Dysfunctional telomeres at senescence signal cell cycle arrest via Chk2

Cell Cycle

Volumn 3, Issue 10, 2004, Pages 1217-1220

  Gire, Véronique ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

Chk2; DNA damage response; p53; Senescence; Telomere; Tumor suppressor

Indexed keywords

CHECKPOINT KINASE 2; DNA; PROTEIN P53; RETINOBLASTOMA PROTEIN;

CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CELL FUNCTION; CHROMOSOMAL INSTABILITY; DNA DAMAGE; FIBROBLAST; GENOMIC INSTABILITY; HUMAN; HYPOTHESIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE;

EID: 13944261190     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.10.1167     Document Type: Review

References (48)

1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25:585-621.
2. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345:458-60.
3. Wright WE, Shay JW. Historical claims and current interpretations of replicative aging. Nat Biotechnol 2002; 20:682-8.
4. Kim NW, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266:2011-5.
5. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. Embo J 1995; 14:4240-8.
6. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999; 283:1321-5.
7. Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J 2002; 21:4338-48.
8. Satyanarayana A, Wiemann SU, Buer J, Lauber J, Dittmar KE, Wustefeld T, et al. Telomere shortening impairs organ regeneration by inhibiting cell cycle reentry of a subpopulation of cells. EMBO J 2003; 22:4003-13.
9. de Lange T. Protection of mammalian telomeres. Oncogene 2002; 21:532-40.
10. Harley CB. Telomere loss: Mitotic clock or genetic time bomb? Mutat Res 1991; 256:271-82.
11. Wynford-Thomas D, Bond JA, Wyllie FS, Jones CJ. Does telomere shortening drive selection for p53 mutation in human cancer? Mol Carcinog 1995; 12:119-23.
12. Bond J, Haughton M, Blaydes JP, Gire V, Wynford-Thomas D, Wyllie F. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. Oncogene 1996; 13:2097-104.
13. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994; 211:90-8.
14. Bond JA, Wyllie FS, Wynford-Thomas D. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 1994; 9:1885-9.
15. Gire V, Wynford-Thomas D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol Cell Biol 1998; 18:1611-21.
16. Serrano M, Blasco MA. Putting the stress on senescence. Curr Opin Cell Biol 2001; 13:748-53.
17. Di Leonardo A, Linke SP, Clarkin K, Wahl GM. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 1994; 8:2540-51.
18. Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J 2004; 25:2554-63.
19. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, von Zglinicki T, et al. A DNA damage checkpoint response in telomereinitiated senescence. Nature 2003; 426:194-8.
20. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 2004; 6:168-70.
21. Herbig U, Jobling WA, Chen BP Chen DJ, Sedivy JM. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 2004; 14:501-13.
22. Bartek J, Falck J, Lukas J. CHK2 kinase-a busy messenger. Nat Rev Mol Cell Biol 2001; 2:877-86.
23. McGowan CH. Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor. Bioessays 2002; 24:502-11.
24. Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, et al. Reversal of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J 2003; 22:4212-22.
25. Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991; 196:33-9.
26. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu C-P, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-52.
27. Zhu J, Wang H, Bishop JM, Blackburn EH. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA 1999; 96:3723-8.
28. Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13:1549-56.
29. Shiloh Y. ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
30. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-9.
31. Stewart SA, et al. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet 2003; 33:492-6.
32. Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science 2002; 295:2446-9.
33. Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T. ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell 2003; 12:1489-98.
34. Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300.
35. Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001; 268:2764-72.
36. Webley K, Bond JA, Jones CJ, Blaydes JP, Craig A, Hupp T, et al. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol Cell Biol 2000; 20:2803-8.
37. Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, et al. Heterozygous germ line hCHK2 mutations in Li-fraumeni syndrome. Science 1999; 286:2528-31.
38. Metcalfe JA, Parkhill J, Campbell L, Stacey M, Biggs P, Byrd PJ, et al. Accelerated telomere shortening in ataxia telangiectasia. Nat Genet 1996; 13:350-3.
39. Chan SW, Chang J, Prescott J, Blackburn EH. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol 2001; 11:1240-50.
40. Craven RJ, Greenwell PW, Dominska M, Petes TD. Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 2002; 161:493-507.
41. Chan SW, Blackburn EH. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell 2003; 11:1379-87.
42. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
43. Khanna KK, Jackson SP. DNA double-strand breaks: Signaling, repair and the cancer connection. Nat Genet 2001; 27:247-54.
44. Nowell PC, Croce CM. Chromosomes, genes, and cancer. Am J Pathol 1986; 125:7-15.
45. Counter CM, Avilion AA, Lefeuvre CE, Stewart NG, Greider CW, Harley CB, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992; 11:1921-9.
46. van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92:401-13.
47. Hackett JA, Feldser DM, Greider CW Telomere dysfunction increases mutation rate and genomic instability. Cell 2001; 106:275-86.
48. Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer. Science 2002; 297:565-9.