Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

Nature Cell Biology

Volumn 14, Issue 4, 2012, Pages 355-365

  Fumagalli, Marzia ^a,i   Rossiello, Francesca ^a   Clerici, Michela ^b   Barozzi, Sara ^c   Cittaro, Davide ^d,e,i,j   Kaplunov, Jessica M ^f   Bucci, Gabriele ^d,e   Dobreva, Miryana ^a,i,k   Matti, Valentina ^a   Beausejour, Christian M ^g   Herbig, Utz ^f   Longhese, Maria Pia ^b   Di Fagagna, Fabrizio D'Adda ^a,h  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^e IFOM IEO Campus   (Italy)

^f New Jersey Medical School University Hospital Cancer Center   (United States)

^g UNIVERSITY OF MONTREAL   (Canada)

^h CNR   (Italy)

ⁱ TTFactor Srl   (Italy)

^j San Raf faele Institute   (Italy)

^k Fresenius Medical Care   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CHECKPOINT KINASE 2; DNA; DNA LIGASE 4; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN P53; TELOMERIC REPEAT BINDING FACTOR 2; TUMOR PROTEIN P53 BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHROMOSOME PAIRING; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA REPAIR; DNA REPLICATION; DNA SEQUENCE; FIBROBLAST; GENE LOCUS; HETEROCHROMATIN; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RADIATION DOSE FRACTIONATION; SINGLE STRANDED DNA BREAK; TELOMERE;

ANIMALS; CELL CYCLE; CELLS, CULTURED; DNA DAMAGE; FIBROBLASTS; HELA CELLS; HUMANS; MICE; NEURONS; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2;

MAMMALIA; PRIMATES;

EID: 84859372986     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2466     Document Type: Article

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