ferrara, J.5    Scher, H.I.6    Cordon-Cardo, C.7
  • 80
    • 0034650587 scopus 로고    scopus 로고
    • Prognostic significance of p16 and CDK4 proteins in localized prostate carcinoma
    • Halvorsen, O. J., Hostmark, J., Haukaas, S., Hoisaeter, P. A., and Akslen, L. A. Prognostic significance of p16 and CDK4 proteins in localized prostate carcinoma. Cancer (Phila.), 88: 416-424, 2000.
    • (2000) Cancer (Phila.) , vol.88 , pp. 416-424
    • Halvorsen, O.J.1    Hostmark, J.2    Haukaas, S.3    Hoisaeter, P.A.4    Akslen, L.A.5
  • 82
    • 0033926203 scopus 로고    scopus 로고
    • INK4a gene expression and methylation in primary breast cancer: Overexpression of p16INK4a messenger RNA is a marker of poor prognosis
    • Hui, R., Macmillan, R. D., Kenny, F. S., Musgrove, E. A., Blamey, R. W., Nicholson, R. I., Robertson, J. F., and Sutherland, R. L. INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis. Clin. Cancer Res., 6: 2777-2787, 2000.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2777-2787
    • Hui, R.1    Macmillan, R.D.2    Kenny, F.S.3    Musgrove, E.A.4    Blamey, R.W.5    Nicholson, R.I.6    Robertson, J.F.7    Sutherland, R.L.8
  • 83
    • 0034895071 scopus 로고    scopus 로고
    • Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype
    • Milde-Langosch, K., Bamberger, A. M., Rieck, G., Kelp, B., and Loning, T. Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype. Breast Cancer Res. Treat., 67: 61-70, 2001.
    • (2001) Breast. Cancer Res. Treat. , vol.67 , pp. 61-70
    • Milde-Langosch, K.1    Bamberger, A.M.2    Rieck, G.3    Kelp, B.4    Loning, T.5
  • 84
    • 0035672499 scopus 로고    scopus 로고
    • P16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy
    • Han, S., Ahn, S. H., Park, K., Bae, B. N., Kim, K. H., Kim, H. J., Kim, Y. D., and Kim, H. Y. P16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy. Breast Cancer Res. Treat., 70: 205-212, 2001.
    • (2001) Breast Cancer Res. Treat. , vol.70 , pp. 205-212
    • Han, S.1    Ahn, S.H.2    Park, K.3    Bae, B.N.4    Kim, K.H.5    Kim, H.J.6    Kim, Y.D.7    Kim, H.Y.8
  • 86
    • 0033560075 scopus 로고    scopus 로고
    • Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer
    • Aaltomaa, S., Lipponen, P., Eskelinen, M., Ala-Opas, M., and Kosma, V. M. Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer. Prostate, 39: 8-15, 1999.
    • (1999) Prostate , vol.39 , pp. 8-15
    • Aaltomaa, S.1    Lipponen, P.2    Eskelinen, M.3    Ala-Opas, M.4    Kosma, V.M.5
  • 87
    • 0032927729 scopus 로고    scopus 로고
    • Proliferationand apoptosis-associated factors in advanced prostatic carcinomas before and after androgen deprivation therapy: Prognostic significance of p21/WAF1/CIP1 expression
    • Baretton, G. B., Klenk, U., Diebold, J., Schmeller, N., and Lohrs, U. Proliferationand apoptosis-associated factors in advanced prostatic carcinomas before and after androgen deprivation therapy: prognostic significance of p21/WAF1/CIP1 expression. Br. J. Cancer, 80: 546-555, 1999.
    • (1999) Br. J. Cancer , vol.80 , pp. 546-555
    • Baretton, G.B.1    Klenk, U.2    Diebold, J.3    Schmeller, N.4    Lohrs, U.5
  • 88
    • 0032793571 scopus 로고    scopus 로고
    • Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa)
    • Sarkar, F. H., Li, Y., Sakr, W. A., Grignon, D. J., Madan, S. S., Wood, D. P., Jr., and Adsay. V. Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa). Prostate, 40: 256-260, 1999.
