XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

Nature Genetics

Volumn 37, Issue 10, 2005, Pages 1063-1071

  Muñoz, Purificación ^a   Blanco, Raquel ^a   Flores, Juana M ^b   Blasco, María A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEASE; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG; XPF NUCLEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; FEMALE; GENOMIC INSTABILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN CANCER; SKIN CARCINOGENESIS; TELOMERE; ULTRAVIOLET IRRADIATION; XERODERMA PIGMENTOSUM;

AGING, PREMATURE; ANIMALS; CATTLE; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; KERATINOCYTES; MICE; MICE, MUTANT STRAINS; RNA, MESSENGER; RNA, NEOPLASM; SEQUENCE DELETION; SKIN NEOPLASMS; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2; TRANS-ACTIVATION (GENETICS); ULTRAVIOLET RAYS;

ANIMALIA;

EID: 27144515686     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1633     Document Type: Article

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