Does damage to DNA and other macromolecules play a role in aging? If so, how?

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 2, 2009, Pages 175-178

  Campisi, Judith ^a,b   Vijg, Jan ^c  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Cellular senescence; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DNA; FREE RADICAL; LIPID; MITOCHONDRIAL DNA; PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SCLEROPROTEIN;

AGING; BACTERIAL ARTIFICIAL CHROMOSOME; CELL ACTIVITY; CELL CYCLE ARREST; CELL DAMAGE; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENE LOCUS; GENE MUTATION; HUMAN; INVERTEBRATE; IONIZING RADIATION; LIFESPAN; MACROMOLECULE; MINICHROMOSOME; NONHUMAN; PHENOTYPE; PLEIOTROPY; PREMATURE AGING; PRIORITY JOURNAL; SENESCENCE; ULTRAVIOLET RADIATION; AGED; ANIMAL; ANIMAL MODEL; APOPTOSIS; CELL AGING; DROSOPHILA; GENETICS; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; RAT; REVIEW; SENSITIVITY AND SPECIFICITY; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; AGING; ANIMALS; APOPTOSIS; CELL AGING; DNA DAMAGE; DROSOPHILA; HUMANS; MACROMOLECULAR SUBSTANCES; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; SENSITIVITY AND SPECIFICITY;

EID: 64949135819     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/gln065     Document Type: Conference Paper

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