Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal

Science

Volumn 327, Issue 5973, 2010, Pages 1657-1661

  Sfeir, Agnel ^a   Kabir, Shaheen ^a   Van Overbeek, Megan ^a,b   Celli, Giulia B ^a   De Lange, Titia ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DNA; RAG1 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 2;

CHROMOSOME; COMPARTMENTALIZATION; DNA; GENE EXPRESSION; GENETIC ENGINEERING; PROTEIN; RECOMBINATION; RODENT;

ARTICLE; CHROMOSOME; DNA DAMAGE; DNA REPAIR; GENE DELETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TELOMERE;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENE DELETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; SISTER CHROMATID EXCHANGE; TELOMERE; TELOMERE-BINDING PROTEINS; TELOMERIC REPEAT BINDING PROTEIN 2; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA; MUS;

EID: 77950196212     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1185100     Document Type: Article

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21. D. White, H. Takai, and the Rockefeller University Transgenics Facility are thanked for help in generating genetically modified mice. We thank L. Jovine for identifying the conserved helix in TRF2. A.S. is supported by Susan G. Komen for the Cure. G.B.C. was supported by the Women in Science Fellowship Program and The Leukemia & Lymphoma Society. Supported by NIH grants AG016642 and GM049046.