    • (1999) Prostate , vol.40 , pp. 256-260
    • Sarkar, F.H.1    Li, Y.2    Sakr, W.A.3    Grignon, D.J.4    Madan, S.S.5    Wood D.P., Jr.6    Adsay, V.7
  • 89
    • 0035918536 scopus 로고    scopus 로고
    • Expression of p21 predicts PSA failure in locally advanced prostate cancer treated by prostatectomy
    • Lacombe, L., Maillette, A., Meyer, F., Veilleux, C., Moore, L., and Fradet, Y. Expression of p21 predicts PSA failure in locally advanced prostate cancer treated by prostatectomy. Int. J. Cancer, 95: 135-139, 2001.
    • (2001) Int. J. Cancer , vol.95 , pp. 135-139
    • Lacombe, L.1    Maillette, A.2    Meyer, F.3    Veilleux, C.4    Moore, L.5    Fradet, Y.6
  • 93
    • 0036468136 scopus 로고    scopus 로고
    • Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis
    • Shariat, S. F., Lamb, D. J., Kattan, M. W., Nguyen, C., Kim, J., Beck, J., Wheeler, T. M., and Slawin, K. M. Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis. J. Clin. Oncol., 20: 833-841, 2002.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 833-841
    • Shariat, S.F.1    Lamb, D.J.2    Kattan, M.W.3    Nguyen, C.4    Kim, J.5    Beck, J.6    Wheeler, T.M.7    Slawin, K.M.8
  • 95
    • 0035964175 scopus 로고    scopus 로고
    • Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
    • Gupta, S., Hastak, K., Ahmad, N., Lewin, J. S., and Mukhtar, H. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc. Natl. Acad. Sci. USA, 98: 10350-10355, 2001.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10350-10355
    • Gupta, S.1    Hastak, K.2    Ahmad, N.3    Lewin, J.S.4    Mukhtar, H.5
  • 96
    • 0037177877 scopus 로고    scopus 로고
    • Novel pathways associated with bypassing cellular senescence in human prostate epithelial cells
    • Schwarze, S. R., DePrimo, S. E., Grabert, L. M., Fu, V. X., Brooks, J. D., and Jarrard, D. F. Novel pathways associated with bypassing cellular senescence in human prostate epithelial cells. J. Biol. Chem., 277: 14877-14883, 2002.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14877-14883
    • Schwarze, S.R.1    DePrimo, S.E.2    Grabert, L.M.3    Fu, V.X.4    Brooks, J.D.5    Jarrard, D.F.6
  • 97
    • 0034667455 scopus 로고    scopus 로고
    • Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgenindependent prostate cancer cells
    • Zi, X., Zhang, J., Agarwal, R., and Pollak, M. Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgenindependent prostate cancer cells. Cancer Res., 60: 5617-5620, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 5617-5620
    • Zi, X.1    Zhang, J.2    Agarwal, R.3    Pollak, M.4
  • 98
    • 0036231748 scopus 로고    scopus 로고
    • Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells
    • Tsubaki. J., Hwa, V., Twigg, S. M., and Rosenfeld, R. G. Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. Endocrinology, 143: 1778-1788, 2002.
    • (2002) Endocrinology , vol.143 , pp. 1778-1788
    • Tsubaki, J.1    Hwa, V.2    Twigg, S.M.3    Rosenfeld, R.G.4
  • 99
    • 0033695791 scopus 로고    scopus 로고
    • Characterization of insulin-like growth factor-binding proteinrelated proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: Potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium
    • Lopez-Bermejo, A., Buckway, C. K., Devi, G. R., Hwa, V., Plymate, S. R., Oh, Y., and Rosenfeld, R. G. Characterization of insulin-like growth factor-binding proteinrelated proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. Endocrinology, 141: 4072-4080, 2000.
    • (2000) Endocrinology , vol.141 , pp. 4072-4080
    • Lopez-Bermejo, A.1    Buckway, C.K.2    Devi, G.R.3    Hwa, V.4    Plymate, S.R.5    Oh, Y.6    Rosenfeld, R.G.7
  • 104
    • 0034093592 scopus 로고    scopus 로고
    • Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells
    • Ling, Y. H., Zou, Y., and Perez-Soler, R. Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells. Anticancer Res., 20: 693-702, 2000.
    • (2000) Anticancer Res. , vol.20 , pp. 693-702
    • Ling, Y.H.1    Zou, Y.2    Perez-Soler, R.3
  • 105
    • 0035855628 scopus 로고    scopus 로고
    • p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
    • Jung, M. S., Yun, J., Chae, H. D., Kim, J. M., Kim, S. C., Choi, T. S., and Shin, D. Y. p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene, 20: 5818-5825, 2001.
    • (2001) Oncogene , vol.20 , pp. 5818-5825
    • Jung, M.S.1    Yun, J.2    Chae, H.D.3    Kim, J.M.4    Kim, S.C.5    Choi, T.S.6    Shin, D.Y.7
  • 106
    • 9844232032 scopus 로고    scopus 로고
    • Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
    • Xu, H. J., Zhou, Y., Ji, W., Perng, G. S., Kruzelock, R., Kong, C. T., Bast, R. C., Mills, G. B., Li, J., and Hu, S. X. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene, 15: 2589-2596, 1997.
    • (1997) Oncogene , vol.15 , pp. 2589-2596
    • Xu, H.J.1    Zhou, Y.2    Ji, W.3    Perng, G.S.4    Kruzelock, R.5    Kong, C.T.6    Bast, R.C.7    Mills, G.B.8    Li, J.9    Hu, S.X.10
  • 107
    • 0033594245 scopus 로고    scopus 로고
    • Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin
    • Wang, Y., Blandino, G., and Givol, D. Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin. Oncogene, 18: 2643-2649, 1999.
    • (1999) Oncogene , vol.18 , pp. 2643-2649
    • Wang, Y.1    Blandino, G.2    Givol, D.3
  • 108
    • 0032850895 scopus 로고    scopus 로고
    • Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: Implication for senescence-directed molecular therapy for cancer
    • Kagawa, S., Fujiwara, T., Kadowaki, Y., Fukazawa, T., Sok-Joo, R., Roth, J. A., and Tanaka, N. Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer. Cell Death Differ., 6: 765-772, 1999.
    • (1999) Cell Death Differ. , vol.6 , pp. 765-772
    • Kagawa, S.1    Fujiwara, T.2    Kadowaki, Y.3    Fukazawa, T.4    Sok-Joo, R.5    Roth, J.A.6    Tanaka, N.7
  • 109
    • 0030876483 scopus 로고    scopus 로고
    • Induction of senescence in human malignant glioma cells by p16INK4A
    • Uhrbom, L., Nister, M., and Westermark, B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene, 15: 505-514, 1997.
    • (1997) Oncogene , vol.15 , pp. 505-514
    • Uhrbom, L.1    Nister, M.2    Westermark, B.3
  • 110
    • 0342656549 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A
    • Fuxe, J., Akusjarvi, G., Goike, H. M., Roos, G., Collins, V. P., and Pettersson, R. F. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ., 11: 373-384, 2000.
    • (2000) Cell Growth Differ. , vol.11 , pp. 373-384
    • Fuxe, J.1    Akusjarvi, G.2    Goike, H.M.3    Roos, G.4    Collins, V.P.5    Pettersson, R.F.6
  • 112
    • 0035997939 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism
    • Wilson, H. M., Birnbaum, R. S., Poot, M., Quinn, L. S., and Swisshelm, K. Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism. Cell Growth Differ., 13: 205-213, 2002.
    • (2002) Cell Growth Differ. , vol.13 , pp. 205-213
    • Wilson, H.M.1    Birnbaum, R.S.2    Poot, M.3    Quinn, L.S.4    Swisshelm, K.5


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